scholarly journals Maxillary Sinus Inflammatory Myofibroblastic Tumors: A Review and Case Report

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Chase C. Hansen ◽  
Colby Eisenbach ◽  
Carlos Torres ◽  
Suzanne Graham ◽  
Fred Hardwicke
Keyword(s):  
Maxillary Sinus ◽  
Tumor Regression ◽  
The Body ◽  
Invasive Potential ◽  
Inflammatory Myofibroblastic Tumors ◽  
Cytogenetic Profile ◽  
Single Lesion ◽  
Complete Tumor

An inflammatory myofibroblastic tumor (IMT) is an immunohistochemically diverse entity demonstrating neoplastic and nonneoplastic qualities. Although IMTs can arise in any area of the body, lesions arising in certain sites, namely, the nasal cavity, paranasal sinuses, and pterygopalatine fossa, demonstrate a heightened neoplastic and invasive potential. Despite case specific complete tumor regression and disease remission in response to pharmacotherapeutics, a subset of IMTs remain resistant to all forms of therapy. We present such a case, a 34-year-old female patient, with a highly resistant, maxillary sinus IMT. Her refractory, ALK-1 negative IMT has not responded well to novel therapies reported in current literature. This case suggests the role of zonal expressivity within a single lesion as a probable mechanism for its highly resistant nature and should promote determination of each IMT’s cytogenetic profile to provide more effective targeted therapy. Paper includes a literature review of all maxillary sinus IMTs from 1985 to 2014 along with their immunohistochemical staining, treatments, and outcomes.

scholarly journals Role of the esc+ gene product in ensuring the selective expression of segment-specific homeotic genes in Drosophila

Development ◽  
1983 ◽  
Vol 76 (1) ◽  
pp. 297-331
Author(s):  
Gary Struhl
Keyword(s):  
Gene Product ◽  
The Body ◽  
Homeotic Genes ◽  
Bithorax Complex ◽  
Sex Combs Reduced ◽  
Sex Combs ◽  
Correct Determination ◽  
Correct Expression

The product of the extra sex combs+ (esc+) gene is required during embryogenesis for the correct determination of segments in Drosophila. If this product is absent, most segments develop like the normal eighth abdominal segment. Here, I extend previous results (Struhl, 1981a) showing that this phenotype results in large part from indiscriminate expression of the bithorax-complex genes which are normally active only in particular segments of the thorax and abdomen. In addition, I test whether the esc+ gene product is required for the correct expression of other homeotic genes. First, I have examined two genes of the Antennapedia-complex (Sex combs reduced+ and Antennapedia+): I find that both genes are normally required in only some of the body segments, but that in the absence of the esc+ gene product, both appear to function adventitiously in other segments. Second, comparing esc+ and esc− embryos lacking both these genes as well as the bithorax-complex, I find that additional homeotic genes (possibly those normally involved in specifying head segments) appear to be expressed indiscriminately when the esc+ gene product is absent. Finally, I present evidence that the products of the esc+ gene and the Polycomb+ gene (a second gene required for the correct regulation of the bithorax-complex) act independently. On the basis of these results, I propose a tentative outline of the roles and realms of action of all of these genes.

scholarly journals The role of osteodystrophy in the pathogenesis of aseptic pododermatitis in cows

2019 ◽  
Vol 21 (96) ◽  
pp. 129-133
Author(s):  
N. M. Khomyn ◽  
A. R. Mysak ◽  
S. V. Tsisinska ◽  
V. V. Pritsak ◽  
Yu. M. Lenyo ◽  
...  
Keyword(s):  
Volumetric Analysis ◽  
The Body ◽  
Farm Animals ◽  
Aseptic Inflammation ◽  
True Value ◽  
Livestock Products ◽  
Final Confirmation

It is well known that the value of full feeding of farm animals is an important condition for the production of livestock products. Because of the researches of many scientists was found that the value of feed is determined by the content of proteins, fats, carbohydrates, as well as vitamins, minerals and so on. However, the true value of the feed is determined by the part that is digestible and can be used by the body in the metabolism process. In the event of a violation of feeding level associated with the lack of nutrients or minerals of animals or their deficiency, the development of osteodystrophic processes is observed, which directly contribute to changes in the tendon-ligamentous apparatus of the finger of animals, there is an occurrence of prolonged osteotendinitis of the finger flexors, which causes to fingers extension, partially or completely removed from the hoof wall support, and overload of crumbs. Tightening of the crumb support is accompanied by the appearance of the skin of the hoof inflammatory process, excessive horn growth and deformation of the horn capsule. The final confirmation of osteodystrophy is the results of a multivariate mass volumetric analysis of the skeleton state and determination of the magnitude of the angles of the joints of the fingers. On the side of the hoof horn, there is an increase in the moisture content and SH-groups and a decrease in g-keratosis, which affects the biophysical properties of the hoof horn, which are shown by a decrease in density and hardness. Such changes indicate a deterioration in the quality of the hoof horn, a confirmation of which is a decrease in the intensity of erasing of the sole horn, the development of deformation and the occurrence of aseptic inflammation of the base of the skin of the sole horn.

The role of the main ingredients of chocolate in the formation of its beneficial properties for the consumer

2021 ◽  
pp. 582-587
Author(s):  
I.V. Goloviznin ◽  
A.V. Ryzhakova
Keyword(s):  
Human Health ◽  
Complete Information ◽  
The Body ◽  
Specific Product ◽  
Regular Process ◽  
The World ◽  
The Impact ◽  
Confectionery Product

Chocolate is the most staple and consumed confectionery product in Russia and the world. The determination of the beneficial properties of such a product as chocolate is an important and regular process of food institutions in every country, since new lines of already well-known manufacturers and new manufacturers with an innovative assortment are added to the retail assortment. Today, it is very relevant and important to understand the impact of new products on human health. In this regard, in order to provide complete information on a specific product, it is necessary to know its composition, ingredients and their effect on the body separately and within the framework of a specific product. Along with its beneficial properties, chocolate can also affect health negatively. It is necessary to understand the mechanism of the effect of chocolate on human health when consumed and to assess the risks that may arise subsequently after its active consumption.

scholarly journals The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma.

1988 ◽  
Vol 167 (3) ◽  
pp. 1086-1099 ◽  
Author(s):  
R J North ◽  
E A Havell
Keyword(s):  
Tumor Regression ◽  
Convincing Evidence ◽  
Cell Mediated Immunity ◽  
Complete Regression ◽  
Essential Requirement ◽  
Hemorrhagic Necrosis ◽  
Complete Tumor

In agreement with the results of previous studies (1), it was shown that intravenous injection of endotoxin into mice bearing 9-d SA1 sarcoma resulted in a tumor hemorrhagic reaction that rapidly caused necrosis of most of the center of the tumor, and then the complete regression of the rim of living tumor tissue that survived the hemorrhagic reaction. The tumor hemorrhagic reaction was confined to the vascular bed of the tumor, and its rate and extent of development were measured in terms of the intratumor extravasation of 51Cr-labeled syngeneic red cells. The development of the hemorrhagic reaction was associated with the presence in the tumor over a 6-h period of endogenous TNF that was measured in terms of its capacity to kill L929B cells in vitro and identified by its susceptibility to neutralization with a monospecific, polyvalent anti-rTNF antibody. The same antibody was capable in vivo of inhibiting the endotoxin-induced tumor hemorrhagic reaction by only approximately 50%, even when present in the tumor in excess. However, it was capable when given in the same quantity of inhibiting the ability of endotoxin to cause complete tumor regression. The fact that TNF was generated in the tumor during the tumor hemorrhagic reaction, and that infusion of a sufficient quantity of anti-rTNF antibody severely interfered with hemorrhagic necrosis and prevented tumor regression represents convincing evidence that TNF is an essential participant in endotoxin-induced regression of an established SA1 sarcoma. Moreover, because tumor regression, as opposed to hemorrhagic necrosis, failed to occur if the tumor was growing in immunoincompetent mice, but did so if the mice were infused with tumor-sensitized T cells, it can be concluded that an adequate level of T cell-mediated immunity is also an essential requirement for endotoxin-induced tumor regression. The participation of other endotoxin-induced mediators in tumor regression cannot be ruled out.

Space Orientation of Total Hip Prosthesis

1986 ◽  
Vol 27 (6) ◽  
pp. 619-627 ◽  
Author(s):  
K. Herrlin ◽  
G. Selvik ◽  
H. Pettersson
Keyword(s):  
Present Method ◽  
Hip Prosthesis ◽  
The Body ◽  
Neutral Position ◽  
Total Hip Prosthesis ◽  
Total Hip ◽  
Prosthetic Loosening

A method for in vivo determination of orientation and relation in space of components of total hip prosthesis is described. The method allows for determination of the orientation of the prosthetic components in well defined anatomic planes of the body. Furthermore the range of free motion from neutral position to the point of contact between the edge of the acetabular opening and the neck of the femoral component can be determined in various directions. To assess the accuracy of the calculations a phantom prosthesis was studied in nine different positions and the measurements of the space oriented parameters according to the present method correlated to measurements of the same parameters according to Selvik's stereophotogrammetric method. Good correlation was found. The role of prosthetic malpositioning and component interaction evaluated with the present method in the development of prosthetic loosening and displacement is discussed.

scholarly journals Determination of Cholesterol and Triglyceride Concentrations in Serum Extracellular Vesicles Using Commercial Kits

2021 ◽  
Vol 4 (2) ◽  
pp. e00148
Author(s):  
A.A. Yakovlev ◽  
V.D. Antonov ◽  
T.A. Druzhkova ◽  
A.B. Guekht ◽  
N.V. Gulyaeva
Keyword(s):  
Blood Serum ◽  
Healthy Volunteers ◽  
Extracellular Vesicles ◽  
The Body ◽  
Control Group ◽  
Sensitivity Threshold ◽  
Commercial Kits ◽  
Average Size

Exosomes and microvesicles, collectively referred to as small extracellular vesicles (sEV) are vesicles with an average size of about 100-150 nm. Currently, the role of sEV in various aspects of signaling in the body is being actively investigated; in addition, sEV can often serve as markers of various pathologies. The active study of the sEV composition is continuing. In this study we have demonstrated that in sEV it is possible to determine cholesterol and triglycerides concentration by using commercial kits designed for serum. The technique was tested on sEV from the blood of patients diagnosed with depression and on healthy volunteers. No differences were found in the concentration of cholesterol and triglycerides in mEV from the blood serum of depressed patients and the control group. The concentration of cholesterol and triglycerides in the samples is several times higher than the sensitivity threshold of the methods set by the manufacturer of the kits.

Determination of Cell Function in an Insect

Development ◽  
1953 ◽  
Vol 1 (3) ◽  
pp. 269-277
Author(s):  
V. B. Wigglesworth
Keyword(s):  
Cell Function ◽  
Single Layer ◽  
Rhodnius Prolixus ◽  
Epidermal Cells ◽  
The Body ◽  
Dermal Glands ◽  
Clear Space

I Propose to consider two kinds of determination and differentiation which have been studied in the hemipteron Rhodnius prolixus. (i) The determination of the cell or group of cells, with their subsequent differentiation to produce a given part of the body, (ii) The determination or control of the characters of that part—whether these are to be juvenile (larval) or adult (imaginal). Discussion of this second type of determination will require consideration of the role of hormones in controlling differentiation in insects. The integument of the abdomen in the Rhodnius larva consists of a single layer of epidermal cells and the overlying cuticle. At regular intervals the cuticle is modified to form little plaques each of which bears an innervated bristle (Wigglesworth, 1933). The cuticle is pierced at intervals by the ducts of dermal glands: these form a cluster of 4 or 5 around each plaque, with occasional single glands in the clear space between (Wigglesworth, 1947) (Fig. 3, A).

Intra-Tumor Injection of CAR-Engineered NK Cells Induces Tumor Regression and Protection Against Tumor Re-Challenge

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 466-466 ◽  
Author(s):  
Laurent Boissel ◽  
Hans Klingemann ◽  
Junaid Khan ◽  
Patrick Soon-Shiong
Keyword(s):  
Nk Cells ◽  
Cancer Cells ◽  
Tumor Size ◽  
Tumor Regression ◽  
The Body ◽  
Immune Memory ◽  
Employment Equity ◽  
Complete Tumor Regression ◽  
Equity Ownership ◽  
Complete Tumor

Abstract In this era of cancer immunotherapy, the long-term goal of treatment is to eliminate tumor cells anywhere in the body through induction of a specific immune memory response. In addition to spontaneous cytotoxicity, ADCC, and cytokine release, NK cells contribute to an adoptive immune response through crosstalk with dendritic cells and T cells. To further characterize the NK cell-induced adoptive response, aNK cells (formerly NK-92) were transduced with a retrovirus construct coding for a second-generation anti-murine CD19-CAR to create targeted activated NK-92 cells (mCD19.taNK). mCD19.taNK cells were injected intra-tumorally (two injections of 5x106 cells, three days apart) into a murine model of syngeneic subcutaneous lymphoma, created by injecting 1x106 A20 cells into BALB/c mice. Tumor size was monitored over time, and mice showing complete tumor regression were re-challenged with another subcutaneous contralateral injection of A20 cells. mCD19.taNK cells effectively killed murine cancer cells in vitro (>60% killing at E:T ratio of 5:1). In vivo, intra-tumor injection of mCD19.taNK induced significant tumor regression versus saline (tumor volumes of 342 mm3 and 936 mm3, respectively at day 16, p<0.05) and significantly improved survival, with 75% of the mice showing complete tumor regression at day 32 (p<0.05). In contrast, injection of parental aNK cells did not significantly affect tumor size in mice (815 mm3at day 16). Upon re-challenge with A20 lymphoma cells, >80% mice remained free of tumor after 14 days. In conclusion, the human aNK cell line expressing an anti-murine CD19-CAR (mCD19.taNK) can effectively kill CD19-positive murine cancer cells. Moreover, intra-tumor injections of mCD19.taNK into a fully immunocompetent mouse model can induce tumor clearance and protection from tumor re-challenge, suggesting induction of a memory ("vaccine") effect after the injection of mCD19.taNK. Disclosures Boissel: NantKwest, Inc.: Employment. Klingemann:NantKwest, Inc.: Employment, Equity Ownership, Patents & Royalties. Khan:NantKwest, Inc.: Employment. Soon-Shiong:NantKwest, Inc.: Employment, Equity Ownership, Membership on an entity's Board of Directors or advisory committees.

scholarly journals Atopic Dermatitis and Psoriasis as Overlapping Syndromes

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
A. Bozek ◽  
M. Zajac ◽  
M. Krupka
Keyword(s):  
Atopic Dermatitis ◽  
Family History ◽  
Atopic Disease ◽  
Skin Lesions ◽  
The Body ◽  
T Helper 17 ◽  
Tnf Α ◽  
History Of

Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2  yrs were compared with 41 similar patients with AD only ( 5.3 ± 5.1  yrs) and 28 patients with PS only ( 6.4 ± 4.3  yrs). All patients underwent dermatological examinations, including determination of SCORAD and PASI scores. TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-12, IL-17, IL-18, IL-22, I:-33, and TARC/CCL17 were measured by ELISA according to the manufacturer’s instructions. Results. Patients with concomitant AD and PS were frequently boys and overweight and had skin lesions equally distributed throughout the body. Children with concomitant AD and PS were more likely to report a family history of atopic disease than children with only AD or PS, and those with AD were more likely to report a family history of atopic disease than those with PS. Significant differences were observed in the concentration of IL-17 between patients with AD and PS and those with only AD or PS: 9.1 ± 3.7  pg/ml vs. 4.8 ± 2.9  pg/ml; and 9.1 ± 3.7  pg/ml vs. 5.2 ± 3.9  pg/ml, respectively (PD vs. AD, p = 0.01 ; PD vs. PS, p = 0.03 ). Conclusions. AD and PS can coexist. The role of T helper 17 cells may be more essential than believed.

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