Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis

Objectives. Published data on resistin levels in patients with colorectal cancer (CRC) were conflicting and heterogeneous. We conducted a meta-analysis of observational studies to examine the association of circulating resistin levels with carcinogenesis of the CRC.Methods. Potentially eligible studies published up to November 2015 were searched through MEDLINE, EMBASE, Science Citation Index Expanded database, CNKI, and WanFang database. The pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) calculated by fixed- or random-effect model were used to estimate the effects.Results. A total of 11 studies involving 965 patients were admitted in our meta-analysis. The pooled effects indicated that resistin levels were higher in CRC patients compared to healthy controls (WMD: 1.47 ng/mL; 95% CI: 0.78 to 2.16), with significant heterogeneity across the studies (I2=72%,p<0.0001). Subgroup analyses and sensitivity analyses revealed that study quality, design, sample type, and resistin assays may account for this heterogeneity. No publication bias was observed.Conclusions. Our meta-analysis suggests that increased circulating resistin levels are associated with greater risk of colorectal cancer. Given the limited number of available studies and significant heterogeneity, larger well-designed randomized studies are warranted.

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Association between circulating leptin levels and multiple sclerosis: a systematic review and meta-analysis

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2017-135397 ◽

2018 ◽

Vol 94 (1111) ◽

pp. 278-283 ◽

Cited By ~ 3

Author(s):

Xue-Feng Xie ◽

Xiao-Hui Huang ◽

Ai-Zong Shen ◽

Jun Li ◽

Ye-Huan Sun

Keyword(s):

Multiple Sclerosis ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Control Group ◽

Sample Type ◽

Healthy Controls ◽

Eligibility Criteria ◽

Effect Model ◽

Healthy Control

AimLeptin, synthesised by adipocytes, has been identified as a hormone that can influence inflammatory activity. Several studies have investigated leptin levels in patients with multiple sclerosis (MS), but the results are not consistent. This study aims to derive a more precise evaluation on the relationship between circulating leptin levels and MS.DesignA comprehensive literature searched up to July 2017 was conducted to evaluate the association of circulating leptin levels and MS. The random-effect model was applied to calculate pooled standardised mean difference (SMD) and its 95% CI.Main outcome measuresCirculating leptin levels of patients with MS and healthy controls.ResultsOf 2155 studies identified, 33 met eligibility criteria and 9 studies with 645 patients with MS and 586 controls were finally included in the meta-analysis. Meta-analysis revealed that, compared with the healthy control group, the MS group had significantly higher plasma/serum leptin levels, with the SMD of 0.70% and 95% CI (0.24 to 1.15). Subgroup analyses suggested that the leptin levels of patients with MS were associated with region, age, study sample size, measurement type, gender and blood sample type.ConclusionOverall, our study suggests that patients with MS have a significantly higher leptin level than in healthy controls. Further mechanism studies and longitudinal large cohort studies are still needed to further reveal the role of leptin in the pathogenesis of MS.

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How much is reasonable to expect about overall survival (OS) benefit when designing studies with new drugs for patients affected by castration resistant prostate cancer (CRPC)? Meta-analysis of 23 randomized clinical trials (RCT) including 17,640 patients.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e16053 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e16053-e16053

Author(s):

Francesco Massari ◽

Francesca Maines ◽

Sara Pilotto ◽

Camillo Porta ◽

Paolo Carlini ◽

...

Keyword(s):

Treatment Strategy ◽

Significant Interaction ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Phase Iii ◽

Sensitivity Analyses ◽

Significant Heterogeneity ◽

Significant Difference

e16053 Background: Treatment decision making in patients affected by CRPC is difficult because the numerous available therapeutic opportunities can significantly affect OS. To demonstrate that comparing results in absence of head-to-head studies may lead to biased survival estimations, a literature-based meta-analysis was conducted. Methods: Hazard Ratios (HR) with 95% confidence intervals (CI) were extracted and cumulated according to a random-effect model from phase III trials. Sensitivity analyses were performed according to: 1) Treatment Strategy (TS, Chemotherapy versus Hormonal versus Immunotherapy versus Other), 2) Comparison (Chemotherapy versus Placebo versus Other), and 3) Disease setting with regard to treatment with Docetaxel (DOC),. Testing for heterogeneity was performed as well. Results: A significant heterogeneity for the 3 sensitivity analyses was found (p<0.0001). The cumulative HR in favor of (any) experimental arm was 0.91 (95% CI 0.84-0.99, p=0.028). We found a significant interaction according to the chosen TS (p<0.0001), in fact a significant difference in OS was more likely to be detected in RCT evaluating hormonal drugs (HR 0.76, 95% CI 0.64-0.92, p=0.005) versus studies testing immunotherapy (HR 1.16, 95% CI 0.86-1.56, p=0.31). With regard to Comparison, a significant interaction (p<0.0001) was found in favor of RCT having placebo as control (HR 0.86, 95% CI 0.76-0.97, p=0.015), versus studies evaluating chemotherapy (HR 1.00, 95% CI 0.84, 1.19, p=0.99). A significant interaction according to DOC-treatment was also detected (p<0.0001), being the Post-DOC the Setting where a significant OS benefit was more likely to be determined (HR 0.77, 95% CI 0.66-0.90, p=0.001). Conclusions: The cross-trials interpretation in absence of formal direct comparisons may drive biased conclusions with regard to OS estimation. When designing trials to evaluate drugs (or strategies) in CRPC, the expected OS benefit must take into account the comparator, the treatment strategy and the (eventual) pre-treatment with DOC.

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The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Journal of Diabetes Research ◽

10.1155/2014/805801 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 19

Author(s):

Liyuan Han ◽

Lina Zhang ◽

Wenhua Xing ◽

Renjie Zhuo ◽

XiaLu Lin ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Recessive Model ◽

Cochrane Library ◽

Published Data ◽

Case Control Studies ◽

Asian Populations ◽

Effect Model

Aims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic.Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF–2578C/A (rs699947), –1154G/A (rs1570360), –460T/C (rs833061), −634G>C (rs2010963), and +936C/T (rs3025039) in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0.Results. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20–8.41, andP(z)=0.01) in Asian and overall populations, while a significant association was also found between –460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12–4.01, andP(z)=0.02).Conclusions. Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061) is associated with elevated DR susceptibility.

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Detecting Melanoma Antigen Family A3 Expression in Solid/Non-Solid Human Tumor

10.21203/rs.3.rs-25597/v1 ◽

2020 ◽

Author(s):

Haoran Jiang ◽

Lihao Zhao ◽

Han Yang ◽

Mengjing Zhao ◽

Yuxia Duan ◽

...

Keyword(s):

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Human Tumor ◽

Squamous Carcinoma ◽

Cochrane Library ◽

Published Data ◽

Melanoma Antigen ◽

Effect Model ◽

Positive Rate

Abstract Background: MAGEA3 is a member of melanoma antigen family and has been recognized to express in many types of human cancers recently. In spite of the development of cancer vaccine, the prognostic value of MAGEA3 has not been well evaluated, due to the variability of clinical data and lack of clinical trials on the prognostic values.Method: Studies that evaluated MAGEA3 expression with a follow-up for at least 36 months were selected by searching in PubMed, WOS, Cochrane library, Embase. Published data was recorded and calculated into odds ratios (OR) for mortality in three or five years with Mantel-Haenszel random-effect model. Results: 11 studies were selected. The median positive rate was 45%. MAGEA3 always combines with worse survival on three or five years survival. The correlation between MAGEA3 and squamous carcinoma seemed stronger than adenocarcinoma on three-year OS while things got a reverse when it came to five-year OS. Most importantly, we found that all solid tumors originated from endoderm seemed to enjoy a strongest correlation among all the three germ layers.Conclusion: In this meta-analysis, we found that the expression of MAGEA3 can connect with worse outcome, and it probably can be a predictor for patients’ prognosis in clinical practice.

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Guided Insertion of Temporary Anchorage Device in Form of Orthodontic Titanium Miniscrews with Customized 3D Templates—A Systematic Review with Meta-Analysis of Clinical Studies

Coatings ◽

10.3390/coatings11121488 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1488

Author(s):

Maciej Jedliński ◽

Joanna Janiszewska-Olszowska ◽

Marta Mazur ◽

Livia Ottolenghi ◽

Katarzyna Grocholewicz ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Surgical Guide ◽

Surgical Guides ◽

Effect Model ◽

Literature Searches ◽

Mean Differences ◽

Temporary Anchorage Device

(1) Background: Miniscrew insertion, using a surgical guide, aims to avoid possible adverse effects or complications. With the higher availability of both 3D imaging and printing, 3D surgical guides have been used more frequently in orthodontics. The aim of the present systematic review was to find scientific clinical evidence concerning the precision of the 3D guided insertion of miniscrews for temporary orthodontic anchorage. (2) Methods: Literature searches were performed in the following five search engines: Pubmed (Medline), Pubmed Central, Scopus, Web of Science and Embase on 10 September 2021 (articles from 1950 to 10 September 2021). A meta-analysis was performed using the random-effect model, with Standardized Mean Differences (SMD) and 95% confidence intervals (95% CI) calculated as effect estimates. The heterogeneity was assessed quantitatively. (3) Results: The search strategy identified 671 potential articles. After the removal of duplicates, 530 articles were analyzed. Subsequently, 487 papers were excluded, because they were not associated with the subject of the study. Of the remaining 43 papers, 34 were excluded because they did not meet the methodological criteria. Finally, only nine papers were subjected to a qualitative analysis. (4) Conclusions: The current literature concerning guided miniscrew insertion reveals, for the most part, a low methodological level. High-quality clinical trials are in the minority. The use of surgical guides increases insertion accuracy, stability and reduces the failure rate of orthodontic miniscrews. Tooth-borne insertion guides supported on the edges of the teeth ensure a higher insertion precision compared to mucosa-borne ones. The study protocol was registered in PROSPERO under the number CRD42021267248.

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Effects of Exercise Interventions on Cognitive Adaptations for Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Exercise Science ◽

10.15857/ksep.2021.30.1.52 ◽

2021 ◽

Vol 30 (1) ◽

pp. 52-60

Author(s):

Hong-Bum Eun ◽

Seung-Soo Baek

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Ability ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Significant Heterogeneity ◽

Exercise Interventions ◽

Effect Model

PURPOSE: Old adults with mild cognitive impairment (MCI) are at high risk for developing dementia. Exercise is a promising intervention for cognitive decline. This study evaluated the effects of exercise interventions on cognitive adaptation for older adults with MCI and attempted to identify which specific modality of exercise is more effective.METHODS: National Assembly library, Research information sharing service, Google scholar databases from 1 January 2010 to 31 Oct 2020 were utilized for searching articles related to research purpose. Meta-analysis was conducted with Comprehensive Meta-Analysis 2.0 using the fixed-effect model for the available data without significant heterogeneity, or the random-effect model was used if appropriate.RESULTS:Through meta-analysis in 13 studies, the combination of aerobic and resistance movements significantly improved cognitive ability and showed that intervention in a particular week and time is of paramount importance to improving cognitive function.CONCLUSIONS: The Combination of aerobic and resistance exercise led to an improvement in cognitive ability and had a positive effect with a middle effect size on cognitive function in older adults with MCI.

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Reduced Risk of Colorectal Cancer With Use of Oral Bisphosphonates: A Systematic Review and Meta-Analysis

Journal of Clinical Oncology ◽

10.1200/jco.2012.42.9530 ◽

2013 ◽

Vol 31 (5) ◽

pp. 623-630 ◽

Cited By ~ 29

Author(s):

Nirav Thosani ◽

Sonali N. Thosani ◽

Sheetanshu Kumar ◽

Zoann Nugent ◽

Camilo Jimenez ◽

...

Keyword(s):

Colorectal Cancer ◽

Inverse Relationship ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Control Studies ◽

Significant Inverse Relationship ◽

Oral Bisphosphonate ◽

Effect Model ◽

Reduced Risk

Purpose The association between oral bisphosphonate (BP) intake and colorectal cancer (CRC) risk has been investigated in several recent studies with conflicting results. We summarized the evidence from the published studies in a categorical, dose-response meta-analysis. Methods Relevant studies were identified by a search of MEDLINE and EMBASE databases through January 15, 2012. We included studies that reported effect size estimates with 95% CIs for the association between exposure to oral BPs and risk of CRC. Results Three case-control studies with a total of 16,998 CRC cases and 108,197 controls and one cohort study with 94,405 individuals exposed to BPs and 283,181 unexposed to BPs were included in meta-analysis. The random effect model meta-analysis suggested reduced risk of CRC with exposure to oral BPs with pooled odds ratio (OR) of 0.87 (95% CI, 0.78 to 0.97). Significant inverse relationship was noted for 10 or more prescriptions categories, with pooled ORs of 0.71 (95% CI, 0.58 to 0.87). Similarly, the analysis for 1 to 3 years of use and more than 3 years of use of BPs suggested a significant inverse relationship, with pooled ORs of 0.76 (95% CI, 0.68 to 0.85) and 0.78 (95% CI, 0.61 to 0.99), respectively. Conclusion This meta-analysis suggests that the use of oral BPs at a dose of 10 or more prescriptions or 1 or more years of duration is associated with reduced risk of CRC. Further randomized controlled trials are needed to prove this association.

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Quantitative Assessment of the Association between Genetic Variants in MicroRNAs and Colorectal Cancer Risk

BioMed Research International ◽

10.1155/2015/276410 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Xiao-Xu Liu ◽

Meng Wang ◽

Dan Xu ◽

Jian-Hai Yang ◽

Hua-Feng Kang ◽

...

Keyword(s):

Colorectal Cancer ◽

Genetic Variants ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Population Based ◽

Effect Model ◽

High Risk Factor ◽

Rs11614913 Polymorphism ◽

Meta Analyses

Background. The associations between polymorphisms in microRNAs and the susceptibility of colorectal cancer (CRC) were inconsistent in previous studies. This study aims to quantify the strength of the correlation between the four common polymorphisms among microRNAs (hsa-mir-146a rs2910164, hsa-mir-149 rs2292832, hsa-mir-196a2 rs11614913, and hsa-mir-499 rs3746444) and CRC risk.Methods. We searched PubMed, Web of Knowledge, and CNKI to find relevant studies. The combined odds ratio (OR) with 95% confidence interval (95% CI) was used to estimate the strength of the association in a fixed or random effect model.Results. 15 studies involving 5,486 CRC patients and 7,184 controls were included. Meta-analyses showed that rs3746444 had association with CRC risk in Caucasians (OR = 0.57, 95% CI = 0.34–0.95). In the subgroup analysis, we found significant associations between rs2910164 and CRC in hospital based studies (OR = 1.24, 95% CI = 1.03–1.49). rs2292832 may be a high risk factor of CRC in population based studied (OR = 1.18, 95% CI = 1.08–1.38).Conclusion. This meta-analysis showed that rs2910164 and rs2292832 may increase the risk of CRC. However, rs11614913 polymorphism may reduce the risk of CRC. rs3746444 may have a decreased risk to CRC in Caucasians.

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Circulating endocan and preeclampsia: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20193219 ◽

2020 ◽

Vol 40 (1) ◽

Author(s):

Xia Lan ◽

Zhaoming Liu

Keyword(s):

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Normal Pregnancy ◽

Case Control ◽

Significant Heterogeneity ◽

Case Control Studies ◽

Effect Model ◽

Matched Case ◽

The Difference

Abstract Background: Endocan, a novel protein involved in inflammation and endothelial dysfunction, has been suggested to be related to preeclampsia, although the results of previous studies were not consistent. The aim of the study was to evaluate the potential difference of circulating endocan in women with preeclampsia and those with normal pregnancy. Methods: Matched case–control studies evaluating the difference of circulating endocan between women with preeclampsia and those with normal pregnancy were identified via systematic search of PubMed and Embase databases. A random-effect model or a fixed-effect model was used to pool the results according to the heterogeneity. Subgroup analysis was performed to evaluate whether the timing of preeclampsia onset affected the outcome. Results: Overall, eight matched case–control studies, including 451 women with preeclampsia and 442 women with normal pregnancy were included. Significant heterogeneity was detected among the included studies (P for Cochrane’s Q test = 0.006, I2 = 65%). Meta-analysis with a random-effect model showed that women with preeclampsia had significantly higher circulating level of endocan compared with women with normal pregnancy (standardized mean difference = 0.37, 95% confidence interval: 0.13–0.62, P = 0.003). Subsequent subgroup analyses showed that the difference of circulating endocan between women with early onset preeclampsia and those with normal pregnancy was not statistically different from that between women with late-onset preeclampsia and those with normal pregnancy (P for subgroup difference = 0.81). Conclusions: Women with preeclampsia have higher circulating endocan than those with normal pregnancy.

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Meta-Analysis of Maternal and Neonatal Outcomes Associated with the Use of Insulin Glargine versus NPH Insulin during Pregnancy

Obstetrics and Gynecology International ◽

10.1155/2012/649070 ◽

2012 ◽

Vol 2012 ◽

pp. 1-11 ◽

Cited By ~ 43

Author(s):

Jacques Lepercq ◽

Jay Lin ◽

Gillian C. Hall ◽

Edward Wang ◽

Marie-Paule Dain ◽

...

Keyword(s):

Insulin Glargine ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Severe Hypoglycemia ◽

Neonatal Outcomes ◽

Nph Insulin ◽

Effect Model ◽

Gestational Age At Delivery ◽

Mean Differences

As glargine, an analog of human insulin, is increasingly used during pregnancy, a meta-analysis assessed its safety in this population. A systematic literature search identified studies of gestational or pregestational diabetes comparing use of insulin glargine with human NPH insulin, with at least 15 women in both arms. Data was extracted for maternal outcomes (weight at delivery, weight gain, 1st/3rd trimesterHbA1c, severe hypoglycemia, gestation/new-onset hypertension, preeclampsia, and cesarean section) and neonatal outcomes (congenital malformations, gestational age at delivery, birth weight, macrosomia, LGA, 5 minute Apgar score>7, NICU admissions, respiratory distress syndrome, neonatal hypoglycemia, and hyperbilirubinemia). Relative risk ratios and weighted mean differences were determined using a random effect model. Eight studies of women using glargine (331) or NPH (371) were analyzed. No significant differences in the efficacy and safety-related outcomes were found between glargine and NPH use during pregnancy.

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