Arterial Stiffness and Extracellular Matrix

2006 ◽  
pp. 76-95 ◽  
Author(s):  
Javier Díez
Keyword(s):  
Extracellular Matrix ◽  
Arterial Stiffness

scholarly journals Collagen Metabolism in Extracellular Matrix May Be Involved in Arterial Stiffness in Older Hypertensive Patients with Left Ventricular Hypertrophy

2005 ◽  
Vol 28 (12) ◽  
pp. 995-1001 ◽  
Author(s):  
Joji ISHIKAWA ◽  
Kazuomi KARIO ◽  
Yoshio MATSUI ◽  
Seiichi SHIBASAKI ◽  
Masato MORINARI ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Arterial Stiffness ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Collagen Metabolism ◽  
Hypertensive Patients

Arterial stiffness correlates with extracellular matrix turnover in heart failure with preserved ejection fraction patients

2016 ◽  
Vol 252 ◽  
pp. e163
Author(s):  
M. Martínez-Marin ◽  
J. Perez-Calvo ◽  
C. Josa-Laorden ◽  
I. Lacambra-Blasco ◽  
I. Gimenez-Lopez ◽  
...  
Keyword(s):  
Heart Failure ◽  
Extracellular Matrix ◽  
Arterial Stiffness ◽  
Ejection Fraction ◽  
Preserved Ejection Fraction

scholarly journals Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth–restricted fetal sheep

2012 ◽  
Vol 73 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Reuben Blair Dodson ◽  
Paul J. Rozance ◽  
Bradley S. Fleenor ◽  
Carson C. Petrash ◽  
Lauren G. Shoemaker ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Arterial Stiffness ◽  
Fetal Sheep ◽  
Intrauterine Growth

Mechanisms involved in extracellular matrix remodeling and arterial stiffness induced by hyaluronan accumulation

2016 ◽  
Vol 244 ◽  
pp. 195-203 ◽  
Author(s):  
Karen Axelgaard Lorentzen ◽  
Song Chai ◽  
Hui Chen ◽  
Carl Christian Danielsen ◽  
Ulf Simonsen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Arterial Stiffness ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals Constitutive interpretation of arterial stiffness in clinical studies: a methodological review

2019 ◽  
Vol 316 (3) ◽  
pp. H693-H709 ◽  
Author(s):  
Koen D. Reesink ◽  
Bart Spronck
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Arterial Stiffness ◽  
Arterial Wall ◽  
Muscle Tone ◽  
Epidemiological Studies ◽  
Model Complexity ◽  
Smooth Muscle Tone ◽  
Modeling Approaches ◽  
Extracellular Matrix Components

Clinical assessment of arterial stiffness relies on noninvasive measurements of regional pulse wave velocity or local distensibility. However, arterial stiffness measures do not discriminate underlying changes in arterial wall constituent properties (e.g., in collagen, elastin, or smooth muscle), which is highly relevant for development and monitoring of treatment. In arterial stiffness in recent clinical-epidemiological studies, we systematically review clinical-epidemiological studies (2012–) that interpreted arterial stiffness changes in terms of changes in arterial wall constituent properties (63 studies included of 514 studies found). Most studies that did so were association studies (52 of 63 studies) providing limited causal evidence. Intervention studies (11 of 63 studies) addressed changes in arterial stiffness through the modulation of extracellular matrix integrity (5 of 11 studies) or smooth muscle tone (6 of 11 studies). A handful of studies (3 of 63 studies) used mathematical modeling to discriminate between extracellular matrix components. Overall, there exists a notable gap in the mechanistic interpretation of stiffness findings. In constitutive model-based interpretation, we first introduce constitutive-based modeling and use it to illustrate the relationship between constituent properties and stiffness measurements (“forward” approach). We then review all literature on modeling approaches for the constitutive interpretation of clinical arterial stiffness data (“inverse” approach), which are aimed at estimation of constitutive properties from arterial stiffness measurements to benefit treatment development and monitoring. Importantly, any modeling approach requires a tradeoff between model complexity and measurable data. Therefore, the feasibility of changing in vivo the biaxial mechanics and/or vascular smooth muscle tone should be explored. The effectiveness of modeling approaches should be confirmed using uncertainty quantification and sensitivity analysis. Taken together, constitutive modeling can significantly improve clinical interpretation of arterial stiffness findings.

Cardiac myocytes cultured on a basement membrane extract of the ehs tumor

1986 ◽  
Vol 44 ◽  
pp. 270-271
Author(s):  
L. Terracio ◽  
A. Dewey ◽  
K. Rubin ◽  
T.K. Borg
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Cardiac Myocytes ◽  
Normal Tissue ◽  
Cell Spreading ◽  
Collagen Iv ◽  
Basement Membrane Extract ◽  
Membrane Extract ◽  
Growth Development ◽  
Multicellular Organisms

The recognition and interaction of cells with the extracellular matrix (ECM) effects the normal physiology as well as the pathology of all multicellular organisms. These interactions have been shown to influence the growth, development, and maintenance of normal tissue function. In previous studies, we have shown that neonatal cardiac myocytes specifically interacts with a variety of ECM components including fibronectin, laminin, and collagens I, III and IV. Culturing neonatal myocytes on laminin and collagen IV induces an increased rate of both cell spreading and sarcomerogenesis.

Neutrophil migration through in vitro interstitial matrix

1992 ◽  
Vol 50 (1) ◽  
pp. 894-895
Author(s):  
J. Roemer ◽  
S.R. Simon
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Cell Migration ◽  
Smooth Muscle Cells ◽  
Inflammatory Cell ◽  
Neutrophil Migration ◽  
Culture Conditions ◽  
Aortic Smooth Muscle ◽  
Specific Culture

We are developing an in vitro interstitial extracellular matrix (ECM) system for study of inflammatory cell migration. Falcon brand Cyclopore membrane inserts of various pore sizes are used as a support substrate for production of ECM by R22 rat aortic smooth muscle cells. Under specific culture conditions these cells produce a highly insoluble matrix consisting of typical interstitial ECM components, i.e.: types I and III collagen, elastin, proteoglycans and fibronectin.

The extracellular matrix of echinoderm and amphibian eggs: Visualization in quick-frozen, deep-etched, and rotary-shadowed specimens

1990 ◽  
Vol 48 (3) ◽  
pp. 60-61
Author(s):  
Barry Bonnell ◽  
Carolyn Larabell ◽  
Douglas Chandler
Keyword(s):  
Extracellular Matrix ◽  
Plasma Membrane ◽  
Sea Urchin ◽  
Crystalline Structure ◽  
Cortical Granule ◽  
Two Dimensional ◽  
Small Peptides ◽  
Deep Etching ◽  
Quick Freezing ◽  
Acrosomal Reaction

Eggs of many species including those of echinoderms, amphibians and mammals exhibit an extensive extracellular matrix (ECM) that is important both in the reception of sperm and in providing a block to polyspermy after fertilization.In sea urchin eggs there are two distinctive coats, the vitelline layer which contains glycoprotein sperm receptors and the jelly layer that contains fucose sulfate glycoconjugates which trigger the acrosomal reaction and small peptides which act as chemoattractants for sperm. The vitelline layer (VL), as visualized by quick-freezing, deep-etching, and rotary-shadowing (QFDE-RS), is a fishnet-like structure, anchored to the plasma membrane by short posts. Orbiting above the VL are horizontal filaments which are thought to anchor the thicker jelly layer to the egg. Upon fertilization, the VL elevates and is transformed by cortical granule secretions into the fertilization envelope (FE). The rounded casts of microvilli in the VL are transformed into angular peaks and the envelope becomes coated inside and out with sheets of paracrystalline protein having a quasi-two dimensional crystalline structure.

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