scholarly journals Radiation-Induced Sarcoma Originating in Recurrent Juvenile Nasopharyngeal Angiofibroma

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Smriti Panda ◽  
Madhu Rajeshwari ◽  
Chirom Amit Singh ◽  
Suresh C. Sharma ◽  
Pirabu Sakthivel
Keyword(s):  
Surgical Excision ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
External Beam Radiation ◽  
Definitive Treatment ◽  
Beam Radiation ◽  
Nasopharyngeal Angiofibroma ◽  
Young Males ◽  
Tumour Extension ◽  
Complete Surgical Excision ◽  
Radiation Induced

Juvenile nasopharyngeal angiofibroma is a benign disease affecting young males with a propensity to invade intracranially and into the orbit along preformed pathways. Complete surgical excision is the mainstay of management. Patients with multiple recurrences along with tumour extension into skull base and orbit can be considered for external beam radiation as either adjuvant or definitive treatment. Possibility of radiation-induced malignancy has been speculated by many authors, proof of which exists in only two studies so far. This report focuses on radiation-induced leiomyosarcoma in a patient with recurrent juvenile nasopharyngeal angiofibroma.

scholarly journals Juvenile Nasopharyngeal Angiofibroma - Excision Through Lateral Rhinotomy and Sublabial Approach - A Case Report

1970 ◽  
Vol 20 (1) ◽  
pp. 78-81
Author(s):  
NK Sinha ◽  
MH Rashid ◽  
MM Shaheen ◽  
DC Talukder ◽  
MAY Fakir ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Complete Removal ◽  
Definitive Treatment ◽  
Surgical Approaches ◽  
Complete Excision ◽  
Nasopharyngeal Angiofibroma ◽  
Male Adolescents ◽  
Large Size ◽  
Complete Surgical Excision ◽  
Sublabial Approach

Juvenile angiofibroma is a rare hypervascular, locally aggressive benign tumour which is exclusively found in the nose and paranasal sinuses of male adolescents. The definitive treatment for this tumour is complete surgical excision. Different surgical approaches are used for complete excision. Most recent development is excision of the tumour using endoscopes. But in certain cases with large size and different extensions, open transfacial approaches are the choice for complete removal and for less operative bleeding, which are the main challenges for surgical excision of this tumour. DOI: http://dx.doi.org/10.3329/jdmc.v20i1.8587 J Dhaka Med Coll. 2011; 20(1) :78-81

Loss of Reflex Tearing: An Expected Consequence of Juvenile Nasopharyngeal Angiofibroma

2005 ◽  
Vol 133 (4) ◽  
pp. 605-610 ◽  
Author(s):  
Alexander T. Hillel ◽  
Rebecca C. Metzinger ◽  
Andrew J. Nemechek ◽  
Daniel W. Nuss
Keyword(s):  
Surgical Treatment ◽  
Hospital Setting ◽  
Case Series ◽  
Surgical Excision ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Retrospective Case ◽  
Nasopharyngeal Angiofibroma ◽  
Complete Surgical Excision ◽  
Major Teaching Hospital ◽  
Pterygopalatine Ganglion

OBJECTIVE: To report the loss of reflex tearing after surgical treatment of juvenile nasopharyngeal angiofibroma (JNA). STUDY DESIGN AND SETTING: A retrospective case series of 8 patients with surgical extirpation of JNA from 1995 to 2003 in a major teaching hospital setting was studied for symptomatic xerophthalmia. RESULTS: One patient was lost to follow-up. Four of the remaining 7 patients reported a dry ipsilateral eye after surgical treatment of JNA. CONCLUSION: The location of the pterygopalatine ganglion and its associated fibers in the pterygopalatine fossa is directly adjacent to the location of origin of JNA. Lacrimal innervation passes through the pterygopalatine ganglion. Given the extensive nature of advanced JNA and mandate for complete surgical excision, lacrimal dysfunction should be considered an expected consequence of surgery. SIGNIFICANCE: The loss of reflex tearing has not been reported as a consequence of JNA or its surgical treatment. EBM Rating: C.

Successful Repair of Large Skull Base Defect Following JNA Excision

2010 ◽  
Vol 3 (1) ◽  
pp. 49-52
Author(s):  
Alok Thakar ◽  
Gaurav Gupta ◽  
Mohnish Grover
Keyword(s):  
Skull Base ◽  
Free Flap ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Intracranial Extension ◽  
Nasopharyngeal Angiofibroma ◽  
Young Males ◽  
Skull Base Defect ◽  
Successful Repair

Abstract Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascular tumor of young males. Surgical excision remains the principal modality of treatment. Tumors with intracranial extension may require major surgical resections which are not devoid of complications. We here present a case of JNA with massive intracranial extension with postsurgery huge skull base defect with resultant encephalocele which was repaired successfully using rectus abdominis free flap.

scholarly journals Liver Tolerance to Repeat 90Y-Microsphere Radioembolization

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
Patrick McNeillie ◽  
Andrew S. Kennedy ◽  
William Dezarn ◽  
Scott L. Sailer ◽  
Mary England ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Tumors ◽  
Liver Volume ◽  
Dose Calculation ◽  
External Beam Radiation ◽  
Beam Radiation ◽  
Resin Microspheres ◽  
Life Threatening ◽  
Radiation Induced ◽  
And Function

Purpose: Liver tolerance to multiple doses of Y90-microspheres is not known. Many patients (pts) are surviving long enough to be considered for a second and third liver treatments with internal radiation. Materials and Methods: The experience of a single center treating liver tumors with resin Y90-microspheres. Pts that received liver radiation prior to or after resin microsphere therapy were studied. Endpoints were toxicity, tumor response, shunting to lung, and effects on liver volume and function. The delivery activity of microspheres selected was not reduced below BSA dose calculation for patients without prior treatment. All patients received bilobar single session delivery. Results: A total of 38 pts; 14 women, 24 men, treated 6∕2003 to 9∕2006, with 33 pts receiving 2 courses and 5 pts with 3 courses of liver radiation. Retreatment with resin microspheres 26 pts, prior external beam radiation in 7 pts, prior glass microspheres in 2 pts, prior systemic radiotherapy in 2 pts, and prior stereotactic liver radiation in 1 pt. Liver function was stable and adequate in all patients after additional liver radiation, and no pts developed radiation-induced liver dysfunction (RILD) or veno-occlusive disease (VOD). The percentage of shunting to the lung decreased with retreatment. Conclusions: Repeated implantation in the liver with Y90-microspheres is safe in patients that have sufficient liver function and reserve based on known and accepted laboratory parameters already used for selection of microsphere therapy. No acute life-threatening, fatal, or late liver damage was observed, RILD or VOD. No specific dose reduction is recommended for retreatment of the liver.

scholarly journals Does the Presence of a Major Psychiatric Disorder Affect Tolerance and Outcomes in Men With Prostate Cancer Receiving Radiation Therapy?

2016 ◽  
Vol 11 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Joseph J. Safdieh ◽  
David Schwartz ◽  
Justin Rineer ◽  
Joseph P. Weiner ◽  
Andrew Wong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Specific Antigen ◽  
Delayed Diagnosis ◽  
External Beam Radiation ◽  
Definitive Treatment ◽  
Biochemical Control ◽  
Cancer Specific Survival ◽  
Beam Radiation ◽  
Propensity Score Adjustment

Prior studies have suggested that men with prostate cancer and psychiatric disorders (+Psy) have worse outcomes compared with those without (−Psy), particularly due to delayed diagnosis or reduced access to definitive treatment. In the current study, the toxicity and outcomes of men who were primarily diagnosed through prostate-specific antigen screening and who underwent definitive treatment with external beam radiation was investigated. The charts of 469 men diagnosed with prostate cancer from 2003 to 2010 were reviewed. The presence of +Psy was based on a Diagnostic and Statistical Manual of Mental Disorders–Fourth edition diagnosis of posttraumatic stress disorder, depression, schizophrenia, bipolar disorder, and/or generalized anxiety disorder. Kaplan–Meier analysis was used to analyze biochemical control, distant control, prostate cancer–specific survival, and overall survival. One hundred patients (21.3%) were identified as +Psy. At a median follow-up of 73 months, there were no differences regarding 6-year biochemical control (79.8% −Psy vs. 80.4% +Psy, p = .50) or 6-year distant metastatic-free survival (96.4% −Psy vs. 98.0% +Psy, p = .36). There were also no differences regarding the 6-year prostate cancer–specific survival (98.4% −Psy vs. 99.0% +Psy, p = .45) or 6-year overall survival (80.2% −Psy vs. 82.2% +Psy, p = .35). Short- and long-term genitourinary and gastrointestinal toxicities were similar between the groups. On multivariate analyses with propensity score adjustment, +Psy was not a significant predictor for toxicity, biochemical recurrence, or survival. The presence of +Psy was not associated with higher toxicity or worse clinical outcomes, suggesting that effective removal of screening and treatment barriers may reduce the survival disparities of these patients.

Prostate Biopsy after Definitive Treatment by Interstitial125Iodine Implant or External Beam Radiation Therapy

1987 ◽  
Vol 137 (5) ◽  
pp. 897-901 ◽  
Author(s):  
Paul F. Schellhammer ◽  
Anas M. El-Mahdi ◽  
Elizabeth M. Higgins ◽  
Timothy E. Schultheiss ◽  
Leopold E. Ladaga ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Prostate Biopsy ◽  
External Beam Radiation Therapy ◽  
External Beam Radiation ◽  
Definitive Treatment ◽  
External Beam ◽  
Beam Radiation

Comprehensive Analysis of the Kinetics of Radiation-Induced Lymphocyte Loss in Patients Treated with External Beam Radiation Therapy

2019 ◽  
Vol 193 (1) ◽  
pp. 73 ◽  
Author(s):  
Susannah G. Ellsworth ◽  
Anirudh Yalamanchali ◽  
Hong Zhang ◽  
Stuart A. Grossman ◽  
Robert Hobbs ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
External Beam Radiation Therapy ◽  
Comprehensive Analysis ◽  
External Beam Radiation ◽  
External Beam ◽  
Beam Radiation ◽  
Radiation Induced ◽  
Kinetics Of

scholarly journals Can Tomato Powder Reduce Radiation-Induced Effects in a Murine Model of Prostate Cancer?

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 348-348
Author(s):  
Joe Rowles III ◽  
Matthew Wallig ◽  
Kimberly Selting ◽  
Timothy Fan ◽  
Rita Miller ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Inflammatory Markers ◽  
Cell Damage ◽  
External Beam Radiation ◽  
Surrounding Tissue ◽  
C Reactive Protein ◽  
Beam Radiation ◽  
Reactive Protein ◽  
Mouse Prostate ◽  
Radiation Induced

Abstract Objectives Tomatoes contain carotenoids and other potent antioxidants that may protect the surrounding tissue from the detrimental effects of external beam radiation therapy, while reducing rates of prostate carcinogenesis. The objective of this study was to determine whether dietary lyophilized tomato paste (TP) alters early inflammatory and oxidative events following a single dose of radiation and leads to a more successful therapeutic outcome. Methods Male Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice (n = 76) were provided a powdered AIN-93 G diet (Control) or a modified AIN-93 G diet containing 10% TP (w/w) at 4 weeks of age. Mice were monitored by ultrasound for in vivo tumor detection and 3-D volumetric measurement biweekly. Once tumors reached a volume of 1000 mm3, the caudal half of the mouse was irradiated with 7.5 gy (Rad, n = 18–19 per diet) or 0 gy (sham, n = 16–20 per diet) with a Cobalt-60 source. Mice were euthanized 24 hours after radiation or sham treatment. Antioxidants (carotenoids and α-tocopherol) were measured by high performance liquid chromatography (HPLC) in the serum, tumor, prostate, and liver. Sections of tumor, liver, kidneys, bladder, lymph, bladder and intestines were stained by hematoxylin and eosin (H&E) and cleaved-caspase 3 were assessed for radiation-induced changes and apoptosis. Inflammatory markers (C-reactive protein, IL-6, IL-17A, TNFα, IFNγ, and IL-10) were measured in serum, liver, prostate, tumor, and epididymal adipose tissues by ELISA. Results This study is the first to explore the effects of TP on the tumor microenvironment following irradiation. Initial results suggest that TP consumption does not alter circulating or tissue (liver and prostate) concentrations of inflammatory markers (C-reactive protein, TNFα, IFNγ, IL-6, IL-17, or IL-10). We hypothesize that TP-Rad will maintain similar levels of circulating concentrations of antioxidants (carotenoids and α-tocopherol) compared to sham-treated mice. Additionally, we hypothesize that TP will reduce markers of cell damage in surrounding tissues. Conclusions This study will provide important preclinical data to inform future clinical trials evaluating approaches to lessen extra-prostatic damage from radiation therapy and thus improve therapeutic outcomes. Funding Sources This work was supported by USDA NIFA ILLU-971–334.

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