scholarly journals A Retrospective Analysis of Patients with Short Stature in the South of China between 2007 and 2015

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Su Wu ◽  
Qian-qi Liu ◽  
Wei Gu ◽  
Shi-ning Ni ◽  
Xing Shi ◽  
...  
Keyword(s):  
Short Stature ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
The South ◽  
Treatment Needs ◽  
Normal Height ◽  
Poor Growth ◽  
Number Of Patients ◽  
Medical University ◽  
Age Range

Objective. To describe the demographic features of children with short stature and poor growth in the south of China and provide better guidance on clinical strategy and decisions. Study Design. This retrospective, chart review study analyzed children with short stature and poor growth admitted to the Department of Endocrinology of Children’s Hospital of Nanjing Medical University from Jan 2007 to Dec 2015. Results. The chart review yielded 4142 patients, including 2546 boys and 1596 girls (P < 0.001); the number of patients gradually increased per year from 2007 to 2015. There was an upward trend in the average levels of height standard deviations (SDs) during the study period (P < 0.001), both in males (P < 0.001) and females (P < 0.001). Mean height SDs were smaller in females (-2.42±1.09) than males (-2.33±1.03; P = 0.01). The percentage of females admitted at normal height (33.83%) was lower than that of males (37.20%; P = 0.028). The peak age range of hospitalization in males was 10–12 years of age, while females were generally admitted earlier—8–10 years. Conclusions. There was an increasing tendency to focus on children’s height. Parents and pediatricians were recommended to pay more attention to the treatment needs of girls while avoiding excessive treatment of those who merely appear not to be tall enough without a clear medical issue related to growth, especially for boys.

Reduction in High-Frequency Hearing Aid Gain Can Improve Performance in Patients With Contralateral Cochlear Implant: A Pilot Study

2015 ◽  
Vol 24 (4) ◽  
pp. 462-468 ◽  
Author(s):  
Jessica J. Messersmith ◽  
Lindsey E. Jorgensen ◽  
Jessica A. Hagg
Keyword(s):  
Speech Perception ◽  
Cochlear Implant ◽  
Chart Review ◽  
Hearing Aid ◽  
Retrospective Chart Review ◽  
Improve Performance ◽  
Bimodal Condition ◽  
Overall Performance ◽  
Age Range ◽  
Clinic Population

Purpose The purpose of this study was to determine whether an alternate fitting strategy, specifically adjustment to gains in a hearing aid (HA), would improve performance in patients who experienced poorer performance in the bimodal condition when the HA was fit to traditional targets. Method This study was a retrospective chart review from a local clinic population seen during a 6-month period. Participants included 6 users of bimodal stimulation. Two performed poorer in the cochlear implant (CI) + HA condition than in the CI-only condition. One individual performed higher in the bimodal condition, but the overall performance was low. Three age range–matched users whose performance increased when the HA was used in conjunction with a CI were also included. The HA gain was reduced beyond 2000 Hz. Speech perception scores were obtained pre- and postmodification to the HA fitting. Results All listeners whose HA was programmed using the modified approach demonstrated improved speech perception scores with the modified HA fit in the bimodal condition when compared with the traditional HA fit in the bimodal condition. Conclusion Modifications to gains above 2000 Hz in the HA may improve performance for bimodal listeners who perform more poorly in the bimodal condition when the HA is fit to traditional targets.

Retrospective Chart Review of Cryopreserved Amniotic Membrane for Knee Pain

2020 ◽  
Author(s):  
Ruben Berrocal Timmons
Keyword(s):  
Quality Of Life ◽  
Adverse Events ◽  
Amniotic Membrane ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Final Analysis ◽  
Mean Values ◽  
Number Of Patients ◽  
The Impact

Objective: Treatment of joint pain with an injection of the amniotic membrane has not been adequately studied. This study retrospectively reviewed Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and analgesic usage data from patients treated with the injection of cryopreserved amniotic membrane (CAM) in their knees to determine the impact of treatment on patients’ pain, quality of life, and analgesic usage. Methods: Chart review was conducted on 40 patients. Institutional Review Board (IRB) approval was obtained prior to initiation of the project. The membrane was utilized as per the FDA guidance of 21CFR1271. Retrospective data, including demographics, medical history, pain score, quality of life score, analgesic usage and adverse events, were collected from their medical records for each consenting patient through 6 months after CAM injection. Results: A total of 40 patients were considered in the final analysis. Mean VAS for pain level improved from 7.0 to 2.6 (p<0.001). WOMAC daily activity function score improved from a mean score of 52 to 28 (p<0.001). Opioid and non-steroidal anti-inflammatory drug (NSAID) usage decreased from 97% to 25% (p<0.001). No adverse events were reported. Conclusion: Mean values for VAS and WOMAC scores significantly improved at all time points and the number of patients who used analgesics decreased as compared to baseline. CAM injection into painful knee joints decreases pain, improves physical function, and decreases the use of analgesics in the absence of adverse events.

scholarly journals Evaluation of referrals for short stature: A retrospective chart review

2018 ◽  
Vol 24 (2) ◽  
pp. e74-e77
Author(s):  
David Yue ◽  
Michael R Miller ◽  
Cheril L Clarson
Keyword(s):  
Short Stature ◽  
Chart Review ◽  
Retrospective Chart Review

scholarly journals Outcomes of eosinophilic esophagitis in patients managed in a multidisciplinary clinic

2022 ◽  
Vol 43 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Jeremy C. McMurray ◽  
Benjamin St Clair ◽  
Sarah W. Spriet ◽  
Steve B. Min ◽  
Daniel I. Brooks ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
Chart Review ◽  
Multidisciplinary Approach ◽  
Complex Disease ◽  
Clinical Symptoms ◽  
Medical Center ◽  
Retrospective Chart Review ◽  
Multidisciplinary Teams ◽  
Poor Growth ◽  
Multidisciplinary Clinic

Background: Eosinophilic esophagitis is a complex disease with an increasing prevalence. Multidisciplinary teams are often needed to manage this difficult-to-treat condition. Objective: To observe the clinical and histologic outcomes of patients with eosinophilic esophagitis after management in a multidisciplinary clinic. Methods: An observational, retrospective chart review was conducted to include all patients referred to the Walter Reed National Military Medical Center multidisciplinary eosinophilic esophagitis clinic between August 2012 and February 2021. Only patients who had at least one esophagogastroduodenoscopy before referral, one or more visits and endoscopy after multidisciplinary management, and documented clinical symptoms were included. Statistical analysis was performed by using McNemar and Wilcoxon tests. Results: A total of 103 patients were included in the study, with a mean age at diagnosis of 17.9 years. Management in the multidisciplinary clinic was associated with a reduction in solid-food dysphagia by 70.9%, poor growth by 70.8%, and emesis or regurgitation by 87.5%. We observed that 48.5% and 62.1% had histologic remission (<15 eosinophils/hpf) on the initial and any post-multidisciplinary endoscopy, respectively. Only seven patients (5.8%) with two or more visits and endoscopies did not achieve histologic remission. More than two-thirds of the patients (68.9%) required combination therapy to achieve remission. Conclusion: Although an observational study, these findings may suggest that the management of patients with eosinophilic esophagitis in a multidisciplinary clinic may improve the likelihood of clinical and histologic remission. Targeted management with a multidisciplinary approach may reduce overall morbidity and slow disease progression; however, more research is needed.

Otitis Media and Hearing Loss in Patients With Nonsyndromic Craniosynostosis: A Multicenter Study

2021 ◽  
pp. 105566562110177
Author(s):  
Jeewanjot S. Grewal ◽  
Jason E. Cohn ◽  
Jacob Burdett ◽  
Alex Tampio ◽  
Jordan Licata ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Demographic Data ◽  
Retrospective Chart Review ◽  
Categorical Variables ◽  
Chi Square ◽  
Entire Cohort ◽  
Medical University ◽  
Age Range

Objectives: The objectives of this study were to: (1) determine the prevalence of otitis media with effusion in patients with nonsyndromic craniosynostosis; (2) determine the prevalence of hearing loss in patients with nonsyndromic craniosynostosis; and (3) identify potential patterns and outcomes in patients with nonsyndromic craniosynostosis. Methods: A retrospective chart review was conducted at 2 academic institutions, St Christopher’s Hospital for Children and SUNY Upstate Medical University, from January 2015 through August 2018, to identify patients having nonsyndromic craniosynostosis with a concurrent diagnosis of otitis media and/or hearing loss. The demographic data and categorical variables were analyzed using descriptive statistics and chi-square testing, respectively. Results: In the entire cohort of patients (N = 113, age range 0-123 months), 36% had otitis media with effusion on either history, physical examination, tympanometry, and/or imaging. Half (50%) of patients with coronal synostosis had otitis media with effusion compared to sagittal (40.7%), metopic (26.3%), multiple (25%), and lambdoid (0%). However, these differences were not statistically significant ( P = .190). Most patients had normal hearing (91%), while a minority had either conductive (7%) or sensorineural (2%) hearing loss. Conclusion: The presence of otitis media in our cohort of patients with nonsyndromic craniosynostosis appears to be at the upper limit of normal when compared to historical rates in normocephalic children. Synostosis subtype did not appear to predict the presence of otitis media. Only 9% of patients with nonsyndromic craniosynostosis were found to have a hearing loss.

scholarly journals Conservative management, a preferred first line method for treatment of epistaxis.

2019 ◽  
Vol 26 (11) ◽  
pp. 1998-2002
Author(s):  
Muhammad Awais Javed
Keyword(s):  
Cold Water ◽  
Nasal Packing ◽  
Treatment Modalities ◽  
Chi Square ◽  
Conservative Method ◽  
Number Of Patients ◽  
Chi Square Test ◽  
Number Of Treatment ◽  
Medical University ◽  
Age Range

Epistaxis is defined as hemorrhage from nose where source of bleeding is inside the nose. There are many factors which can precipitate epistaxis. A number of treatment modalities are used for its treatment, conservative measures and nasal packing being the commonest method of treatment. Conservative method is an effective method of treatment and avoids potential complications of nasal packing. Objectives: To assess efficacy of conservative mode of treatment for epistaxis. Study Design: Prospective study. Settings: Department of Otorhinolaryngology, E.N.T. Unit-I, Allied Hospital/ Faisalabad Medical University, Faisalabad. Period: Three months i.e. from 16-10-2018 to 15-01-2019. Sample Size: 60. Material and Method: Procedure: 60 patients were enrolled according to inclusive and exclusive criteria. Conservative measures were applied to patients including cold water gargles, nasal pinching and Trotter’s method. Patients were observed for control of epistaxis and number of patients noted in whom conservative measures were not successful and nasal packing was done. No patient among the sample needed the surgical intervention due to failed conservative measures or nasal packing. Frequency and percentage calculated for data and chi-square test applied and level of <0.05 taken significant. Results: 60 patients enrolled with age range from 5-75 years and mean age as 39.53 years. Out of 60 patients, 38 were male and 22 were females. Out of 60 patients, 42 patients (70%) were treated successfully using conservative measures and 18 patients (30%) were treated with nasal packing. Conclusion: Based upon results of this study, it is concluded that conservative method of treatment of epistaxis is an effective and safe method and avoids potential complications which can occur due to nasal packing.

Concussion Subtyping in Patients With Persistent Post-Concussive Symptoms Using a New Concussion Clinical Profile Screen Tool (CP Screen)

Neurology ◽  
2021 ◽  
Vol 98 (1 Supplement 1) ◽  
pp. S11.1-S11
Author(s):  
Monica Pita ◽  
Luke Muratalla Maes ◽  
Andrew Ortiz ◽  
Saikaashyap Sarva ◽  
Mohammad Mortazavi
Keyword(s):  
Symptom Score ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Pediatric Age ◽  
Screen Tool ◽  
Cognitive Fatigue ◽  
Outcome Scores ◽  
Symptom Scores ◽  
Clinical Profiles ◽  
Age Range

ObjectiveTo identify the prevalence of subtypes in Persistent Post Concussion Symptoms (PPCS) and investigate their potential relationships.BackgroundThe CP-Screen is designed to evaluate 5 clinical profiles and 2 modifiers that are predominant within concussion patients. The CP screen includes 29 items that are expressed as weighted outcome scores for each of the 7 concussion subtypes.Design/MethodsThis was a retrospective-chart review of 1,136 visits for 362 patients with PPCS at a concussion center. Age range was 12–81 and average age was 32, 65.7% were female and 34.3% male. 360 visits were in the 12–21 pediatric age range. Each patient completed an electronic CP-Screen prior to each visit, which was uploaded to the EHR. All patients were seen between October 2020 and April 2021.ResultsOverall, the most common subtypes were cognitive (34.0%), neck (17.8%), and mood (16.8%). The highest overall observed subtype average CP symptom score was mood (32.8/89) and the lowest was visual (23.6/89). For pediatric the most common phenotypes were cognitive (36.7%), mood (17.9%), and visual (15.4%). The highest observed pediatric average CP symptom score was mood (30.8/89) and the lowest was sleep (20.1/89). For those with cognitive primary profile, neck and ocular were the most common secondary and tertiary profiles in both groups. Females presented with cognitive, mood, neck as their most common profiles compared to cognitive, neck, ocular in males in both groups. Neck, mood, and visual primary profiles all presented with cognitive fatigue as their secondary profile.ConclusionsCP screen was overall a useful tool in helping identify clinical profiles in PPCS. Cognitive fatigue was a predominant profile in PPCS across all ages and sexes. Those with predominant mood profiles presented with the highest symptom scores. Mood profile was more predominant in females. Cognitive primary profile was found to be most linked to cervical, mood, and visual profiles.

Enrolment of adolescents and young adults with cancer (AYAWC) to clinical trials at the Children’s Hospital of Eastern Ontario (CHEO).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18043-e18043
Author(s):  
Sarah Lum ◽  
Isabelle Laforest ◽  
Kenneth Tang ◽  
Lesleigh S. Abbott
Keyword(s):  
Clinical Trials ◽  
Chart Review ◽  
Tertiary Care ◽  
Age Groups ◽  
Retrospective Chart Review ◽  
Pediatric Hospital ◽  
Best Interest ◽  
Younger Patients ◽  
Time Period ◽  
Number Of Patients

e18043 Background: Five-year survival among AYAWC has seen less improvement than in other age groups. One hypothesized reason is low accrual to clinical trials, for which the reasons need further determination. Our objectives were to determine the enrolment of AYAWC on treatment clinical trials at CHEO, a tertiary care pediatric hospital in Ottawa, Canada and to determine barriers to enrolment of AYAWC compared to younger patients. Methods: A retrospective chart review of patients diagnosed at CHEO over 10 years from January 1, 2006 to December 31, 2015 was performed. AYAWC included 15-18 year olds, and younger patients included 0-14 year olds. Patients 18 years and older are treated at adult centers. The number of patients enrolled on an upfront treatment clinical trial was collected while those not enrolled were reviewed for documented non-enrolment reasons. Clinical trials available at CHEO during this time period were also recorded. Results: A total of 733 patients were diagnosed with 96 AYAWC and 637 younger patients. The proportion of patients enrolled on clinical trials was 19.8% (19) AYAWC and 27.3% (174) younger patients (p = 0.12). Trials were not available for 57.3% (55) of AYAWC and 53.7% (342) of younger patients for their disease type (p = 0.51). For the remaining 41 AYAWC, 46.3% were enrolled. For AYAWC not enrolled, 40.9% had a reason documented: for 22.2% a physician felt it was not in the patient’s best interest, 44.4% did not meet eligibility, 33.3% of families/patients declined. For the remaining 295 of younger patients that had trials available, 59% enrolled on a trial. For younger patients not enrolled, 25.6% had another reason documented: for 25.8% a physician felt it was not in the patient’s best interest, 45.2% did not meet trial eligibility, 25.8% of families/patients declined, 3.2% other reason. Conclusions: There were fewer AYAWC enrolled on trials compared to younger children. There were not fewer trials available for AYAWC patients than younger children. For patients not enrolled, the majority did not have an open trial available and otherwise, reasons for non-enrolment did not differ significantly between groups. Next steps could include data from local adult centers.

Are aromatase inhibitors in boys with predicted short stature and/or rapidly advancing bone age effective and safe?

2017 ◽  
Vol 30 (3) ◽  
Author(s):  
Jessica A. Ferris ◽  
Mitchell E. Geffner
Keyword(s):  
Short Stature ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Tanner Stage ◽  
Bone Age ◽  
Long Term Study ◽  
Group 2 ◽  
Endocrinology Clinic ◽  
Group 1

AbstractBackground:The aim of this study was to assess aromatase inhibitor (AI) efficacy in increasing predicted adult height (PAH) and to describe clinical and biochemical safety profiles of AI-treated boys.Methods:A retrospective chart review was conducted at an academic children’s hospital endocrinology clinic. Twenty-one boys with predicted short stature and/or rapidly advancing bone age, divided as Tanner stage (TS) I–III Group 1 (G1, n=9) and TS IV–V Group 2 (G2, n=12), were treated with AIs, either letrozole or anastrozole (mean duration, G1: 2.4 years and G2: 0.9 years). Primary outcomes included PAH, hormonal/biochemical analytes, and clinical data.Results:PAH did not significantly change in either group. Mean peak testosterone significantly increased from baseline to 650±458 ng/dL (p=0.008) in G1 and to 1156±302 ng/dL (p=0.002) in G2. Estradiol did not significantly change in either group. Compared to baseline, G2 showed increased mean FSH (p=0.002), LH (p=0.002), hematocrit (p=0.0001), body mass index (BMI) z-score (p=0.0005), and acne (p=0.01).Conclusions:AIs did not increase PAH, regardless of TS. Boys in late puberty had significant increases in testosterone, gonadotropins, hematocrit, acne, and BMI, but no reduction in estradiol. The potential consequences of these findings are concerning and require long-term study, especially if AIs are started in late puberty.

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