Choroidal Thickness in Relation to Bone Mineral Density with Swept-Source Optical Coherence Tomography

Purpose. To assess whether bone mineral density, indicated by the lumbar X-ray scan, is related to changes in choroid thickness in normal subjects. Methods. This study included 355 patients with decreased bone mineral density and 355 age- and sex-matched healthy subjects. Lumbar BMD was measured by dual-energy X-ray absorptiometry (DXA). Choroidal thickness was measured using swept-source optical coherence tomography (SS-OCT). Blood pressure (BP), cholesterol, triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were recorded on the same day. Results. There was a significant difference in average choroidal thickness between low BMD subjects and normal subjects p = 0.003 . The BP, cholesterol, triglyceride, HDL, and LDL showed no significant difference between the two groups. The correlations showed that average choroidal thicknesses were associated with BMD in the entire population (r = 0.125, p = 0.001 ). Conclusion. The choroidal thickness is thinner in low BMD populations compared with normal individuals. There is a strong positive correlation of choroidal thickness with BMD, regardless of age, sex, and other demographic and clinical factors.

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Peripheral and Central Bone Mineral Density in Charcot’s Neuroarthropathy Compared in Diabetic and Nondiabetic Populations

Journal of the American Podiatric Medical Association ◽

10.7547/1020213 ◽

2012 ◽

Vol 102 (3) ◽

pp. 213-222 ◽

Cited By ~ 7

Author(s):

Robert M. Greenhagen ◽

Dane K. Wukich ◽

Rachel H. Jung ◽

Vassilios Vardaxis ◽

Robert M. Yoho

Keyword(s):

Diabetes Mellitus ◽

Bone Mineral Density ◽

Bone Mineral ◽

Serum Vitamin ◽

Control Group ◽

Mineral Density ◽

X Ray ◽

Serum Vitamin D ◽

Significant Difference ◽

Patients With Diabetes

Background: This prospective study was performed to compare calcaneal and lumbar bone mineral density (BMD) in individuals with and without diabetes mellitus. We compared bone density with the time from onset of Charcot’s neuroarthropathy (CN) in patients with unilateral, nonoperative, reconstructive-stage CN. The final purpose was to investigate the role that sex, age, and serum vitamin D level may have in osseous recovery. Methods: Thirty-three individuals were divided into three groups: controls and patients with diabetes mellitus with and without CN. Peripheral instantaneous x-ray imaging and dual-energy x-ray absorptiometry were performed. Results: The calcaneal BMD of patients with diabetes mellitus and CN was lower than that of the control group (P < .01) but was not significantly lower than that of patients with diabetes mellitus alone. There was no statistically significant difference in lumbar T-scores between groups. Women demonstrated lower BMD than did men (P = .02), but patients 60 years and older did not demonstrate significantly lower BMD than did patients younger than 60 years (P = .135). A negative linear relationship was demonstrated between time and BMD in patients with CN. Conclusions: The results of this study suggest that lumbar BMD does not reflect peripheral BMD in patients with diabetes mellitus and reconstructive-stage CN. This study has clinical implications when reconstructive osseous surgery is planned in patients with CN. (J Am Podiatr Med Assoc 102(3): 213–222, 2012)

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Bone Mineral Density Is Not Related to Osteophyte Formation in Osteoarthritis of the Hip

The Journal of Rheumatology ◽

10.3899/jrheum.100533 ◽

2010 ◽

Vol 38 (2) ◽

pp. 358-361 ◽

Cited By ~ 4

Author(s):

KUNIHIKO OKANO ◽

KIYOSHI AOYAGI ◽

KO CHIBA ◽

SATORU MOTOKAWA ◽

TOMOKO MATSUMOTO

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Mineral Density ◽

Osteoarthritis Of The Hip ◽

Osteophyte Formation ◽

X Ray ◽

Ultradistal Radius ◽

Significant Difference ◽

Different Types

Objective.Reports have suggested that bone mineral density (BMD) is higher in patients with osteoarthritis (OA) of the hip than in healthy controls. Various types of OA of the hip caused by osteophyte formation were observed on radiographs during progression to the advanced degenerative stage, and the preoperative type of OA was reported to influence the results of surgical treatment. However, the mechanism underlying the development of different types of OA is still unknown. We measured BMD of patients with hip OA and determined whether higher BMD was observed in patients with osteophyte formation than in those without osteophytes.Methods.We measured BMD of the lumbar spine, radius, and calcaneus using dual-energy x-ray absorptiometry in 88 women who were scheduled to undergo total hip arthroplasty for endstage OA. Hips were evaluated for osteophyte formation using Bombelli’s classification; 31 were graded as atrophic type, 30 as normotrophic, and 27 as hypertrophic. BMD at different skeletal sites were compared among the 3 types of OA.Results.No significant difference in BMD of the lumbar spine, ultradistal radius, mid-radius, or calcaneus was observed among the atrophic, normotrophic, and hypertrophic types of OA.Conclusion.Our data suggest that osteophyte formation is not related to general BMD. Factors other than general bone status, for example the morphology of the hip joint, need to be analyzed to determine the pathomechanism of osteophyte formation in the osteoarthritic hip.

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Bone Mineral Density Status of Women with Intellectual Disability

Adapted Physical Activity Quarterly ◽

10.1123/apaq.18.1.49 ◽

2001 ◽

Vol 18 (1) ◽

pp. 49-59 ◽

Cited By ~ 4

Author(s):

Bernadette L. Foster ◽

Jeff W. Walkley ◽

Viviene A. Temple

Keyword(s):

Bone Mineral Density ◽

Intellectual Disability ◽

Lumbar Spine ◽

Bone Mineral ◽

Comparison Group ◽

Dual Energy ◽

Mineral Density ◽

X Ray ◽

Significant Difference ◽

Status Of Women

The purpose of this study was to describe and compare the bone mineral density of women with intellectual disability (WID) and a comparison group (WOID) matched for age and sex. One hundred and five women, ages 21 to 39, M = 29, were tested for their bone mineral density levels at the lumbar spine and three sites of the proximal femur using dual energy X-ray absorptiometry. No significant difference between groups existed (λ = 0.94, F(4, 98) = 1.68, p = .16, η2 = .06); however, one-sample t tests revealed that bone mineral density for the WID group (n = 35) was significantly lower than zero at the Ward’s triangle (p < .01) and the lumbar spine (p < .05). Approximately one-quarter of WID had low bone density at these two sites, suggesting that WID may be at risk of osteoporotic fracture as they age.

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Comparación de la densidad mineral ósea en futbolistas y árbitros de nivel profesional

SPORT TK-Revista EuroAmericana de Ciencias del Deporte ◽

10.6018/sportk.461601 ◽

2021 ◽

Vol 10 (1) ◽

pp. 45-49

Author(s):

R. López García ◽

JO. Lagunes Carrasco ◽

LE. Carranza García ◽

R. Navarro Orocio

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

The Body ◽

Soccer Players ◽

Mineral Density ◽

X Ray ◽

Professional Soccer ◽

Significant Difference ◽

Statistical Program ◽

Full Body

El objetivo de este estudio fue comparar la densidad mineral ósea (DMO) de los futbolistas y árbitros de nivel profesional. Se realizaron mediciones de la densidad mineral del hueso con el equipo de absorciometría dual de rayos X (DEXA) en el cual se evaluaron las regiones de la columna, cadera, costillas, brazos, piernas y cuerpo completo a 27 futbolistas (19.81 ± 1.14 años de edad) y 22 árbitros (24.95 ± 3.54 años de edad) de la segunda división de la liga profesional de fútbol MX de México. Se utilizo el programa estadístico SPSS (21.0), utilizando la prueba para muestras independientes de la t de Student, considerando el valor de significancia de p ≤ .05. Los futbolistas lograron una mayor DMO que los árbitros en la mayoría de las regiones del cuerpo, encontrándose solamente diferencia significativa en las piernas y en la cadera (p ≤ .05). La alta mineralización de las piernas de los futbolistas se debe al alto contacto de repetidas ocasiones con el balón de juego, aunque también se obtuvo un alta DMO en los árbitros que en otros deportes de otros estudios. Concluyendo así que la práctica del arbitraje en el fútbol es positivo para el fortalecimiento del hueso. Sin embargo hacen falta realizar más estudios sobre la DMO en árbitros, réferi y jueces en el fútbol y en otras disciplinas. The aim of this study was to compare bone mineral density (BMD) of soccer players and professional referees. There were made bone mineral density measurements with the dual x-ray absorptiometry equipment (DEXA) to 27 players (19.81 ± 1.14 years old) and 22 referees (24.95 ± 3.54 years old) from the second division of the Mexican professional soccer league (Liga MX) where the areas of the spine, hip, ribs, arms, legs and full body were evaluated. It was used the statistical program SPSS (21.0), using the test for independent samples of the t of Student, considering the significance value of p ≤ .05. The players achieved a higher BMD than the referees in most regions of the body, finding only significant difference in the legs and hip (p ≤ .05). The high mineralization of the legs of the players is due to the high contact repeatedly to the game ball, although a higher BMD was also obtained in the referees than in other sports of other studies. Thus concluding that the practice of refereeing in football is positive for bone strengthening. However, more studies on BMD in referees, officials and judges in football and in other disciplines are needed.

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Bone health index by hand X-ray compared with bone mineral density by dual-energy X-ray absorptiometry in children with Duchenne muscular dystrophy

Bone Abstracts ◽

10.1530/boneabs.7.p91 ◽

2019 ◽

Author(s):

Jonathan J Bowden ◽

Ramkumar Krishnamurthy ◽

Houchun Hu ◽

Brent Adler ◽

Rajesh Krishnamurthy ◽

...

Keyword(s):

Bone Mineral Density ◽

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Bone Mineral ◽

Bone Health ◽

Dual Energy ◽

Health Index ◽

Mineral Density ◽

X Ray ◽

Bone Health Index

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Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18158144 ◽

2021 ◽

Vol 18 (15) ◽

pp. 8144

Author(s):

Gabriella Martino ◽

Federica Bellone ◽

Carmelo M. Vicario ◽

Agostino Gaudio ◽

Andrea Caputo ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Rating Scale ◽

Osteoporotic Fractures ◽

Oral Bisphosphonates ◽

Mineral Density ◽

X Ray ◽

Hamilton Anxiety Rating Scale ◽

Anxiety Levels

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

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SAT0462 ASSESSMENT OF BONE MINERAL DENSITY IN INFLAMMATORY BOWEL DISEASE

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6007 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1188.1-1188

Author(s):

C. Daldoul ◽

N. El Amri ◽

K. Baccouche ◽

H. Zeglaoui ◽

E. Bouajina

Keyword(s):

Bone Mineral Density ◽

Inflammatory Bowel Disease ◽

Bone Mineral ◽

Bowel Disease ◽

Mineral Density ◽

Femoral Site ◽

Significant Difference ◽

History Of ◽

Inflammatory Bowel ◽

The Mean

Background:Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is considered as a risk factor of low bone mineral density (BMD). In fact, the prevalence of osteoporosis ranges from 17% to 41% in IBD patients. The possible contributing factors may include malabsorption, glucocorticoid treatment and coexisting comorbiditiesObjectives:The purpose of our work was to determine the frequency and the determinants of osteoporosis in patients with IBD and to assess whether there is a difference in BMD status between UC and CD.Methods:This is a retrospective study, over a period of 5 years (from January 2014 to December 2018) and including patients followed for IBD who had a measurement of BMD by DEXA. Clinical, anthropometric and densitometric data (BMD at the femoral and vertebral site) were recorded. The WHO criteria for the definition of osteoporosis and osteopenia were applied.Results:One hundred and five patients were collected; among them 45 were men and 60 were women. The average age was 45.89 years old. The average body mass index (BMI) was 25.81 kg/m2 [16.44-44.15]. CD and UC were diagnosed in respectively 57.1% and 42.9%. A personal history of fragility fracture was noted in 4.8%. Hypothyroidism was associated in one case. Early menopause was recorded in 7.6%. 46.8% patients were treated with corticosteroids. The mean BMD at the vertebral site was 1.023 g/cm3 [0.569-1.489 g/cm3]. Mean BMD at the femoral site was 0.920g/cm3 [0.553-1.286g / cm3]. The mean T-score at the femoral site and the vertebral site were -1.04 SD and -1.27 SD, respectively. Osteoporosis was found in 25.7% and osteopenia in 37.1%. Osteoporosis among CD and UC patients was found in respectively 63% and 37%. The age of the osteoporotic patients was significantly higher compared to those who were not osteoporotic (52.23 vs 43.67 years, p = 0.01). We found a significantly higher percentage of osteoporosis among men compared to women (35.6% vs 18.3%, p=0.046). The BMI was significantly lower in the osteoporotic patients (23.87 vs 26.48 kg/m2, p=0.035) and we found a significant correlation between BMI and BMD at the femoral site (p=0.01). No increase in the frequency of osteoporosis was noted in patients treated with corticosteroids (27.9% vs 21.6%, p=0.479). Comparing the UC and CD patients, no difference was found in baseline characteristics, use of steroids or history of fracture. No statistically significant difference was found between UC and CD patients for osteoporosis(p=0.478), BMD at the femoral site (p=0.529) and at the vertebral site (p=0.568).Conclusion:Osteoporosis was found in 25.7% of IBD patients without any difference between CD and UC. This decline does not seem to be related to the treatment with corticosteroids but rather to the disease itself. Hence the interest of an early screening of this silent disease.Disclosure of Interests:None declared

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POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3819 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 227.2-228

Author(s):

D. Claire ◽

M. Geoffroy ◽

L. Kanagaratnam ◽

C. Isabelle ◽

A. Hittinger ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

General Population ◽

Bone Mineral ◽

Bone Densitometry ◽

Dual Energy ◽

Mineral Density ◽

Least Significant Change ◽

X Ray ◽

Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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