scholarly journals Analysis of Extended Resection of Limb Soft Tissue Leiomyosarcoma

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Qiang Liu ◽  
Lijun Tang ◽  
Xinhua Hu ◽  
Jianxing Ye ◽  
Pengcheng Liang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Soft Tissue ◽  
Pathological Examination ◽  
Patient Records ◽  
Extended Resection ◽  
Epithelioid Cells ◽  
Histological Features ◽  
Eosinophilic Cytoplasm ◽  
Distinct Features ◽  
Thigh Region

Leiomyosarcoma is an uncommon soft tissue sarcoma that composed of malignant mesenchymal cells with distinct features of the smooth muscle lineage. Typically affects the uterus and gastrointestinal tract, it can rarely be seen in large blood vessels, lymphatic and glandular duts, the mesentery, the omentum, retroperitoneum, and limbs. Occurrence is particularly rare in the limb region. Retrospective study based on patient records and postoperative pathological histological features. Four patients with limb leiomyosarcoma that were operated between 2016 and 2020 were included, three of them arising in the subcutis of the thigh region and one in cubitus. Extend resection with satisfactory outcomes is reported. Pathological examination showed that masses were composed of a fascicular arrangement of hyperchromatic spindle-shaped cells, characterized by the proliferation of epithelioid cells with eosinophilic cytoplasm for epithelioid leiomyosarcoma. Leiomyosarcomas that arise in the soft tissue, although rare, should be differentiated from other lesions, such as neurilemoma, neurofibroma, liomyoma,lipomyoma, synoviosarcoma, rhabdomyosarcoma, malignant fibrous histiotoma, and malignant neurinoma.

Soft-tissue changes after Class II malocclusion treatment using the Sander bite-jumping appliance: a retrospective study

2019 ◽  
Vol 68 (3) ◽  
Author(s):  
Michele Tepedino ◽  
Maria V. Della Noce ◽  
Domenico Ciavarella ◽  
Patrizia Gallenzi ◽  
Massimo Cordaro ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Soft Tissue ◽  
Class Ii ◽  
Class Ii Malocclusion ◽  
Tissue Changes ◽  
Soft Tissue Changes

scholarly journals Extragastrointestinal stromal tumor of the abdominal subcutaneous tissue: Report of a very rare case at an unusual site

2017 ◽  
Vol 45 (3) ◽  
pp. 1273-1278 ◽  
Author(s):  
Xue He ◽  
Nannan Chen ◽  
Li Lin ◽  
Congyang Wang ◽  
Yan Wang
Keyword(s):  
Tumor Cells ◽  
Subcutaneous Tissue ◽  
Dermatofibrosarcoma Protuberans ◽  
Pathological Examination ◽  
Chinese Han ◽  
Unusual Site ◽  
Stromal Tumors ◽  
Activating Mutations ◽  
Eosinophilic Cytoplasm ◽  
Exon 11

Extragastrointestinal stromal tumors (EGISTs) are rare tumors that arise outside the digestive tract. We report a case of an EGIST arising in the subcutaneous tissue of the abdominal wall, which at this site can often be misdiagnosed as dermatofibrosarcoma protuberans. The tumor was surgically resected from a 72-year-old male Chinese Han patient, and pathological examination revealed spindle-shaped tumor cells with eosinophilic cytoplasm and an oval nucleus. Immunohistochemically, the tumor cells showed strong cytoplasmic positivity for CD34, c-KIT (CD117), and DOG1. Tests for activating mutations of GISTs showed that the tumor cells carried an in-frame deletion (NP_000213.1:p.Lys550_Gln556del) in exon 11 of c-KIT (CD117). Thus, an EGIST should be considered in patients with abdominal subcutaneous tumors with an epithelioid, spindle-shaped, or mixed morphology. Immunohistochemistry of c-KIT (CD117) and DOG1 and genetic testing for activating mutations are recommended to aid in the differential diagnosis of subcutaneous tumors. In short, although EGISTs are rare in the abdominal subcutaneous tissue, pathologists must be aware of their possibility.

Surgical management of soft tissue tumors of the abdominal wall: A retrospective study in a high‐volume sarcoma center

2021 ◽  
Author(s):  
Maud Neuberg ◽  
Olivier Mir ◽  
Antonin Levy ◽  
Isabelle Sourrouille ◽  
Sarah Dumont ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Soft Tissue ◽  
Abdominal Wall ◽  
Surgical Management ◽  
High Volume ◽  
Soft Tissue Tumors

scholarly journals A multicenter retrospective study of heterogeneous tissue aggregates obstructing ventricular catheters explanted from patients with hydrocephalus

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Prashant Hariharan ◽  
Jeffrey Sondheimer ◽  
Alexandra Petroj ◽  
Jacob Gluski ◽  
Andrew Jea ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Retrospective Study ◽  
Foreign Body ◽  
Foreign Body Giant Cell ◽  
Clinical Factors ◽  
Histological Features ◽  
Ventricular Catheters ◽  
Heterogeneous Tissue ◽  
Histology And Immunohistochemistry ◽  
Macroscopic Analysis

Abstract Background Implantation of ventricular catheters (VCs) to drain cerebrospinal fluid (CSF) is a standard approach to treat hydrocephalus. VCs fail frequently due to tissue obstructing the lumen via the drainage holes. Mechanisms driving obstruction are poorly understood. This study aimed to characterize the histological features of VC obstructions and identify links to clinical factors. Methods 343 VCs with relevant clinical data were collected from five centers. Each hole on the VCs was classified by degree of tissue obstruction after macroscopic analysis. A subgroup of 54 samples was analyzed using immunofluorescent labelling, histology and immunohistochemistry. Results 61.5% of the 343 VCs analyzed had tissue aggregates occluding at least one hole (n = 211) however the vast majority of the holes (70%) showed no tissue aggregates. Mean age at which patients with occluded VCs had their first surgeries (3.25 yrs) was lower than in patients with non-occluded VCs (5.29 yrs, p < 0.02). Mean length of time of implantation of occluded VCs, 33.22 months was greater than for non-occluded VCs, 23.8 months (p = 0.02). Patients with myelomeningocele had a greater probability of having an occluded VC (p = 0.0426). VCs with occlusions had greater numbers of macrophages and astrocytes in comparison to non-occluded VCs (p < 0.01). Microglia comprised only 2–6% of the VC-obstructing tissue aggregates. Histologic analysis showed choroid plexus occlusion in 24%, vascularized glial tissue occlusion in 24%, prevalent lymphocytic inflammation in 29%, and foreign body giant cell reactions in 5% and no ependyma. Conclusion Our data show that age of the first surgery and length of time a VC is implanted are factors that influence the degree of VC obstruction. The tissue aggregates obstructing VCs are composed predominantly of astrocytes and macrophages; microglia have a relatively small presence.

PEDIATRIC PALATAL FOCAL FIBROUS HYPERPLASIA

2021 ◽  
pp. 72-73
Author(s):  
Shalini Shalini ◽  
Vandana Chhabra ◽  
Hemant Batra
Keyword(s):  
Soft Tissue ◽  
Oral Cavity ◽  
Traumatic Injury ◽  
Soft Tissue Lesion ◽  
Histological Features ◽  
Tissue Lesion ◽  
True Neoplasm

Fibroma is a common soft tissue lesion of the oral cavity, however, the origin of broma in a palatal region is rare. It may arise as a hyperplastic inammatory reaction in response to a local inciting agent, inammatory source, or chronic traumatic injury. These masses represent hyperplasia instead of true neoplasm. We present a case of broma present on the palatal region in an 8- year-old child diagnosed based on clinical, radiological, and histological features.

Rare case of angiofibroma presenting as perineal hernia

2021 ◽  
Vol 14 (1) ◽  
pp. e236661
Author(s):  
Ruchika Kumari ◽  
Cherring Tandup ◽  
Ambuj Agarwal ◽  
Anish Chowdhury
Keyword(s):  
Soft Tissue ◽  
Case Reports ◽  
En Bloc Resection ◽  
Perineal Hernia ◽  
Pathological Examination ◽  
Soft Tissue Tumour ◽  
Open Approach ◽  
En Bloc ◽  
Rare Tumour ◽  
Tissue Tumour

Angiofibroma is a benign soft tissue tumour presenting as a gradually progressive swelling in the vulvovaginal area in women and in the inguinoscrotal region in men. Being a rare tumour, there are only a few case reports in the literature, and among them, presentation as perineal herniation is very rare. En bloc resection of angiofibroma either via laparoscopic or open approach is the choice of treatment to avoid recurrence. Detailed pathological examination and immunohistochemistry workup are imperative to distinguish it from various mesenchymal tumours. Perineal hernia is itself rare and may occur spontaneously or following abdominoperineal resection, sacrectomy or pelvic exenteration. Surgical repair via open transabdominal and transperineal approaches has been described. Here, we report a case of a young woman who presented with spontaneous reducible perineal hernia with a soft tissue tumour as its content, which on histopathological investigation was found to be an angiofibroma.

scholarly journals Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
N. Almaani ◽  
A. H. Al-Tarawneh ◽  
H. Msallam
Keyword(s):  
Middle Eastern ◽  
Sudden Onset ◽  
Clinicopathological Features ◽  
Inflammatory Disorder ◽  
Histological Features ◽  
The Third ◽  
Strict Diet ◽  
Postinflammatory Hyperpigmentation ◽  
High Index Of Suspicion ◽  
Distinct Features

Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. Lesions typically heal within weeks leaving a reticulated and mottled postinflammatory hyperpigmentation. The majority of reported cases originate from Japan with much fewer cases described worldwide without predominant ethnicity. The histopathological features of prurigo pigmentosa can be nonspecific; however, distinct features exist for each stage of the disease. The aetiology of prurigo pigmentosa is not fully understood. However, ketoacidosis has been implicated in the pathogenesis and indeed prurigo pigmentosa has been associated with ketoacidotic states such as diabetes mellitus, fasting, dieting, and anorexia nervosa. In this report, we present 3 Jordanian patients with prurigo pigmentosa and describe their clinicopathological features. One patient developed prurigo pigmentosa while fasting during the month of Ramadan and another was undertaking a strict diet. No associations were identified in the third patient. In view of the largely nonspecific clinical and histological features, a high index of suspicion is required as many cases of prurigo pigmentosa are probably undiagnosed.

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