scholarly journals The Relationship between Body Mass Index, Obesity, and LINE-1 Methylation: A Cross-Sectional Study on Women from Southern Italy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Andrea Maugeri ◽  
Martina Barchitta ◽  
Roberta Magnano San Lio ◽  
Giuliana Favara ◽  
Claudia La Mastra ◽  
...  

Uncovering the relationship between body mass index (BMI) and DNA methylation could be useful to understand molecular mechanisms underpinning the effects of obesity. Here, we presented a cross-sectional study, aiming to evaluate the association of BMI and obesity with long interspersed nuclear elements (LINE-1) methylation, among 488 women from Catania, Italy. LINE-1 methylation was assessed in leukocyte DNA by pyrosequencing. We found a negative association between BMI and LINE-1 methylation level in both the unadjusted and adjusted linear regression models. Accordingly, obese women exhibited lower LINE-1 methylation level than their normal weight counterpart. This association was confirmed after adjusting for the effect of age, educational level, employment status, marital status, parity, menopause, and smoking status. Our findings were in line with previous evidence and encouraged further research to investigate the potential role of DNA methylation markers in the management of obesity.

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Resmiye Özdilek ◽  
Yılda Arzu Aba ◽  
Sena Dilek Aksoy ◽  
Bulat Aytek Şık ◽  
Yaşam Kemal Akpak

Objective: To investigate the adaptation of pregnant women to the recommended weight gain range according to body mass index (BMI) and to determine the factors affecting them. Methods: This cross-sectional study was performed in a university hospital’s obstetrics and gynecology unit (tertiary center) in Turkey. This study was conducted between March 2018 and August 2018 (6 months) in pregnant women. Pregnant women with chronic disease and receiving treatment during antenatal follow-up, with twin pregnancy, with a fetus with a congenital abnormality, and nutritional disturbance were excluded from the study. Eight hundred twelve pregnant women with normal antenatal follow-up and who volunteered to participate were included in the study. Results: The mean age of the participants was 27.66±5.05 years. The mean weight and BMI before pregnancy were near standard in all participants. The group with the highest rate of recommended weight gain according to BMI before pregnancy was the group with low weight pregnant women. The ideal weight gain rate in all groups was 32%. Conclusions: The groups with overweight and obese pregnant women according to BMI before pregnancy had the highest rates of weight gain, above the recommended limits. BMI before pregnancy directly affects weight gain during pregnancy and the importance of pre-pregnancy counseling and weight loss is emphasized once again. doi: https://doi.org/10.12669/pjms.35.5.133 How to cite this:Ozdilek R, Aba YA, Aksoy SD, Sik BA, Akpak YK. The relationship between body mass index before pregnancy and the amount of weight that should be gained during pregnancy: A cross-sectional study. Pak J Med Sci. 2019;35(5):---------.  doi: https://doi.org/10.12669/pjms.35.5.133 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2021 ◽  
Author(s):  
Komei Iwai ◽  
Tetsuji Azuma ◽  
Takatoshi Yonenaga ◽  
Daisuke Ekuni ◽  
Kazutoshi Watanabe ◽  
...  

Abstract This cross-sectional study investigated the relationship between self-reported chewing status and glycemic control in 32,137 Japanese adults who participated in health checkups. Chewing status was evaluated using a self-reported questionnaire. We defined poor glycemic control as a hemoglobin A1c (HbA1c) level ≥6.5% or the use of medication to control diabetes; 1,891 (5.9%) respondents met these criteria. After adjusting for gender, age, smoking status, exercise habits, body mass index, and eating speed, poor glycemic control was found to be positively associated with male gender (odds ratio [OR], 2.142; 95% confidence interval [CI], 1.903 to 2.411; p < 0.001), older age (OR, 1.093; 95% CI, 1.087 to 1.099; p < 0.001), higher body mass index (OR, 1.234; 95% CI, 1.219 to 1.249; p < 0.001), current smoker status (OR, 1.378; 95% CI, 1.223 to 1.552; p < 0.001), and ability to chew well (OR, 0.795; 95% CI, 0.699 to 0.904; p < 0.001). Furthermore, a negative association was found between the ability to chew well and poor glycemic control in those ≥40 years of age, but not in those between 20 and 39 years of age. In conclusion, self-reported ability to chew well was associated with poor glycemic control in Japanese adults aged ≥40 years.


2021 ◽  
Vol 19 (3) ◽  
pp. 233-240
Author(s):  
Aysel Topan ◽  
◽  
Tülay Kuzlu Ayyıldız ◽  
Müge Seval ◽  
Aylin Kurt ◽  
...  

Introduction. One of the reasons of obesity in university students might be mindful eating. Aim. This study was performed to evaluate the relationship between mindful eating, body mass index (BMI) and physical activity in nursing students. Material and methods. This cross-sectional study was conducted with 718 nursing students in a university in Turkey. “Personal Information Form” and “Mindful Eating Questionnaire (MEQ)” were used as data collection tools. Results. Statistically significant differences were found between some mean subscale and total scores of MEQ based on sex of the students, their state of exercising regularly, number of their meals, their state of having snacks, the type of bread they often consumed and the frequency of eating fast foods (p<0.05). A significant relationship was found between age and BMI of the students and their mean subscale and total scores of MEQ (p<0.05). Conclusion. The older the nursing students grew, the higher their level of mindful eating became. Sociodemographic characteristics such as sex and presence of a person with obesity within the family affected subscales of their mindful eating. Mindful eating decreased as body mass index increased; and besides, mindful eating increased as physical activity increased.


Author(s):  
Sikander Ali Sial ◽  
Jagdesh Kumar ◽  
Attia Ayoob ◽  
Anwar Ali Jamali ◽  
Amir Hamzo Dahri ◽  
...  

Background: Hypertension is a common health issue all over the world; increased Body Mass Index (BMI) is alone one strong risk factor for the HTN. Objective: To assess the relationship between HTN & BMI in patients visited at department of Medicine PMCH Nawabshah. Methodology: This cross sectional study was conducted at PMC Hospital Nawabshah during March 2019 to February 2020. Sample size was 385. This study was conducted after ethical approval of institutional committee and willing male and female subjects with hypertension were included in present study after consent. Age ranges from 15 years and above. Those having other co morbidities like, DM, IHD, stroke and other metabolic and endocrine disorders were excluded from the study. Patients with history of drugs causing weight gain were also excluded. Results: there were total 385 subjects included, 130 were females and 245 were males1:2 ratio of female and male. Mean age of patients was 46.50 sd ± 8.65 years, mean BMI was 26.18 sd ± 4.73, mean systolic HTN was158.35sd ± 30.40 and mean diastolic blood pressure was 95.75 sd ± 12.91 mmHg. Conclusion: There is strong association between hypertension and BMI, as the BMI will increase the risk of HTN will increase.


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