The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review

Malaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been investigated as adjuvant therapy for malaria, so this systematic review summarizes 46 primary articles published until December 2020 that discuss curcumin and piperine as antimalarial agents. The selected articles discussed their antioxidant, anti-inflammatory, and antiapoptosis properties, as well as their mechanism of action against Plasmodium species. Curcumin is a potent antioxidant, damages parasite DNA, and may promote an immune response against Plasmodium by increasing reactive oxygen species (ROS), while piperine is also a potent antioxidant that potentiates the effects of curcumin. Hence, combining these compounds is likely to have the same effect as chloroquine, that is, attenuate and restrict parasite development, thereby reducing parasitemia and increasing host survival. This systematic review presents new information regarding the development of a curcumin-piperine combination for future malaria therapy.

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Ex vivo susceptibility to new antimalarial agents differs among human-infecting Plasmodium species

International Journal for Parasitology Drugs and Drug Resistance ◽

10.1016/j.ijpddr.2021.07.002 ◽

2021 ◽

Vol 17 ◽

pp. 5-11

Author(s):

Donelly A. van Schalkwyk ◽

Robert W. Moon ◽

Maëlle Duffey ◽

Didier Leroy ◽

Colin J. Sutherland

Keyword(s):

Ex Vivo ◽

Plasmodium Species ◽

Antimalarial Agents

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Comorbidity of Geo-Helminthes among Malaria Outpatients of the Health Facilities in Ethiopia: Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18030862 ◽

2021 ◽

Vol 18 (3) ◽

pp. 862

Author(s):

Minyahil Tadesse Boltena ◽

Ziad El-Khatib ◽

Abraham Sahlemichael Kebede ◽

Benedict Oppong Asamoah ◽

Andualem Tadesse Boltena ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Protein Energy Malnutrition ◽

Random Effect ◽

Plasmodium Species ◽

Intestinal Helminth ◽

Parasitic Infections ◽

Intestinal Helminths ◽

Soil Transmitted Helminths ◽

Pooled Prevalence

Background: Coinfection of malaria and intestinal helminths affects one third of the global population, largely among communities with severe poverty. The spread of these parasitic infections overlays in several epidemiological locations and the host shows different outcomes. This systematic review and meta-analysis determine the pooled prevalence of malaria and intestinal helminthiases coinfections among malaria suspected patients in Ethiopia. Methods: Primary studies published in English language were retrieved using appropriate search terms on Google Scholar, PubMed/MEDLINE, CINHAL, Scopus, and Embase. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used for critical appraisal of studies. A pooled statistical meta-analysis was conducted using STATA Version 14.0 software. The heterogeneity and publication bias were assessed using the I2 statistics and Egger’s test, respectively. Duval and Tweedie’s nonparametric trim and fill analysis using the random-effect analysis. The Random effects model was used to estimate the summary prevalence of comorbidity of malaria and soil transmitted helminthiases and the corresponding 95% confidence intervals (CI). The review protocol has registered in PROSPERO number CRD42019144803. Results: We identified ten studies (n = 6633 participants) in this study. The overall pooled result showed 13% of the ambulatory patients infected by malaria and intestinal helminths concurrently in Ethiopia. The pooled prevalence of Plasmodium falciparum and Plasmodium vivax, and mixed infections were 12, 30, and 6%, respectively. The most common intestinal helminth parasites detected were Hookworm, Ascaris lumbricoides, and Tirchuris trichiura. Conclusions: The comorbidity of malaria and intestinal helminths causes lower hemoglobin level leading to maternal anemia, preterm delivery, and still birth in pregnant women and lactating mother. School-aged children and neonates coinfected by plasmodium species and soil transmitted helminths develop cognitive impairment, protein energy malnutrition, low birth weight, small for gestational age, and gross motor delay. The Ministry of Health of Ethiopia and its international partners working on malaria elimination programs should give more emphasis to the effect of the interface of malaria and soil transmitted helminths, which calls for an integrated disease control and prevention.

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Audiovisual Bimodal and Interactive Effects for Soundscape Design of the Indoor Environments: A Systematic Review

Sustainability ◽

10.3390/su13010339 ◽

2021 ◽

Vol 13 (1) ◽

pp. 339

Author(s):

Yoshimi Hasegawa ◽

Siu-Kit Lau

Keyword(s):

Systematic Review ◽

Visual Information ◽

Web Of Science ◽

Interactive Effects ◽

Indoor Environments ◽

Sound Sources ◽

Noise Annoyance ◽

Visual Variable ◽

Soundscape Studies ◽

Potential Use

A growing number of soundscape studies involving audiovisual factors have been conducted; however, their bimodal and interactive effects on indoor soundscape evaluations have not yet been thoroughly reviewed. The overarching goal of this systematic review was to develop the framework for designing sustainable indoor soundscapes by focusing on audiovisual factors and relations. A search for individual studies was conducted through three databases and search engines: Scopus, Web of Science, and PubMed. Based on the qualitative reviews of the selected thirty papers, a framework of indoor soundscape evaluation concerning visual and audiovisual indicators was proposed. Overall, the greenery factor was the most important visual variable, followed by the water features and moderating noise annoyance perceived by occupants in given indoor environments. The presence of visual information and sound-source visibility would moderate perceived noise annoyance and influence other audio-related perceptions. Furthermore, sound sources would impact multiple perceptual responses (audio, visual, cognitive, and emotional perceptions) related to the overall soundscape experiences when certain visual factors are interactively involved. The proposed framework highlights the potential use of the bimodality and interactivity of the audiovisual factors for designing indoor sound environments in more effective ways.

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MicroRNA roles and their potential use as selection tool to cold tolerance of domesticated teleostean species: A systematic review

Aquaculture ◽

10.1016/j.aquaculture.2021.736747 ◽

2021 ◽

Vol 540 ◽

pp. 736747

Author(s):

Eduardo B. Blödorn ◽

William B. Domingues ◽

Leandro S. Nunes ◽

Eliza R. Komninou ◽

Danillo Pinhal ◽

...

Keyword(s):

Systematic Review ◽

Cold Tolerance ◽

Selection Tool ◽

Potential Use

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Structural activity relationship of metallo-aminoquines as a next generation antimalarials

Current Topics in Medicinal Chemistry ◽

10.2174/1568026622666220105103751 ◽

2022 ◽

Vol 22 ◽

Author(s):

Mohammad Abid ◽

Shailja Singh ◽

Timothy J. Egan ◽

Mukesh C. Joshi

Keyword(s):

Plasmodium Species ◽

Toxic Metal ◽

Multi Drug Resistance ◽

Drug Candidates ◽

Malaria Therapy ◽

The Past ◽

Common Infectious Disease ◽

Structural Activity Relationship ◽

Relationship Of ◽

Children Under 5

Apicomplexian parasite of the genus Plasmodium is the causative agent of malaria, one of the most devastating, furious and common infectious disease throughout the world. According to the latest World malaria report, there were 229 million cases of malaria in 2019 majorly consisting of children under 5 years of age. Some of known analogues viz. quinine, quinoline-containing compounds have been used for last century in the clinical treatment of malaria. Past few decades have witnessed the emergence of multi-drug resistance (MDR) strains of Plasmodium species to existing antimalarials pressing the need for new drug candidates. For the past few decades bioorganometallic approach to malaria therapy has been introduced which led to the discovery of noval metalcontaining aminoquinolines analogues viz. ferroquine (FQ or 1), Ruthenoquine (RQ or 2) and other related potent metal-analogues. It observed that some metal containing analogues (Fe-, Rh-, Ru-, Re-, Au-, Zn-, Cr-, Pd-, Sn-, Cd-, Ir-, Co-, Cu-, and Mn-aminoquines) were more potent; however, some were equally potent as Chloroquine (CQ) and 1. This is probably due to the intertion of metals in the CQ via various approaches, which might be a very attractive strategy to develop a SAR of novel metal containing antimalarials. Thus, this review aims to summarize the SAR of metal containing aminoquines towards the discovery of potent antimalarial hybrids to provide an insight for rational designs of more effective and less toxic metal containing amoniquines.

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Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

10.20944/preprints201808.0210.v1 ◽

2018 ◽

Author(s):

M. Saad Khan ◽

Jangsun Hwang ◽

Kyungwoo Lee ◽

Yonghyun Choi ◽

Kyobum Kim ◽

...

Keyword(s):

Photodynamic Therapy ◽

Oxygen Supply ◽

Photoacoustic Imaging ◽

Supply And Demand ◽

Flexible Structures ◽

Synthesis Methods ◽

Oxygen Species ◽

Hypoxic Conditions ◽

Potential Use ◽

Resistance To Chemotherapy

Microbubbles and nanobubbles can be prepared using various shells, such as phospholipids, polymers, proteins, and surfactants. They are echogenic and can be used as contrast agents for ultrasonic and photoacoustic imaging. These bubbles can be engineered in various sizes as vehicles for gas and drug delivery applications with novel properties and flexible structures. Hypoxic areas in tumors develop owing to an imbalance of oxygen supply and demand. In tumors, hypoxic regions have shown more resistance to chemotherapy, radiotherapy, and photodynamic therapies. The efficacy of photodynamic therapy depends on the availability of oxygen in the tumor to generate reactive oxygen species. Micro/nanobubbles have been shown to reverse hypoxic conditions and increase tissue oxygen levels. This review summarizes the synthesis methods and shell compositions of micro/nanobubbles and methods deployed for oxygen delivery. In addition, the shortcomings and prospects of engineering micro/nanobubbles are discussed for their potential use in photodynamic therapy.

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The Provenance of Marbles and Alabasters Used in the Monuments of Hierapolis in Phrygia (Turkey): New Information from a Systematic Review and Integration of Archaeological and Archaeometric Data

Heritage ◽

10.3390/heritage2010035 ◽

2019 ◽

Vol 2 (1) ◽

pp. 519-552

Author(s):

Giuseppe Scardozzi

Keyword(s):

Systematic Review ◽

Multidisciplinary Approach ◽

Building Stone ◽

Time Span ◽

Research Activities ◽

New Information ◽

Byzantine Period ◽

Procurement Strategies ◽

The City ◽

Chronological Time

Determining the provenance of the stones used for ancient architectures is very important in order to reconstruct many social and economic questions linked to the life of a city. This paper integrates previous and new archaeometric data about marble and alabaster quarries in south-western Phrygia (Lykos valley), and offers a review of some results of the research activities carried out between the years 2013–2018 and aimed to reconstruct the building stone procurement strategies adopted in the city of Hierapolis in Phrygia across a broad chronological time span from the Hellenistic age to the Byzantine period. The research activities based on a multidisciplinary approach, integrating the archaeological and art-historian study of the monuments, the topographical investigation of the quarries, and the archaeometric characterisation both of extraction sites and marbles and alabasters used in the building sites of the urban area and in the necropolises.

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Prediction of human Plasmodium sex specific gene by homology search: a systematic review and meta-synthesis

10.1101/199141 ◽

2017 ◽

Author(s):

Mitsuhiro Odaka ◽

Amen Sassy ◽

Shymmaa Khatab ◽

Linh Tran ◽

Khaled Ismaeil ◽

...

Keyword(s):

Systematic Review ◽

Candidate Genes ◽

Plasmodium Species ◽

Homology Search ◽

Specific Gene ◽

Published Data ◽

Malaria Parasites ◽

Human Malaria ◽

Search Terms ◽

Human Plasmodium

Human Plasmodium species have a sex specific process in the life cycle namely gametocytogenesis or gametogenesis. Gametocytes production and subsequent gametes zygosis are critical for malaria parasites to link to mosquito stage and to merge to sexual reproduction. Here, we aimed at the identification of genes related to gametocytogenesis or gametogenesis in human malaria using systematic review, meta-synthesis and homology search. Based on our search terms, we conducted a systematic search of published data in nine databases resulting in 96 finally included papers with a total of 255 genes from apicomplexan species. We found more papers involved in Plasmodium than we had expected, which reflects that the extensive amount of research on Plasmodium genes have been examined. Subsequently we searched sequence homology between FASTA sequences of apicomplexan sex specific genes other than human malaria parasites and those of human malaria parasites genome on PlasmoDB. We focused on eight candidate genes of Plasmodium falciparum (PF). Finally we predicted that PRPF6, SMC1 and SMC2 can be the especially promising candidate genes.

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Smoking cessation interventions for potential use in the lung cancer screening setting: A systematic review and meta-analysis

Lung Cancer ◽

10.1016/j.lungcan.2019.06.024 ◽

2019 ◽

Vol 135 ◽

pp. 205-216 ◽

Cited By ~ 3

Author(s):

Christopher J. Cadham ◽

Jinani C. Jayasekera ◽

Shailesh M. Advani ◽

Shelby J. Fallon ◽

Jennifer L. Stephens ◽

...

Keyword(s):

Lung Cancer ◽

Systematic Review ◽

Smoking Cessation ◽

Cancer Screening ◽

Meta Analysis ◽

Lung Cancer Screening ◽

Potential Use

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Transfusion-Transmitted Malaria: A Systematic Review and Meta-analysis

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz283 ◽

2019 ◽

Vol 6 (7) ◽

Cited By ~ 5

Author(s):

Ehsan Ahmadpour ◽

Masoud Foroutan-Rad ◽

Hamidreza Majidiani ◽

Sirous Mehrani Moghaddam ◽

Kareem Hatam-Nahavandi ◽

...

Keyword(s):

Systematic Review ◽

Blood Transfusion ◽

Blood Donors ◽

Meta Analysis ◽

Plasmodium Species ◽

Diagnostic Methods ◽

Sub Saharan Africa ◽

Screening Methods ◽

Original Research ◽

Malaria Parasitemia

Abstract Background Malaria transmission through blood transfusion is an accidental but preventable cause of malaria infection and is increasingly becoming a matter of concern for blood transfusion services. This systematic review was conducted to provide a summary of evidence about the prevalence of Plasmodium infection in asymptomatic blood donors and the effectiveness of screening methods used based on the available literature. Methods PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1982 to October 10, 2017. All peer-reviewed original research articles describing the prevalence of malaria parasitemia in blood donors with different diagnostic methods were included. The random-effects model was applied to assess the effects of heterogeneity among the selected studies. Incoherence and heterogeneity between studies were quantified by I2 index and Cochran’s Q test. Publication and population bias was assessed with funnel plots and Egger’s regression asymmetry test. All statistical analyses were performed using Stata (version 2.7.2). Results Seventy-one studies from 21 countries, 5 continents, were included in the present systematic review. The median prevalence of malaria parasitemia among 984 975 asymptomatic healthy blood donors was 10.54%, 5.36%, and 0.38% by microscopy, molecular methods (polymerase chain reaction), and rapid diagnostic tests, respectively. The most commonly detected Plasmodium species was P. falciparum. Conclusions This systematic review demonstrates that compared with other transfusion-linked infections, that is, HIV, HCV, and HBV, transfusion-transmitted malaria is one of the most significant transfusion-associated infections especially in Sub-Saharan Africa. Future work must aim to understand the clinical significance of transfusion-transmitted malaria in malaria-endemic settings.

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