scholarly journals Production of Sterilizing Agents fromCalendula officinalisExtracts Optimized by Response Surface Methodology

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Fatih Mehmet Goktas ◽  
Bilgesu Sahin ◽  
Sibel Yigitarslan
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Maximum Yield ◽  
Extraction Yield ◽  
Extraction Temperature ◽  
Optimum Conditions ◽  
Calendula Officinalis ◽  
Liquid Ratio ◽  
Symbiotic Relation ◽  
Temperature Time

The aim of this study was to produce hand sterilizing liquid and wet wipes with the extracts ofCalendula officinalis. Since this plant has well known antimicrobial activity due to its phytochemical constituents, the increase in the extraction yield was chosen as the principle part of the production process. To achieve the maximum yield, parameters of solid-to-liquid ratio, extraction temperature, and time were studied. The optimum conditions were determined by response surface methodology as 41°C, 7 h, and 3.3 g/200 mL for temperature, time, and solid-to-liquid ratio, respectively. The yield achieved at those conditions was found to be 90 percent. The highest amounts of flavonoids were detected at optimum, whereas the highest triterpene and saponin constituents were determined at different design points. The microbial efficiencies of extracts were determined by the inhibition of the growth of selected microorganisms. Different dilution rates and interaction times were used as parameters of inhibition. Not any of the constituent but symbiotic relation in-between reached the highest inhibition of 90 percent. The pH values of the extracts were 5.1 to 5.4. As a result, the extraction ofCalendula officinalisat the optimum conditions can be used effectively in the production of wet wipes and hand sterilizing liquid.

scholarly journals Optimization of Supercritical Carbon Dioxide Extraction of Quercus infectoria Oil

2015 ◽  
Vol 74 (7) ◽  
Author(s):  
Liza Md Salleh ◽  
Stashia ELeaness Rosland Abel ◽  
Gholamreza Zahedi ◽  
Russly Abd Rahman ◽  
Hasmida Mohd Nasir ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Goodness Of Fit ◽  
Maximum Yield ◽  
Extraction Yield ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Predicted Values ◽  
Artificial Neural Network Ann ◽  
Quercus Infectoria

This current study focuses on the modelling and optimization of supercritical fluid extraction of Quercus infectoria galls oil. In this case, response surface methodology (RSM) and artificial neural network (ANN) were applied for the modelling and prediction of extraction yield of galls oil. A 17-run Box-Behnken Design (BBD) was employed to statistically optimize the process parameters of SC-CO2 extraction of Quercus infectoria galls at a condition as follows: pressure (5000, 6000, 7000 Psi), temperature (40, 50, 60°C) and extraction time (30, 45, 60 min). The maximum yield of the extracted oil is1.12 % and the optimum conditions are at an extraction pressure of 5574 Psi; extraction temperature of 75°C and extraction time of 54 min. Under the optimal conditions, the experimental results agree with the predicted values obtained through analysis of variance (ANOVA). This indicates a successful response surface methodology and highly satisfactory goodness of fit of the model used. The analysis of experimental design for process optimization results demonstrates that temperature and extraction time are the main parameters that influence the oil extraction of Quercus infectoria.

scholarly journals Optimization of DHEA Extraction from Sweet Potato Pomace by Ultrasonic-Microwave Synergistic Employing Response Surface Methodology

2019 ◽  
Vol 102 (2) ◽  
pp. 680-682
Author(s):  
Junjian Ran ◽  
Xinhong Liang ◽  
Hanmei Du ◽  
Junliang Sun
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Sweet Potato ◽  
Extraction Method ◽  
Extraction Efficiency ◽  
Extraction Yield ◽  
Extraction Temperature ◽  
Liquid Ratio ◽  
Solid Liquid ◽  
Optimum Extraction

Abstract Background: A lot of sweet potato residues (SPR) were discarded and wasted. Objective: To make full use of the SPR. Methods: Ultrasonic microwave synergistic (UMS) extraction method was used to extractdehydroepiandrosterone (DHEA) in SPR. The extraction conditions were optimized by response surface methodology based on single factors. Results: The optimum extraction conditions were 1:25 (solid–liquid ratio), 300 W (microwave power), 30 min (extraction time), and 30°C (extraction temperature). The extraction yield of DHEA from SPR reached 117.25 μg/100 g. Conclusions: The advantage of UMS extractiontechnology is to make full use of the synergistic effect of ultrasound and microwave to improve extraction efficiency. Highlights: The technology provides an effective way to improve the DHEA extraction yield from the SPR in industrial production.

Optimization of Extraction of Tannins from Banana Peel Using Response Surface Methodology

2014 ◽  
Vol 678 ◽  
pp. 566-571
Author(s):  
Ting Ru Wu ◽  
Hong Ling Wang ◽  
Shi Wen Jiang ◽  
Dan Dan Liu ◽  
Fei Wei
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Extraction Yield ◽  
Extraction Time ◽  
Banana Peel ◽  
Extraction Temperature ◽  
Liquid Ratio ◽  
Optimized Conditions ◽  
Tannin Extraction

Response surface methodology (RSM) was employed to optimize the extraction conditions of tannins from banana peels. Based on the single-factor experiments, four independent variables including ethanol concentration, solid to liquid ratio, extraction time and extraction temperature were selected as affecting factors. According to central composite design (CCD) the four factor, five levels experiments were carried out with the tannin extraction yield as evaluation index. The results show that the optimized conditions are as follows: ethanol concentration of 75.44%, solid to liquid ratio of 1:35.34, extraction time of 7.94 h, extraction temperature of 62.85°C. Under the optimized conditions, the predicted tannin extraction yield reaches 58.55%, while the actual extraction yield is 57.42% with the relative error of 1.13%.

EXTRACTION OPTIMIZATION OF THREE INDEPENDENT VARIABLES OF ANTIOXIDANTS FROM BASIL LEAVES USING RESPONSE SURFACE METHODOLOGY

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (04) ◽  
pp. 20-28 ◽  
Author(s):  
Sulaiman M. Alnasser ◽  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Radical Scavenging ◽  
Extraction Yield ◽  
Extraction Time ◽  
Total Phenolic ◽  
Extraction Temperature ◽  
Optimum Conditions ◽  
Antioxidant Power ◽  
Independent Variables

The current study reports the antioxidant activity of Ocimum basilicum. Central composite design (CCD) was used to study the effect of variables on the extraction using magnetic stirrer (MST). Three independent variables including temperature, extraction speed, and extraction time were studied that optimize particular responses of total phenolic content, ferric reducing antioxidant power (FRAP), and DPPH free radical scavenging activity. The effect of the extraction temperature on extraction process was investigated in the range from 26.3oC to 93.6oC, extraction time, from 1 to 30 h, and extraction speed, in the range from 263 to 936 rpm. The extraction yield was significantly (P < 0.05) affected by all the variables. Temperature and extraction speed were found to have a marked effect while the extraction time was found to have possible minor effects. Graphical optimization determined the optimum conditions for the extraction. The optimum condition predicted an extraction yield of 20.49g/100g at 75.33oC for five hours at 73 rpm. Optimum conditions were determined to obtain highest extraction yield. Results showed that water/seed ratio was the most significant parameter, followed by temperature and time. All quantitative modeling and response surface methodology recommended that extraction temperature and time were the most effective parameters of MST process. However, extraction time was found out to be an insignificant factor in MST extraction of antioxidant and total phenolic compounds of O. basilicum.

scholarly journals Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Yingpeng Tong ◽  
Yu Jiang ◽  
Dan Guo ◽  
Yongqiu Yan ◽  
Shiping Jiang ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Extraction Yield ◽  
Extraction Time ◽  
Process Conditions ◽  
Extraction Temperature ◽  
Single Factor ◽  
Extraction Voltage ◽  
Homogenate Extraction

Saffron, which has many kinds of biological activities, has been widely used in medicine, cosmetics, food, and other fields of health promotion industries. Crocins are the main component of saffron (Crocus sativus L.). At present, most of the extraction methods for crocins require long time or special instruments to complete the process and some of them are not suitable for industrial production at present. In this article, homogenate extraction technology which is a convenient and efficient method was developed for crocins extraction from saffron. Firstly, the influences of extraction voltage, extraction time, ethanol concentration, and temperature on crocins yield were studied by single factor experiments; and then response surface methodology (RSM) was used to optimize levels of four variables based on the result of single factor experiments. Results showed that the optimum extraction process conditions for crocins were as follows: extraction voltage, 110 V; ethanol concentration, 70%; extraction temperature, 57°C; and extraction time, 40 s. Based on these conditions, the extraction yield of crocins can reach 22.76% which is higher than ultrasonic extraction method. Therefore, homogenate extraction is an effective way to extract crocins from saffron with higher extraction yield and shorter extraction time.

Optimization of the Ultrasonic Extraction of Gypenoside III from Gynostemma pentaphyllum by Response Surface Methodology

2012 ◽  
Vol 550-553 ◽  
pp. 1866-1870
Author(s):  
Xiao Dan Tang ◽  
Hai Yang Hang ◽  
Shao Yan Wang ◽  
Jing Xiang Cong
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Extraction Yield ◽  
Raw Material ◽  
Extraction Temperature ◽  
Optimal Conditions ◽  
Gynostemma Pentaphyllum ◽  
Bioactive Component ◽  
Yield Value ◽  
Ultrasonic Time

Gypenosides III is a major bioactive component which is rich in Gynostemma pentaphyllum. For better utilization of the native resource, response surface methodology was used to optimize the extraction conditions of gypenosides III from G. pentaphyllum. The effects of three independent variables on the extraction yield of gypenosides III were investigated and the optimal conditions were evaluated by means of Box-Behnken design. The optimal conditions are as follows: ratio of ethanol to raw material 25, extraction temperature 58°C and ultrasonic time 25min. Under these conditions, the yield of gypenoside III is 1.216±0.05%, which is agreed closely with the predicted yield value.

Optimization of aqueous extraction of orevactaene and flavanoid pigments produced by Epicoccum nigrum

2019 ◽  
Vol 48 (4) ◽  
pp. 301-308 ◽  
Author(s):  
Sawinder Kaur ◽  
Paramjit S. Panesar ◽  
Sushma Gurumayum ◽  
Prasad Rasane ◽  
Vikas Kumar
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Maximum Yield ◽  
Polynomial Equation ◽  
Extraction Process ◽  
Aqueous Extraction ◽  
Extraction Temperature ◽  
Content Type ◽  
Epicoccum Nigrum ◽  
Broken Rice

Purpose The extraction of bioactive compounds such as pigments from natural sources, using different solvents, is a vital downstream process. The present study aims to investigate the effect of different variables, namely, extraction temperature, mass of fermented rice and time on the extraction process of orevactaene and flavanoid pigment from Epicoccum nigrum fermented broken rice. Design/methodology/approach Central composite rotatable design under response surface methodology was used for deducing optimized conditions. The pigments were extracted under conditions of extraction temperature (40-70°C), mass of fermented rice (0.5-1.5 g) and time (30-90 min), using water as the extraction media. The experimental data obtained were studied by analysis of variance. Data were fitted to a second-order polynomial equation using multiple regression analysis. Findings The optimum conditions generated by the software for aqueous extraction process, i.e. extraction temperature of 55.7°C, 0.79 g of fermented matter and extraction time of 56.6 min, resulted in a pigment yield of 52.7AU/g orevactaene and 77.2 AU/g flavanoid. Research limitations/implications The developed polynomial empirical model for the optimal recovery of the orevactaene and flavanoid pigments could be used for further studies in prediction of yield under specified variable conditions. Practical implications The response surface methodology helped in optimizng the conditions for the eco-friendly low-cost aqueous extarction process for orevactaene and flavanoid pigments, produced by Epicoccum nigrum during solid state fermentation of broken rice. This optimization can provide the basis for scaling up for industrial extraction process. Originality/value This paper focuses on optimizing the extraction conditions to get the maximum yield of orevactaene and flavanoid pigments, using water as the extracting media. No literature is available on the optimization of the extraction process of Epicoccum nigrum pigments, to the best of the authors’ knowledge.

Optimization of Ultrasonic Extraction of Phenolics from Litchi Seed by Response Surface Methodology

2012 ◽  
Vol 610-613 ◽  
pp. 3387-3393
Author(s):  
Xiao Bing Huang ◽  
Li Jing Lin ◽  
Ji Hua Li ◽  
Xu Ran ◽  
Yong Fu Tang
Keyword(s):  
Response Surface Methodology ◽  
Regression Model ◽  
Response Surface ◽  
Maximum Yield ◽  
Methanol Concentration ◽  
Ultrasonic Extraction ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Quadratic Regression ◽  
Box Behnken Design

Optimization conditions for ultrasonic extraction of phenolics from litchi seed were studied using response surface methodology. A Box–Behnken design (BBD) was applied to determine the effects of extraction temperature, methanol concentration and extraction time on yield of phenolics. Then a quadratic regression model was developed and found to be statistically significant by examining its adequacy. According to the model, the maximum yield of phenolics was obtained at the theoretical extraction conditions described as follows: extraction temperature 90°C, methanol concentration 59% and extraction time 70 min. Under this condition, the experimental value was 5.48 ± 0.03% (n = 3) with gallic acid as the equivalent, which agreed with the predicted value (5.52%) closely.

Optimization of Crude Polysaccharides Extraction from Plantago ovata Forsk Seed by Response Surface Methodology

2020 ◽  
Vol 16 (3) ◽  
pp. 354-363
Author(s):  
Ehsan Sadeghi ◽  
Reza Mohammadi ◽  
Mohammad H. Shirgardoun ◽  
Fatemeh Askari ◽  
Masoumeh Taghizadeh ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Food Packaging ◽  
Polynomial Equation ◽  
Edible Films ◽  
Extraction Yield ◽  
Raw Material ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Plantago Ovata

Background: Plantago ovata Forsk (Psyllium seed) is an annual plant of plantago genus. This plant widely grows in India and Iran. The Psyllium seed contains mucilage, protein, sugar, fat and tannins. Seed’s husk is a known source to extract hydrocolloid. Objective: The aim of this study was to optimize gum extraction from the Psyllium seed. Methods: The response surface methodology (RSM) was used to estimate the effect of independent variables on the extraction yield of Psyllium gum. The obtained experimental data were fitted to a second- order polynomial equation using multiple regression analysis and analyzed by appropriate statistical methods. A central composite design (CCD) was used for experimental design and analysis of the results to obtain the best possible combination of extraction temperature (X1= 60-80°C), extraction time (X2= 1-3 h), and the ratio of water to raw material (X3= 30-70%) for the maximum gum extraction. Results: Optimum extraction conditions were extraction temperature of 79°C, extraction time of 2.5 h, and the ratio of water to the raw material of 57%. The experimental extraction yield under optimal conditions was found to be 9 ± 0.25%, which was in agreement with the predicted value of 9.4%. Conclusion: This study showed that Psyllium gum can be used as a hydrocolloid source for pharmaceutical and food industry such as edible films for food packaging.

scholarly journals Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Salamet Edirs ◽  
Ablajan Turak ◽  
Sodik Numonov ◽  
Xuelei Xin ◽  
Haji Akber Aisa
Keyword(s):  
Response Surface Methodology ◽  
Quantitative Analysis ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Extraction Yield ◽  
Solvent Ratio ◽  
Extraction Temperature ◽  
Inhibition Rate ◽  
Main Components ◽  
Ptp 1B

By using extraction yield, total polyphenolic content, antidiabetic activities (PTP-1B and α-glycosidase), and antioxidant activity (ABTS and DPPH) as indicated markers, the extraction conditions of the prescription Kursi Wufarikun Ziyabit (KWZ) were optimized by response surface methodology (RSM). Independent variables were ethanol concentration, extraction temperature, solid-to-solvent ratio, and extraction time. The result of RSM analysis showed that the four variables investigated have a significant effect (p<0.05) for Y1, Y2, Y3, Y4, and Y5 with R2 value of 0.9120, 0.9793, 0.9076, 0.9125, and 0.9709, respectively. Optimal conditions for the highest extraction yield of 39.28%, PTP-1B inhibition rate of 86.21%, α-glycosidase enzymes inhibition rate of 96.56%, and ABTS inhibition rate of 77.38% were derived at ethanol concentration 50.11%, extraction temperature 72.06°C, solid-to-solvent ratio 1 : 22.73 g/mL, and extraction time 2.93 h. On the basis of total polyphenol content of 48.44% in this optimal condition, the quantitative analysis of effective part of KWZ was characterized via UPLC method, 12 main components were identified by standard compounds, and all of them have shown good regression within the test ranges and the total content of them was 11.18%.

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