Oxidative Stress in Benign Prostatic Hyperplasia: A Systematic Review

Background: Several parameters including inflammatory mediators, hormones, dietary factors, inflammatory genes, and oxidative stress (OS) have been considered to play a role in the development of benign prostatic hyperplasia (BPH). Prostate tissue damage and OS may lead to compensatory cellular proliferation with resulting hyperplastic growth. Methods: We searched MEDLINE for articles in English published up to March 2014 using the key words ‘oxidative stress', ‘antioxidants' and ‘benign prostatic hyperplasia'. Results: Prostatic inflammation can cause the generation of free radicals. The extent of oxidative damage can be exacerbated by a decreased efficiency of antioxidant defense mechanisms. The balance between OS and the antioxidant component also has a role in developing prostate disease. Several works show the role of oxidant products and of depletion of antioxidant substances in BPH patients. It is accepted that free radicals play a role in carcinogenesis and that BPH should be considered a premalignant condition which may evolve into prostate cancer. High OS parameters and low antioxidant activity are more prominent in prostate cancer patients compared with BPH and controls. Conclusions: Further studies are needed to clarify the potential role of antioxidants in BPH also in view of preventing the progression to prostate cancer.

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Role of gangliosides in prostate pathology

Romanian Journal of Infectious Diseases ◽

10.37897/rjid.2016.1.2 ◽

2016 ◽

Vol 19 (1) ◽

pp. 10-15

Author(s):

Ilinca Nicolae ◽

◽

Corina-Daniela Ene ◽

Simona Roxana Georgescu ◽

◽

...

Keyword(s):

Oxidative Stress ◽

Prostate Cancer ◽

Differential Diagnosis ◽

Benign Prostatic Hyperplasia ◽

Molecular Pathology ◽

Potential Role ◽

Prostatic Hyperplasia ◽

Immunologic Markers ◽

Immunological Interactions

Molecular pathology of benign prostatic hyperplasia is multifactorial and involves endocrine, biochemical, immunological interactions. The mechanisms involved in the onset and progression of benign prostatic hyperplasia are: infections, 50 years of age, hormones and neurotransmitters imbalances, inflammation, oxidative stress. The potential role of glycosylation in the pathogenesis of prostate disease has been neglected. In this study we documented the profile of gangliosides in normal and pathological prostatic tissues together with the pathologic changes seen in the level of extracellular gangliosides in patients with prostate pathology. Analysis of the data in the literature suggests that gangliosides may represent immunologic markers useful in the differential diagnosis between prostate cancer and benign prostatic hyperplasia.

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Impact of cyclin D1 and DJ-1 on diagnosis, clinico-pathological features and outcome in prostate cancer and benign prostatic hyperplasia

Forum of Clinical Oncology ◽

10.2478/fco-2019-0005 ◽

2020 ◽

Vol 10 (2) ◽

pp. 15-25

Author(s):

Amrallah A. Mohammed ◽

Hanna M. Ibrahim ◽

Hanna A. Atwa ◽

Ayman Elshentenawy ◽

Amira Elwan

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Cyclin D1 ◽

Tumor Stage ◽

Prostatic Hyperplasia ◽

Common Finding ◽

Tissue Sampling ◽

Benign Lesions ◽

Significant Difference

AbstractBackgroundDisturbance in cell cycle regulatory genes is a common finding among many types of cancers. The aim of this study is to evaluate the role of cyclin D1 and DJ-1 in benign prostatic hyperplasia (BPH) and prostate cancer (PC).MethodThe current study enclosed 40 patients diagnosed with PC and 40 cases of BPH. The expression level of cyclin D1 and DJ-1 were evaluated by immunohistochemistry (IHC). Cyclin D1 scored depending on the percentage of stained nuclear tumor cells. While scoring of DJ-1 was based on intensity. The results were correlated with clinicopathological features and outcome.ResultsIn the PC group, cyclin D1 was detected in 95% and overexpressed in 42.5%, DJ-1 was positively stained in 85% and overexpressed in 47.5%. Meanwhile, in the BPH group, cyclin D1 was not detected and DJ-1 stained in only 2.5%. There was a statistically significant difference in Gleason score (GS), tumor stage, size, and treatment failure (p =< 0.001). In the terms of PC diagnosis prediction, although cyclin D1 was more specific (100%), DJ-1 is more sensitive than cyclin D1 (80%, 70%, respectively) (p = 0.000).ConclusionsCyclin D1 and DJ-1 may emerge as a promising way for diagnosis of PC in certain circumstances, as the presence of insufficient tissue sampling, small foci of carcinoma or benign lesions mimic PC. This is in addition to the known role of cyclin D1 and DJ-1 in PC prognosis.

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Oxidative stress marker 8-hydroxyguanosine is more highly expressed in prostate cancer than in benign prostatic hyperplasia

Molecular and Clinical Oncology ◽

10.3892/mco.2018.1665 ◽

2018 ◽

Cited By ~ 1

Author(s):

Shinji Ohtake ◽

Takashi Kawahara ◽

Yukari Ishiguro ◽

Teppei Takeshima ◽

Shinnosuke Kuroda ◽

...

Keyword(s):

Oxidative Stress ◽

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

Oxidative Stress Marker ◽

Stress Marker

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The role of partial androgen deficiency in aging men in the development of benign prostatic hyperplasia and prostate cancer

Molecular inhibitors in targeted therapy ◽

10.1515/motth-2016-0001 ◽

2016 ◽

Vol 2 (1) ◽

pp. 1-13

Author(s):

Alexander V. Pechersky

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Pluripotent Stem Cells ◽

Proliferative Activity ◽

Older Men ◽

Prostatic Hyperplasia ◽

Androgen Deficiency ◽

Aging Men ◽

Reduce Insulin Resistance

AbstractOnce people reach 35-40 years, they have a decrease in their pool of pluripotent stem cells, and show a violation of tissue renewal, a decrease in the number of cell-producers of testosterone (Leidig cells) and a reduction in testosterone circulating in the blood. Partial androgen deficiency in aging men violates division and differentiation of androgen-dependent cells and increases the risk for development of benign prostatic hyperplasia and prostate cancer. The recovery of testosterone production and regeneration helps make a decrease in proliferative activity, and the rehabilitation of regulation of androgen-dependent cells of the prostate and other tissues and organs, as well as reduce insulin resistance among older men.

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PCN4 Role of 5-Alpha-Reductase Inhibitors, Statins, Aspirin, Nsaids on the Development of Prostate Cancer in Benign Prostatic Hyperplasia Patients-a Population Based Study

Value in Health ◽

10.1016/j.jval.2012.08.302 ◽

2012 ◽

Vol 15 (7) ◽

pp. A653

Author(s):

S.H. Chen ◽

Y.H. Wen ◽

Y.B. Huang ◽

J.J. Chen ◽

Y.H. Yang

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Population Based ◽

Prostatic Hyperplasia ◽

Population Based Study ◽

Reductase Inhibitors ◽

5 Alpha Reductase Inhibitors

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Battle between plants as antioxidants with free radicals in human body

Journal of Herbmed Pharmacology ◽

10.34172/jhp.2020.25 ◽

2020 ◽

Vol 9 (3) ◽

pp. 191-199 ◽

Cited By ~ 3

Author(s):

Fatemeh Jamshidi-kia ◽

Joko Priyanto Wibowo ◽

Mostafa Elachouri ◽

Rohollah Masumi ◽

Alizamen Salehifard-Jouneghani ◽

...

Keyword(s):

Oxidative Stress ◽

Free Radicals ◽

Human Body ◽

Defense Mechanisms ◽

Natural Antioxidants ◽

Redox Status ◽

The Body ◽

Antioxidant Agents ◽

Endogenous Antioxidants

Free radicals are constructed by natural physiological activities in the human cells as well as in the environment. They may be produced as a result of diet, smoking, exercise, inflammation, exposure to sunlight, air pollutants, stress, alcohol and drugs. Imbalanced redox status may lead to cellular oxidative stress, which can damage the cells of the body, resulting in an incidence of various diseases. If the endogenous antioxidants do not stop the production of reactive metabolites, they will be needed to bring about a balance in redox status. Natural antioxidants, for example plants, play an important part in this context. This paper seeks to report the available evidence about oxidative stress and the application of plants as antioxidant agents to fight free radicals in the human body. For this purpose, to better understand oxidative stress, the principles of free radical production, the role of free radicals in diseases, antioxidant defense mechanisms, and the role of herbs and diet in oxidative stress are discussed.

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THE DIAGNOSTIC ROLE OF SERUM IGF-1 AND IGFBP-3 IN PATIENTS WITH PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA

The Journal of Urology ◽

10.1097/00005392-199904010-00838 ◽

1999 ◽

pp. 209

Author(s):

Patrik Finne ◽

Hannu Koistinen ◽

Wan-Ming Zhang ◽

Anssi Auvinen ◽

Riitta Koistinen ◽

...

Keyword(s):

Prostate Cancer ◽

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

Diagnostic Role ◽

Igfbp 3

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Squalene: More than a Step toward Sterols

Antioxidants ◽

10.3390/antiox9080688 ◽

2020 ◽

Vol 9 (8) ◽

pp. 688 ◽

Cited By ~ 1

Author(s):

Marco Micera ◽

Alfonso Botto ◽

Federica Geddo ◽

Susanna Antoniotti ◽

Cinzia Margherita Bertea ◽

...

Keyword(s):

Oxidative Stress ◽

Free Radicals ◽

Cardiovascular Diseases ◽

Defense Mechanisms ◽

Current Knowledge ◽

Ex Vivo ◽

Antioxidant Properties ◽

Metabolic Intermediate ◽

Cellular Models

Squalene (SQ) is a natural triterpene widely distributed in nature. It is a metabolic intermediate of the sterol biosynthetic pathway and represents a possible target in different metabolic and oxidative stress-related disorders. Growing interest has been focused on SQ’s antioxidant properties, derived from its chemical structure. Strong evidence provided by ex vivo models underline its scavenging activity towards free radicals, whereas only a few studies have highlighted its effect in cellular models of oxidative stress. Given the role of unbalanced free radicals in both the onset and progression of several cardiovascular diseases, an in depth evaluation of SQ’s contribution to antioxidant defense mechanisms could represent a strategic approach in dealing with these pathological conditions. At present experimental results overall show a double-edged sword role of squalene in cardiovascular diseases and its function has to be better elucidated in order to establish intervention lines focused on its features. This review aims to summarize current knowledge about endogenous and exogenous sources of SQ and to point out the controversial role of SQ in cardiovascular physiology.

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