scholarly journals Effects of Buzhong Yiqi Decoction Combined with THP Bladder Perfusion on Postoperative Efficacy in Patients with Bladder Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yunfeng Wang ◽  
Yan Zhang ◽  
Zhongguo Liu ◽  
Qiuying Li ◽  
Huijing Jin
Keyword(s):  
Bladder Cancer ◽  
Blood Cell ◽  
Cell Count ◽  
Cancer Patients ◽  
Recurrence Rate ◽  
White Blood Cell Count ◽  
Adverse Reactions ◽  
Control Group ◽  
Blood Cell Count ◽  
Experimental Group

Background. As a traditional Chinese medicine tonic, Buzhong Yiqi decoction has the effects of invigorating Qi and lifting Yang. In this study, the effects of Buzhong Yiqi Shenge decoction combined with THP bladder perfusion on postoperative efficacy in bladder cancer were investigated. Methods. A total of 70 cases of bladder cancer patients were divided into the experimental group and control group according to the random number table method, with 35 cases in each group. The control group was treated with THP bladder perfusion. The experimental group was treated with Buzhong Yiqi Shenge decoction on the basis of the control group. The number of urine white blood cells, VEGF level, the incidence of adverse reactions, and KPS score were compared between the two groups before and after treatment. Results. After 3 and 6 months of therapy, the KPS score of the experimental group increased significantly compared with the control group. However, after 12 months of treatment, there was no difference in KPS scores between the two groups. Moreover, there was no significant variation in serum VEGF between two groups after 3 months of treatment. However, Buzhong Yiqi decoction notably reduced the level of VEGF after 6 months and 12 months. After 3 months, the urine white blood cell count was lower in the experimental group than in the control group. After 6 and 12 months, there was no difference in urine white blood cell count between the two groups. Furthermore, a total of 14 patients in two groups had reoccurrence after one year. Our results showed that there was no significant difference in postoperative recurrence rate between the experimental group and the control group. The occurrence rates of frequent and urgent urination, nausea/loss, and abnormal urine routine of appetite in the experimental group were significantly lower than those in the control group. But there was no difference in the occurrence rate of low heat, hematuria between the experimental group and the control group. Conclusion. Buzhong Yiqi decoction combined with THP bladder perfusion has no advantage in the short-term recurrence rate of bladder cancer patients. However, Buzhong Yiqi decoction can alleviate the symptoms of adverse reactions and improve the quality of life of patients.

EVALUATION OF HAEMATOLOGICAL PARAMETERS AMONG TRIBAL MENOPAUSAL WOMEN IN EASTERN INDIA

2021 ◽  
pp. 34-35
Author(s):  
Himansu Sekhar Sahu ◽  
Gargee Mohanty
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Test Group ◽  
Haematological Parameters ◽  
Control Group ◽  
Eastern India ◽  
Blood Cell Count ◽  
Menopausal Women

Studies reveal that haematological parameters vary with ageing process. Thus, the present study was carried out to examine the variation in white blood cell count, red blood cell count, haematocrit percentage, haemoglobin percentage in Tribal Menopausal women of Mayurbhanj, a tribal dominated district of Eastern India. A total of one hundred and eight tribal women participated in the study. They were divided into two groups. A test group of sixty-two post-Menopausal women (46 - 65 years) and a control group of women ageing between 20-35 years. Mean and standard errors along with T-test for comparison between control and test groups were carried out with Excel 2016. Results show that there is a signicant difference in white blood cell count, haematocrit percentage, haemoglobin percentage at p≤0.05. There also exists a signicant difference in the neutrophil and basophil count. The results suggest that anaemic condition is not prevalent in menopausal women. However, rise of neutrophil and basophil count is indicative of having underlying infections.

scholarly journals Patient self‐testing of white blood cell count and differentiation: A study of feasibility and measurement performance in a population of Danish cancer patients

2019 ◽  
Vol 29 (1) ◽  
Author(s):  
Thea Otto Mattsson ◽  
Christina Louise Lindhart ◽  
Jonas Schöley ◽  
Lennart Friis‐Hansen ◽  
Jørn Herrstedt
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Cancer Patients ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cell Count ◽  
Self Testing

scholarly journals Suppression of tumor immunity by electromagnetic fields and glucocorticoids in mice with implanted Ehrlich carcinoma

2005 ◽  
Vol 58 (11-12) ◽  
pp. 609-613 ◽  
Author(s):  
Dusko Knezevic
Keyword(s):  
Immune Response ◽  
Blood Cell ◽  
Cell Count ◽  
Tumor Cells ◽  
Electromagnetic Fields ◽  
White Blood Cell Count ◽  
Low Frequency ◽  
Control Group ◽  
Blood Cell Count ◽  
Extremely Low Frequency

Introduction The immune system plays a major role in the origin, growth and evolution of tumors: factors that decrease the immune response in any way can cause higher tumor incidence and its faster or uncontrolled growth and evolution. Material and methods The research included 18 healthy male Han- NMRI mice, weighing between 25 and 30g, with ten-day-old tumor deposits, divided into three groups consisting of six mice each. The first group was continuously exposed to extremely low frequency electromagnetic fields (intensity 70-320 ?T). The second group was treated with high doses of Corticosteroids (dexamethasone). The control group was not treated with Corticosteroids, nor was exposed to extremely low frequency electromagnetic fields. The exposure period lasted for ten days. The criteria used to evaluate tumor immunity were: histologicai findings of leukocyte infiltration around the tumor cells and white blood cell count. The control group presented with excellent immune response to tumor cells. Lymphoplasmacytic infiltrates widely surrounded the tumor. Numerous tumor cells showed signs of cell death. The results showed that exposure of animals to high doses of glucocorticoids resulted in extremely decreased leukocyte infiltration in the tumor tissue (single lymphocytes), while exposure to extremely low frequency electromagnetic fields significantly-decreased leukocyte infiltration in comparison to the control group. Comparison of white blood cell count in treated groups revealed that the white blood cell count in both treated groups was decreased, compared with the control group. Conclusion Extremely low frequency electromagnetic fields significantly suppress the immune response to tumor cells. Dexamethasone treatment resulted in almost complete absence of immune response to tumor cells. Electromagnetic fields and dexamethosone both decrease the while blood cell count. .

scholarly journals PROTECTIVE EFFECT OF BEE PROPOLIS AGAINST ANTI-TUBERCULOSIS DRUGS (RIFAMPICIN AND ISONIAZID)-INDUCED HEMATOLOGICAL TOXICITY IN SPRAGUE DAWLEY RATS

2017 ◽  
Vol 10 (3) ◽  
pp. 188 ◽  
Author(s):  
Umesh Bharti ◽  
Neelima R Kumar ◽  
Jaspreet Kaur
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Protective Effect ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Hematological Toxicity ◽  
Control Group ◽  
Sprague Dawley ◽  
Blood Cell Count

ABSTRACTObjective: Protective effect of bee propolis against anti-tuberculosis (TB) drugs (rifampicin and isoniazid)-induced hematological toxicity in SpragueDawley (SD) rats.Methods: Experimental male SD rats weighing 180±20 g were randomly assigned into eight groups (n=6), the Group 1 served as control; Group 2received 200 mg bee propolis/kg body weight; Groups 3, 5, and 7 were treated with drugs 100 mg rifampicin/kg body weight, 50 mg isoniazid/kgbody weight, and 100 mg rifampicin+50 mg isoniazid/kg body weight, respectively. Groups 4, 6, and 8 were treatment groups receiving 200 mg beepropolis/kg body weight+100 mg rifampicin/kg body weight, 200 mg bee propolis/kg body weight+50 mg isoniazid/kg body weight, and 200 mg beepropolis/kg body weight+100 mg rifampicin+50 mg isoniazid/kg body weight, respectively. All the treatments were given for 30 days, and then, therats were sacrificed under light esthesia by cervical dislocation and blood was collected for physiological studies.Results: Bee propolis supplementation (200 mg/kg body weight) showed increased level of hemoglobin with respect to rifampicin (15.45%),isoniazid (11.34%), and rifampicin plus isoniazid (5.04%) administered groups after 30 days of treatment. Moreover, the decreased level of red bloodcell count and white blood cell count by anti-TB drugs rifampicin, isoniazid, and rifampicin plus isoniazid together was also elevated in treatmentgroup with bee propolis.Conclusion: Coadministration of propolis (200 mg bee propolis/kg body weight) with drugs helped modulate the toxic effects by restoring testedvalues to near normal.Keywords: Propolis, Rifampicin, Isoniazid, Hemoglobin, Red blood cell count, White blood cell count.

Influence of increased doses of fenbendazole supramolecular complex on sheep’s organism

2018 ◽  
Vol 12 (2) ◽  
pp. 46-52 ◽  
Author(s):  
A.I. Varlamova
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Biochemical Parameters ◽  
Negative Influence ◽  
Supramolecular Complex ◽  
Control Group ◽  
Blood Cell Count ◽  
Russian Scientific ◽  
Russian Scientific Research Institute ◽  
Hematological And Biochemical Parameters

The purpose of the research: study of the influence of increased doses of fenbendazole supramolecular complex (FSMC) on sheep’s organism. Materials and methods. The experiment was carried out at the Podolsk Department of All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin on 20 manorial invasion-free sheep aged 2-3 years old. Animals were divided according to the principle of analogues into 4 groups, 5 heads in each group. Animals of the 1, 2 and 3 group were orally administered with FSMC given as a single dose of 2, 6, 10 mg/kg, respectively, according to the active substance, i.e in therapeutic and in a dose increased by 3 and 5 times. Sheep of the fourth group didn’t receive the drug and they were as control. Study of clinical, hematological and biochemical parameters of animals from all groups was conducted 1 day before and in 1, 3, 5 days after administration of the drug by means of standard methods. Results and discussion. FSMC in therapeutic dose as well as in a dose increased by 3 and 5 times doesn’t have negative influence on clinical, hematological and biochemical parameters of the sheep. State of the sheep, which received the drug in doses of 20, 60, 100 mg/kg, was within the physiologically normal state and didn’t differ from the state before administration of the drug and from the animals of the control group. Drug security index exceeds 5. Red blood cell count, white blood cell count, hemoglobin count, leukogram parameters as well as biochemical parameters of blood: activity of alkaline phosphatase and amylase, bilirubin, creatinine, urea and glucose counts were within normal limits and didn’t differ from the parameters of the control animals.

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