scholarly journals Effect of Using a Plastic Stent with Apically Repositioned Flap in Peri-Implant Soft Tissue Augmentation: A Randomized Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Ahmed Hamdy ◽  
Hala K. Abd El Gaber ◽  
Dalia M. Ghalwash ◽  
Waleed M. Abbas
Keyword(s):  
Statistical Significance ◽  
Test Group ◽  
Soft Tissue Augmentation ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Stent Group ◽  
Plastic Stent ◽  
Keratinized Tissue ◽  
Significant Difference ◽  
Keratinized Mucosa

Objectives. This study aimed to clinically assess and compare the width of peri-implant keratinized mucosa following the use of a readymade plastic stent with apically repositioned flap versus conventional apically repositioned flap with papillary sparing incisions during single-stage implant placement protocol. Materials and Methods. A total of 20 patients were enrolled in this study. In the test group, a prefabricated implant-retained stent was clipped on the healing abutment after implant surgery to reposition the keratinized tissue buccoapically. In the control group, simple interrupted sutures were applied instead of using a stent. After the surgical procedure, the width of the buccal keratinized mucosa was measured at the mesial, middle, and distal aspects of the healing abutment. The change in the width of the buccal keratinized mucosa was assessed at 3 months and 6 months. Results. No statistically significant difference was found between the stent group and control group in 6 months’ interval where p = 0.840 , where both groups showed the same mean value of 4.70 ± 0.35 and 4.70 ± 0.63, respectively. The percent of change in the width of KM was found to be higher in the stent group than in the control group with no statistical significance. Conclusion. The use of a readymade plastic stent in combined full/partial-thickness apically repositioned flap shows to be effective in increasing the width of KM compared to the conventional technique. This trial is registered with NCT03754894.

scholarly journals Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2604
Author(s):  
Jin-Young Park ◽  
Kyung-A Ko ◽  
Ji-Yeong Lee ◽  
Jae-Woon Oh ◽  
Hyun-Chang Lim ◽  
...  
Keyword(s):  
Patient Reported Outcomes ◽  
Daily Intake ◽  
Test Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Immunological Parameters ◽  
Significant Difference ◽  
Patient Reported ◽  
And Control

Background: Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate the clinical and immunological efficacy of MAEC as well as safety and patient-reported outcomes (PROMs) on gingivitis and incipient periodontitis. Methods: This study was performed on 104 patients diagnosed with gingivitis or incipient periodontitis. At baseline, the participants were randomly allocated to either the test group, with daily intake of a single capsule containing 194 mg of MAEC for eight weeks, or control group, with placebo. Clinical periodontal evaluation and immunological parameters from saliva and gingival sulcular fluid were assessed at baseline, four, and eight weeks. Individual PROMs were assessed by OHIP-14 questionnaires. Results: There was a significant difference of modified gingival index at four and eight weeks between the test and control groups. In the test group, crevicular interleukin (IL)-6 was reduced, and the salivary matrix metalloproteinase (MMP)-9 was increased after eight weeks. PROMs were improved up to four weeks compared to placebo. Conclusion: Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.

scholarly journals Regenerative Therapy Modality for Treatment of True Combined Endodontic-Periodontal Lesions: A Randomized Controlled Clinical Trial

2021 ◽  
Vol 18 (12) ◽  
pp. 6220
Author(s):  
Reham AlJasser ◽  
Sundus Bukhary ◽  
Mohammed AlSarhan ◽  
Dalal Alotaibi ◽  
Saleh AlOraini ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Grafting ◽  
Endodontic Treatment ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Bony Defect ◽  
Keratinized Tissue ◽  
Group I ◽  
Significant Difference ◽  
Grafting Procedure

The aim of this in-vivo study was to evaluate/compare the clinical periodontal parameters in patients with true combined endo-perio lesions (EPL), treated with gutta-percha (GP) and mineral trioxide (MTA) as an obturation material alone and with addition of bone grafting in such lesions. 120 Saudi patients (mean age = 41yrs) diagnosed with true combined EPL participated in this study. Group I (control group, n = 30) was treated with conventional endodontic treatment using GP for obturation. Group II (n = 30) was treated with conventional endodontic treatment using MTA for obturation. Group III (n = 30) was treated with conventional endodontic treatment using GP for obturation + grafting procedure to fill the bony defect. Group IV (n = 30) was treated with conventional endodontic treatment using MTA for obturation + grafting procedure to fill the bony defect. Clinical parameters (Pocket depth (PD); Clinical attachment loss (CAL); keratinized tissue width (KTW); gingival phenotype (G.Ph.) and Cone Beam Computed Tomography Periapical Index (CBCTPAI)) were recorded and compared at baseline, 3, 6, 12 months’ interval. For the groups III and IV, CBCTPAI showed significant difference (p < 0.0001) with the other groups at 6 months and 1-year interval. The group with MTA + bone graft showed 76% and 90% patients with 0 score at 6 months and 1-year follow-up, respectively. Comparison of mean values of PD among study groups at 3 months, 6 months and 1 year showed significant difference at 3 months, whereas the mean PD values of subjects in GP + bone graft showed significantly higher PD values than other 3 groups (p = 0.025). Use of GP and MTA for root canal obturation along with periodontal therapy and bone augmentation helps in resolving complex endo-perio lesions. Bone grafting in addition to obturation with MTA was found to be the best treatment strategy in management of EPL cases and is recommended for clinicians who are treating EPL patients.

scholarly journals Analysis of differential expression of protease-activated receptors in patients with allergic fungal rhinosinusitis

2018 ◽  
Vol 9 ◽  
pp. 215265671876419
Author(s):  
Shikhar Sawhney ◽  
Sandeep Bansal ◽  
Madhur Kalyan ◽  
Indu Verma ◽  
Ramandeep Singh Virk ◽  
...  
Keyword(s):  
Differential Expression ◽  
Chronic Rhinosinusitis ◽  
Messenger Rna ◽  
Statistical Significance ◽  
Test Group ◽  
Control Group ◽  
Protease Activated Receptors ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Significant Difference

Background Ever since its characterization in the 1970s, allergic fungal rhinosinusitis (AFRS) has been the subject of much controversy, especially regarding its pathogenesis. In this study, we analyzed the differential expression of genes that encode protease-activated receptors (PAR) in patients with AFRS and patients with chronic rhinosinusitis, and tried to understand the pathogenic basis of this disease. Objective To analyze the differential expression of PAR genes in patients with AFRS and in patients with chronic rhinosinusitis. Methods Mucosa from ethmoid sinuses of 51 patients (tests and controls) was biopsied and evaluated for messenger RNA expression of PAR genes by using reverse transcriptase–polymerase chain reaction. Each of the four PAR genes, i.e., par1, par2, par3 and par4 was amplified, the final gene products were run on 1.8% agarose gel and analyzed by densitometry to calculate differential expression. The significance level was determined as p ≤ 0.05. Results It was observed that the expressions of all four par genes were higher in the test samples compared with the controls, but statistical significance was achieved only for par1 (p=0.004) and par2 (p=0.05). Comparative expression of the four PAR genes was also performed within the test and control groups, and a statistically significant difference was seen between par1 and par2 (p=0.007), par1 and par3 (p=0.029), par1 and par4 (p=0.0001), par2 and par4 (p=0.002), and par3 and par4 (p=0.009) in the test group. In the control group as well, par1, par2, and par3 exhibited a higher expression compared with par4 but the difference was significant between par3 and par4 genes only. Conclusion Patients with AFRS expressed increased levels of PAR genes in their nasal mucosa, and, of the four PAR genes, a higher expression of par1, par2, and par3 was observed in both the groups compared with par4. This information contributes toward our understanding of pathogenesis and possibly treatment of AFRS.

scholarly journals A Prospective and Controlled Clinical Trial on Stromal Vascular Fraction Enriched Fat Grafts in Secondary Breast Reconstruction

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
L. A. L. Tissiani ◽  
N. Alonso
Keyword(s):  
Breast Reconstruction ◽  
Controlled Trial ◽  
Statistical Significance ◽  
Stromal Vascular Fraction ◽  
Cell Counting ◽  
Fat Graft ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Fat Grafts ◽  
Significant Difference

Background.Fat grafting is a tremendous tool in secondary breast reconstruction. Stromal vascular fraction (SVF) enriched fat grafts have been presenting promising results regarding volume maintenance.Methods.We developed a method that produces a superior SVF enrichment rate (2 : 1) in the operating theatre. This prospective and controlled trial analyzed quantitatively and qualitatively fat grafts with (stem cells group, SG) and without (control group, CG) SVF enrichment in secondary breast reconstruction, through MRI-based volumetry, immunophenotyping, and cell counting. Also, patient satisfaction, aesthetic outcomes, and complications were analyzed.Results.Volumetric persistence in the SG was 78,9% and 51,4% in the CG; however it did not reach statistical significant difference. CD90 was the only marker highly expressed in the SG and showed a positive correlation with volumetric persistence (r=0.651,p=0.03). Fat necrosis occurred in 4 patients in the SG and in none in the CG. Patients in the CG showed a trend to be more satisfied. Considering aesthetics, both groups presented improvements. No locoregional recurrences were observed.Conclusions.Results are encouraging despite the fact that SVF enrichment in a higher supplementation rate did not improve, with statistical significance, fat graft volumetric persistence. Enriched fat grafts have proven to be safe in a 3-year follow-up.

scholarly journals Non routine use of alveolar incision in Von Langenbeck technique palatoplasty in children; a safe and viable technique in our centre

2019 ◽  
Vol 6 (7) ◽  
pp. 2239
Author(s):  
Philemon E. Okoro ◽  
Benjamin M. Kejeh
Keyword(s):  
Blood Loss ◽  
Cleft Palate ◽  
Statistical Significance ◽  
Test Group ◽  
Control Group ◽  
Significant Difference ◽  
Duration Of Surgery ◽  
Prospective Comparative Study ◽  
And Gender ◽  
Isolated Cleft Palate

Background: Repair of the palate is among the challenging reconstructive surgeries in children. No single technique has achieved completely satisfactory results. The von Langenbeck technique (VLT) is one of the techniques in common use. We have sort to find out if the lateral alveolar incision in VLT can be safely avoided in selected cases.Methods: This is a prospective comparative study of cases of isolated unilateral cleft palate in children 18 years and below which were repaired using the VLT with and without lateral alveolar incision in our centre between January 2013 and December 2018. Outcome parameters obtained included duration of surgery, blood loss, complication and fistula rates. Data was analyzed using SPSS 21. Statistical significance was set at p<0.05.Results: Eighty four patients were included in the study; 36 were in the test group and 48 were in the control group. There was no significant difference in the age, weight and gender of the two groups. The duration of surgery was significantly shorter in the test group and fistula and complication rate was less.Conclusions:This study has demonstrated that comparable, if not better results can be achieved in well selected patients with unilateral isolated cleft palate using only dissection along the margin of the cleft. This new technique reduces the duration of surgery and anaesthesia and may reduce blood loss and complications. 

Aromatherapy reduces fatigue among women with hypothyroidism: A randomized placebo-controlled clinical trial

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Jessie Hawkins ◽  
Christy Y. Hires ◽  
Elizabeth W. Dunne ◽  
Lindsey A. Keenan
Keyword(s):  
Clinical Trial ◽  
Primary Outcome ◽  
Statistical Significance ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
General Fatigue ◽  
Significant Difference ◽  
History Of ◽  
Oil Blend ◽  
Validated Instrument

AbstractBackgroundThis randomized, blinded, placebo-controlled clinical trial identifies the effect of an aromatherapy blend of essential oils on fatigue, which is one of the most commonly unaddressed symptoms of hypothyroidism, by evaluating the effects of daily aromatherapy inhalation.MethodsParticipants included women aged 18–55 with a diagnosis of hypothyroidism. Women who had a history of thyroid cancer were excluded, due to the confounding effects of cancer on fatigue as the outcome of interest. Participants were randomized into two groups: the aromatherapy group, treated with inhalation of the essential oil blend, and the control group, treated with an odorless vegetable oil blend. The primary outcome was change from baseline in fatigue scores as measured by the Multidimensional Fatigue Symptom Inventory (MFSI), a validated instrument which measures multiple patterns of fatigue.ResultsAfter adjusting for baseline scores, no significant difference was found between the aromatherapy group and the control group at midpoint. Both groups experienced a reduction in symptoms during the first week of the intervention. At the endpoint, participants in the aromatherapy group had improved fatigue scores across all ten subscales, as compared to the control group. Not all improvements achieved statistical significance, indicating that the aromatherapy treatment has a greater effect on the subscales of global, affective, and general fatigue.ConclusionsThis is the first study to evaluate the effects of aromatherapy on fatigue among women with hypothyroidism. These findings provide evidence that regular inhalation of an aromatherapy blend may reduce fatigue among women with hypothyroidism, particularly in the areas of global, affective, and general fatigue.

scholarly journals The Effects of 6-Month Vitamin D Supplementation during the Non-Surgical Treatment of Periodontitis in Vitamin-D-Deficient Patients: A Randomized Double-Blind Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2940
Author(s):  
Marina Perić ◽  
Dominique Maiter ◽  
Etienne Cavalier ◽  
Jérôme F. Lasserre ◽  
Selena Toma
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Test Group ◽  
Controlled Study ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Significant Difference

Background: This study assessed the effects of weekly vitamin D (VD) supplementation on clinical and biological parameters after scaling and root planning (SRP) in the treatment of periodontitis and served to validate the VD dosage regimen. Methods: It was a monocentric, randomized, double-blind, placebo-controlled clinical trial with 6 months follow-up. Healthy Caucasian periodontitis patients presenting serum 25(OH) vitamin D3 below 30 ng/mL were randomly allocated to test group (SRP + VD 25,000 international units (IU)/week) or the control group (SRP + placebo). Results: A total of 59 patients were screened, 27 were included and 26 completed 3 months (M) and 21 completed 6M control. Test (n = 13) and control groups (n = 14) had similar 25(OH) vitamin D3 levels at baseline (17.6 ± 7.4 vs. 14.4 ± 5.2, respectively). After one month, there was a significant difference between groups (32.9 ± 5.2 vs. 16.1 ± 4.7), also seen at M3 and M6 (t-test, p < 0.001). Periodontal treatment was successful in both groups, since it resulted in a reduction of all measured clinical parameters at M3 and M6 (probing pocket depth (PPD), full mouth bleeding and plaque). However, the reduction in PPD was greater in the test group. Conclusions: In this short-term pilot study, no significant differences were observed between two groups. However, supplementation with VD tended to improve the treatment of periodontitis in patients with initial 25(OH) vitamin D3 < 30 ng/mL and proved safe and efficacious. NCT03162406.

Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans

2010 ◽  
Vol 11 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Sérgio Luís da Silva Pereira ◽  
Cristiane Simões Barros ◽  
Thiago Daher Yunes Salgado ◽  
Vicente Paulo Pereira Filho ◽  
Flávio Nogueira Costa
Keyword(s):  
Treatment Options ◽  
Test Group ◽  
Clinical Results ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Posterior Teeth ◽  
Treatment And Prevention ◽  
Significant Difference ◽  
Oral Conditions

Abstract Aim The aim of this in vivo study was to evaluate the antiplaque and antigingivitis effect of Copaifera sp (Cp). Methods and Materials Twenty-three subjects participated in a randomized controlled clinical trial using a 21-day, partial-mouth experimental model of gingivitis. A custom tooth shield was fabricated for each subject to prevent the brushing of the four experimental posterior teeth in the lower-left quadrant. The subjects were randomly assigned to either the control group (using a placebo gel) or the test group (using the test gel containing 10% Cp). Results The clinical results showed statistically significant differences for plaque (PLI), bleeding (BI), and gingival (GI) indexes at days 0 and 21 in both groups (p<0.05). However, on day 21 there was no statistically significant difference between groups for all indexes (p>0.05). Conclusions The test gel containing 10% Cp did not prevent plaque formation and development of gingivitis. Clinical Significance Several medicinal herbs are used empirically by persons in the treatment and prevention of oral conditions. Research in this area must be encouraged to determine which herbal agents would be a useful addition to the current range of chemotherapeutic periodontal treatment options. Citation Pereira SLS, Barros CS, Salgado THY, Filho VPP, Costa FN. Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans. J Contemp Dent Pract [Internet]. 2010 Jan; 11(1):057-064. Available from: http://www.thejcdp. com/journal/view/volume11-issue1-pereira.

scholarly journals The effect of vitamin C on bone mineral density of menopausal women with equilibrated regime: A randomized clinical trial study, 2012-2013

2014 ◽  
Vol 8 (4) ◽  
pp. 26-30
Author(s):  
Jokar Azam ◽  
Farahi Farzaneh ◽  
Asadi Nasrin ◽  
Salehi Mosa ◽  
Foruhari Sedeghe ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin C ◽  
Block Design ◽  
Test Group ◽  
Control Group ◽  
Placebo Control ◽  
Controlled Clinical Trial ◽  
Mineral Density ◽  
Menopausal Women ◽  
Significant Difference

The objective of the current study was to estimate the effect of vitamin C on BMD in menopausal women with balanced dietary. In the randomized controlled clinical trial, 150 menopausal women suffering from osteoporosis were chosen in purposive sampling method. In randomized block design, the individuals were placed in the received vitamin C (test) and placebo (control) groups. After integrating groups, the test group received 1000 mg of vitamin C in two divided doses for 6 months and the placebo control group received in the same method. There was a significant correlation between obstetric history with lumbar BMD (r= -295 and p<0.001) and femoral BMD (r= -0.226 and p=0.006). The average index changes of vertebral bone density did not indicate a statistically significant difference in the vitamin C group (0.02±0.05, P=0.001) and the placebo group (0.02±0.04, P<0.001) before and after treatment. With respect to the findings of the study about the effects of vitamin C on BMD, antioxidant is suggested to add to the current treatments.DOI: http://dx.doi.org/10.3126/ijls.v8i4.10930

scholarly journals Variations in Soft and Hard Tissues following Immediate Implant Placement versus Delayed Implant Placement following Socket Preservation in the Maxillary Esthetic Region: A Randomized Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Muthukumar Santhanakrishnan ◽  
Nithyakalyani Ramesh ◽  
R. Kamaleeshwari ◽  
Vedavalli Subramanian
Keyword(s):  
Plate Thickness ◽  
Test Group ◽  
Clinical Information ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Bovine Bone ◽  
Individual Values ◽  
Socket Preservation ◽  
Implant Placement ◽  
Significant Difference

Introduction. Although retrospective analysis has shown immediate placement of implants (IIP) in the maxillary esthetic zone showing promising outcomes compared to delayed placement of implants following socket preservation (DIP), a direct comparison in a prospective, well-designed randomized fashion with adequate power analysis between the two implant placement protocols is still lacking. This study is aimed at radiographically evaluating the effect of IIP after extraction as compared to implant placed in preserved sockets 4 months following extraction (DIP) in terms of changes in buccal plate thickness(CBT) after 6 months of healing and evaluation of pink esthetic score (PES) for assessment of soft tissue changes and patient-related outcome measures (PROMs) using visual analogue scale (VAS). Materials and Methods. 25 implants were placed immediately following extraction in the IIP group, and 25 implants were placed four months following socket preservation with demineralized bovine bone mineral (DBBM) and advanced platelet-rich fibrin (A-PRF) in the DIP group, control group, in the maxillary esthetic region. CBCT was taken preoperatively and 6 months postoperatively to assess the dimensional changes in the buccal bone plates(CBT). PES and PROMs for pain threshold and patient satisfaction using VAS were evaluated at the time of implant placement and 6 months postoperatively. Results. Significant differences in mean reduction in buccal plate thickness (CBT) were found in the test group (IIP) 0.2 ± 0.02 compared to the control group (DIP) which showed a mean reduction in CBT of 0.4 ± 0.1 ( p < 0.001 ) at the end of 6 months. Although there was no statistically significant difference in PES between the groups, there was a significant difference between the groups when individual values of PES were compared at p < 0.001 . Conclusion. The IIP group showed lesser reduction in CBT and a better PES which is an important clinical information which could be translated clinically in situations where implant placement is planned in the maxillary esthetic region. This trial is registered with CTRI/2019/06/019723.

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