scholarly journals Allergic Fungal Rhinosinusitis: A Study in a Tertiary Care Hospital in India

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Ravinder Kaur ◽  
S. Lavanya ◽  
Nita Khurana ◽  
Achal Gulati ◽  
Megh S. Dhakad
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Nasal Discharge ◽  
Care Hospital ◽  
Deviated Nasal Septum ◽  
Direct Microscopy ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis

The study was conducted to study the occurrence and clinical presentation of allergic fungal rhinosinusitis (AFRS), characterize the same, and correlate with the microbiological profile. Clinically suspected cases of fungal rhinosinusitis (FRS) depending upon their clinical presentation, nasal endoscopy, and radiological evidences were included. Relevant clinical samples were collected and subjected to direct microscopy and culture and histopathological examination. 35 patients were diagnosed to have AFRS. The average age was 28.4 years with a range of 18–48 years. Allergic mucin was seen in all the AFRS patients but fungal hyphae were detected in only 20%. 80% of cases were positive for IgE. All the patients had nasal obstruction followed by nasal discharge (62.8%). Polyps were seen in 95% (unilateral (48.57%) and bilateral (45.71%)), deviated nasal septum was seen in 28.57%, and greenish yellow secretion was seen in 17.14%. Direct microscopy and septate hyphae were positive in 71.42% of cases. 91.4% of cases were positive by culture. 5.7% yielded mixed growth of A. flavus and A. niger. Prompt clinical suspicion with specific signs and symptoms along with timely sampling of the adequate patient specimens and the optimal and timely processing by microscopy and culture and histopathological examination is a must for early diagnosis and management.

scholarly journals Clinicopathological study of testicular tumors: an experience in a tertiary care hospital in Kashmir valley, Jammu and Kashmir, India

2017 ◽  
Vol 5 (6) ◽  
pp. 2741
Author(s):  
Ambreen Beigh ◽  
Sheikh Junaid ◽  
Arshi Beg ◽  
Summyia Farooq ◽  
Lateef Ahmed Wani ◽  
...  
Keyword(s):  
Prospective Study ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Published Data ◽  
Care Hospital ◽  
Kashmir Valley ◽  
Testicular Tumors ◽  
Rare Type ◽  
Jammu And Kashmir

Background: Testicular and paratesticular neoplasia are rare type of tumors affecting adolescents and young adults in India, as observed by paucity of published data. This study was undertaken to analyze the patterns of testicular tumors at a tertiary level hospital in Kashmir valley, Jammu and Kashmir, India highlighting the patient’s demography, clinical presentation, diagnostic evaluation and pathological finding.Methods: This 5-year (retrospective and prospective) study was performed in the Department of Pathology, Government Medical College Srinagar, Jammu and Kashmir, India from January 2012 to December 2016. For the retrospective study, all cases of testicular tumors, their histopathological reports and required clinical details were searched from records maintained in the Department of Pathology, GMC Srinagar, Jammu and Kashmir, India. For the prospective study, the orchiedectomy specimens received in our department were subjected to routine histopathological processing followed by a detailed gross and microscopic examination. Tumour typing and subtyping was done according to WHO classification (2004).Results: A total of 37 cases of testicular and paratesticular neoplasia were included in present study with a mean age of 35.1 years. Out of these 37 cases, 31 (83.78%) were malignant and 6 cases (16.22%) were benign. Right testis was affected in 70.3% of cases. The most common clinical presentation was scrotal swelling. Germ cell tumor was the most common type accounting for 89.2% of tumors followed by lymphomas (8.1%).Conclusions:It is concluded that despite new techniques in imaging and tumor marker assay, the diagnosis of testicular tumors is dependent upon histopathological examination. The present study fairly provides an insight into the clinical presentations, prevalence and patterns of testicular tumors. 

scholarly journals Clinicopathological Profile of Sino-nasal Masses at a Tertiary Care Hospital: A Descriptive Study

2021 ◽  
Vol 29 (2) ◽  
pp. 133-139
Author(s):  
Nitin Deosthale ◽  
Priyal Patil ◽  
Sonali Khadakkar ◽  
Pavani Garikapati ◽  
Kanchan Dhote ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Descriptive Study ◽  
Careful Examination ◽  
Care Hospital ◽  
Male Predominance ◽  
Neoplastic Lesion ◽  
Number Of Patients

Introduction The Sino-nasal mass is a common clinical entity. Although it has varied aetiology ranging from non-neoplastic to neoplastic, clinical presentation is overlapping that poses diagnostic dilemma. Objective of the study was to study the clinical profile of Sino-nasal masses in terms of demographic profile, clinical presentation and clinicopathological diagnosis. Materials and Methods A descriptive study was carried out at tertiary care hospital for 2 years. Clinically diagnosed cases of sino-nasal masses were included in the study. Previously treated cases, congenital lesions were excluded. Provisional diagnosis was made based on clinical and radiological evaluation. Diagnosis on histopathological examination was considered as definitive. Results Total of 75 patients were included in the study. Demographic data showed slight male predominance (M:F= 1.08:1), with most patients from age group 31-40 years (26.67%). Nasal obstruction was the most common presenting symptom. The number of patients with non-neoplastic lesion was 48; 17 patients had neoplastic benign lesions while 6 patients had neoplastic malignant lesions. Conclusion Large number of patients presents with trivial symptoms but need careful examination and appropriate diagnosis. Inflammatory lesions outnumbered neoplastic lesions in our study. Clinical suspicion and appropriate investigations can guide in timely intervention and management of these patients reducing the morbidity and mortality in these patients.

scholarly journals MICROBIOLOGICAL ASPECT OF FUNGAL RHINOSINUSITIS: STUDY CONDUCTED IN TERTIARY CARE HOSPITAL OF NORTH INDIA.

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Shubhdeep Kaur
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
North India ◽  
Treatment Modalities ◽  
Fungal Culture ◽  
Care Hospital ◽  
Direct Microscopy ◽  
Fungal Rhinosinusitis ◽  
Microbiological Aspect ◽  
Isolated Species

Introduction: Fungal rhinosinusitis is the emerging disease of current era, so isolation of fungus is important aspect to plan the treatment modalities accordingly. Methods: 50 samples of suspected patients of fungal rhinosinusitis were studied. Various samples like nasal secretion, nasal lavage and tissue were examined on direct microscopy using KOH and processed by standard protocols for fungal culture. Result: Out of 50 suspected cases fungal rhinosinusitis was seen in 23 (46%) cases. The 40% of cases were positive by direct microscopy using 20%KOH and 46% were positive by fungal culture. The most common fungal  isolates was Aspergillus flavus (65.5%) followed by  Aspergillus niger (13%). Conclusion: Aspergillus spp. was the most common isolated species among all the cases of fungal rhinosinusitis. Keywords: Aspergillus spp., Fungal, Rhinosinusitis.

Frequency and antibiogram of Acinetobacter species isolated from various clinical samples in a tertiary care hospital

2017 ◽  
Vol 4 (3) ◽  
pp. 263-268
Author(s):  
Tanu Arora ◽  
◽  
Shailpreet K Sidhu ◽  
Pushpa Devi ◽  
Sita Malhotra ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Acinetobacter Species

scholarly journals Prevalence of multidrug-resistant and extended-spectrum beta-lactamase producing Gram-negative isolates from clinical samples in a tertiary care hospital of Nepal

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Aryatara Shilpakar ◽  
Mehraj Ansari ◽  
Kul Raj Rai ◽  
Ganesh Rai ◽  
Shiba Kumar Rai
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Polymyxin B ◽  
Multidrug Resistant ◽  
Confirmatory Test ◽  
Clinical Samples ◽  
Care Hospital ◽  
Gram Negative ◽  
Extended Spectrum ◽  
Esbl Producers

Abstract Background The existence of multidrug-resistant organisms, including extended-spectrum beta-lactamases (ESBLs), is on rise across the globe and is becoming a severe problem. Knowledge of the prevalence and antibiogram profile of such isolates is essential to develop an appropriate treatment methodology. This study aimed to study the prevalence of Gram-negative isolates exhibiting ESBL at a tertiary care hospital and study their antibiogram profile. Methods A cross-sectional study was conducted at Shahid Gangalal National Heart Centre, Kathmandu, Nepal, from June 2018 to November 2018. A total of 770 clinical samples were collected and identified using the conventional biochemical tests following the Clinical and Laboratory Standard Institute (CLSI) guidelines. Antimicrobial susceptibility testing (AST) was performed using the standardized Kirby-Bauer disk diffusion method. The screening test for ESBL producers was performed as recommended by the CLSI and the confirmatory test was performed phenotypically using the E-test. Results Out of the 92 isolates, 84 (91.3%) were multidrug-resistant, and 47 (51.1%) were found to be potential ESBL producers. Of these, 16 isolates were confirmed ESBL producers by the E-test. Escherichia coli and Klebsiella pneumoniae were the predominant isolates and were also the major ESBL producers. Besides polymyxin B (100% sensitive), meropenem and imipenem showed high efficacy against the ESBL producers. Conclusion Multidrug resistance was very high; however, ESBL production was low. Polymyxin B and carbapenems are the choice of drugs against ESBL producers but should be used only as the last line drugs.

scholarly journals Prevalence of Non-Albicans Candida Among the Patients Attending a Tertiary Care Hospital in Kathmandu, Nepal

2016 ◽  
Vol 4 (1) ◽  
pp. 43-46
Author(s):  
Manisha Sharma ◽  
Narayan Dutt Pant ◽  
Pratikshya Pandey
Keyword(s):  
Color Change ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Temperature Tolerance ◽  
Vaginal Swab ◽  
Clinical Samples ◽  
Care Hospital ◽  
Candida Spp ◽  
Test Characteristic ◽  
India Ink

The main objective of this study was to determine the prevalence of non-albicans Candida among the patients attending a tertiary care hospital in Kathmandu, Nepal. Candida spp. isolated from different clinical samples (sputum, urine, vaginal swab, blood, endotracheal (ET) secretion, pus) from 250 patients between the period of February 2013 and December 2015 were included in the study. Of those 250 patients, 20% were immunocompromised. Sabouraud dextrose agar was used for the isolation of Candida spp. and the identification was performed on the basis of colony morphology, Gram’s stain, India ink preparation, germ tube test, temperature tolerance test, characteristic color change in CHROMagar, chlamydospore production, sugar fermentation test and sugar assimilation test.Out of total 300 Candida spp., majority were isolated from sputum (43.33%) followed by urine (40%) and vaginal swab (6.67%). Of total 151 (50.33%) non-albicans Candida, the most common species isolated were C. tropicalis (62.25%) followed by C. glabrata (23.84%). High prevalence of non-albicans Candida among the patients attending a hospital in Kathmandu, Nepal was noted.

scholarly journals Antibiotic Susceptibility Pattern of Nosocomial Isolates of Staphylococcus aureus in a Tertiary Care Hospital, Nepal

2009 ◽  
Vol 48 (175) ◽  
Author(s):  
Bidya Shrestha ◽  
B M Pokhrel ◽  
T M Mohapatra
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Tertiary Care ◽  
Test Method ◽  
University Teaching ◽  
Clinical Samples ◽  
Resistance Pattern ◽  
Care Hospital ◽  
Biochemical Tests ◽  
Methicillin Resistant

Introduction: Methicillin resistant Staphylococcus aureus (MRSA), the most common cause ofnosocomial infection has been a major cause of morbidity and mortality around the world. They arenormally resistant to most of the antibiotics used in clinical practice. This study has been carried outto fi nd out the resistance pattern among S. aureus.Methods: During November 2007 to June 2008, clinical samples from patients with nosocomialinfection were processed for culture and sensitivity following standard methodology in microbiologylaboratory, Tribhuvan University teaching hospital, Kathmandu, Nepal.Results: Among 149 Staphylococcus aureus isolates, highest resistance was observed against Penicillin(91.94%) followed by Fluoroquinolone (61.74%), Erythromycin (52.94%), Gentamicin (46.98%),Cotrimoxazole (42.95%), Tetracycline (40.94%) and others, whereas susceptibility was observedmaximum against Chloramphenicol (94.85%) followed by Rifampicin (92.61%), Tetracycline(59.06%), Cotrimoxazole (57.04%), and others. None of the isolates were resistant to Vancomycinand Teicoplanin. Of these isolates 44.96 % of the isolates were Methicillin resistant S. aureus (MRSA).Resistance to Penicillin, Fluoroquinolone, Erythromycin, Gentamicin, Co-trimoxazole and Tetracyclinewere associated signifi cantly with MRSA isolates (X2= 8.779, p<0.05, X2= 74.233, p<0.05, X2= 84.2842,p<0.05, X2= 108.2032, p<0.05, X2= 88.1512, p<0.05 and X2= 79.1876, p<0.05 respectively). Althoughmost of the Methicillin sensitive S. aureus (MSSA) isolates were susceptible to both Rifampicinand Chloramphenicol, only Rifampicin susceptibility was signifi cantly associated with them (X2=10.1299, p<0.05). Among three Biochemical tests for the detection of β lactamase detection namelychromogenic, iodometric and acidimetric test, chromogenic test method had highest sensitivity andspecifi city.Conclusions: Since MRSA comprised a greater part of S. aureus isolates and were multi-resistant,patients infected by such strains should be identifi ed and kept in isolation for hospital infectioncontrol and treated with second line of drug like vancomycin.Key Words: β lactamase, methicillin resistant Staphylococcus aureus,methicillin sensitive Staphylococcus aureus, resistance pattern

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