Circulating Adiponectin: Associations with Risk Factors and the Reynolds Risk Score in Women without Prior Major Cardiovascular Events

Cardiology ◽  
2010 ◽  
Vol 115 (1) ◽  
pp. 64-70
Author(s):  
Nicoleta Calomfirescu ◽  
Calin Popa ◽  
Ruxandra Jurcut ◽  
Marinela Serban ◽  
Carmen Ginghina
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Cardiovascular Events ◽  
Major Cardiovascular Events ◽  
Reynolds Risk Score

The Extent of Subclinical Atherosclerosis Is Partially Predicted by the Inflammatory Load: A Prospective Study over 5 Years in Patients with Rheumatoid Arthritis and Matched Controls

2015 ◽  
Vol 42 (6) ◽  
pp. 935-942 ◽  
Author(s):  
Anna Södergren ◽  
Kjell Karp ◽  
Christine Bengtsson ◽  
Bozena Möller ◽  
Solbritt Rantapää-Dahlqvist ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Linear Regression ◽  
Prospective Study ◽  
Risk Score ◽  
Subclinical Atherosclerosis ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
A Prospective Study ◽  
Reynolds Risk Score

Objective.This prospective followup study investigated subclinical atherosclerosis in relation to traditional cardiovascular disease (CVD) risk factors and inflammation in patients with rheumatoid arthritis (RA) recruited at diagnosis compared with controls.Methods.Patients diagnosed with early RA were consecutively recruited into a prospective study. From these, a subgroup aged ≤ 60 years (n = 71) was consecutively included for ultrasound measurement of intima-media thickness (IMT) and flow-mediated dilation (FMD) at inclusion (T0) and after 5 years (T5). Age- and sex-matched controls (n = 40) were also included.Results.In the Wilcoxon signed-rank test, both IMT and FMD were significantly aggravated at T5 compared to baseline in patients with RA, whereas only IMT was significantly increased in controls. In univariate linear regression analyses among patients with RA, the IMT at T5 was significantly associated with age, systolic blood pressure (BP), cholesterol, triglycerides, Systematic Coronary Risk Evaluation (SCORE), and Reynolds Risk Score at baseline (p < 0.05). Similarly, FMD at T5 was significantly inversely associated with age, smoking, systolic BP, SCORE, and Reynolds Risk Score (p < 0.05). A model with standardized predictive value from multiple linear regression models including age, smoking, BP, and blood lipids at baseline significantly predicted the observed value of IMT after 5 years. When also including the area under the curve for the 28-joint Disease Activity Score over 5 years, the observed value of IMT was predicted to a large extent.Conclusion.This prospective study identified an increased subclinical atherosclerosis in patients with RA. In the patients with RA, several traditional CVD risk factors at baseline significantly predicted the extent of subclinical atherosclerosis 5 years later. The inflammatory load over time augmented this prediction.

scholarly journals Predictors for development of major cardiovascular events in elderly patients with severe and extremely severe chronic obstructive pulmonary disease in combination with early stages of chronic kidney disease

Kardiologiia ◽  
2019 ◽  
Vol 59 (3S) ◽  
pp. 52-60 ◽  
Author(s):  
E. V. Bolotova ◽  
V. V. Yavlyanskaya ◽  
A. V. Dudnikova
Keyword(s):  
Risk Factors ◽  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Elderly Patients ◽  
Cardiovascular Events ◽  
Roc Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Major Cardiovascular Events ◽  
Stage 1

Aim. To study the structure of major cardiovascular events (MCVE) and to identify their independent predictors in elderly patients with severe and extremely severe chronic obstructive pulmonary disease (COPD) in combination with early stages of chronic kidney disease (CKD). Materials and methods. The study included 172 elderly patients with stage 3–4 COPD associated with stage 1–2 CKD. Initially, risk factors for MCVE were identified and levels of vitamin D (25 (ОН) D) were measured for all patients. In 12 months, MCVE anamnesis was collected, and patients were divided into two groups with and without MCVE during the observation period. The risk factors for MCVE, which were significantly different between the two groups according to results of a one-way analysis, were successively included into a logistic regression for identifying independent predictors of MCVE. A ROC analysis was performed for the identified variables to identify a predictive cut-off point. Results. 21 MCVEs were observed in 8.7% (15) patients. Heart rhythm disorders (HRD) not reversed at the prehospital stage were observed in 38.1% patients; acute cerebrovascular disease and transient ischemic attack – in 23.8%, acute coronary syndrome – in 23.8%, and pulmonary thromboembolism (PTE) – in 14.3%. Two MCVEs, namely, a combination of HRD not reversed at the prehospital stage and PTE, were observed in 3 (20%) patients. The ROC analysis showed that the incidence of COPD exacerbation for the previous 12 months >3 had the highest predictive value for the 12-month risk of MCVE in patients with COPD associated with early CKD (95% CI, 0.823–0.925, р=0.001). A total PROCAM score <50 (95% CI, 0.882–0.964, р=0.001); GFR ≥80 ml/min/1.73 m2 (95% CI, 0.750–0.870, р=0.001); and a level of vitamin D ≥33 ng/ml (95% CI, 0.730–0.855, р=0.001) reduced the risk for MCVE. Conclusions. In elderly patients with grade 3–4 COPD associated with stage 1–2 CKD, the development of MCVE within 12 months was determined by the incidence of COPD exacerbations for the previous 12 months >3 while a total PROCAM score <50, GFR >80 ml/min/1.73 m3 , and levels of vitamin D >33 ng/ml reduced the risk of MCVE in these patients

scholarly journals Associations of Adiposity and Diet Quality with Serum Ceramides in Middle-Aged Adults with Cardiovascular Risk Factors

2019 ◽  
Vol 8 (4) ◽  
pp. 527 ◽  
Author(s):  
Margaret A. Drazba ◽  
Ida Holásková ◽  
Nadine R. Sahyoun ◽  
Melissa Ventura Marra
Keyword(s):  
Risk Factors ◽  
Risk Score ◽  
Diet Quality ◽  
Cardiovascular Events ◽  
Weight Status ◽  
Smoking Status ◽  
Healthy Eating Index ◽  
Risk Scores ◽  
Middle Aged ◽  
Middle Aged Adults

Rates of adverse cardiovascular events have increased among middle-aged adults. Elevated ceramides have been proposed as a risk factor for cardiovascular events. Diet quality and weight status are inversely associated with several traditional risk factors; however, the relationship to ceramides is less clear. This study aimed to determine associations of adiposity and diet quality with circulating ceramides in middle-aged adults (n = 96). Diet quality was estimated using the Healthy Eating Index 2015 (HEI-2015). Serum ceramide concentrations were determined by liquid chromatography–mass spectrometry. A ceramide risk score was determined based on ceramides C16:0, C18:0, and C24:1 and their ratios to C24:0. Participants who were classified as at ‘moderate risk’ compared to ‘lower-risk’ based on a ceramide risk score had significantly higher body mass index (BMI) values, as well as higher rates of elevated fibrinogen levels, metabolic syndrome, and former smoking status. BMI was positively associated with the ceramide C18:0 (R2 = 0.31, p < 0.0001), the ratio between C18:0/C24:0 ceramides (R2 = 0.30, p < 0.0001), and the ceramide risk score (R2 = 0.11, p < 0.009). Total HEI-2015 scores (R2 = 0.42, p = 0.02), higher intakes of vegetables (R2 = 0.44, p = 0.02) and whole grains (R2 = 0.43, p = 0.03), and lower intakes of saturated fats (R2 = 0.43, p = 0.04) and added sugar (R2 = 0.44, p = 0.01) were associated with lower C22:0 values. These findings suggest that circulating ceramides are more strongly related to adiposity than overall diet quality. Studies are needed to determine if improvements in weight status result in lower ceramides and ceramide risk scores.

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