scholarly journals Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Christopher S. Hong ◽  
Edwin Partovi ◽  
James Clune ◽  
Anita Huttner ◽  
Henry S. Park ◽  
...  
Keyword(s):  
Genomic Analysis ◽  
Disease Entity ◽  
First Line ◽  
Clinical Prognosis ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Genomic Studies ◽  
Radiation Induced ◽  
Genomic Characterization

Intracranial undifferentiated pleomorphic sarcoma remains a rare pathology within the sarcoma literature that may arise primarily or secondary after radiation therapy. Despite first-line treatment with maximal surgical resection, followed by nonstandardized adjuvant chemotherapy/radiation regimens, clinical prognosis remains exceedingly poor. Furthermore, there is a lack of genetic or molecular characterization to guide potential for targeted therapies. We present genomic analysis of a radiation-induced intracranial undifferentiated pleomorphic sarcoma in an 83-year-old woman with notable KIT and PDGFRA alterations. Further similar genomic studies of intracranial pleomorphic sarcoma are needed to develop better therapies for this rare but challenging disease entity.

scholarly journals Genomic characterization of world's longest selection experiment in mouse reveals the complexity of polygenic traits.

2021 ◽  
Author(s):  
Sergio Eliseo Palma-Vera ◽  
Henry Reyer ◽  
Martina Langhammer ◽  
Norbert Reinsch ◽  
Lorena Derezanin ◽  
...  
Keyword(s):  
Muscle Growth ◽  
Genomic Analysis ◽  
Control Line ◽  
Selection Experiment ◽  
Long Distance ◽  
Long Distance Running ◽  
Genomic Characterization ◽  
Selected Traits

A unique set of mouse outbred lines has been generated through selective breeding in the longest selection experiment ever conducted on mice. Over the course of >140 generations, selection on the control line has given rise to two extremely fertile lines (>20 pups per litter each), two giant growth lines (one lean, one obese) and one long-distance running line. Genomic analysis revealed line-specific patterns of genetic variation among lines and high levels of homozygosity within lines as a result of long-term intensive selection, genetic drift and isolation. Detection of line-specific patterns of genetic differentiation and structural variation revealed multiple candidate genes behind the improvement of the selected traits. We conclude that the genomes of these lines are rich in beneficial alleles for the respective selected traits and represent an invaluable resource for unraveling the polygenic basis of fertility, obesity, muscle growth and endurance fitness.

scholarly journals Genomic Characterization of MDR Escherichia coli Harboring blaOXA-48 on the IncL/M-type Plasmid Isolated from Blood Stream Infection

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
S. Alousi ◽  
T. Salloum ◽  
H. Arabaghian ◽  
G. M. Matar ◽  
G. F. Araj ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Blood Stream Infection ◽  
Genomic Analysis ◽  
Blood Stream ◽  
Population Movements ◽  
E Coli ◽  
Resistance Determinants ◽  
Genomic Characterization ◽  
Hospital Acquired

Escherichia coli is responsible for a wide variety of community and hospital acquired extraintestinal infections, and the emergence of ESBL resistant isolates is a major clinical concern. In this study, we characterized the genomic attributes of an OXA-48 and CTX-M-3 producing E. coli EC-IMP153. Whole-genome initial assembly produced 146 contigs with a combined 5,504,170 bp in size and a G+C content of 50.5%. wgSNPs-based phylogenetic comparison with 36 publically available genomes was also performed. Comprehensive genomic analysis showed that EC-IMP153 belonged to sequence type ST-405 and harbored several resistance determinants including the β-lactam resistance genes blaOXA-48, blaCTX-M-3, blaTEM-1B, blaOXA-1, and blaCMY-70, aminoglycoside fyuA and aac(3)IId, tetracycline tet(A) and tet(R), and fluoroquinolone gyrA, parC, and mfd resistance determinants. Plasmids with the following incompatibility groups were detected in silico and confirmed using PBRT: IncI1-α, IncL, IncW, Col (BS512), and IncF. To our knowledge this is the first in-depth genomic analysis of an OXA-48 producing E. coli ST-405 isolated from a patient in Lebanon and linked to a blood stream infection. Continuous monitoring is necessary to better understand the continued diffusion of such pathogens, especially in view of the population movements triggered by unrest in the Middle East.

scholarly journals Abstract 3857: Characterization of immune cell biomarkers in undifferentiated pleomorphic sarcoma

2020 ◽  
Author(s):  
Carmelia M. Barreto ◽  
Luisa M. Solis-Soto ◽  
Ruth Salazar ◽  
Swati Gite ◽  
Edwin R. Parra ◽  
...  
Keyword(s):  
Immune Cell ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma

scholarly journals A comparative genomic analysis of the barley pathogen Pyrenophora teres f. teres identifies sub-telomeric regions as drivers of virulence

2019 ◽  
Author(s):  
Nathan A. Wyatt ◽  
Jonathan K. Richards ◽  
Robert S. Brueggeman ◽  
Timothy L. Friesen
Keyword(s):  
Genomic Analysis ◽  
Effector Proteins ◽  
Comparative Genomic ◽  
Pyrenophora Teres ◽  
Structural Variations ◽  
Evolution Of Virulence ◽  
Reference Quality ◽  
Genomic Characterization ◽  
Genomic Regions

AbstractPyrenophora teres f. teres causes net form net blotch of barley and is an economically important pathogen throughout the world. However, P. teres f. teres is lacking in the genomic resources necessary to characterize the mechanisms of virulence. Recently a high quality reference genome was generated for P. teres f. teres isolate 0-1. Here, we present the reference quality sequence and annotation of four new isolates and we use the five available P. teres f. teres genomes for an in-depth comparison resulting in the generation of hypotheses pertaining to the potential mechanisms and evolution of virulence. Comparative analyses were performed between all five P. teres f. teres genomes examining genomic organization, structural variations, and core and accessory genomic content, specifically focusing on the genomic characterization of known virulence loci and the localization of genes predicted to encode secreted and effector proteins. We showed that 14 of 15 currently published virulence quantitative trait loci (QTL) span accessory genomic regions consistent with these accessory regions being important drivers of host adaptation. Additionally, these accessory genomic regions were frequently found in sub-telomeric regions of chromosomes with 10 of the 14 accessory region QTL localizing to sub-telomeric regions. Comparative analysis of the sub-telomeric regions of P. teres f. teres chromosomes revealed translocation events where homology was detected between non-homologous chromosomes at a significantly higher rate than the rest of the genome. These results indicate that the sub-telomeric accessory genomic compartments not only harbor most of the known virulence loci, but also that these regions have the capacity to rapidly evolve.

Establishment and characterization of NCC-UPS3-C1: a novel patient-derived cell line of undifferentiated pleomorphic sarcoma

Human Cell ◽  
2021 ◽  
Author(s):  
Ryuto Tsuchiya ◽  
Yuki Yoshimatsu ◽  
Rei Noguchi ◽  
Yooksil Sin ◽  
Takuya Ono ◽  
...  
Keyword(s):  
Cell Line ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma

scholarly journals Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma

PLoS ONE ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. e8075 ◽  
Author(s):  
Jeffrey K. Mito ◽  
Richard F. Riedel ◽  
Leslie Dodd ◽  
Guy Lahat ◽  
Alexander J. Lazar ◽  
...  
Keyword(s):  
Mouse Model ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Genomic Analysis ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma

Genomic characterization of IncpA1763-KPC: IncFIIK7 type plasmids p13294-KPC and pA1966-NR from Klebsiella pneumoniae

2020 ◽  
Vol 15 (9) ◽  
pp. 713-721
Author(s):  
Qifeng Sun ◽  
Jiao Feng ◽  
Yigang Tong ◽  
Luhua Liang ◽  
Fei Zhai ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Resistance Gene ◽  
Resistance Genes ◽  
Genomic Analysis ◽  
Mobile Elements ◽  
Is Elements ◽  
Genomic Characterization ◽  
Insight Into

Aim: To characterize two plasmids p13294-KPC and pA1966-NR from clinical Klebsiella pneumoniae strains. Materials & methods: Plasmids p13294-KPC and pA1966-NR were fully sequenced and then detailed genomic analysis was performed in this work. The antimicrobial resistance phenotypes were determined. Results: p13294-KPC and pA1966-NR displayed IncpA1763-KPC:IncFIIK7 dual-replicon structures. The backbone of these two plasmids were closely related to each other. p13294-KPC contained two accessory modules, namely ΔIS Kpn25 and blaKPC-2 region, and the blaKPC-2 region carried a range of mobile elements and resistance gene blaKPC-2. while pA1966-NR contained four individual IS elements in its backbone and carried no resistance genes. Conclusion: This study provided a deeper insight into the genomic characterization of IncpA1763-KPC: IncFIIK7 type plasmids p13294-KPC and pA1966-NR.

Radiation-induced undifferentiated pleomorphic sarcoma of the heart: A case report

2018 ◽  
Vol 8 (2) ◽  
pp. 136-139 ◽  
Author(s):  
Alexander K. Tsai ◽  
Melissa A.L. Vyfhuis ◽  
Martha Francis ◽  
Fikru Merechi ◽  
Allen P. Burke ◽  
...  
Keyword(s):  
Case Report ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Radiation Induced
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