scholarly journals The Effects of Preoperative Oral Carbohydrate on Frequency of T and NK Cells in Patients with Cervical Cancer Treated Using Neoadjuvant Chemotherapy and Surgery: A Prospective Cohort Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Fuqing Zhang ◽  
Mengxia Yao ◽  
Zhiping Lin ◽  
Yili Chen ◽  
Hui Jiang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
T Cells ◽  
Cohort Study ◽  
Neoadjuvant Chemotherapy ◽  
Nk Cells ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Gynecologic Oncology ◽  
Tube Removal ◽  
Surgical Methods

Background. Immune dysfunction can occur after neoadjuvant chemotherapy (NAC) and surgery for cancer. We investigated whether preoperative oral carbohydrate affected the postoperative percentages of T cells (CD4+ and CD8+) and natural killer (NK) cells in patients with cervical cancer treated with NAC and surgery. Methods. This prospective cohort study enrolled consecutive patients with cervical cancer treated by radical hysterectomy with PLND at the Gynecologic Oncology Department of Fujian Provincial Cancer Hospital (China) between January 2018 and December 2018. Patients were divided into three groups according to the treatment method: NAC (two cycles, surgery 1 month later), NAC+CHO (chemotherapy and surgical methods same as with the NAC group but with 300 mL of oral carbohydrate administered 2 h before surgery), and non-NAC (surgery alone). Percentages of NK, CD3+, CD4+, and CD8+ cells were evaluated by flow cytometry the day after the first admission, just before surgery, immediately after tracheal tube removal, and the day after surgery. This trial is registered with NCT03872635 at clinicaltrials.com. Results. The final analysis included 77 patients (non-NAC group, n=26; NAC group, n=25; and NAC-CHO group, n=26). Baseline characteristics and preoperative NK, CD3+, CD4+, and CD8+ cell percentages were similar between groups. Postoperatively, all groups exhibited reductions in NK, CD3+, and CD4+ cell percentages and increases in CD8+ cell percentages (all P<0.05). The changes in NK, CD3+, CD4+, and CD8+ cell percentages were attenuated in the NAC-CHO group (P<0.05 vs. both other groups). Conclusion. Preoperative oral carbohydrate can improve the postoperative populations of NK and T cells after the treatment of cervical cancer by NAC and surgery.

scholarly journals High levels of circulating GM-CSF+CD4+ T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study

2018 ◽  
Vol 16 (6) ◽  
pp. 602-610 ◽  
Author(s):  
Huihuang Huang ◽  
Siyu Wang ◽  
Tianjun Jiang ◽  
Rong Fan ◽  
Zheng Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Cd4 T Cells ◽  
Prospective Cohort ◽  
Gm Csf ◽  
Poor Outcomes

scholarly journals Feasibility and first results of a prospective cohort study to investigate cisplatin-associated ototoxicity amongst cancer patients in South Africa

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jessica Paken ◽  
Cyril D. Govender ◽  
Mershen Pillay ◽  
Birhanu T. Ayele ◽  
Vikash Sewram
Keyword(s):  
South Africa ◽  
Cervical Cancer ◽  
Hearing Loss ◽  
Cohort Study ◽  
Cancer Patients ◽  
Prospective Cohort Study ◽  
High Frequency ◽  
Prospective Cohort ◽  
Multidisciplinary Approach ◽  
Limited Resource

Abstract Background Cervical cancer, one of the most common cancers affecting females in South Africa, commonly requires a cisplatin-based-treatment regimen, which has been associated with ototoxic side effects. However, cisplatin-associated ototoxicity is largely under-reported in South Africa, despite its impact of hearing loss having serious overt ramifications on the quality of life of these patients. Hence, a prospective cohort study was undertaken to assess the audiological changes in female cervical cancer patients receiving cisplatin therapy. Objective To present details of the feasibility study and initial results on hearing patterns in cervical cancer patients receiving cisplatin chemotherapy. . Methods Fifty cervical cancer patients commencing with cisplatin chemotherapy underwent audiological assessments at a hospital in South Africa at various time intervals. Assessments included case history, otoscopic examination, immittance audiometry, pure tone audiometry (including high-frequency audiometry), speech audiometry, and distortion product otoacoustic emission testing. Data analysis involved the use of descriptive statistics and the Cochran-Armitage trend test for a linear trend in proportions. Results Fifty participants, aged between 32 and 79 years (Mean: 53 years; SD = 11.00), were recruited. Clinical findings revealed an incidence of 100% ototoxic hearing loss at the one-month post-treatment, i.e., 98%  after three cycles of cisplatin and 2%  at one-month post-chemotherapy. Sensorineural hearing loss and high-frequency tinnitus were most common. Deterioration in hearing thresholds was more evident in the extended high-frequency range, with the number of “no-responses,” from 11,200 Hz to 20,000 Hz, increasing with each successive audiological evaluation. This study further indicated that recruitment and follow-up of study participants within a limited resource setting are possible. However, cognizance must be given to a multidisciplinary approach and constant engagement with participants through regular contact either telephonically or via a short-message-system. Conclusion Exposure to cisplatin treatment contributed to hearing loss in females with cervical cancer, highlighting the need for ototoxicity monitoring during chemotherapy treatments. Furthermore, the results indicate that it is possible to conduct prospective cohort studies, using a multidisciplinary approach in limited-resource environments with appropriate planning and training strategies, as this study was able to achieve its aim successfully.

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