scholarly journals Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Jing Yan ◽  
Ailin Luo ◽  
Rao Sun ◽  
Xiaole Tang ◽  
Yilin Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Elderly Population ◽  
Cognitive Deficit ◽  
Neurological Complication ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly ◽  
Dependent Manner ◽  
Promising Avenue ◽  
Tau Acetylation

Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological complication in the elderly population. As the global acceleration of population ageing, POCD is proved to be a great challenge to the present labor market and healthcare system. In the present study, our findings showed that tau acetylation mediated by SIRT1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged POCD model and consequently contributed to cognitive impairment. Interestingly, pretreatment with resveratrol almost restored the expression of SIRT1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. What is more, we observed that microglia-derived neuroinflammation resulting from SIRT1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro. Our findings supported the notion that activation SIRT1 provided dually beneficial effect in the aged POCD model. Taken together, our findings provided the initial evidence that tau acetylation was associated with cognitive impairment in the aged POCD model and paved a promising avenue to prevent POCD by inhibiting tau acetylation in a SIRT1-dependent manner.

scholarly journals APOE-ε4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha

2008 ◽  
Vol 66 (2b) ◽  
pp. 298-302 ◽  
Author(s):  
Anália Nusya Garcia ◽  
Helker Albuquerque da Silva ◽  
Renan Carlos Silva ◽  
Eliane Maria Medeiros Leal ◽  
Lorena Rodrigues ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Elderly Population ◽  
Cognitive Deficit ◽  
The Elderly ◽  
Clock Drawing Test ◽  
Apoe Ε4 ◽  
Pcr Rflp ◽  
Fernando De Noronha ◽  
Ε4 Allele

BACKGROUND: Polymorphism of the gene for apolipoprotein E (APOE) is an important risk factor for the development of Alzheimer's disease. The ε4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations. OBJECTIVE: To identify APOE-ε4 polymorphism and correlate this with cognitive deficit among the elderly population of the island of Fernando de Noronha. METHOD: Neuropsychiatric tests (mini-mental state examination, verbal fluency test and clock drawing test) were applied to 52 elderly people without Alzheimer's disease. DNA was isolated from peripheral blood and genotyping of APOE was done by the PCR-RFLP method. RESULTS: 87% of the elderly population (mean age 69.6±7.0) had cognitive deficit. CONCLUSION: The observed frequency of the ε4 allele was 10%, but the correlation between the presence of ε4 and cognitive deficit in this population was not statistically significant.

A Short Mental Status Questionnaire

1982 ◽  
Vol 1 (1-2) ◽  
pp. 16-20 ◽  
Author(s):  
Duncan Robertson ◽  
Kenneth Rockwood ◽  
Paul Stolee
Keyword(s):  
Cognitive Impairment ◽  
Mental Status ◽  
Clinical Assessment ◽  
Elderly Population ◽  
The Elderly ◽  
False Positives ◽  
False Negatives ◽  
Institutionalized Elderly ◽  
Severe Cognitive Impairment ◽  
Mild Impairment

ABSTRACTA mental status questionnaire (MSQ) developed tor use in surveys of the non-institutionalized elderly has been validated against clinical assessment. The MSQ identities moderate and severe cognitive impairment in the elderly. However, using the suggested scoring subjects with mild impairment cannot be separated from normals.The test is short, acceptable and reproducible and rate for false-positives and false-negatives fall well within acceptable limits for use in estimating the prevalence of dementia in the non-institutionalized elderly population.

scholarly journals Investigation of the prevalence of Cognitive Impairment and its risk factors within the elderly population in Shanghai, China

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Longbing Ren ◽  
Yongtao Zheng ◽  
Lezhou Wu ◽  
Yijun Gu ◽  
Yusheng He ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Elderly Population ◽  
The Elderly

scholarly journals Impact of cognitive performance on the functional capacity of an elderly population in Natal, Brazil

2008 ◽  
Vol 66 (4) ◽  
pp. 809-813 ◽  
Author(s):  
Keithlen Cruz Moreira de Castro ◽  
Ricardo Oliveira Guerra
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Performance ◽  
Functional Capacity ◽  
Elderly Population ◽  
Population Sample ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Elderly Persons ◽  
Cross Sectional ◽  
State Examination

Functional incapacity and cognitive impairment are conditions related to the process of human aging. Cognitive impairment is considered an important predicitve factor for functional impairment in elderly populations. This cross-sectional study analyzes the association between cognitive performance and functional capacity in an elderly population sample in Natal, Brazil. A total of 213 elderly persons were assessed by the BOAS Multidimensional Questionnaire (Brazil Old Age Schedule) and the Mini-Mental State Examination (MMSE). The results of multivariate analysis and linear regression showed that age and schooling level are factors associated with cognitive performance in the elderly of this study. The final explicative model, elaborated by logistic regression, found that cognitive performance was the only predicitve variable of functional incapacity for the activities of daily living even when adjusted for sociodemographic variables.

scholarly journals Rheum tanguticum Alleviates Cognitive Impairment in APP/PS1 Mice by Regulating Drug-Responsive Bacteria and Their Corresponding Microbial Metabolites

2021 ◽  
Vol 12 ◽  
Author(s):  
Demin Gao ◽  
Huizhen Zhao ◽  
Zhihui Yin ◽  
Chen Han ◽  
Ying Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Neuronal Damage ◽  
Intestinal Bacteria ◽  
Dependent Manner ◽  
Microbial Metabolites ◽  
Therapeutic Mechanisms ◽  
Polymerase Chain ◽  
Important Nodes ◽  
Rheum Tanguticum

Drugs targeting intestinal bacteria have shown great efficacy for alleviating symptoms of Alzheimer’s disease (AD), and microbial metabolites are important messengers. Our previous work indicated that Rheum tanguticum effectively improved cognitive function and reshaped the gut microbial homeostasis in AD rats. However, its therapeutic mechanisms remain unclear. Herein, this study aimed to elaborate the mechanisms of rhubarb for the treatment of AD by identifying effective metabolites associated with rhubarb-responsive bacteria. The results found that rhubarb reduced hippocampal inflammation and neuronal damage in APP/PS1 transgenic (Tg) mice. 16S rRNA sequencing and metabolomic analysis revealed that gut microbiota and their metabolism in Tg mice were disturbed in an age-dependent manner. Rhubarb-responsive bacteria were further identified by real-time polymerase chain reaction (RT-PCR) sequencing. Four different metabolites reversed by rhubarb were found in the position of the important nodes on rhubarb-responsive bacteria and their corresponding metabolites combined with pathological indicators co-network. Furthermore, in vitro experiments demonstrated o-tyrosine not only inhibited the viabilities of primary neurons as well as BV-2 cells, but also increased the levels of intracellular reactive oxygen species and nitric oxide. In the end, the results suggest that rhubarb ameliorates cognitive impairment in Tg mice through decreasing the abundance of o-tyrosine in the gut owing to the regulation of rhubarb-responsive bacteria. Our study provides a promising strategy for elaborating therapeutic mechanisms of bacteria-targeted drugs for AD.

scholarly journals Neutrophil Elastase Induces Chondrocyte Apoptosis and Facilitates the Occurrence of Osteoarthritis via Caspase Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Ganyu Wang ◽  
Weiqiang Jing ◽  
Yuxuan Bi ◽  
Yue Li ◽  
Liang Ma ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Neutrophil Elastase ◽  
Elderly Population ◽  
The Elderly ◽  
Chondrocyte Apoptosis ◽  
Intracellular Ros ◽  
Induced Apoptosis

Osteoarthritis (OA) is the most common and prevalent chronic joint disorders in the elderly population across the globe, resulting in severe disability and impairment of quality of life. Existing treatment can only alleviate the symptoms and delay the progression of OA. Therefore, novel and effective therapeutics strategies for OA need to be developed. Our present study first found that neutrophil elastase (NE) was significantly increased in OA patients’ synovial fluid. Next, we examined the effect of neutrophil elastase (NE) on chondrocytes in vitro and in vivo. The results showed that NE suppressed cell proliferation, induced apoptosis and prevented cell migration in chondrocytes in vitro, accompanied by the elevation of intracellular ROS and calcium level. Moreover, NE enhanced the cleaved caspase-3 levels and disrupted the mitochondrial transmembrane potential balance. Meanwhile, chondrocytes apoptosis induced by NE can be alleviated by caspase inhibitor, zVAD-FMK and antioxidants, GSH. Besides, treatment of sivelestat, the inhibitor of NE, significantly reduced the pathological processes in OA model rats in vivo. The results of our study suggested that NE is an important factor in OA, which induces chondrocyte apoptosis and facilitates the occurrence of OA via caspase signaling pathway, and targeting the crucial signal centering around NE may be the potential therapies for OA.

scholarly journals Neuropsychiatric Score for Early Detection of Mild Cognitive Impairment of Elderly Populations in The Community

2021 ◽  
Author(s):  
Gea Pandhita ◽  
Prasila Darwin ◽  
Bety Lakhsmi
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Elderly Population ◽  
Health Workers ◽  
The Elderly ◽  
Accurate Method ◽  
Semantic Fluency ◽  
Subjective Memory ◽  
Low Education

Abstract Background: The increase in the elderly population in a developing country like Indonesia will increase people with cognitive impairment. Mild Cognitive Impairment (MCI) is the most common cognitive impairment among the elderly. However, some health workers are not satisfied with the current tools for detecting MCI in the community.Objective: This study intends to develop a novel, easy, and accurate method for early detection of MCI of the elderly population in the community in Indonesia.Methods: This study analyzed the database of 110 elderly population in East Jakarta, Indonesia. We explored several brief neuropsychiatric battery and developed a neuropsychiatric score to detect MCI.Results: The abnormal verbal semantic fluency test (p = 0.000), the existence of subjective memory complaints (p = 0.007), and low education level (p = 0.049) were found to be good predictors to detect MCI. The neuropsychiatric score, a combination of those variables, with a cut-off point of 2, has good accuracy to detect MCI (Sensitivity = 91.20%; Specificity = 78.9%).Conclusion: The neuropsychiatric score is a novel, easy, and accurate method for early detection of MCI of the elderly population in the community in Indonesia.

scholarly journals The Validity of the Alcohol-Use-Disorder-Identification-Test and a Novel Proxy Test in the Assessment of Alcohol Consumption in the Cognitively Impaired Elderly

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Cognitive Impairment ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Alcohol Intake ◽  
Elderly Population ◽  
Screening Tool ◽  
Alcohol Misuse ◽  
The Elderly ◽  
Identification Test ◽  
Disorder Identification

Aims: Alcohol is consumed excessively by almost a quarter of the population. A report by highlighted underdiagnosis of alcohol misuse in the elderly [1]. There is a lack of research focusing on assessment of alcohol use and its impact in older people. This study aimed to assess the validity of the Alcohol-Use-Disorder-Identification-Test (AUDIT) in an elderly population with cognitive impairment and to establish the validity of a novel adaption of the AUDIT used as a proxy measure. Methods: Opportunistic observational study examining the assessment of alcohol consumption in an elderly population with mild cognitive impairment or mild dementia. The study aimed to evaluate the self-report AUDIT versus a “proxy” AUDIT compared to a plasma Carbohydrate-deficientTransferrin (CDT) level. Findings: Scores were comparable between the “proxy” AUDIT and the AUDIT. Neither measure of alcohol intake correlated significantly with CDT levels. There was no association between alcohol intake and cognition or quality of life ratings. Conclusions: We suggest the AUDIT could be a useful screening tool in detecting alcohol misuse in the elderly with cognitive impairment. The “proxy” AUDIT was also found to be a valid screening tool, however further work is needed to confirm these findings.

scholarly journals Direct and indirect neurological, cognitive and behavioral effects of COVID-19 on the normal elderly, Mild-Cognitive-Impairment and Alzheimer’s Disease populations

2020 ◽  
Author(s):  
Francesco Iodice ◽  
Valeria Cassano ◽  
Paolo Maria Rossini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Indirect Effects ◽  
Elderly Population ◽  
Health Resources ◽  
The Elderly ◽  
Recovery Phase ◽  
Healthy Elderly

Abstract This article reviews the main articles that have been published so far about the direct and indirect effects of the COVID-19 pandemic on a particularly fragile population represented by the healthy elderly people as well as those with Mild Cognitive Impairment and Alzheimer's disease. Such populations have been among the most affected in the early stages of the pandemic due to the direct effects of the virus and numerous indirect effects now emerge and will have to be carefully assessed over time. The pandemic associated to COVID-19 has shifted most of the health resources to the emergency area and has consequently left the three main medical areas that dealing with the elderly population (oncology, time-dependent diseases and degenerative disease) temporarily “uncovered”. In the phase following the emergency, it will be crucial to guarantee to each area the economic and organizational resources to quickly return to the level of support of the pre-pandemic state. The emergency phase represented an important moment of discussion on the possibilities of telemedicine which will inevitably become increasingly important but all the limits of its use in the elderly population have to be considered. In the post-lockdown recovery phase, alongside the classic medical evaluation, the psychological evaluation must become even more important for doctors caring about people with cognitive decline.

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