scholarly journals Safety and Efficacy of Ferric Carboxymaltose in Anemic Pregnant Women: A Retrospective Case Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Anouk Pels ◽  
Wessel Ganzevoort
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Ferric Carboxymaltose ◽  
Control Group ◽  
Efficient Treatment ◽  
Safety And Efficacy ◽  
Anemia During Pregnancy ◽  
Control Study

Background. Anemia during pregnancy is commonly caused by iron deficiency and can have severe consequences for both the mother and the developing fetus. The aim of this retrospective study was to assess the safety and efficacy of intravenous ferric carboxymaltose (FCM) in pregnant women.Methods. All women treated with FCM for anemia during pregnancy between 2010 and 2012 at our institution were included. A matched control group was selected, including women who either were nonanemic or had anemia but were not considered for intravenous iron. Main outcome measures were maternal safety and pregnancy outcomes.Results. The study included 128 patients (FCM: 64; control: 64). Median FCM dose was 1000 mg and median gestational age at the time of first treatment was 34 weeks and 6 days. Median Hb increased from 8.4 g/dL (interquartile range 7.7; 8.9 g/dL) at the first FCM administration to 10.7 g/dL (9.8; 11.5 g/dL;n=46with available Hb at delivery) at the time of delivery, achieving levels similar to those in the control group (10.8 g/dL [9.8; 11.8 g/dL;n=48]). No treatment-related adverse events were reported and no statistically significant differences in pregnancy outcomes were observed between groups.Conclusions. Within the limitations of this case control study, FCM was a safe and efficient treatment of anemia during pregnancy.

scholarly journals Pregnancy outcomes among SARS-CoV-2-infected pregnant women with and without underlying diseases: a case-control study

2021 ◽  
Vol 14 (4) ◽  
pp. 518-522
Author(s):  
Samereh Ghelichkhani ◽  
◽  
Ensiyeh Jenabi ◽  
Ebrahim Jalili ◽  
Azam Alishirzad ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Preterm Labor ◽  
Case Control Study ◽  
Risk Groups ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Underlying Diseases ◽  
Control Study

This study aimed to examine the pregnancy outcomes in women infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without underlying diseases in western Iran. This case-control study compared 49 pregnant women with Coronavirus disease (COVID-19) with underlying diseases (the case group) and 49 women with COVID-19 without underlying diseases (the control group). The groups were pregnant women with COVID-19 admitted to Hamadan hospitals for delivery. COVID-19 was diagnosed by using the reverse transcriptase-polymerase chain reaction (real-time RT-PCR). Data were evaluated using a checklist. Further, the Statistical Package for the Social Sciences (SPSS) version 16 was used for data analysis. A value of p<0.05 was considered statistically significant. The odds of preterm labor were five times higher in women with underlying diseases (OR=5.95, 95% CI (3.01, 7.15), p=0.034). Moreover, the odds of preeclampsia and eclampsia in women with underlying diseases was (OR=3.35, 95% CI (1.18, 4.93), p=0.048) and (OR=2.65, 95% CI (1.43, 3.54), p=0.035), respectively. The results revealed that preterm labor, preeclampsia, and eclampsia were significantly higher in women with COVID-19 and underlying diseases compared to those without underlying diseases. Thus, the need to identify and educate pregnant mothers on underlying diseases and attention to prenatal care, particularly in high-risk groups, is necessary for the COVID-19 pandemic.

Pregnancy outcomes in adolescents: a case-control study in the West of Iran

2021 ◽  
Vol 17 ◽  
Author(s):  
Salman Khazaei ◽  
Saeid Bashirian ◽  
Akram Bathaei ◽  
Mohadese Sadri ◽  
Fateme Shirani ◽  
...  
Keyword(s):  
Prenatal Care ◽  
Pregnant Women ◽  
Adolescent Pregnancy ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Adult Women ◽  
The West ◽  
Adolescent Women ◽  
Control Study

Background: Adolescent pregnancy, pregnancy in women aged between 13-19 years, is considered a major health problem. Objective: This study was performed to determine the maternal, perinatal, and neonatal outcomes of adolescent pregnancies. Materials and Methods: The present hospital-based case-control study was performed on pregnant women who were referred to Fatemieh Hospital in Hamadan City for delivery. The case group was pregnant women whose gestational age was less than 19 years (adolescent pregnancy) and the control group included pregnant women whose gestational age was at 19-35 years (adult women pregnancy). Data were analyzed using Stata software version 14. The significant level was considered less than 0.05. Results: The unwanted pregnancy was significantly higher in adolescent women (45% vs. 28.5%, P=0.002). 18% of adolescent women had the experience of spouse violence compared to 4.25% in the control group (P<0.001). Accessing prenatal care and supplements were significantly higher in adult women (P<0.05). The adult mothers had significantly higher cesarean section delivery compared adolescent group (54.91% vs. 33%, P<0.001). Also, there was a significant association between postpartum hemorrhages and the study group (22% in cases compared to 13.75% in the control group, P=0.04). The Apgar score 1 minute was significantly higher in adult mothers (8.05±2.08 vs. 7.39±2.05, P<0.001). Conclusion: In conclusion, adolescent mothers in the west of Iran had a higher risk of inadequate prenatal care, low Apgar score and postpartum hemorrhage. Therefore, society should focus on public health policies that can improve the adequacy of prenatal care among adolescents.

scholarly journals Mode of Delivery in Drug-Dependent Pregnant Women: A Case Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Ana Raquel Neves ◽  
Fabiane Neves ◽  
Isabel Santos Silva ◽  
Maria do Céu Almeida ◽  
Pitorra Monteiro
Keyword(s):  
Pregnant Women ◽  
Vaginal Delivery ◽  
Case Control Study ◽  
Mode Of Delivery ◽  
Case Control ◽  
Control Group ◽  
Maternal Characteristics ◽  
Drug Dependent ◽  
Route Of Delivery ◽  
Control Study

Objective. To determine the contribution of drug use during pregnancy to the route of delivery.Methods. A case-control study was conducted at a hospital in Coimbra, Portugal, between 2001 and 2014. Drug-dependent pregnant women (n=236) were compared with a control group of low risk women (n=228) in terms of maternal characteristics, obstetric history, pregnancy complications, and labor details. Factors that influenced the mode of delivery were determined. Statistical analysis was performed with SPSS v. 23.0 (IBM Corp.).pvalues < 0.05 were considered statistically significant.Results. Drug-dependent women presented a lower rate of cesarean delivery (18.2 versus 28.9%,p=0.006). After adjusting for the factors that were significantly related to the mode of delivery, drug dependency influenced the rate of cesarean section (β=0.567; 95% CI = 0.328–0.980). Within the drug-dependent group, the mode of delivery was significantly related to previous cesarean or vaginal delivery (p=0.008andp<0.001, resp.) and fetal presentation (p<0.001), but not with the type of drug, route of administration, or substitution maintenance therapy.Conclusions. The drug-dependent group presented a significantly higher rate of vaginal delivery. However, this was not associated with the behavioral factors analyzed. We hypothesize that other social and psychological factors might explain this difference.

scholarly journals Is gross morphology of placenta, umbilical cord, and neonatal outcome in well-controlled gestational diabetes mellitus pregnancy different? A case-control study

2020 ◽  
Author(s):  
Parichehr Pooransari ◽  
Atefeh Ebrahimi ◽  
Nataliya Nazemi ◽  
Fariba Yaminifar ◽  
Zhila Abediasl
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Pregnancy Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Placental Weight ◽  
Control Study

Background: The relation of placental gross morphology and the outcome of pregnancies complicated with diabetes mellitus in comparison with healthy pregnancies is not known. Identifying significant differences in pregnancy outcomes in Gestational Diabetes Mellitus (GDM) and healthy pregnancies by the means of morphologic measurements can induce the use of antenatal ultrasonography of placental parameters to predict pregnancy outcomes. Objective: This study aimed to evaluate the relationship between placental morphological parameters of the placenta and cord and the outcomes of pregnancies complicated with diabetes mellitus. Materials and Methods: In this case-control study, which was conducted at two referral perinatology center in Tehran between March 2017 and November 2018, 60 pregnant women with GDM who were controlled with either diet or insulin as the case group and 60 pregnant women without GDM as the control group were enrolled. The study population were selected from patients who had their prenatal care and delivery in Mahdieh and Shohadaye Tajrish Hospital. The data was collected by taking sickness history, using data from patients files, and measuring of placental and newborn parameters after delivery. GDM was diagnosed either by 75 gr or 100 gr oral glucose tolerance tests. Placenta parameters, umbilical cord features, and newborn outcomes were compared between the two groups. Results: Placental weight, diameter, number of lobes, thickness, placental weight tonewborn weight ratio, place of umbilical cord insertion, length, coiling, and diameter of the umbilical cord are similar in two groups. Newborn weight, NICU admission, ABG, and Apgar score are also the same in well-controlled GDM pregnancy and pregnancy without GDM. Conclusion: Good controlled GDM causes no difference in placental gross morphology and pregnancy outcome compared to a healthy pregnancy. Key words: Placenta, Umbilical cord, Gestational diabetes mellitus.

scholarly journals PREGNANCY OUTCOMES

2018 ◽  
Vol 21 (02) ◽  
pp. 347-353
Author(s):  
Manzoor Ahmad Naeem ◽  
Usra Naeem ◽  
Asif Hanif
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Pregnancy Outcomes ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorder ◽  
Pregnant Females ◽  
History Of ◽  
Control Study

Introduction: Pregnancy is a normal physiological event but some pregnancyspecific or other medical conditions can cause maternal as well as fetal morbidities and evenmortalities. Among them, raised blood pressure during pregnancy adversely affects bothmaternal and fetal outcomes. Objectives: In this study, risk factors associated with hypertensivedisorders of pregnancy are explored and pregnancy outcomes of hypertensive women withnormotensive pregnant women are compared. Design: Case control study. Settings: Obstetricsand gynecology department of Jinnah hospital Lahore. Period: 1st October 2011 to 24 February2012. Subjects and methods: The case control study of 250 cases (pregnant females withhypertensive disorders) and controls (pregnant females without hypertensive disorder),presented at obstetrics & gynecology department of Jinnah hospital during 1st October 2011 to24 February 2012 was conducted. SPSS software (16) and MS excel were used for statisticalanalysis. Results: Mean age for cases and controls was 26.96 ± 5.29yearsand 25.25 ±4.60years, respectively. Age and history of pregnancy was found to be significantly associatedwith hypertensive disorders of pregnancy. Comparison of neonatal outcome between casegroup and control group showed that hypertensive pregnant women were at higher risk of havingadverse pregnancy outcome. Conclusions: Women with hypertension during pregnancy are atincreased risk of having adverse pregnancy outcome as compared to normotensive women andage, history of pregnancy induced hypertension are contributing risk factors for developinghypertension during pregnancy.

scholarly journals Hyperthyroidism as a Potential Risk Factor for Placental Abruption: A Case Control Study

2021 ◽  
Author(s):  
Tomomi Kotani ◽  
Kenji Imai ◽  
Takafumi Ushida ◽  
Yoshinori Moriyama ◽  
Tomoko Kobayashi ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Case Control Study ◽  
Placental Abruption ◽  
Case Control ◽  
University Hospital ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Increased Risk ◽  
Control Study

Abstract BackgroundOvert hyperthyroidism and hypothyroidism are associated with pregnancy complications; however, most women with these conditions are diagnosed before conception and are under treatment during pregnancy, especially in the developed countries. The purpose of this study was to investigate pregnancy complications among these women.MethodsA retrospective case-control study was conducted, and data on 3824 pregnant women who gave birth at Nagoya University Hospital located in Japan from 2005 to 2014 was collected. The pregnancy outcomes were divided and compared among three groups: the control group (n = 3709), the hyperthyroidism group (n = 52) and the hypothyroidism group (n = 63). Risk factors for placental abruption were also evaluated in singleton pregnancies (n = 3588) by multivariable logistic regression analysis. Moreover, in hyperthyroidism, thyroid function was also compared between successful and failed placentation group, and the latter group included placental abruption and preeclampsia. ResultsThe incidence of placental abruption was significantly higher in hyperthyroidism than in control and hypothyroidism groups (p < 0.01). Hyperthyroidism was independently associated with an increased risk of placental abruption (adjusted odds ratio = 12.52, 95% confidence interval = 2.91–53.88). Thyroid stimulating hormone (TSH) was significantly lower in failed placentation group than in successful placentation group (p < 0.05). ConclusionAccording to the results of our study, pregnancy outcomes in women with treated hypothyroidism were comparable with those in women without thyroid disease. Conversely, women with treated hyperthyroidism showed an independent risk of placental abruption, which might be related with lower TSH level at early gestation. However, further research is required to validate our findings.

Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sule Goncu Ayhan ◽  
Atakan Tanacan ◽  
Aysegul Atalay ◽  
Selcan Sinaci ◽  
Eda Ozden Tokalioglu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Case Control ◽  
Ductus Venosus ◽  
Control Group ◽  
City Hospital ◽  
Fetal Doppler ◽  
Control Study ◽  
Prospective Case Control Study ◽  
Demographic Features

Abstract Objectives To investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on fetal Doppler parameters. Methods This was a prospective case-control study conducted in Ankara City Hospital with confirmed SARS-CoV-2 infected pregnants between August 1, 2020 and October 1, 2020. There were 54 COVID-19 confirmed pregnant women and 97 age-matched pregnant women as a control group between 28 and 39 weeks. Infection was confirmed based on positive real-time polymerase-chain reaction results. Demographic features, uterine artery (right, left), umblical artery, middle cerebral artery, ductus venosus, cerebro-placental ratio, and cerebral-placental-uterine ratio Doppler parameters were investigated in both groups. Results Two groups were similar in terms of demographic features and no difference was found for fetal Doppler parameters. Conclusions COVID-19 seems to have no adverse effect on fetoplacental circulation in mild and moderate patients during the acute phase of the infection.

scholarly journals Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Yao Cheng ◽  
Haoyue Teng ◽  
Yue Xiao ◽  
Mengxin Yao ◽  
Jieyun Yin ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Control Group ◽  
Neurobehavioral Development ◽  
Ages And Stages Questionnaires ◽  
Group 5 ◽  
Larger Sample ◽  
Control Study

Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of this study was to evaluate the potential influence of SARS-CoV-2 on infant neurobehavioral development.Methods: A case-control study was conducted in Wuhan Maternal and Child Health Hospital, China. Nine pregnant women with SARS-CoV-2 infection and 9 controls matched by maternal age, parity, and status of chronic disease were included. Infantile neurobehavioral development was assessed through the Ages and Stages Questionnaires Edition 3 (ASQ-3).Results: The majority of pregnant women with SARS-CoV-2 experienced cesarean section (7 of 9), which was higher than the control group (5 of 9). The throat swabs of all newborn were negative. We found that compared with the control group, neonates of mothers with SARS-CoV-2 infection during pregnancy had lower scores in communication, gross movement, fine movement, problem solving, and personal-social domains; but only fine movement domain yielded statistical significance (P = 0.031).Conclusion: Infection with SARS-CoV-2 during pregnancy may have a certain impact on infant neurobehavioral development. Further studies with larger sample size are warranted for validation.

scholarly journals Serum Calcium Level in Patients with Pre Eclampsia : A Case Control Study

2021 ◽  
Vol 20 (1) ◽  
pp. 33-36
Author(s):  
Rajasree Bhowmick ◽  
Juthi Bhowmik ◽  
Shiuly Chowdhury ◽  
Ayesha Najma Nur ◽  
Firoza Begum
Keyword(s):  
Pregnant Women ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Case Control Study ◽  
Calcium Supplementation ◽  
Case Control ◽  
Control Group ◽  
Group Data ◽  
Control Study

Background: To compare serum calcium level in pre-eclamptic women and normal pregnant women. Materials and methods: It was a case-control study carried out in patient Department of Fetomaternal Medicine unit in the Department of Obstetrics & Gynaecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. From September 2010 to February 2011. Total 60 cases, among them 30 comprising control group and 30 were cases. This was a non interventional case control study that was carried out on total 60 women with age range 18 to 38 years of them 30 healthy gravid women as control group and 30 pregnancy with pre eclampsia as case. Serum calcium level of the groups were measured, and compare between this two group. Data were analyzed by computer with the help of SPSS (Statistical Package for Social Sciences) win 13 software package. Results: Serum calcium in pre-eclamptic women was significantly low [7.88±0.75mg/dl vs 9.9267±0.58 mg/dl] than in normal pregnant women. Conclusion: Serum calcium may be used for earlier detection of preeclampsia. Further studies are required to investigate whether calcium supplementation can be used as a preventable measure for the development of preeclampsia. Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 33-36

scholarly journals Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study

2020 ◽  
Author(s):  
Na Li ◽  
Lefei Han ◽  
Min Peng ◽  
Yuxia Lv ◽  
Yin Ouyang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Vaginal Delivery ◽  
Respiratory Symptoms ◽  
Case Control Study ◽  
Case Control ◽  
Neonatal Outcomes ◽  
Control Group ◽  
Neonatal Complications ◽  
Maternal And Neonatal Outcomes ◽  
Control Study

AbstractBackgroundThe ongoing epidemics of coronavirus disease 2019 (COVID-19) have caused serious concerns about its potential adverse effects on pregnancy. There are limited data on maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia.MethodsWe conducted a case-control study to compare clinical characteristics, maternal and neonatal outcomes of pregnant women with and without COVID-19 pneumonia.ResultsDuring January 24 to February 29, 2020, there were sixteen pregnant women with confirmed COVID-19 pneumonia and eighteen suspected cases who were admitted to labor in the third trimester. Two had vaginal delivery and the rest took cesarean section. Few patients presented respiratory symptoms (fever and cough) on admission, but most had typical chest CT images of COVID-19 pneumonia. Compared to the controls, COVID-19 pneumonia patients had lower counts of white blood cells (WBC), neutrophils, C-reactive protein (CRP), and alanine aminotransferase (ALT) on admission. Increased levels of WBC, neutrophils, eosinophils, and CRP were found in postpartum blood tests of pneumonia patients. There were three (18.8%) and two (10.5%) of the mothers with confirmed or suspected COVID-19 pneumonia had preterm delivery due to maternal complications, which were significantly higher than the control group. None experienced respiratory failure during hospital stay. COVID-19 infection was not found in the newborns and none developed severe neonatal complications.ConclusionSevere maternal and neonatal complications were not observed in pregnant women with COVID-19 pneumonia who had vaginal delivery or caesarean section. Mild respiratory symptoms of pregnant women with COVID-19 pneumonia highlight the need of effective screening on admission.

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