Serum Matrix Metalloproteinase 9 and Macrophage Migration Inhibitory Factor (MIF) Are Increased in Young Healthy Nonobese Subjects with Positive Family History of Type 2 Diabetes

Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proinflammatory proatherogenic factors and biomarkers of endothelial activation was observed in diabetes and CVD. The aim of our study was to assess serum proatherogenic and proinflammatory factors in young healthy nonobese subjects with positive family history of type 2 diabetes. We studied 74 young healthy nonobese subjects with normal glucose tolerance (age < 35 years, BMI < 30 kg/m2), 29 with positive family history of type 2 diabetes (relatives, 25 males and 4 females) and 45 subjects without family history of diabetes (control group, 39 males and 6 females). Hyperinsulinemic-euglycemic clamp was performed, and serum concentrations of monocyte chemoattractant protein-1 (MCP-1), interleukin 18 (IL-18), macrophage inhibitory cytokine 1 (MIC-1), macrophage migration inhibitory factor (MIF), matrix metalloproteinase (MMP-9), and soluble forms of adhesion molecules were measured. Relatives had markedly lower insulin sensitivity (p=0.019) and higher serum MMP-9 (p<0.001) and MIF (p=0.006), but not other chemokines and biomarkers of endothelial function. Insulin sensitivity correlated negatively with serum MMP-9 (r=−0.23, p=0.045). Our data show that young healthy subjects with positive family history of type 2 diabetes already demonstrate an increase in some nonclassical cardiovascular risk factors.

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Serum matrix metalloproteinase 9 and macrophage migration inhibitory factor are increased in healthy nonobese subjects with positive family history of type 2 diabetes

Atherosclerosis ◽

10.1016/j.atherosclerosis.2015.04.1052 ◽

2015 ◽

Vol 241 (1) ◽

pp. e225

Author(s):

M. Straczkowski ◽

M. Stefanowicz ◽

N. Matulewicz ◽

A. Nikolajuk ◽

M. Karczewska-Kupczewska

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Matrix Metalloproteinase ◽

Migration Inhibitory Factor ◽

Macrophage Migration Inhibitory Factor ◽

Positive Family History ◽

Macrophage Migration ◽

History Of ◽

Metalloproteinase 9

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Potential risk factors for developing diabetes mellitus type 2

Medicinski pregled ◽

10.2298/mpns1004231z ◽

2010 ◽

Vol 63 (3-4) ◽

pp. 231-236 ◽

Cited By ~ 1

Author(s):

Dusica Zivanovic ◽

Sandra Sipetic ◽

Marina Stamenkovic-Radak ◽

Jelena Milasin

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Physical Inactivity ◽

Positive Family History ◽

Diabetes Type 2 ◽

Diabetes Type ◽

Family History Of Diabetes ◽

History Of

Introduction Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing diabetes type 2 among diabetic individuals and to compare the presence of risk factors among diabetic individuals with and without positive family history for type 2 diabetes. Material and methods This study was conducted in Cuprija during the period from February to June 2002. The case group included 137 individuals having diagnosis type 2 diabetes. The control group included 129 subjects having the following diagnoses: hypertension, angina pectoris, chronic obstructive lung disease, gastric ulcer or duodenal ulcer. All participants were interviewed at the Medical Center Cuprija using structural questionnaire. The data were collected regarding demographic characteristics, exposure to various chemical and physical agents, stress, smoking, obesity, physical inactivity and family history of diabetes. In the statistical analysis chi square test was used. Results The diabetic individuals were statistically significantly older (40 and more years old) (p=0,000), and they came from rural areas more frequently (p=0,006) than the individuals without diabetes. Significantly more diabetics had lower educational level (p=0,000) and they were agriculture workers and housewives significantly more frequently (p=0,000) than nondiabetic individuals. Furthermore, obesity (p=0,000) and physical inactivity (p=0,003) were significantly more frequent among the diabetic individuals than the nondiabetics. The diabetic individuals had significanly (p=0,000) more numbers of relatives with diabetes mellitus type 2 than the nondiabetics. The diabetic individuals with positive family history of diabetes were significantly older (p=0,021) and more frequently from urban areas (p=0,018) than the diabetic individuals without the positive family history of diabetes. Also they were significantly less exposed to physical agents (p=0,004). Discussion In our study, like in many others, age, place of residence, education, occupation, obesity, physical inactivity, positive family history of diabetes type 2 and exposure to physical agents were identified as potential risk factors for diabetes type 2. Conclusion Different risk factors are probably responsible for developing type 2 diabetes among individuals with and without positive family history of type 2 diabetes.

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We are Family

Californian Journal of Health Promotion ◽

10.32398/cjhp.v8i1.2034 ◽

2010 ◽

Vol 8 (1) ◽

pp. 88-97 ◽

Cited By ~ 4

Author(s):

Alexander Omolafe ◽

Michele Mouttapa ◽

Shari McMahan ◽

Sora Park Tanjasiri

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

African Americans ◽

Positive Family History ◽

Self Report ◽

Cross Sectional ◽

History Of

This cross-sectional study sought to describe an association between family history of type-2 diabetes and the awareness of risk factors, perceived threat and physical activity levels in African Americans. With a prevalence of 11.8%, African Americans remain disproportionately affected by the epidemic of diabetes. A risk factor that cannot be modified, but is important and closely linked with diabetes expression, family history, can be a considerable tool in promoting behavior change and reducing the risk of developing the condition in African Americans. A self-report questionnaire was administered to 133 church going African Americans, with 55 of them with a positive family history of type-2 diabetes (41.4%) and 78 (58.6%) without. None of the participants had been previously been diagnosed with type-2 diabetes. The results from the study indicated that African Americans with positive family history had a greater knowledge of risk factors, were more likely to indicate that their concern about the disease influences their eating habits and physical activity, and engaged in significantly more physical activity than those with no family history.

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Diabetes type 2 in young people. Clinical case from the practice of endocrinologist

Clinical review for general practice ◽

10.47407/kr2021.2.1.00028 ◽

2021 ◽

Vol 2 (1) ◽

pp. 18-21

Author(s):

Galina A. Batrak ◽

◽

Maria V. Zhaburina ◽

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Family History ◽

Young People ◽

Young Patients ◽

Overweight And Obesity ◽

Young Age ◽

History Of

In recent decades, type 2 diabetes is increasingly recorded in young people, adolescents and children. The most significant risk factors for type 2 diabetes in young patients are family history of the disease, overweight and obesity, and the presence of insulin resistance. The main diagnostic criteria for type 2 diabetes mellitus in young patients, in addition to the traditional ones (hyperglycemia and glycosylated hemoglobin), are a high level of C-peptide and insulin resistance in the absence of antibodies to ICA, insulin, GAD. In connection with the projected increase in the incidence of type 2 diabetes at a young age, it is necessary to pay attention to the implementation of preventive measures and timely clinical examination among groups of children and adolescents with the presence of abdominal obesity, burdened with a family history of obesity and type 2 diabetes, in order to prevent or delay the early development of disorders carbohydrate metabolism among this group at an earlier age. Given the predominance of insulin resistance in the pathogenesis of type 2 diabetes in young people, it is necessary to give priority to drugs from the metformin group when prescribing treatment. Thus, the global growth of type 2 diabetes, the tendency to "rejuvenate" diabetes, insufficient information on the prevalence, risk factors and clinical manifestations of the disease at a young age emphasize the urgency of studying this problem.

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Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

BMC Research Notes ◽

10.1186/s13104-021-05703-8 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Uzair Abbas ◽

Bushra Imdad ◽

Sikander Adil Mughal ◽

Israr Ahmed Baloch ◽

Afshan Mehboob Khan ◽

...

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Positive Family History ◽

Cross Sectional Study ◽

Vital Role ◽

Micro Rna ◽

Cross Sectional ◽

Family History Of Diabetes ◽

History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

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Differing Contributions of Classical Risk Factors to Type 2 Diabetes in Multi-Ethnic Malaysian Populations

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15122813 ◽

2018 ◽

Vol 15 (12) ◽

pp. 2813

Author(s):

Noraidatulakma Abdullah ◽

Nor Abdul Murad ◽

John Attia ◽

Christopher Oldmeadow ◽

Mohd Kamaruddin ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Characteristic Curve ◽

Lifestyle Factors ◽

Predictive Utility ◽

Family History Of Diabetes ◽

History Of

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

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Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes

Healthcare ◽

10.3390/healthcare9081010 ◽

2021 ◽

Vol 9 (8) ◽

pp. 1010

Author(s):

Wei-Hao Hsu ◽

Chin-Wei Tseng ◽

Yu-Ting Huang ◽

Ching-Chao Liang ◽

Mei-Yueh Lee ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Insulin Sensitivity ◽

Cell Function ◽

Diabetic Patients ◽

Β Cell ◽

Tyg Index ◽

Β Cell Function

Prediabetes should be viewed as an increased risk for diabetes and cardiovascular disease. In this study, we investigated its prevalence among the relatives and spouses of patients with type 2 diabetes or risk factors for prediabetes, insulin resistance, and β-cell function. A total of 175 individuals were included and stratified into three groups: controls, and relatives and spouses of type 2 diabetic patients. We compared clinical characteristics consisting of a homeostatic model assessment for insulin resistance (HOMA-IR) and beta cell function (HOMA-β), a quantitative insulin sensitivity check index (QUICKI), and triglyceride glucose (TyG) index. After a multivariable linear regression analysis, the relative group was independently correlated with high fasting glucose, a high TyG index, and low β-cell function; the relatives and spouses were independently associated with a low QUICKI. The relatives and spouses equally had a higher prevalence of prediabetes. These study also indicated that the relatives had multiple factors predicting the development of diabetes mellitus, and that the spouses may share a number of common environmental factors associated with low insulin sensitivity.

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