scholarly journals Delayed Diagnosis of a Diffuse Invasive Gastrointestinal Aspergillosis in an Immunocompetent Patient

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
S. Guglielmetti ◽  
C. M. Jaccard ◽  
K. Mühlethaler ◽  
A. Bigler ◽  
D. Springe ◽  
...  
Keyword(s):  
Invasive Aspergillosis ◽  
Primary Infection ◽  
Surgical Intervention ◽  
Delayed Diagnosis ◽  
Immunocompetent Patient ◽  
High Morbidity ◽  
Delay Of Treatment ◽  
Gastrointestinal Aspergillosis ◽  
Portal Of Entry ◽  
Immunocompetent Patients

Invasive aspergillosis represents a clinical picture frequently associated with host’s immunosuppression which usually involves a high morbidity and mortality. In general, the most frequent fungal entry is the lungs with secondary hematogenous dissemination, but there are other hypotheses like a gastrointestinal portal of entry. There are some rare publications of cases with invasive aspergillosis in immunocompetent patients. We present the case of an immunocompetent patient without any risk factors except for age, ICU stay, and surgical intervention, who developed a septic shock by invasive gastrointestinal aspergillosis as primary infection. Due to the unusualness of the case, despite all the measures taken, the results were obtained postmortem. We want to emphasize the need not to underestimate the possibility for an invasive aspergillosis in an immunocompetent patient. Not only pulmonary but also gastrointestinal aspergillosis should be taken into account in the differential diagnosis to avoid a delay of treatment.

scholarly journals Invasive aspergillosis in an immunocompetent patient with fever and a cardiac mass

2011 ◽  
Vol 3 (2) ◽  
pp. 12 ◽  
Author(s):  
Matthew LaBarbera ◽  
Lester B. Jacobson
Keyword(s):  
Differential Diagnosis ◽  
Invasive Aspergillosis ◽  
Respiratory Infection ◽  
Respiratory Illness ◽  
Immunocompetent Patient ◽  
Cardiac Mass ◽  
Immunocompromised Patients ◽  
Fatal Disease ◽  
Febrile Respiratory Illness ◽  
Immunocompetent Patients

Invasive aspergillosis is an often fatal disease that usually occurs in immunocompromised patients. We report a case of invasive aspergillosis presenting as a febrile respiratory infection with a cardiac mass in an immunocompetent patient. Invasive aspergillosis should be considered in the differential diagnosis of an otherwise undiagnosed febrile respiratory illness, even in immunocompetent patients. Echocardiography should be peformed to evaluate for endocarditis in such cases. Prompt initiation of appropriate antifungal therapy is warranted, even before the diagnosis of invasive aspergillosis is confirmed.

scholarly journals An Immunocompetent Patient with Isolated Cryptococcosis of the Nasal Cavity: Surgical Treatment without Systemic Antifungal Agents

2017 ◽  
Vol 10 (1) ◽  
pp. 36-38
Author(s):  
Seong K Park ◽  
Do H Kim
Keyword(s):  
Surgical Treatment ◽  
Nasal Cavity ◽  
Antifungal Agents ◽  
Surgical Intervention ◽  
Healthy Woman ◽  
Immunocompetent Patient ◽  
Immunocompetent Patients

ABSTRACT The mode of cryptococcal transmission to humans is believed to be through inhalation of aerosolized droppings, which cause asymptomatic pulmonary granulomata in immunocompetent patients. Extrapulmonary infections have been associated with various immunocompromised states, and these infections are relatively rare in immunocompetent patients. In general, cryp tococcal sinus infections are treated with surgical intervention and administration of systemic antifungal agents. However, there is doubt that systemic antifungal agents are necessary in immunocompetent patients with no complications. We report an otherwise healthy woman with cryptococcosis of the nasal cavity who was treated surgically without systemic antifungal agents. How to cite this article Park SK, Kim DH. An Immunocom petent Patient with Isolated Cryptococcosis of the Nasal Cavity: Surgical Treatment without Systemic Antifungal Agents. Clin Rhinol An Int J 2017;10(1):36-38.

scholarly journals Isolated Mycobacterium Tuberculosis Tenosynovitis and Osteomyelitis of the Foot in an Immunocompetent Patient

2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Elgazzar A ◽  
◽  
Cecchini A ◽  
Elmezayen RI ◽  
◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Delayed Diagnosis ◽  
Pulmonary Involvement ◽  
Immunocompetent Patient ◽  
Complete Healing ◽  
Radiological Findings ◽  
Intravenous Antibiotics ◽  
Healing Wounds ◽  
High Index Of Suspicion ◽  
Immunocompetent Patients

Tubercular osteomyelitis must be considered in the differential diagnosis of immunocompetent patients who present with non-healing wounds with underlying osteomyelitis. Clinical and radiological findings may be indistinguishable from typical bacteria osteomyelitis. A high index of suspicion may prevent delayed diagnosis, and early treatment may prevent subsequent complications. This is a case report of an immunocompetent patient who presented with a chronic non-healing foot wound complicated by abscess and osteomyelitis that did not improve with an appropriate course of intravenous antibiotics. Wound cultures subsequently grew Mycobacterium tuberculosis without evidence of pulmonary involvement. The patient was treated with an initial two-month regimen of rifampin, isoniazid, pyridoxine, pyrazinamide and ethambutol, followed by a tenmonth regimen of rifampin, isoniazid and pyridoxine. The patient experienced significant improvement and complete healing of the foot wound after approximately the first two months of therapy.

scholarly journals Multiple invasive aspergillus brain abscess in an immunocompetent patient without any history of trauma

2019 ◽  
Vol 7 (1) ◽  
pp. 181
Author(s):  
Akshay K. Barde ◽  
Pankaj Soni
Keyword(s):  
Invasive Aspergillosis ◽  
Brain Abscess ◽  
Poor Prognosis ◽  
Immunocompetent Patient ◽  
High Morbidity ◽  
Rare Manifestation ◽  
Invasive Infections ◽  
Life Threatening ◽  
History Of ◽  
Intracranial Aspergillosis

Aspergillus is a fungus found in the environment. In an immunocompetent person, inhalation of spores may cause localized infection. In immune compromised patients, these fungi can cause life-threatening invasive infections which has high morbidity and mortality. Invasive aspergillosis has a poor prognosis. Intracranial aspergillosis is an extremely rare manifestation of invasive aspergillosis in immunocompetent individuals. A case of 60-year-old immunocompetent male is reported who had multiple Aspergillus brain abscess.

scholarly journals Septic shock due to Yersinia pseudotuberculosis infection in an adult immunocompetent patient: a case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takehiro Hashimoto ◽  
Ryuichi Takenaka ◽  
Haruka Fukuda ◽  
Kazuhiko Hashinaga ◽  
Shin-ichi Nureki ◽  
...  
Keyword(s):  
Septic Shock ◽  
Therapeutic Strategy ◽  
Yersinia Pseudotuberculosis ◽  
Immunocompromised Host ◽  
Immunocompetent Patient ◽  
Case Presentation ◽  
Gram Negative ◽  
Old Japanese ◽  
The Right ◽  
Immunocompetent Patients

Abstract Background Yersinia pseudotuberculosis infection can occur in an immunocompromised host. Although rare, bacteremia due to Y. pseudotuberculosis may also occur in immunocompetent hosts. The prognosis and therapeutic strategy, especially for immunocompetent patients with Y. pseudotuberculosis bacteremia, however, remains unknown. Case presentation A 38-year-old Japanese man with a mood disorder presented to our hospital with fever and diarrhea. Chest computed tomography revealed consolidation in the right upper lobe with air bronchograms. He was diagnosed with pneumonia, and treatment with intravenous ceftriaxone and azithromycin was initiated. The ceftriaxone was replaced with doripenem and the azithromycin was discontinued following the detection of Gram-negative rod bacteria in 2 sets of blood culture tests. The isolated Gram-negative rod bacteria were confirmed to be Y. pseudotuberculosis. Thereafter, he developed septic shock. Doripenem was switched to cefmetazole, which was continued for 14 days. He recovered without relapse. Conclusions We herein report a case of septic shock due to Y. pseudotuberculosis infection in an adult immunocompetent patient. The appropriate microorganism tests and antibiotic therapy are necessary to treat patients with Y. pseudotuberculosis bacteremia.

scholarly journals Heterotopic caval valve implantation for the management of severe tricuspid regurgitation: a case series

2020 ◽  
Author(s):  
Aidan Sharkey ◽  
Ronny Munoz Acuna ◽  
Kiran Belani ◽  
Ravi K Sharma ◽  
Omar Chaudhary ◽  
...  
Keyword(s):  
Medical Therapy ◽  
Tricuspid Regurgitation ◽  
Surgical Intervention ◽  
Symptom Relief ◽  
Vena Cava ◽  
Case Series ◽  
High Morbidity ◽  
Severe Tricuspid Regurgitation ◽  
Maximal Medical Therapy ◽  
Valve Implantation

Abstract Background Severe tricuspid regurgitation (TR) is a complex condition that can be difficult to treat medically, and often surgical intervention is prohibited due to the high morbidity and mortality associated with this intervention. In patients who have failed maximal medical therapy and have progressive symptoms related to their severe TR, heterotopic caval valve implantation (CAVI) offers potential for symptom relief for these patients. Case summary We present two cases of patients with severe TR with symptoms of heart failure that were refractory to medical therapy. Due to extensive comorbidities in these patient’s surgical intervention was deemed unsuitable and the decision was made to proceed with heterotopic CAVI in order to try and control their symptoms. Both patients successfully underwent the procedure and had an Edwards SAPIEN 3 valve (Edwards Lifesciences, Irvine, CA, USA) implanted in the inferior vena cava/right atrium junction. In both patients, there was improvement in the postoperative haemodynamics as measured by invasive and non-invasive methods. Successful discharge was achieved in both patients with improvement in their symptoms. Discussion Selective use of heterotopic CAVI to treat symptomatic severe TR that is refractory to medical therapy may be a viable option to improve symptoms in those patients that are unsuitable for surgical intervention.

scholarly journals Orbital Apex Syndrome due to Invasive Aspergillosis in an Immunocompetent Patient

IDCases ◽  
2021 ◽  
pp. e01232
Author(s):  
Grace D. Cullen ◽  
Tara M. Davidson ◽  
Zachary Yetmar ◽  
Bobbi S. Pritt ◽  
Daniel C. DeSimone
Keyword(s):  
Invasive Aspergillosis ◽  
Immunocompetent Patient ◽  
Orbital Apex ◽  
Orbital Apex Syndrome

scholarly journals Prostatic tuberculosis: case report

2008 ◽  
Vol 126 (4) ◽  
pp. 227-228 ◽  
Author(s):  
Daniel Sáenz-Abad ◽  
Santiago Letona-Carbajo ◽  
José Luis de Benito-Arévalo ◽  
Isabel Sanioaquín-Conde ◽  
Francisco José Ruiz-Ruiz
Keyword(s):  
Computed Tomography ◽  
Mycobacterium Tuberculosis ◽  
Case Report ◽  
Urine Culture ◽  
Immunocompetent Patient ◽  
Immunocompromised Patients ◽  
Tuberculosis Case ◽  
Immunocompetent Patients

CONTEXT: Tuberculosis of the prostate has mainly been described in immunocompromised patients. However, it can exceptionally be found as an isolated lesion in immunocompetent patients. CASE REPORT: We report a case of prostatic tuberculosis in a young, healthy and immunocompetent patient with unremarkable findings from intravenous urographic examination. Computed tomography showed an abscess in the prostate and Mycobacterium tuberculosis was isolated in a urine culture. Treatment with isoniazid, rifampin and pyrazinamide was successful.

scholarly journals A case series on post-covid deadly fungal infection: mucormycosis

2021 ◽  
Vol 7 (9) ◽  
pp. 1503
Author(s):  
Kalpana G. ◽  
Amol A. Patil ◽  
Manohar Shaan ◽  
Mitusha Verma ◽  
Gayatri Harshe
Keyword(s):  
Fungal Infection ◽  
Opportunistic Infection ◽  
Surgical Intervention ◽  
Case Series ◽  
Medical Intervention ◽  
Morbidity And Mortality ◽  
Diabetic Patients ◽  
High Morbidity ◽  
Per Se

<p class="abstract">The prevailing pandemic situation by SARS-CoV-2 infection is not only worrisome by the disease per se but also for the accompanying opportunistic infection are in the rise especially in diabetic patients. We presented a case series of post-covid rhino orbital cerebral mucormycosis infection in diabetic patients resulting in high morbidity. The need to present this was to emphasis on the timely surgical and medical intervention needed to reduce morbidity and mortality by the infection. The study highlighted the importance of surgical intervention in the deadly infection.</p>

scholarly journals Pulmonary Nocardiosis in Immunocompetent Patient: A Rare Case Report

2020 ◽  
Author(s):  
Kusum V Shah ◽  
Saket Kumar ◽  
Yash Rana ◽  
Arti D Shah
Keyword(s):  
Case Report ◽  
Bacterial Infection ◽  
Rare Case ◽  
Severe Disease ◽  
Immunocompetent Patient ◽  
Nocardia Species ◽  
Pulmonary Nocardiosis ◽  
Rare Case Report ◽  
Bronchial Alveolar Lavage ◽  
Immunocompetent Patients

Pulmonary nocardiosis is a rare bacterial infection that may lead to severe disease in immunodeficient patients and usually not so common in immunocompetent patients. The report is about a 57-year-old male with Norcardiosis. His sputum and Bronchial Alveolar Lavage (BAL) were negative for acid-fast bacilli. Nocardia species was isolated in BAL culture. He was started on Trimethoprim/Sulfamethoxazole and Clarithromycin, which was later continued for six months.

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