scholarly journals Evaluation of 25-Hydroxyvitamin D Levels in Central Anatolia, Turkey

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Ibrahim Solak ◽  
Fatma Goksin Cihan ◽  
Seher Mercan ◽  
Tugba Kethuda ◽  
Mehmet Ali Eryılmaz
Keyword(s):  
Vitamin D ◽  
Cost Effective ◽  
Vitamin D Insufficiency ◽  
Current Approach ◽  
Central Anatolia ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
One Year ◽  
A Current

Background/Aim. The aim of this study is to evaluate serum 25-hydroxyvitamin D levels measured within one year at an Education and Research Hospital in Turkey to identify vitamin D insufficiency/deficiency (which is very commonly seen in the society) and to provide a current approach to treatment management. Materials and Methods. This retrospective descriptive study was carried out by examining the data relating to 35,667 individuals. Results. Of the individuals participating in the study, 94.47% had a serum 25-hydroxyvitamin D level less than 30 ng/ml, 76.25% had a serum 25-hydroxyvitamin D level less than 20 ng/ml, and 32.20% had a serum 25-hydroxyvitamin D level less than 10 ng/ml. The mean serum 25-hydroxyvitamin D level of all individuals included in the study was 15.2±8.8 ng/ml. The mean serum 25-hydroxyvitamin D level was 14.5±8.8 ng/ml among women and 18.1±8.4 ng/ml among men, respectively (p<0.001). Conclusion. Vitamin D deficiency/insufficiency is widespread in the world and in Turkey. The data obtained from this study suggest that without measuring serum 25-hydroxyvitamin D level will be cost-effective in every age group (except for those are at risk of toxicity) as in children aged 0-1 year old in Turkey and that making a decision in this direction will make a great contribution to the economy of the country.

scholarly journals Prospective study on food fortification with vitamin D among adolescent females in Finland: minor effects

2008 ◽  
Vol 100 (2) ◽  
pp. 418-423 ◽  
Author(s):  
Marjo Lehtonen-Veromaa ◽  
Timo Möttönen ◽  
Aila Leino ◽  
Olli J. Heinonen ◽  
Essi Rautava ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adolescent Girls ◽  
Vitamin D Insufficiency ◽  
Adolescent Females ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
One Year ◽  
The Impact ◽  
Dietary Vitamin D

Vitamin D insufficiency is common particularly during wintertime. After the recommendation by the Ministry of Social Affairs and Health, Finnish fluid milks and margarines have been fortified with vitamin D since February 2003. The aims of the present study were to examine the impact of vitamin D fortification of food supplies on serum 25-hydroxyvitamin D (S-25(OH)D) concentrations and on daily dietary vitamin D intake among adolescent females. One hundred and forty-two girls of Caucasian ethnicity aged 12–18 years completed semi-quantitative FFQ from which the dietary vitamin D and Ca intakes were calculated. S-25(OH)D was measured by radioimmunoassay. The study was performed from February–March 2000 to February–March 2004, one year after the initiation of fortification. The mean dietary intake of vitamin D was < 7·5 μg in 91·5 % of the adolescent girls in 2000 and 83·8 % in 2004. The midwinter mean S-25(OH)D concentration did not change significantly during the follow-up period (48·3 v. 48·1 nmol/l, NS). The proportion of participants who had S-25(OH)D concentration < 50 nmol/l was 60·6 % in 2000 and 65·5 % in 2004. Only 7·0 % of the participants had an adequate S-25(OH)D ( ≥ 75 nmol/l) level in 2000 or 4 years later. The vitamin D fortification of fluid milks and margarines was inadequate to prevent vitamin D insufficiency. There are numerous adolescent girls and women who are not reached by the current fortification policy. Therefore new innovative and feasible ways of improving vitamin D nutrition are urged.

Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children

2016 ◽  
Vol 29 (4) ◽  
Author(s):  
Mohammad Shafi Kuchay ◽  
Ganesh Sudhakar Jevalikar ◽  
Ambrish Mithal ◽  
Sunil Kumar Mishra ◽  
Navin Dang
Keyword(s):  
Vitamin D ◽  
School Children ◽  
Cost Effective ◽  
Vitamin D Supplementation ◽  
Efficacy And Safety ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
To Receive ◽  
Monthly Dose

AbstractThis study aimed to evaluate the efficacy and safety of a single monthly dose of cholecalciferol in healthy school children.A total of 118 children of class VI of a residential school were selected to receive vitamin D supplementation in the form of oral cholecalciferol 60,000 IU monthly. Serum calcium and 25-hydroxyvitamin D (25OHD) levels were estimated at 0 and 12 months. The proportion of subjects achieving vitamin D sufficiency was assessed.The mean 25OHD levels increased significantly from 12.04±5.27 ng/mL at baseline to 32.6±7.05 ng/mL after 12 months of supplementation (p<0.001). None developed hypercalcemia.Vitamin D supplementation in the doses of 60,000 IU monthly is a reasonable, safe and cost-effective regimen for children to attain and maintain vitamin D sufficiency.

Vitamin D Level Stability in Dystrophinopathy Patients on Vitamin D Supplementation

2021 ◽  
pp. 1-7
Author(s):  
Naomi Vather-Wu ◽  
Matthew D. Krasowski ◽  
Katherine D. Mathews ◽  
Amal Shibli-Rahhal
Keyword(s):  
Vitamin D ◽  
Retrospective Cohort ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Frequent Monitoring ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
Stable Maintenance ◽  
Mean Time

Background: Expert guidelines recommend annual monitoring of 25-hydroxyvitamin D (25-OHD) and maintaining 25-OHD ≥30 ng/ml in patients with dystrophinopathies. Objective: We hypothesized that 25-OHD remains stable and requires less frequent monitoring in patients taking stable maintenance doses of vitamin D. Methods: We performed a retrospective cohort study, using the electronic health record to identify 26 patients with dystrophinopathies with a baseline 25-OHD ≥30 ng/mL and at least one additional 25-OHD measurement. These patients had received a stable dose of vitamin D for ≥3 months prior to their baseline 25-OHD measurement and throughout follow-up. The main outcome measured was the mean duration time the subjects spent with a 25-OHD ≥30 ng/mL. Results: Only 19% of patients dropped their 25-OHD to <  30 ng/ml, with a mean time to drop of 33 months and a median nadir 25-OHD of 28 ng/mL. Conclusions: These results suggest that measurement of 25-OHD every 2–2.5 years may be sufficient in patients with a baseline 25-OHD ≥30 ng/mL and who are on a stable maintenance dose of vitamin D. Other patients may require more frequent assessments.

To screen or not to screen? Vitamin D deficiency in chronic mental illness

2017 ◽  
Vol 26 (1) ◽  
pp. 56-59
Author(s):  
Ivana Goluza ◽  
Jay Borchard ◽  
Nalin Wijesinghe ◽  
Kishan Wijesinghe ◽  
Nagesh Pai
Keyword(s):  
Vitamin D ◽  
Length Of Stay ◽  
P Value ◽  
Hydroxyvitamin D ◽  
Psychiatric Setting ◽  
Retrospective Audit ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
The Mean

Objectives: The objective of the current study was to examine the pathology test utilisation of 25-hydroxyvitamin D (25(OH)D) within an Australian inpatient psychiatric setting. Method: A retrospective audit of 300 random hospital files of those admitted as inpatients between Nov 2014 and Nov 2015 was undertaken. Data was quantitatively analysed and described. Results: The number of inpatients who had a vitamin D determination during their admission was 37/300 (12.33%). The mean vitamin D level of those tested was 51.63 nmol/l. Of those that were tested, 18/37 (48.6%) were mildly to moderately deficient. There was a statistically significant difference in age and length of stay between those that were and were not tested for vitamin D levels, p-value <0.001 and 0.017, respectively. In addition, a simple linear regression indicated a weak association between length of stay and vitamin D levels. Conclusion: This audit highlights vitamin D screening inadequacy. More research is recommended to establish tangible benefits of supplementation, while local practice provides valuable data for education and policy purposes.

scholarly journals Determinants of serum 25-hydroxyvitamin D in Hong Kong

2015 ◽  
Vol 114 (1) ◽  
pp. 144-151 ◽  
Author(s):  
Cuiling Xu ◽  
Ranawaka A. P. M. Perera ◽  
Yap-Hang Chan ◽  
Vicky J. Fang ◽  
Sophia Ng ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hong Kong ◽  
Southern China ◽  
Age Groups ◽  
Dietary Vitamin ◽  
Skeletal Health ◽  
Mean Values ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Mean

Vitamin D plays an important role in skeletal health throughout life. Some studies have hypothesised that vitamin D may reduce the risk of other diseases. Our study aimed to estimate age-specific and sex-specific serum 25-hydroxyvitamin D (25(OH)D) status and to identify the determinants of serum 25(OH)D status in Hong Kong, a subtropical city in southern China. In 2009–2010, households in Hong Kong were followed up to identify acute respiratory illnesses, and sera from 2694 subjects were collected in three to four different study phases to permit measurement of 25(OH)D levels at different times of the year. A questionnaire survey on diet and lifestyle was conducted among children, with simultaneous serum collection in April and May 2010. The mean of serum 25(OH)D levels in age groups ranged from 39 to 63 nmol/l throughout the year with the mean values in all age groups in spring below 50 nmol/l. Children aged 6–17 years, and girls and women had significantly lower serum 25(OH)D levels than adults, and boys and men, respectively (allP< 0·001). We estimated that serum 25(OH)D levels in Hong Kong followed a lagged pattern relative to climatic season by 5 weeks with lowest observed levels in early spring (March). For children aged 6–17 years, reporting a suntan, having at least 1 servings of fish/week and having at least 1 serving of eggs/week were independently associated with higher serum 25(OH)D levels. Adequate sunlight exposure and increased intake of dietary vitamin D could improve vitamin D status, especially for children and females in the winter and spring.

scholarly journals Vitamin D Status among Young Children Aged 6 to 23 Months from 4 Different Ethnic Groups in Yunnan, China

2018 ◽  
Vol 39 (2) ◽  
pp. 260-265
Author(s):  
Yanhong Li ◽  
Yan Li ◽  
Xian Zhang ◽  
Lin Zhao ◽  
Liqin Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Young Children ◽  
Vitamin D Deficiency ◽  
Ethnic Groups ◽  
Venous Blood ◽  
Hydroxyvitamin D ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
Venous Blood Sampling

Objectives: To determine the prevalence of vitamin D deficiency in 6- to 23-month-old children from 4 different ethnic groups, Han, Lisu, Hani, and Bai, in Yunnan Province of China. Methods: A large cohort of 938 young children aged 6 to 23 months who were living in Yunnan, China (23°28′-27°52′ N), were selected and recruited in this study. Venous-blood sampling was conducted in all the participants, and serum 25-hydroxyvitamin D [25(OH)D] levels were measured. The children’s physical status was measured. Results: General mean serum 25(OH)D level was 21.46 ± 7.95 ng/mL, which was obtained from a total of 938 cases. No significant difference was found in age, gender, height, and weight of participants from different ethnic groups. The mean 25(OH)D level was significantly lower in children of Lisu ethnic groups compared with that of Han and Hani participants, respectively ( P < .05). In addition, Bai children had lower 25(OH)D content than Hani children ( P < .001). Among the children with 25(OH)D sufficiency, the number of Lisu participants was significantly lower than Han children ( P < .001). Conclusion: The prevalence of vitamin D deficiency varied among the ethnically different children in Yunnan, China, and significantly fewer Lisu children maintained vitamin D sufficiency compared with other ethnic children. Recognizing these ethnic differences in treating children with vitamin D deficiency may improve the therapeutic outcome.

scholarly journals Vitamin D Status in Japanese Adults: Relationship of Serum 25-Hydroxyvitamin D with Simultaneously Measured Dietary Vitamin D Intake and Ultraviolet Ray Exposure

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 743 ◽  
Author(s):  
Keiko Asakura ◽  
Norihito Etoh ◽  
Haruhiko Imamura ◽  
Takehiro Michikawa ◽  
Takahiro Nakamura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Exposure Time ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Uv Exposure ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Ultraviolet Ray

Vitamin D insufficiency/deficiency is prevalent worldwide. We investigated the effect of vitamin D intake and ultraviolet ray (UV) exposure on serum vitamin D concentration in Japan. A total of 107 healthy adult participants were recruited from Hokkaido (43° N) and Kumamoto (33° N) prefectures. All participants undertook surveys in both summer and winter. Serum 25-hydroxyvitamin D (25(OH)D3) was examined, and vitamin D intake was assessed with a diet history questionnaire. UV exposure was measured with a wearable UV dosimeter. Regression analysis was performed to investigate the relationship between these factors, with covariates such as sun avoidance behavior. The prevalence of vitamin D insufficiency (serum 25(OH)D3; 12 ng/mL (30 nmol/L) ≤ and <20 ng/mL (50 nmol/L))/deficiency (<12 ng/mL) was 47.7% in summer and 82.2% in winter. UV exposure time was short in Kumamoto (the urban area), at 11.6 min in summer and 14.9 min in winter. In Hokkaido (the rural area), UV exposure time was 58.3 min in summer and 22.5 min in winter. Vitamin D intake was significantly associated with serum 25(OH)D3, and a 1 μg/1000kcal increase in intake was necessary to increase 25(OH)D3 by 0.88 ng/mL in summer and by 1.7 ng/mL in winter. UV exposure time was significantly associated with serum 25(OH)D3 in summer, and a 10 min increase in UV exposure time was necessary to increase 25(OH)D3 by 0.47 ng/mL. Although consideration of personal occupation and lifestyle is necessary, most Japanese may need to increase both vitamin D intake and UV exposure.

scholarly journals Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation

2003 ◽  
Vol 88 (11) ◽  
pp. 5175-5179 ◽  
Author(s):  
Franck Grados ◽  
Michel Brazier ◽  
Saïd Kamel ◽  
Marc Mathieu ◽  
Nathalie Hurtebize ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Remodeling ◽  
Elderly Women ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Hydroxyvitamin D ◽  
Bone Remodeling Markers ◽  
25 Hydroxyvitamin D ◽  
Total Body

Abstract The aim of this study was to determine whether early changes in bone markers could predict long-term response in bone mineral density (BMD) after calcium (500 mg) and vitamin D (400 IU) supplementation twice daily in ambulatory elderly women with vitamin D insufficiency (25-hydroxyvitamin D, &lt;12 ng/ml). One hundred and ninety-two women (mean age, 75 ± 7 yr) were randomized to receive either the supplementation (n = 95) or a placebo (n = 97) in a double-blind, controlled clinical trial for 1 yr. In comparison with the placebo group, supplementation significantly increased BMD, normalized 25-hydroxyvitamin D and significantly decreased intact PTH and bone remodeling markers. The initial values of telopeptide cross-links were correlated with improvement in total body BMD [urinary N-telopeptides (NTX), r = 0.38; C-telopeptides (CTX), r = 0.32; serum CTX, r = 0.28], and the 3-month changes in the same markers were correlated with improvement in total body (urinary N-telopeptides, r = −0.29; serum CTX, r = −0.26) and vertebral BMD (CTX, r = −0.26; all P &lt; 0.05). We concluded that short-term changes in bone resorption markers can predict long-term variations in BMD in elderly women with vitamin D insufficiency receiving calcium and vitamin D supplementation.

scholarly journals Very high rates of vitamin D insufficiency in women of child-bearing age living in Beijing and Hong Kong

2008 ◽  
Vol 99 (6) ◽  
pp. 1330-1334 ◽  
Author(s):  
Jean Woo ◽  
Christopher W. K. Lam ◽  
Jason Leung ◽  
Winny Y. Lau ◽  
Edith Lau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hong Kong ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Vitamin D Insufficiency ◽  
Dietary Intakes ◽  
Hydroxyvitamin D ◽  
The North ◽  
25 Hydroxyvitamin D ◽  
The Relationship

We aimed to describe the vitamin D status of young women living in two Chinese cities in the spring – Beijing in the north (latitude 39° north) and Hong Kong (latitude 22° north) in the south. We also examined the relationship between serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations to determine a threshold for serum 25-hydroxyvitamin D above which there is no further suppression of PTH. Finally, we examined whether dietary Ca intake influences this relationship. Non-pregnant women aged 18–40 years (n 441) were recruited between February and June. Fasting blood was collected and dietary intakes were assessed using 5 d food records. Mean serum 25-hydroxyvitamin D concentration was lower in Beijing than Hong Kong women (29 v. 34 nmol/l; P < 0·001). Vitamin D deficiency ( ≤  25 nmol/l) was indicated in 40 % of Beijing and 18 % of Hong Kong women, and over 90 % of women in both cities were insufficient ( ≤ 50 nmol/l). Mean Ca and vitamin D intakes were 478 mg/d and 2·0 μg/d, respectively. The relationship between 25-hydroxyvitamin D concentration and PTH was linear throughout the range with a slope of − 0·36 (different from 0; P < 0·001; R 0·26), with no apparent threshold. There was no influence of Ca intake on the relationship between 25-hydroxyvitamin D and PTH concentration. Vitamin D deficiency is common and insufficiency is very common in non-pregnant women in Hong Kong and Beijing during spring. Serum 25-hydroxyvitamin D was inversely associated with PTH with no apparent threshold. Strategies such as vitamin D fortification or supplementation may be required.

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