Abstract 308: Therapeutic implications of silver nanoparticles in the management of skin cancer

Silver nanoparticles (NPs) have attracted a considerable interest in the field of cancer research due to their potential utility in cancer therapy. In the present study, we developed bovine serum albumin (BSA)-coated silver NPs (BSA-Silver NPs) and characterized in vitro multimodal therapeutic activities of NPs for the treatment of skin cancer. BSA-Silver NPs were synthesized by a single-step reduction process, and the successful preparation was verified through a list of physical characterizations, including transmission electron microscopy (TEM), ultraviolet-visible (UV–VIS) light spectroscopy, dynamic light scattering (DLS), and Fourier transform infrared (FT-IR) spectroscopy. The synthesized BSA-Silver NPs showed marked cytocidal effects on B16F10 melanoma cells, which was likely caused by oxidative stress. BSA-Silver NPs also elicited significant anti-angiogenic effects on HUVEC (human umbilical vein endothelial cell) by inhibiting their proliferation, migration, and tube formation. Moreover, BSA-Silver NPs showed a considerable light-to-heat conversion ability, suggesting their utility as photothermal agents. Overall, our findings suggest that BSA-Silver NPs may be promising candidates for the multimodal therapy of skin cancer.

Download Full-text

Perineural Invasion of Head and Neck Skin Cancer: Diagnostic and Therapeutic Implications

Current Oncology Reports ◽

10.1007/s11912-012-0288-y ◽

2012 ◽

Vol 15 (2) ◽

pp. 128-133 ◽

Cited By ~ 19

Author(s):

Benedict Panizza ◽

Timothy Warren

Keyword(s):

Skin Cancer ◽

Head And Neck ◽

Perineural Invasion ◽

Therapeutic Implications ◽

Cancer Diagnostic

Download Full-text

Bioactive Surfaces of Polylactide and Silver Nanoparticles for the Prevention of Microbial Contamination

Materials ◽

10.3390/ma13030768 ◽

2020 ◽

Vol 13 (3) ◽

pp. 768 ◽

Cited By ~ 4

Author(s):

Oana Gherasim ◽

Alexandru Mihai Grumezescu ◽

Valentina Grumezescu ◽

Florin Iordache ◽

Bogdan Stefan Vasile ◽

...

Keyword(s):

Silver Nanoparticles ◽

Microbial Contamination ◽

Protective Coatings ◽

Clinical Importance ◽

Metallic Silver ◽

Bacterial Strains ◽

Therapeutic Implications ◽

Microbial Biofilms ◽

Physiological Processes ◽

Conventional Drug

Thanks to its peculiar interactions with biological molecules and structures, metallic silver in the form of silver nanoparticles achieved a remarkable comeback as a potential antimicrobial agent. The antimicrobial use of silver nanoparticles is of clinical importance, as several pathogenic microorganisms developed resistance against various conventional drug treatments. Hence, given the extensive efficiency of silver nanoparticles against drug-sensitive and drug-resistant pathogens, their therapeutic implications were demonstrated in multiple medical applications, such as silver-based dressings, silver-coated biomedical devices and silver-containing nanogels. Bacterial strains possess an intrinsic ability to form well-organized microbial communities, capable of developing adaptive mechanisms to environmental aggression and self-protective pathways against antibiotics. The formation of these mono- or poly-microbial colonies, called biofilms, is closely related with the occurrence of infectious processes which result in severe and chronic pathologies. Therefore, substantial efforts were oriented to the development of new protective coatings for biomedical surfaces, capable of sustaining the physiological processes within human-derived normal cells and to disrupt the microbial contamination and colonization stages. Nanostructured materials based on polylactic acid and silver nanoparticles are herein proposed as bioactive coatings able to prevent the formation of microbial biofilms on biomedical relevant surfaces.

Download Full-text

Thyme Leaves Aqueous Extract and its Formulations. A comparative study based on chemical structures and biological activity

Revista de Chimie ◽

10.37358/rc.19.5.7236 ◽

2019 ◽

Vol 70 (5) ◽

pp. 1875-1878 ◽

Cited By ~ 1

Author(s):

Maria Proks ◽

Alina Heghes ◽

Adelina Cheveresan ◽

Simona Nita ◽

Mirela Voicu ◽

...

Keyword(s):

Breast Cancer ◽

Silver Nanoparticles ◽

Biological Activity ◽

Skin Cancer ◽

Cell Line ◽

Aqueous Extract ◽

Chemical Structures ◽

Non Melanoma Skin Cancer ◽

Mcf 7 ◽

Melanoma Skin

The present study was conducted in order to evaluate the biological activity of thyme aqueous extract as compared to the silver nanoparticles obtained on it on four different cancer lines: non-melanoma skin cancer (A431 cell line), melanoma skin cancer (A375cell line), hormone dependent breast cancer (MCF-7 cell line), and non-hormone dependent breast cancer (MDA-MB-231 cell line). Of particular importance in the study of biological activity is the chemical composition. Formulas rich in compounds of classes like those of flavonoids are recognized for their efficacy and important antioxidant effect. The extract tested at various concentrations ranging from 10-1000 �g/mL exhibited a pronounced effect only on MCF-7 cells at the highest concentration tested and regarding the biosynthesized silver nanoparticles, the effect can be noted even at 1 � M also only in the case of MCF-7 cells.

Download Full-text

Therapeutic strategies and potential implications of silver nanoparticles in the management of skin cancer

Nanotechnology Reviews ◽

10.1515/ntrev-2020-0117 ◽

2020 ◽

Vol 9 (1) ◽

pp. 1500-1521

Author(s):

Shaloam Dasari ◽

Clement G. Yedjou ◽

Robert T. Brodell ◽

Allison R. Cruse ◽

Paul B. Tchounwou

Keyword(s):

United States ◽

Silver Nanoparticles ◽

Skin Cancer ◽

Cell Carcinoma ◽

Treatment Options ◽

The United States ◽

Major Health Problem ◽

Major Health ◽

Treatment Regimens ◽

Excisional Surgery

Abstract Skin cancer (SC) is the most common carcinoma affecting 3 million people annually in the United States and millions of people worldwide. It is classified as melanoma SC (MSC) and non-melanoma SC (NMSC). NMSC represents approximately 80% of SC and includes squamous cell carcinoma and basal cell carcinoma. MSC, however, has a higher mortality rate than SC because of its ability to metastasize. SC is a major health problem in the United States with significant morbidity and mortality in the Caucasian population. Treatment options for SC include cryotherapy, excisional surgery, Mohs surgery, curettage and electrodessication, radiation therapy, photodynamic therapy, immunotherapy, and chemotherapy. Treatment is chosen based on the type of SC and the potential for side effects. Novel targeted therapies are being used with increased frequency for large tumors and for metastatic disease. A scoping literature search on PubMed, Google Scholar, and Cancer Registry websites revealed that traditional chemotherapeutic drugs have little effect against SC after the cancer has metastasized. Following an overview of SC biology, epidemiology, and treatment options, this review focuses on the mechanisms of advanced technologies that use silver nanoparticles in SC treatment regimens.

Download Full-text