Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells: Fig. 1.

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-2966 ◽

2007 ◽

Vol 13 (6) ◽

pp. 1625-1629 ◽

Author(s):

Wanping Xu ◽

Len Neckers

Keyword(s):

Heat Shock Protein ◽

Cell Signaling ◽

Cancer Cells ◽

Signaling Pathways ◽

Molecular Chaperone ◽

Heat Shock Protein 90 ◽

Cell Signaling Pathways

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430: Modulation of Heat-Shock Protein 90 (HSP90) Client Protein Expression in Prostate Cancer Cells by a Novel Novobiocin Analog

The Journal of Urology ◽

10.1016/s0022-5347(18)32686-7 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 140-140

Author(s):

Manlio A. Goetzl ◽

Brian S. Blagg ◽

Benjamin Cronk ◽

Len Neckers ◽

Jeffrey M. Holzbeierlein

Keyword(s):

Prostate Cancer ◽

Heat Shock Protein ◽

Protein Expression ◽

Cancer Cells ◽

Heat Shock Protein 90 ◽

Client Protein ◽

Prostate Cancer Cells ◽

Hsp90 Client Protein

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Faculty Opinions recommendation of Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1082926.535884 ◽

2007 ◽

Author(s):

Homer Pearce

Keyword(s):

Heat Shock Protein ◽

Molecular Chaperone ◽

Heat Shock Protein 90

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UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

Cell Death and Disease ◽

10.1038/cddis.2014.378 ◽

2014 ◽

Vol 5 (9) ◽

pp. e1411-e1411 ◽

Author(s):

H Landmann ◽

D A Proia ◽

S He ◽

L S Ogawa ◽

F Kramer ◽

...

Keyword(s):

Colorectal Cancer ◽

Heat Shock Protein ◽

Cancer Cells ◽

Heat Shock Protein 90 ◽

Expression Levels ◽

Colorectal Cancer Cells ◽

Udp Glucuronosyltransferase

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Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-07-0410 ◽

2007 ◽

Vol 6 (11) ◽

pp. 2868-2878 ◽

Author(s):

Christian Moser ◽

Sven A. Lang ◽

Silvia Kainz ◽

Andreas Gaumann ◽

Stefan Fichtner-Feigl ◽

...

Keyword(s):

Colon Cancer ◽

Heat Shock Protein ◽

Cancer Cells ◽

Heat Shock Protein 90 ◽

Human Colon ◽

Colon Cancer Cells ◽

Human Colon Cancer ◽

Human Colon Cancer Cells

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319 Factors that govern the cell death response induced by inhibition of the molecular chaperone heat shock protein 90

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(04)80327-6 ◽

2004 ◽

Vol 2 (8) ◽

pp. 97 ◽

Author(s):

M. Sherriff ◽

P.A. Clarke ◽

P. Workman

Keyword(s):

Heat Shock Protein ◽

Molecular Chaperone ◽

Heat Shock Protein 90 ◽

Cell Death Response

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A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-06-0496 ◽

2007 ◽

Vol 6 (3) ◽

pp. 1112-1122 ◽

Author(s):

Anthea Hardcastle ◽

Peter Tomlin ◽

Clair Norris ◽

Juliet Richards ◽

Matthew Cordwell ◽

...

Keyword(s):

Heat Shock Protein ◽

Molecular Chaperone ◽

Simultaneous Detection ◽

Heat Shock Protein 90 ◽

Phenotypic Screen

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Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins

Cancer Science ◽

10.1111/j.1349-7006.2011.01944.x ◽

2011 ◽

Vol 102 (7) ◽

pp. 1388-1395 ◽

Author(s):

Kyung-Hun Lee ◽

Ju-Hee Lee ◽

Sae-Won Han ◽

Seock-Ah Im ◽

Tae-You Kim ◽

...

Keyword(s):

Gastric Cancer ◽

Antitumor Activity ◽

Heat Shock Protein ◽

Cancer Cells ◽

Heat Shock Protein 90 ◽

Proteasomal Degradation ◽

Human Gastric Cancer ◽

Gastric Cancer Cells ◽

Client Proteins

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Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor β-activated kinase 1 (TAK1) in interleukin-1β-induced cell signaling

Molecular Immunology ◽

10.1016/j.molimm.2008.07.019 ◽

2009 ◽

Vol 46 (4) ◽

pp. 541-550 ◽

Author(s):

Lijun Shi ◽

Zhengping Zhang ◽

Shuping Fang ◽

Junfeng Xu ◽

Junhong Liu ◽

...

Keyword(s):

Growth Factor ◽

Heat Shock Protein ◽

Cell Signaling ◽

Transforming Growth Factor ◽

Heat Shock Protein 90 ◽

Transforming Growth Factor Β ◽

Interleukin 1Β ◽

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Correction to Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone

Journal of Medicinal Chemistry ◽

10.1021/jm201675k ◽

2012 ◽

Vol 55 (1) ◽

pp. 564-564

Author(s):

François Vallée ◽

Chantal Carrez ◽

Fabienne Pilorge ◽

Alain Dupuy ◽

Annick Parent ◽

...

Keyword(s):

Heat Shock Protein ◽

Molecular Chaperone ◽

Heat Shock Protein 90 ◽

Hsp90 Inhibitors

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E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1322412111 ◽

2014 ◽

Vol 111 (18) ◽

pp. 6834-6839 ◽

Author(s):

R. S. Samant ◽

P. A. Clarke ◽

P. Workman

Keyword(s):

Heat Shock Protein ◽

Cancer Cells ◽

Ubiquitin Ligase ◽

Human Cancer ◽

E3 Ubiquitin Ligase ◽

Heat Shock Protein 90 ◽

Cellular Responses ◽

Human Cancer Cells ◽

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