Ultrasonic Image Restoration Algorithm for Prevention of Nervous Disorders during the Recovery Period of Patients Receiving Sevoflurane Anesthesia

In this article, dexmedetomidine (Dex) was used to prevent neurological disorders in patients anesthetized with sevoflurane and the effect was analyzed using ultrasound images based on the restoration algorithm of the linear system model. Children injected with Dex were in the experimental group, while children injected with normal saline were in the control group. The mean arterial pressure (MAP), arterial oxygen saturation (SpO2), heart rate (HR), Pediatric anesthesia agitation scale (PAED) score, Face, Legs, Activity, Cry, Consolability (FLACC) score, and adverse drug event (ADE) in the two groups were compared before the injection (T1), at 5 min (T2), 10 min (T3), and 20 min (T4) after the injection, and when the patient came to himself (T5). It was found that in contrast with the control group, the MAP in the experimental group at T2, T3, and T4 periods was lower, while it was higher at T5 period and its HR at T2, T3, T4, and T5 periods was higher ( P < 0.05); the PAED and FLACC scores were lower ( P < 0.05), and the incidence of ADE (10.53%) was lower than that in the control group (31.58%) ( P < 0.05). However, SpO2 at different periods showed no obvious differences between the two groups ( P > 0.05). In conclusion, the restoration algorithm-based ultrasound images had high quality, and they demonstrated good application value in evaluating the effect of Dex to prevent neurological disorders in patients anesthetized by sevoflurane.

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Swallowing and urine flow responses of ovine fetuses to 24 h of hypoxia

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1994.266.4.r1345 ◽

1994 ◽

Vol 266 (4) ◽

pp. R1345-R1352 ◽

Cited By ~ 4

Author(s):

R. A. Brace ◽

M. E. Wlodek ◽

G. J. McCrabb ◽

R. Harding

Keyword(s):

Oxygen Saturation ◽

Arterial Oxygen Saturation ◽

Recovery Period ◽

Urine Flow ◽

Late Gestation ◽

Arterial Oxygen ◽

Flow Rates ◽

Arterial Ph ◽

Pregnant Sheep ◽

Fetal Urine

The aim of this study was to determine the effects of 24 h of hypoxia on fetal swallowing and urine flow rates. The study design included successive 24-h control, hypoxia, and recovery periods. To induce hypoxia, we infused nitrogen into the trachea of late-gestation pregnant sheep. During hypoxia, there were decreases in fetal arterial oxygen saturation [from 62.7 +/- 2.2 to 30.9 +/- 2.9% (SE)] and PO2 (from 21.1 +/- 1.0 to 14.1 +/- 0.9 mmHg) (n = 7). Fetal arterial pH decreased maximally by 0.04 +/- 0.01 at 6 h and returned to control thereafter. Fetal swallowing decreased from 13.4 +/- 2.1 to 0.6 +/- 0.2 ml.h-1.kg fetal wt-1 with the onset of hypoxia and gradually increased, but only to one-half control levels, during the last 12 h of hypoxia. Fetal urine flow gradually decreased from 9.6 +/- 1.6 ml.h-1.kg-1 to a minimum of 5.3 +/- 0.5 ml.h-1.kg-1 at 2-3 h of hypoxia and returned to control thereafter. During the first hour of the recovery period, fetal swallowing transiently increased to twice control levels before returning to control. This was followed by a delayed, transient increase in urine flow to 63% above control levels at 2-6 h after hypoxia. We conclude that the fetal swallowing and urine flow responses to prolonged hypoxia in the absence of acidemia are distinctly different from the initial inhibitory responses, in that swallowing partially and urine flow fully recovers from the initial suppression.

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Testing individual baroreflex responses to hypoxia-induced peripheral chemoreflex stimulation

Clinical Autonomic Research ◽

10.1007/s10286-019-00660-6 ◽

2020 ◽

Vol 30 (6) ◽

pp. 531-540

Author(s):

Hendrik Kronsbein ◽

Darius A. Gerlach ◽

Karsten Heusser ◽

Alex Hoff ◽

Fabian Hoffmann ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Pressor Response ◽

Human Subjects ◽

Arterial Oxygen Saturation ◽

Recovery Period ◽

Arterial Oxygen ◽

Heart Rate Regulation ◽

Peripheral Chemoreflex ◽

Collective Influence

Abstract Introduction Baroreflexes and peripheral chemoreflexes control efferent autonomic activity making these reflexes treatment targets for arterial hypertension. The literature on their interaction is controversial, with suggestions that their individual and collective influence on blood pressure and heart rate regulation is variable. Therefore, we applied a study design that allows the elucidation of individual baroreflex–chemoreflex interactions. Methods We studied nine healthy young men who breathed either normal air (normoxia) or an air–nitrogen–carbon dioxide mixture with decreased oxygen content (hypoxia) for 90 min, with randomization to condition, followed by a 30-min recovery period and then exposure to the other condition for 90 min. Multiple intravenous phenylephrine bolus doses were applied per condition to determine phenylephrine pressor sensitivity as an estimate of baroreflex blood pressure buffering and cardiovagal baroreflex sensitivity (BRS). Results Hypoxia reduced arterial oxygen saturation from 98.1 ± 0.4 to 81.0 ± 0.4% (p < 0.001), raised heart rate from 62.9 ± 2.1 to 76.0 ± 3.6 bpm (p < 0.001), but did not change systolic blood pressure (p = 0.182). Of the nine subjects, six had significantly lower BRS in hypoxia (p < 0.05), two showed a significantly decreased pressor response, and three showed a significantly increased pressor response to phenylephrine in hypoxia, likely through reduced baroreflex buffering (p < 0.05). On average, hypoxia decreased BRS by 6.4 ± 0.9 ms/mmHg (19.9 ± 2.0 vs. 14.12 ± 1.6 ms/mmHg; p < 0.001) but did not change the phenylephrine pressor response (p = 0.878). Conclusion We applied an approach to assess individual baroreflex–chemoreflex interactions in human subjects. A subgroup exhibited significant impairments in baroreflex blood pressure buffering and BRS with peripheral chemoreflex activation. The methodology may have utility in elucidating individual pathophysiology and in targeting treatments modulating baroreflex or chemoreflex function.

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Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction

European Journal of Dentistry ◽

10.4103/1305-7456.184168 ◽

2016 ◽

Vol 10 (03) ◽

pp. 381-385 ◽

Cited By ~ 4

Author(s):

Jehona Ahmedi ◽

Enis Ahmedi ◽

Osman Sejfija ◽

Zana Agani ◽

Vjosa Hamiti

Keyword(s):

Recovery Period ◽

Third Molar ◽

Control Group ◽

Third Molars ◽

Dry Socket ◽

Third Molar Extraction ◽

Surgical Extraction ◽

Prophylactic Use ◽

Experimental Group

ABSTRACT Objective: The objective of this study was to assess the efficacy of ozone gas (O3) on the reduction of dry socket (DS) occurrence following surgical extraction of lower jaw third molars, influence of the indication for the extraction, and the difficulty of extraction on the incidence of DS. Materials and Methods: This study included thirty patients with bilaterally impacted third molars of mandible requiring surgical procedure for extraction. Following extraction, in the control group, saline solution was used for irrigation of extraction sockets and in the experimental group, intra-alveolar O3 was applied for 12 s (Prozone, W and H, UK, Ltd.). The surgeries were performed by the same oral surgeon. The follow-up visits were performed at 48 h and on day seven, postsurgery where the symptoms of DS were evaluated and intensity of pain has been recorded using visual analog scale 0–100. Results: In this pilot study, DS was present in 16.67% and 3.33% of cases in the control and experimental groups, respectively (P = 0.20). Conclusion: The application of O3 may reduce the incidence of DS and accelerates the recovery period after the surgery. Prophylactic use of O3 may be suggested in all patients, especially in the patients at a risk of development of DS.

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Efficacy of Zhifei Kangfu Decoction in the Treatment of Infantile Pneumonia in the Recovery Period

E3S Web of Conferences ◽

10.1051/e3sconf/202127103031 ◽

2021 ◽

Vol 271 ◽

pp. 03031

Author(s):

Yingying Zhang ◽

Caihong Cao ◽

Xin Guo ◽

Haijun Shan

Keyword(s):

Adverse Reaction ◽

Reaction Rate ◽

Treatment Time ◽

Recovery Period ◽

Research Work ◽

Effective Rate ◽

Control Group ◽

Pediatric Pneumonia ◽

The Difference ◽

Experimental Group

The objective of this article is to explore the effect of applying Zhifei Kangfu Decoction on the treatment effect of patients during the recovery period of children with pneumonia. The method of this research is to take patients who were treated in our hospital from December 2019 to December 2020 as an example to carry out the research work. The researchers selected all patients in the recovery period of pediatric pneumonia, and the number was selected as 100 cases, who were divided into two groups, and the treatment methods used are conventional western medicine and Zhifei Kangfu Decoction treatment, who were named the control group and the experimental group, and the clinical treatment effects of the two groups of patients are compared and analyzed. The effective rate and adverse reaction rate of children in the experimental group were 96.00% and 4.00%, respectively. The effective rate and adverse reaction rate of children in the control group were 82.00% and 30.00%, respectively. Asthma, cough relieving, and treatment time were shorter than those of the control group, and the difference in the data was P<0.05, which was statistically significant. The experimental group had better results. The treatment of children in the recovery period of pneumonia and the application of Zhifei Kangfu Decoction can promote the improvement of clinical efficacy, reduce the incidence of adverse reactions in children, and have a positive significance in promoting the recovery of children.

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High sodium intake during postnatal phases induces an increase in arterial blood pressure in adult rats

British Journal Of Nutrition ◽

10.1017/s0007114514002918 ◽

2014 ◽

Vol 112 (12) ◽

pp. 1923-1932 ◽

Cited By ~ 5

Author(s):

M. C. S. Moreira ◽

E. F. da Silva ◽

L. L. Silveira ◽

Y. B. de Paiva ◽

C. H. de Castro ◽

...

Keyword(s):

Sodium Intake ◽

Tap Water ◽

Recovery Period ◽

Control Group ◽

Adult Rats ◽

High Sodium ◽

Arterial Blood ◽

Hypertension Development ◽

Lower Magnitude ◽

Experimental Group

Epigenetic studies suggest that diseases that develop in adulthood are related to certain conditions to which the individual is exposed during the initial stages of life. Experimental evidence has demonstrated that offspring born to mothers maintained on high-Na diets during pregnancy have higher mean arterial pressure (MAP) in adulthood. Although these studies have demonstrated the importance of prenatal phases to hypertension development, no evidence regarding the role of high Na intake during postnatal phases in the development of this pathology has been reported. Therefore, in the present study, the effects of Na overload during childhood on induced water and Na intakes and on cardiovascular parameters in adulthood were evaluated. Experiments were carried out in two groups of 21-d-old rats: experimental group, maintained on hypertonic saline (0·3 m-NaCl) solution and food for 60 d, and control group, maintained on tap water and food. Later, both groups were given water and food for 15 d (recovery period). After the recovery period, chronic cannulation of the right femoral artery was performed in unanaesthetised rats to record baseline MAP and heart rate (HR). The experimental group was found to have increased basal MAP (98·6 (sem 2·6) v. 118·3 (sem 2·7) mmHg, P< 0·05) and HR (365·4 (sem 12·2) v. 398·2 (sem 7·5) beats per min, P< 0·05). There was a decrease in the baroreflex index in the experimental group when compared with that in the control group. A water and Na intake test was performed using furosemide. Na depletion was found to induce an increase in Na intake in both the control and experimental groups (12·1 (sem 0·6) ml and 7·8 (sem 1·1), respectively, P< 0·05); however, this increase was of lower magnitude in the experimental group. These results demonstrate that postnatal Na overload alters behavioural and cardiovascular regulation in adulthood.

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Evaluation of the Efficacy of Budesonide Combined with Pulmonary Surfactants on the Neonatal Respiratory Distress Syndrome by Pulmonary Ultrasonography

Scientific Programming ◽

10.1155/2021/2329524 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Chuanlong Zhang

Keyword(s):

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Premature Infants ◽

Distress Syndrome ◽

Lung Ultrasound ◽

Control Group ◽

Ultrasound Images ◽

Neonatal Respiratory Distress ◽

Experimental Group ◽

Paco2 Level

Objective. This study aimed to investigate the value of lung ultrasound images in evaluating the efficacy of budesonide combined with pulmonary surfactant (PS) in the treatment of neonatal respiratory distress syndrome (NRDS) in premature infants. Methods. 76 NRDS premature infants admitted to the hospital were randomly divided into experimental group and control group, with 38 children in each group. The premature infants in control group underwent PS, and those in experimental group underwent budesonide combined with PS. After treatment, lung ultrasound imaging was used to evaluate the curative effect, and X-ray results were used as a reference. The changes in clinical signs of two groups were detected, and the pulmonary ultrasound was used to evaluate the clinical efficacy of two groups. The changes in the lung ultrasound score (LUS) and arterial blood gas (ABG) indexes of two groups were compared before and after treatment. Results. LUS and improvement of patients of experimental group were obviously higher than those of the control group after treatment. LUS of experimental group was 12.1 ± 3.7, and that of control group was 18.2 ± 2.3, respectively. The differences were statistically significant ( P < 0.05). The arterial partial oxygen pressure (PaO2) and oxygenation index (PaO2/FiO2) levels of two groups of patients increased dramatically after treatment. PaO2 and PaO2/FiO2 levels of experimental group were 65.59 ± 12.46 mmHg and 112.57 ± 19.3 mmHg, and those of control group were 45.12 ± 11.21 mmHg and 101.28 ± 21.36 mmHg, respectively. However, arterial partial pressure of carbon dioxide (PaCO2) level was significantly decreased in two groups after treatment. PaCO2 level of experimental group was 40.24 ± 8.92 mmHg, and that of control group was 41.22 ± 9.24 mmHg, respectively ( P < 0.05). The diagnostic accuracy of lung ultrasound images in two groups was 95.3% and 96.2%, respectively. Conclusion. Pulmonary ultrasonography showed a high diagnostic accuracy in evaluating the efficacy of budesonide combined with PS in the treatment of NRDS in premature infants. It can evaluate the cardiopulmonary function of premature infants with NRDS and effectively improve the respiratory status of premature infants. In conclusion, this study provided some reference value for upgrading the clinical treatment of NRDS in premature infants.

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Deep-Learning-Based Color Doppler Ultrasound Image Feature in the Diagnosis of Elderly Patients with Chronic Heart Failure Complicated with Sarcopenia

Journal of Healthcare Engineering ◽

10.1155/2021/2603842 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Peng Bian ◽

Xiyu Zhang ◽

Ruihong Liu ◽

Huijie Li ◽

Qingqing Zhang ◽

...

Keyword(s):

Deep Learning ◽

Doppler Ultrasound ◽

Color Doppler ◽

Ultrasound Image ◽

Color Doppler Ultrasound ◽

Control Group ◽

Learning Technology ◽

Ultrasound Images ◽

Before And After ◽

Experimental Group

The neural network algorithm of deep learning was applied to optimize and improve color Doppler ultrasound images, which was used for the research on elderly patients with chronic heart failure (CHF) complicated with sarcopenia, so as to analyze the effect of the deep-learning-based color Doppler ultrasound image on the diagnosis of CHF. 259 patients were selected randomly in this study, who were admitted to hospital from October 2017 to March 2020 and were diagnosed with sarcopenia. Then, all of them underwent cardiac ultrasound examination and were divided into two groups according to whether deep learning technology was used for image processing or not. A group of routine unprocessed images was set as the control group, and the images processed by deep learning were set as the experimental group. The results of color Doppler images before and after processing were analyzed and compared; that is, the processed images of the experimental group were clearer and had higher resolution than the unprocessed images of the control group, with the peak signal-to-noise ratio (PSNR) = 20 and structural similarity index measure (SSIM) = 0.09; the similarity between the final diagnosis results and the examination results of the experimental group (93.5%) was higher than that of the control group (87.0%), and the comparison was statistically significant ( P < 0.05 ); among all the patients diagnosed with sarcopenia, 88.9% were also eventually diagnosed with CHF and only a small part of them were diagnosed with other diseases, with statistical significance ( P < 0.05 ). In conclusion, deep learning technology had certain application value in processing color Doppler ultrasound images. Although there was no obvious difference between the color Doppler ultrasound images before and after processing, they could all make a better diagnosis. Moreover, the research results showed the correlation between CHF and sarcopenia.

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Indicators of a Cardiovascular System at 14–15 Years Old Boys at Short-term Biofeedback Training for Controlling of General Heart Rate Variability After Speed and Power Training: Experimental Controlled Study

Вопросы современной педиатрии ◽

10.15690/vsp.v18i3.2033 ◽

2019 ◽

Vol 18 (3) ◽

pp. 167-174

Author(s):

Liliya V. Poskotinova ◽

Olga V. Krivonogova ◽

Oleg S. Zaborsky

Keyword(s):

Heart Rate ◽

Recovery Period ◽

Biofeedback Training ◽

Total Power ◽

Control Group ◽

Power Training ◽

Short Term ◽

Power Parameter ◽

And Control ◽

Experimental Group

Background. Cardiovascular system recovery after physical activity with explosive exercises is essential for cardiovascular pathology prevention. The efficiency of short-term biofeedback training (BFB training) in such conditions in adolescents have not been studied earlier. Objective. Our aim was to study the effect of BFB training on cardiovascular rehabilitation after speed and power training in adolescents according to general heart rate variability (HRV) spectrum total power parameter. Methods. The research has included healthy eighth-grade students (14–15 years old boys) from regular school. Inclusion in experimental and control groups was regulated by researches. Such indicators as total power (TP) of HRV spectrum, tension index (TI), systolic and diastolic arterial blood pressure (ABP), heart rate (HR) were registered initially, after three standing long jumps with double take-off and after recovery. All members of experimental group performed BFB training in order to increase TP (3 min) during recovery period. Members of control group were resting. Results. Initially all members of experimental (n = 17) and control (n = 10) groups were compared on age, height, weight and TP, TI, ABP and HR indicators. The TP level in boys of experimental group was higher than in control group during recovery period after BFB training: 3.22 (1.96; 6.13) against 1.36 (1.15; 1.84) X 1000 ms2 respectively (р = 0.041). There were no differences in TI, ABP and HR levels between two groups during recovery period. Conclusion. Implementation of short-term BFB training according to general HRV spectrum total power parameter in 14–15 years old boys after speed and power training perpetuates vagal impact on heart rate during recovery period.

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The Efficacy of Treating Pulmonary Fibrosis and Pulmonary Function Injury in COVID-19 with the Fuzheng Huayu Tablets: study protocol for a multicenter randomized controlled trial

10.21203/rs.3.rs-37422/v1 ◽

2020 ◽

Author(s):

Fei Jing ◽

Haina Fan ◽

Zhimin Zhao ◽

Feng Xing ◽

Yingchun He ◽

...

Keyword(s):

Quality Of Life ◽

Lung Function ◽

Pulmonary Fibrosis ◽

Pulmonary Function ◽

Recovery Period ◽

Life Assessment ◽

Control Group ◽

Pulmonary Dysfunction ◽

Experimental Group

Abstract Background: Some patients with COVID-19 have been found pulmonary dysfunction and/or fibrosis in the recovery period, especially severe cases, but there are no certain drugs or treatment to cope with this situation. Previous studies proved the efficacy of FZHY on lung fibrosis induced by Bleomycin in animals and improvement of pulmonary function in COPD patients. We design this trial to carry out the clinical study that the effects of FZHY Tablets on pulmonary fibrosis and/or pulmonary function injury in the recovery period of COVID-19 and expect to improve the prognosis.Methods/design: This is a double-blind, placebo-controlled, randomized, multicenter clinical trial. It enrolls 160 patients who had been diagnosed with COVID-19, but currently they are negative for viral testing and have developed pulmonary fibrosis or pulmonary dysfunction. They are randomly divided equally into control group and experimental group. All patients are given basic treatment such as respiratory function rehabilitation training and vitamin C. The control group is given placebo of FZHY, and the experimental group is given FZHY. Each patient will be observed for 24 weeks and followed up for 8 weeks. The primary outcome for the trial is a composite endpoint consisting of lung function and HRCT. Secondary outcomes include clinical symptoms, oxygen saturation and quality of life assessment. Discussion: The trial is designed to test the hypothesis that treating pulmonary fibrosis or pulmonary dysfunction after SARS-CoV-2 infection with FZHY will improve the patient’s lung function or the pathological manifestation of pulmonary fibrosis, and improve the quality of life. Trial registration: Clinical Trials.gov, ID: NCT04279197. Registered on 12 April 2020.

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FEATURES OF THE RESPONSE OF THE RESPIRATORY CENTER OF NEWBORN RATS THAT WERE EXPOSED TO PRENANTAL PASSIVE SMOKING TO HYPOXIA (IN VITRO)

Bulletin physiology and pathology of respiration ◽

10.12737/20046 ◽

2016 ◽

Vol 1 (60) ◽

pp. 23-27

Author(s):

Зинченко ◽

Evgeniy Zinchenko ◽

Болычевский ◽

Stanislav Bolychevsky ◽

Мирошниченко ◽

...

Keyword(s):

Cigarette Smoke ◽

Passive Smoking ◽

Recovery Period ◽

Respiratory Rhythm ◽

Hypoxic Exposure ◽

Control Group ◽

Newborn Rats ◽

Baseline Values ◽

Experimental Group

It is expected that in neonates that underwent prenatal chronic effect of nicotine the identification of the reduction of intensiveness of respiratory response to hypoxic exposure may be the cause of sudden infant death. The effect of cigarette smoke may differ from the effect of nicotine. The study was performed on brain stem spinal cord preparations (BSS) in the brain of newborn rats (n=38) in vitro. In the experimental group (EG) the modeling of passive smoking was carried out by fumigation of cigarette smoke of rat females from the 1st to 20th day of gestation. Hypoxia was simulated by an artificial cerebrospinal fluid saturated with a gas mixture of 5% CO2 and 95% N2. Hypoxic depression of BSS respiratory rhythm of the control group (CG) occurred at the 5th minute; the restoration took place in 10 minutes at normoxia, at the same time there was an increase of the amplitude of the inspiratory discharges which did not return to baseline values (15 minutes). In preparations of CG at the 10th minute of hypoxia the duration of inspiratory discharges decreased and restored after 10 minutes at normoxia. The increase of the ratio of the power of low-frequency and medium-frequency oscillations was observed in the CG at the 15th minute of hypoxia with the restoration during 10 minutes. In the experimental group (EG) the increase of the duration of the respiratory cycle occurred at the 10th minute of hypoxia with the dynamics of recovery similar to that of CG. The increase of the amplitude of inspiratory discharges occurred at the 10th minute of hypoxia; a recovery period took 10 minutes. In the BSS of EG the reduction in the duration of the inspiratory discharges and the increase of the ratio of the power oscillations of low- and mid-range occurred at the 5th and 10th minutes of hypoxia and these parameters never returned to baseline values. Our data suggest that prenatal exposure to secondhand smoke has an effect on the mechanisms of central chemosensitivity in the offspring in the early postnatal period.

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