Abstract 674: A pilot study of physical activity and breast cancer risk in Africa

Author(s):  
Ningqi Hou ◽  
Antony Gakwaya ◽  
Paul Ndom ◽  
Oladosu Ojengbede ◽  
Olufunmilayo I. Olopade ◽  
...  
2020 ◽  
Vol 182 (2) ◽  
pp. 451-463 ◽  
Author(s):  
Anna H. Wu ◽  
Chiuchen Tseng ◽  
Cheryl Vigen ◽  
Yang Yu ◽  
Wendy Cozen ◽  
...  

2020 ◽  
Vol 122 (5) ◽  
pp. 726-732 ◽  
Author(s):  
Wenji Guo ◽  
Georgina K. Fensom ◽  
Gillian K. Reeves ◽  
Timothy J. Key

Abstract Background Previous studies suggest a protective role of physical activity in breast cancer risk, largely based on self-reported activity. We aimed to clarify this association by examining breast cancer risk in relation to self-reported physical activity, informed by accelerometer-based measures in a large subset of participants. Methods We analysed data from 47,456 premenopausal and 126,704 postmenopausal women in UK Biobank followed from 2006 to 2014. Physical activity was self-reported at baseline, and at resurvey in a subsample of 6443 participants. Accelerometer data, measured from 2013 to 2015, were available in 20,785 women. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated by using multivariable-adjusted Cox regression. Results A total of 3189 cases were diagnosed during follow-up (mean = 5.7 years). Women in the top compared with the bottom quartile of self-reported physical activity had a reduced risk of both premenopausal (RR 0.75; 95% CI 0.60–0.93) and postmenopausal breast cancer (RR 0.87; 95% CI 0.78–0.98), after adjusting for adiposity. In analyses utilising physical activity values assigned from accelerometer measurements, an increase of 5 milli-gravity was associated with a 21% (RR 0.79; 95% CI 0.66–0.95) reduction in premenopausal and a 16% (RR 0.84; 95% CI 0.73–0.96) reduction in postmenopausal breast cancer risk. Conclusions Greater physical activity is associated with a reduction in breast cancer risk, which appears to be independent of any association it may have on risk through its effects on adiposity.


2017 ◽  
Vol 37 (6) ◽  
pp. 657-669 ◽  
Author(s):  
Stephanie L. Fowler ◽  
William M. P. Klein ◽  
Linda Ball ◽  
Jaclyn McGuire ◽  
Graham A. Colditz ◽  
...  

2015 ◽  
Vol 8 (10) ◽  
pp. 912-921 ◽  
Author(s):  
Carol J. Fabian ◽  
Bruce F. Kimler ◽  
Teresa A. Phillips ◽  
Jessica A. Box ◽  
Amy L. Kreutzjans ◽  
...  

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