A family history of type 2 diabetes increases risk factors associated with overfeeding

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

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Potential risk factors for developing diabetes mellitus type 2

Medicinski pregled ◽

10.2298/mpns1004231z ◽

2010 ◽

Vol 63 (3-4) ◽

pp. 231-236 ◽

Cited By ~ 1

Author(s):

Dusica Zivanovic ◽

Sandra Sipetic ◽

Marina Stamenkovic-Radak ◽

Jelena Milasin

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Physical Inactivity ◽

Positive Family History ◽

Diabetes Type 2 ◽

Diabetes Type ◽

Family History Of Diabetes ◽

History Of

Introduction Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing diabetes type 2 among diabetic individuals and to compare the presence of risk factors among diabetic individuals with and without positive family history for type 2 diabetes. Material and methods This study was conducted in Cuprija during the period from February to June 2002. The case group included 137 individuals having diagnosis type 2 diabetes. The control group included 129 subjects having the following diagnoses: hypertension, angina pectoris, chronic obstructive lung disease, gastric ulcer or duodenal ulcer. All participants were interviewed at the Medical Center Cuprija using structural questionnaire. The data were collected regarding demographic characteristics, exposure to various chemical and physical agents, stress, smoking, obesity, physical inactivity and family history of diabetes. In the statistical analysis chi square test was used. Results The diabetic individuals were statistically significantly older (40 and more years old) (p=0,000), and they came from rural areas more frequently (p=0,006) than the individuals without diabetes. Significantly more diabetics had lower educational level (p=0,000) and they were agriculture workers and housewives significantly more frequently (p=0,000) than nondiabetic individuals. Furthermore, obesity (p=0,000) and physical inactivity (p=0,003) were significantly more frequent among the diabetic individuals than the nondiabetics. The diabetic individuals had significanly (p=0,000) more numbers of relatives with diabetes mellitus type 2 than the nondiabetics. The diabetic individuals with positive family history of diabetes were significantly older (p=0,021) and more frequently from urban areas (p=0,018) than the diabetic individuals without the positive family history of diabetes. Also they were significantly less exposed to physical agents (p=0,004). Discussion In our study, like in many others, age, place of residence, education, occupation, obesity, physical inactivity, positive family history of diabetes type 2 and exposure to physical agents were identified as potential risk factors for diabetes type 2. Conclusion Different risk factors are probably responsible for developing type 2 diabetes among individuals with and without positive family history of type 2 diabetes.

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We are Family

Californian Journal of Health Promotion ◽

10.32398/cjhp.v8i1.2034 ◽

2010 ◽

Vol 8 (1) ◽

pp. 88-97 ◽

Cited By ~ 4

Author(s):

Alexander Omolafe ◽

Michele Mouttapa ◽

Shari McMahan ◽

Sora Park Tanjasiri

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

African Americans ◽

Positive Family History ◽

Self Report ◽

Cross Sectional ◽

History Of

This cross-sectional study sought to describe an association between family history of type-2 diabetes and the awareness of risk factors, perceived threat and physical activity levels in African Americans. With a prevalence of 11.8%, African Americans remain disproportionately affected by the epidemic of diabetes. A risk factor that cannot be modified, but is important and closely linked with diabetes expression, family history, can be a considerable tool in promoting behavior change and reducing the risk of developing the condition in African Americans. A self-report questionnaire was administered to 133 church going African Americans, with 55 of them with a positive family history of type-2 diabetes (41.4%) and 78 (58.6%) without. None of the participants had been previously been diagnosed with type-2 diabetes. The results from the study indicated that African Americans with positive family history had a greater knowledge of risk factors, were more likely to indicate that their concern about the disease influences their eating habits and physical activity, and engaged in significantly more physical activity than those with no family history.

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Life style factors associated with the risk of type 2 diabetes mellitus

Grande Medical Journal ◽

10.3126/gmj.v1i2.27057 ◽

2019 ◽

Vol 1 (2) ◽

pp. 77-83 ◽

Cited By ~ 1

Author(s):

Bikash Shrestha ◽

Bipin Nepal ◽

Yagya Laxmi Shakya ◽

Binaya Regmi

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Family History ◽

Alcohol Use ◽

Modifiable Risk Factors ◽

Cross Sectional ◽

History Of

Introduction: Type 2 diabetes mellitus is the commonest form of diabetes affecting more than 90% of the diabetic population worldwide. The prevalence of type 2 diabetes and its complications are increasing in the world, including developing nations like Nepal. This study aimed to determine the association between the lifestyle risk factors and the risk of type 2 diabetes mellitus in Nepalese population. Methods: This is hospital based cross sectional observational study done in the urban area of Nepal. Records of clients coming for the general health checkup in Grande International Hospital were evaluated in this study. Comparisons of the lifestyle factors in participants having and not having type 2 diabetes mellitus were done. Results: Significant associations with diagnosis of diabetes mellitus (DM) type 2 were seen in age (P ≤ 0.001), associated hypertension (P ≤ 0.001), dyslipidemia, family history of DM (P ≤ 0.001), alcohol use (P ≤ 0.001), and tobacco use (P ≤ 0.001). Logistic regression analysis showed that the odds of having diabetes were high in age group above 40 (OR – 6.9, CI 3.82 – 12.47), history of hypertension (OR- 3.84, CI 2.42 – 6.08), tobacco users (OR-2.26, CI 1.12 – 4.53), alcohol users (OR-3.99, CI 2.47 – 6.44), family history of DM (OR-2.44, CI 1.53 – 3.89), and abdominal obesity in both males (OR-3.9, CI 2 – 7.4) and females (OR-9.6, CI 3.78 – 24.35). Conclusions: The modifiable risk factors - obesity, smoking and alcohol use carry significant risks of developing type 2 diabetes. These red flag signs call for urgent attention to look for and rectify the modifiable risk factors in Nepalese population to prevent diabetes.

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Serum Matrix Metalloproteinase 9 and Macrophage Migration Inhibitory Factor (MIF) Are Increased in Young Healthy Nonobese Subjects with Positive Family History of Type 2 Diabetes

International Journal of Endocrinology ◽

10.1155/2018/3470412 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Agnieszka Nikołajuk ◽

Natalia Matulewicz ◽

Magdalena Stefanowicz ◽

Monika Karczewska-Kupczewska

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Insulin Sensitivity ◽

Family History ◽

Macrophage Migration Inhibitory Factor ◽

Positive Family History ◽

Macrophage Migration ◽

History Of

Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proinflammatory proatherogenic factors and biomarkers of endothelial activation was observed in diabetes and CVD. The aim of our study was to assess serum proatherogenic and proinflammatory factors in young healthy nonobese subjects with positive family history of type 2 diabetes. We studied 74 young healthy nonobese subjects with normal glucose tolerance (age < 35 years, BMI < 30 kg/m2), 29 with positive family history of type 2 diabetes (relatives, 25 males and 4 females) and 45 subjects without family history of diabetes (control group, 39 males and 6 females). Hyperinsulinemic-euglycemic clamp was performed, and serum concentrations of monocyte chemoattractant protein-1 (MCP-1), interleukin 18 (IL-18), macrophage inhibitory cytokine 1 (MIC-1), macrophage migration inhibitory factor (MIF), matrix metalloproteinase (MMP-9), and soluble forms of adhesion molecules were measured. Relatives had markedly lower insulin sensitivity (p=0.019) and higher serum MMP-9 (p<0.001) and MIF (p=0.006), but not other chemokines and biomarkers of endothelial function. Insulin sensitivity correlated negatively with serum MMP-9 (r=−0.23, p=0.045). Our data show that young healthy subjects with positive family history of type 2 diabetes already demonstrate an increase in some nonclassical cardiovascular risk factors.

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The E23K variant in the Kir6.2 subunit of the ATP-sensitive K+ channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes

Journal of Endocrinology ◽

10.1677/joe.1.06117 ◽

2005 ◽

Vol 185 (3) ◽

pp. 439-444 ◽

Cited By ~ 4

Author(s):

Chidum Ezenwaka ◽

Risha Kalloo ◽

Mathias Uhlig ◽

Robert Schwenk ◽

Juergen Eckel

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Diabetic Patients ◽

Family History Of Diabetes ◽

Control Subjects ◽

History Of

The E23K variant of the Kir6.2 gene has been shown to be associated with type 2 diabetes mellitus in Caucasian subjects. Because offspring of type 2 diabetic patients have a genetically increased risk of developing diabetes, we sought to identify the E23K variant of the Kir6.2 gene in offspring of Caribbean patients with type 2 diabetes and assess the contribution of this variant to impaired glucose tolerance in these subjects. Forty-six offspring of patients with type 2 diabetes and 39 apparently healthy subjects whose immediate parents were not diabetic (‘control’) were studied after an overnight fast. Anthropometric indices were measured and blood samples were collected. Fasting and 2 h plasma glucose, insulin and lipids were subsequently determined. Insulin resistance was calculated using the homeostatic model assessment technique. The offspring and control subjects had similar frequencies of the E23K polymorphism (52.6 vs 45.5%, P>0.05) and the frequency of the E23K variant did not differ significantly between gender and ethnic distributions, irrespectively of a family history of diabetes (P>0.05). There were no significant differences in biochemical risk factors for developing diabetes in offspring carriers of the E23K variant compared with offspring non-carriers of the mutation. Offspring with the E23K mutation had even significantly higher 2 h insulin concentrations when compared with control subjects. It is concluded that the presence of the Kir6.2 E23K genotype in Caribbean subjects with an immediate positive family history of diabetes does not confer significantly higher levels of biochemical risk factors for the development of type 2 diabetes.

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Prevalence and Risk Factors Associated with Type 2 Diabetes in Elderly Patients Aged 45-80 Years at Kanungu District

Journal of Diabetes Research ◽

10.1155/2020/5152146 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Debrah Asiimwe ◽

Godfrey O. Mauti ◽

Ritah Kiconco

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Elderly Patients ◽

Health Centre ◽

Health Concern ◽

Diabetic Patients ◽

Cross Sectional ◽

Factors Associated

Background. Type 2 diabetes is a worldwide disaster including in Uganda, specifically in Kanungu District which had a rise in diabetic patients in 2018/2019 as compared to the 2017/2018 financial year. This research was determined to access the prevalence and risk factors associated with type 2 diabetes on elderly patients aged 45-80 years attending Kanungu Health Centre IV, Kanungu District. Methods. A cross-sectional study was conducted among patients aged 45-80 years attending Kanungu Health Centre IV from June to August 2019. The prevalence of type 2 diabetes was determined by the blood sugar of patients. Questionnaires were used to collect data for factors associated with type 2 diabetes. Data were statistically analyzed using the statistical package for social sciences (SPSS) version 25 (SPSS Inc., USA) at P<0.05. Results. The overall prevalence of type 2 diabetes was 18.7% among the tested patients. 22.8% of diabetic patients were females as 7.8% were males. The age group most affected by diabetes was 61-65 years. Alcoholism, smoking, body mass index (BMI), and family history were found to be significantly associated with type 2 diabetes at P value < 0.05. Conclusion. There was a high prevalence of type 2 diabetes observed in this study compared to studies done in previous years which raise a public health concern. This study also found that females and patients aged 61-65 years were most affected by diabetes. Lastly, the presence of family history for diabetes, overweight, and being obese increases the chances of acquiring type 2 diabetes.

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Risk Factors of Hypertension among Type 2 Diabetic Patients in Imo state, South East of Nigeria

Asian Journal of Medicine and Health ◽

10.9734/ajmah/2020/v18i1030253 ◽

2020 ◽

pp. 65-72

Author(s):

Ugonma, Winnie Dozie ◽

Nnenna, Vivian Okonkwo ◽

Okwuchi, Blessed Nworuh ◽

Somtochukwu, Mercy Orji ◽

Chidozie Joakin Nwaokoro ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Dietary Pattern ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

History Of ◽

Family History Of Hypertension ◽

Type 2 Diabetic

Background: Hypertension is among the important causes of non-communicable disease burden worldwide. It has raised public health concerns in both developed and developing nations. It mostly occurs in patients with diabetes and the prevalence depends on duration, type and age of the patient. The study aimed at determining the risk factors of hypertension among type 2 diabetic patients in Imo State, Nigeria. Methods: A hospital-based descriptive survey design involving 50 patients attending hospital was used. Structured questionnaire complemented with interview schedule was used to collect data from the respondents. Data were analyzed using frequency and mean score. Hypotheses were tested using Chi-square at 5% significance level. Results: The result showed that the majority (70.0%) of the patients was hypertensive, 54.0% of the patients used dietary control and drugs in the treatment of the diseases. Furthermore, it was found that 54.0% ate salty foods always, 58.0% of the patients added extra table salt in their meals, 54.0% ate canned foods and 82.0% took sugary drinks always. It was also found that 66.0% ate always from restaurants and 58.0% ate more of starchy foods. The result further showed that 74.0% of the patients avoided physical exercise and 70.0% indicated that doing stress works made them get anxious. Eighty percent of the patients had hypertension in their family history and the 74.0% indicated it was their brother/sister. The X2 result showed a significantly association between family history of hypertension and type 2 diabetes X2(121, N = 50) = 187, p = 0.000. It was also found that dietary pattern was significantly associated with risk of type 2 diabetes X2(121, N = 50) = 187, p = 0.000. Conclusion: Dietary pattern and family history of hypertension were significantly associated with type 2 diabetes. It was recommended that sensitization campaigns be organized to educate women on the effect of diets on diabetes. Also, family history of hypertension should be ascertained from patients to ensure early detection and treatment of diabetes.

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Diabetes type 2 in young people. Clinical case from the practice of endocrinologist

Clinical review for general practice ◽

10.47407/kr2021.2.1.00028 ◽

2021 ◽

Vol 2 (1) ◽

pp. 18-21

Author(s):

Galina A. Batrak ◽

◽

Maria V. Zhaburina ◽

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Family History ◽

Young People ◽

Young Patients ◽

Overweight And Obesity ◽

Young Age ◽

History Of

In recent decades, type 2 diabetes is increasingly recorded in young people, adolescents and children. The most significant risk factors for type 2 diabetes in young patients are family history of the disease, overweight and obesity, and the presence of insulin resistance. The main diagnostic criteria for type 2 diabetes mellitus in young patients, in addition to the traditional ones (hyperglycemia and glycosylated hemoglobin), are a high level of C-peptide and insulin resistance in the absence of antibodies to ICA, insulin, GAD. In connection with the projected increase in the incidence of type 2 diabetes at a young age, it is necessary to pay attention to the implementation of preventive measures and timely clinical examination among groups of children and adolescents with the presence of abdominal obesity, burdened with a family history of obesity and type 2 diabetes, in order to prevent or delay the early development of disorders carbohydrate metabolism among this group at an earlier age. Given the predominance of insulin resistance in the pathogenesis of type 2 diabetes in young people, it is necessary to give priority to drugs from the metformin group when prescribing treatment. Thus, the global growth of type 2 diabetes, the tendency to "rejuvenate" diabetes, insufficient information on the prevalence, risk factors and clinical manifestations of the disease at a young age emphasize the urgency of studying this problem.

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