A NOVEL METHOD FOR RAPID FABRICATION OF PMMA MICROFLUIDIC CHIP BY LASER CUTTING AND SEALING INTEGRATION

2019 ◽  
Vol 26 (08) ◽  
pp. 1950042 ◽  
Author(s):  
XUEYE CHEN ◽  
TIECHUAN LI ◽  
QI GAO
Keyword(s):  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Laser Cutting ◽  
Cost Effective ◽  
Cover Plate ◽  
Microfluidic Chips ◽  
Pmma Substrate ◽  
Rapid Fabrication ◽  
Novel Method ◽  
Liquid Pools

In this paper, we present a new method that is capable of manufacturing microfluidic chips of polymethyl methacrylate (PMMA) rapidly and cheaply. This technique, which we call Tape adhering-Laser Cutting and Sealing Integration (TLCSI), only utilizes a CO2 laser and a piece of double-sided tape to produce a microfluidic chip in several minutes. It only has three main steps. First, the double-sided tape sticks to the surface of a PMMA substrate. Second, the microchannel should be cut on the surface of the double-sided tape. At last, a PMMA cover plate with liquid pools is pressed onto the surface of the double-sided tape and a CO2 laser is used to cut edges of the chip for sealing the chip. We present a qualified microfluidic chip with regular microchannels and sealing strength of 1.2[Formula: see text]Mpa. Compared with most current fabrication methods, TLCSI is a quick and cost-effective way to produce microfluidic chips of PMMA.

A STUDY ON THE SURFACE QUALITIES OF FOUR POLYMER SUBSTRATE MICROCHANNELS USING CO2 LASER FOR MICROFLUIDIC CHIP

2019 ◽  
Vol 26 (03) ◽  
pp. 1850160
Author(s):  
ZENGLIANG HU ◽  
XUEYE CHEN ◽  
YI REN
Keyword(s):  
Polyethylene Terephthalate ◽  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Laser Power ◽  
Laser Cutting ◽  
Cutting Speed ◽  
Processing Parameters ◽  
Polymer Substrate ◽  
Laser Machine ◽  
Polymer Substrates

The paper demonstrates four different polymer substrate microchannels are fabricated by CO2 laser machine. The four different polymer substrates are Polymethyl-methacrylate (PMMA), Polycarbonate (PC), Polystyrene (PS) and Polyethylene Terephthalate (PET), respectively. A number of microchannels are obtained and all roughness is measured. The four different polymer substrate microchannels are processed with different processing parameters. Laser power is set from 4[Formula: see text]W to 32[Formula: see text]W and laser cutting speed is set from 5[Formula: see text]mm/s to 30[Formula: see text]mm/s. The results show the roughness of PS substrate microchannel is lower than that of other three polymer substrate microchannels at the same parameters. When laser power is below 4[Formula: see text]W, the roughness of four polymer substrates are similar. The roughness of different polymer substrate microchannels decreases with the increase of laser power. The roughness of different polymer substrate microchannels also happens to change with increase of laser cutting speed.

scholarly journals A Method for Manufacturing Flexible Microfluidic Chip Based on Soluble Material

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Junyao Wang ◽  
Xingyu Chen ◽  
Huan Liu ◽  
Gongchen Sun ◽  
Yunpeng Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Dissolution Rate ◽  
Microfluidic Chip ◽  
Experimental Studies ◽  
Bonding Process ◽  
Manufacturing Cost ◽  
Processing Conditions ◽  
Microfluidic Chips ◽  
Novel Method ◽  
Soluble Material

In this paper, a novel method for manufacturing flexible microfluidic chips without bonding process is proposed, which combines 3D printing technology and material dissolution technology. The manufacturing process of the microfluidic chip is as follows: a soluble HIPS mold with a preset shape is manufactured by 3D printing and placed in a molten PDMS solution for solidification. Soak in the limonene material to dissolve the mold and form a microchannel in the cured PDMS. Experimental studies have shown that the temperature and concentration of the limonene solution have an important effect on the dissolution rate. A 0.62 cm3 HIPS mold has the fastest dissolution rate at 100°C and 50% concentration. The proposed method provided a new idea for fabricating flexible microfluidic chip. Compared to bonding process, it has the characteristics of not relying on complicated processing conditions and low manufacturing cost.

scholarly journals Novel Cost-Effective Microfluidic Chip Based on Hybrid Fabrication and Its Comprehensive Characterization

Sensors ◽  
2019 ◽  
Vol 19 (7) ◽  
pp. 1719 ◽  
Author(s):  
Sanja P. Kojic ◽  
Goran M. Stojanovic ◽  
Vasa Radonic
Keyword(s):  
High Reliability ◽  
Low Cost ◽  
Modern Science ◽  
Cost Effective ◽  
Middle Layer ◽  
Microfluidic Chips ◽  
Fabrication Technology ◽  
Rapid Fabrication ◽  
Wide Range ◽  
Good Potential

Microfluidics, one of the most attractive and fastest developed areas of modern science and technology, has found a number of applications in medicine, biology and chemistry. To address advanced designing challenges of the microfluidic devices, the research is mainly focused on development of efficient, low-cost and rapid fabrication technology with the wide range of applications. For the first time, this paper presents fabrication of microfluidic chips using hybrid fabrication technology—a grouping of the PVC (polyvinyl chloride) foils and the LTCC (Low Temperature Co-fired Ceramics) Ceram Tape using a combination of a cost-effective xurography technique and a laser micromachining process. Optical and dielectric properties were determined for the fabricated microfluidic chips. A mechanical characterization of the Ceram Tape, as a middle layer in its non-baked condition, has been performed and Young’s modulus and hardness were determined. The obtained results confirm a good potential of the proposed technology for rapid fabrication of low-cost microfluidic chips with high reliability and reproducibility. The conducted microfluidic tests demonstrated that presented microfluidic chips can resist 3000 times higher flow rates than the chips manufactured using standard xurography technique.

Effect of Joule Heat on Hydrophily of Microchannel

2014 ◽  
Vol 609-610 ◽  
pp. 606-610
Author(s):  
Xiao Wei Han ◽  
Xiao Wei Liu ◽  
Li Tian ◽  
He Zhang ◽  
Yao Liu ◽  
...  
Keyword(s):  
Transfer Coefficient ◽  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Room Temperature ◽  
Joule Heat ◽  
Microfluidic Chips ◽  
Interior Surface

We discuss the effect of joule heat which comes from eletroosmosis flow on the microfluidic chip. Our microfluidic chips are fabricated from polymethyl methacrylate (PMMA). As everyone knows, PMMA is a poor conductor of heat, and its transfer coefficient is only 0.19W/m·K in room temperature. So, the heat is generated by eletroosmosis canʼt conduct outside the microchannels of microfluidic chip easily. We research the effect joule heat on walls of microchannels which are made of PMMA. During our study, interior surface of microchannelsʼ hydrophobicity is changed by effect of joule heat.

Heating Carve Technique for Polymer Microfluidic Microchannel

2012 ◽  
Vol 503 ◽  
pp. 103-107
Author(s):  
Xiao Wei Han ◽  
Wei Wang ◽  
G.H. Ye ◽  
Xiao Wei Liu ◽  
Li Tian ◽  
...  
Keyword(s):  
Polymethyl Methacrylate ◽  
Microfluidic Chip ◽  
Mass Production ◽  
Hot Embossing ◽  
Direct Write ◽  
Microfluidic Chips ◽  
Movement Velocity ◽  
Laser Direct Write

A new manufacture mainly for polymethyl methacrylate (PMMA) microfluidic chips is presented in this paper. In this technique, polymer microfluidic microchannels were fabricated by microcutter which temperature is controlled and stabilized by PID methord. There are so many techniques, such as hot embossing, laser direct-write, for mass-production of polymer microfluidic chip. However, we may feel different kinds of shortages when we use these techniques. In this paper, the experiment result shows that microcutter’s movement velocity and temperature have effert on microfluidic microchannel’s roughness.

scholarly journals A Novel Method for the Preparation of Fibrous CeO2–ZrO2–Y2O3 Compacts for Thermochemical Cycles

Crystals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 885
Author(s):  
Nicole Knoblauch ◽  
Peter Mechnich
Keyword(s):  
Large Scale ◽  
Preparation Method ◽  
Cost Effective ◽  
High Porosity ◽  
Thermochemical Cycles ◽  
Redox Cycles ◽  
Redox Kinetics ◽  
Direct Infiltration ◽  
Novel Method ◽  
Functional Components

Zirconium-Yttrium-co-doped ceria (Ce0.85Zr0.13Y0.02O1.99) compacts consisting of fibers with diameters in the range of 8–10 µm have been successfully prepared by direct infiltration of commercial YSZ fibers with a cerium oxide matrix and subsequent sintering. The resulting chemically homogeneous fiber-compacts are sinter-resistant up to 1923 K and retain a high porosity of around 58 vol% and a permeability of 1.6–3.3 × 10−10 m² at a pressure gradient of 100–500 kPa. The fiber-compacts show a high potential for the application in thermochemical redox cycling due its fast redox kinetics. The first evaluation of redox kinetics shows that the relaxation time of oxidation is five times faster than that of dense samples of the same composition. The improved gas exchange due to the high porosity also allows higher reduction rates, which enable higher hydrogen yields in thermochemical water-splitting redox cycles. The presented cost-effective fiber-compact preparation method is considered very promising for manufacturing large-scale functional components for solar-thermal high-temperature reactors.

Study on the Manufacture of Microfluidic Chip with Coated Glass

2012 ◽  
Vol 548 ◽  
pp. 254-257 ◽  
Author(s):  
Yan He ◽  
Bai Ling Huang ◽  
Yong Lai Zhang ◽  
Li Gang Niu
Keyword(s):  
Microfluidic Chip ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Critical Factor ◽  
Wet Etching ◽  
Microfluidic Chips ◽  
Etching Technique ◽  
Chip Quality ◽  
Wet Chemical ◽  
Wet Chemical Etching

In this paper, a simple and facile technique for manufacturing glass-based microfluidic chips was developed. Instead of using expensive dry etching technology, the standard UV lithography and wet chemical etching technique was used to fabricate microchannels on a K9 glass substrate. The fabrication process of microfluidic chip including vacuum evaporation, annealing, lithography, and BHF (HF-NH4F-H2O) wet etching were investigated. Through series experiments, we found that anneal was the critical factor for chip quality. As a representative example, a microfluidic channel with 20 m of depth, and 80 m of width was successfully prepared, and the channel surfaces are quite smooth. These results present a simple, low cost, flexible and easy way to fabricate glass-based microfluidic chips.

On-Chip Fabrication of None-Dead-Volume Microtips for ESI-MS Applications

2007 ◽  
Vol 121-123 ◽  
pp. 611-614
Author(s):  
Che Hsin Lin ◽  
Jen Taie Shiea ◽  
Yen Lieng Lin
Keyword(s):  
Surface Tension ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Dead Volume ◽  
Esi Ms ◽  
Rapid Fabrication ◽  
Chip Fabrication ◽  
Novel Method ◽  
On Chip ◽  
Highly Uniform

This paper proposes a novel method to on-chip fabricate a none-dead-volume microtip for ESI-MS applications. The microfluidic chip and ESI tip are fabricated in low-cost plastic based materials using a simple and rapid fabrication process. A constant-speed-pulling method is developed to fabricate the ESI tip by pulling mixed PMMA glue using a 30-μm stainless wire through the pre-formed microfluidic channel. The equilibrium of surface tension of PMMA glue will result in a sharp tip after curing. A highly uniform micro-tip can be formed directly at the outlet of the microfluidic channel with minimum dead-volume zone. Detection of caffeine, myoglobin, lysozyme and cytochrome C biosamples confirms the microchip device can be used for high resolution ESI-MS applications.

scholarly journals Cost-effective surveillance of invasive species using info-gap theory

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yang Liu ◽  
Penghao Wang ◽  
Melissa L. Thomas ◽  
Dan Zheng ◽  
Simon J. McKirdy
Keyword(s):  
Invasive Species ◽  
Native Species ◽  
Cost Effective ◽  
Expert Assessment ◽  
Parameter Estimates ◽  
Model Parameters ◽  
Surveillance Systems ◽  
Effective Manner ◽  
Novel Method ◽  
Population Threshold

AbstractInvasive species can lead to community-level damage to the invaded ecosystem and extinction of native species. Most surveillance systems for the detection of invasive species are developed based on expert assessment, inherently coming with a level of uncertainty. In this research, info-gap decision theory (IGDT) is applied to model and manage such uncertainty. Surveillance of the Asian House Gecko, Hemidactylus frenatus Duméril and Bibron, 1836 on Barrow Island, is used as a case study. Our research provides a novel method for applying IGDT to determine the population threshold ($$K$$ K ) so that the decision can be robust to the deep uncertainty present in model parameters. We further robust-optimize surveillance costs rather than minimize surveillance costs. We demonstrate that increasing the population threshold for detection increases both robustness to the errors in the model parameter estimates, and opportuneness to lower surveillance costs than the accepted maximum budget. This paper provides guidance for decision makers to balance robustness and required surveillance expenditure. IGDT offers a novel method to model and manage the uncertainty prevalent in biodiversity conservation practices and modelling. The method outlined here can be used to design robust surveillance systems for invasive species in a wider context, and to better tackle uncertainty in protection of biodiversity and native species in a cost-effective manner.

Sign in / Sign up

Export Citation Format

Share Document