Functional Vitamin Status Assessment

2015 ◽  
pp. 142-149
Author(s):  
H. van den Berg
Keyword(s):  
Vitamin Status ◽  
Status Assessment

scholarly journals Are we appropriately testing for vitamin B12 and folate deficiency?

2018 ◽  
Vol 3 (1) ◽  
pp. 8-14
Author(s):  
Nawaal Davids ◽  
Mariza Hoffmann ◽  
Nasheen Naidoo ◽  
Thandiwe Manjati ◽  
Rajiv T Erasmus
Keyword(s):  
Vitamin B12 ◽  
Folate Deficiency ◽  
Academic Hospital ◽  
Diagnostic Dilemma ◽  
Vitamin Status ◽  
Retrospective Audit ◽  
Normocytic Anaemia ◽  
Status Assessment ◽  
Cell Volumes ◽  
Metabolite Screening

Background:  The most common reason for assessing vitamin B12 and folate status is a clinical suspicion of deficiency along with the haematological abnormality of macrocytic anaemia.However, there is often a lack of a precise clinical or haematological picture to guide the appropriate investigation of these patients. Normal haemoglobin or mean cell volumes are often found, masking the need for appropriate investigation. When abnormal haematological parameters are found, it is often a sign of advanced deficiency. In this study we investigated whether patients with haematological findings of macrocytosis and/or anaemia are appropriately investigated for vitamin B12 and folate deficiencies and whether clinicians request metabolite screening to assist with the diagnosis.Methods:  This was a retrospective audit of data obtained from the laboratory information system for a six month period at a tertiary academic hospital.  Adult patients with macrocytosis, anaemia or both were selected and laboratory records reviewed to determine whether they were investigated for vitamin B12 and folate deficiency.Results:  Only 16.2% of patients with macrocytic anaemia, 7.8% of patients with isolated macrocytosis and 6.5% of patients with normocytic anaemia were tested for vitamin B12 and/or folate deficiency. Metabolite assays such as homocysteine and methylmalonic acid were not requested as part of a vitamin status assessment. Conclusions:  In our setting, vitamin B12 and folate assessment is a diagnostic dilemma, delaying identification of potentially debilitating disease. Clinicians need to be informed about earlier investigation and of the availability of metabolite screening and their use in establishing early deficiency.

Metabolomics in Vitamin Status Assessment

2018 ◽  
Vol 24 (26) ◽  
pp. 3028-3033 ◽  
Author(s):  
Yurgita R. Varaeva ◽  
Elena N. Livantsova ◽  
Igor V. Ukrainets ◽  
Svetlana D. Kosyura ◽  
Antonina V. Starodubova
Keyword(s):  
Fluorescence Analysis ◽  
Vitamin Deficiency ◽  
Potential Usefulness ◽  
Metabolic Phenotyping ◽  
Major Health ◽  
Physiological Processes ◽  
Vitamin Status ◽  
Status Assessment ◽  
Microbiological Assays ◽  
Major Health Issue

The issue of vitamin deficiency persists to be a major health issue worldwide despite the advancements in medicine. At the same time, the effect of marginal vitamin deficiency status on physiological processes is proven. However, general methods such as immune-enzyme and fluorescence analysis, microbiological assays, for example, have limitations in vitamin status assessment and are not able to reliably reflect personal vitamin demand. The potential usefulness of modern metabolomics methods in vitamin status assessment is described in this review. These methods can be used for vitamin metabolites detection as well as for comprehensive metabolic phenotyping that makes them even more valuable.

Research Recommendations for Applying Vitamin A-Labelled Isotope Dilution Techniques to Improve Human Vitamin A Nutrition

2014 ◽  
Vol 84 (Supplement 1) ◽  
pp. 52-59 ◽  
Author(s):  
Sherry A. Tanumihardjo ◽  
Anura V. Kurpad ◽  
Janet R. Hunt
Keyword(s):  
Public Health ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Human Subjects ◽  
The Body ◽  
Pool Size ◽  
Serum Retinol ◽  
Vitamin A Status ◽  
Status Assessment ◽  
Total Body

The current use of serum retinol concentrations as a measurement of subclinical vitamin A deficiency is unsatisfactory for many reasons. The best technique available for vitamin A status assessment in humans is the measurement of total body pool size. Pool size is measured by the administration of retinol labelled with stable isotopes of carbon or hydrogen that are safe for human subjects, with subsequent measurement of the dilution of the labelled retinol within the body pool. However, the isotope techniques are time-consuming, technically challenging, and relatively expensive. There is also a need to assess different types of tracers and doses, and to establish clear guidelines for the use and interpretation of this method in different populations. Field-friendly improvements are desirable to encourage the application of this technique in developing countries where the need is greatest for monitoring the risk of vitamin A deficiency, the effectiveness of public health interventions, and the potential of hypervitaminosis due to combined supplement and fortification programs. These techniques should be applied to validate other less technical methods of assessing vitamin A deficiency. Another area of public health relevance for this technique is to understand the bioconversion of β-carotene to vitamin A, and its relation to existing vitamin A status, for future dietary diversification programs.

scholarly journals Dietary Pattern Is Associated with Homocysteine and B Vitamin Status in an Urban Chinese Population

2003 ◽  
Vol 133 (11) ◽  
pp. 3636-3642 ◽  
Author(s):  
Xiang Gao ◽  
Manjiang Yao ◽  
Megan A. McCrory ◽  
Guansheng Ma ◽  
Yanping Li ◽  
...  
Keyword(s):  
Dietary Pattern ◽  
Chinese Population ◽  
Vitamin Status ◽  
B Vitamin

P4-111: Longitudinal effects on cognitive function associated with homocysteine and B vitamin status in late adulthood

2008 ◽  
Vol 4 ◽  
pp. T701-T701
Author(s):  
Lawrence J. Whalley ◽  
Kellie Rance ◽  
Susan Duthie ◽  
Helen Fox ◽  
John Starr ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Late Adulthood ◽  
Vitamin Status ◽  
Longitudinal Effects ◽  
B Vitamin

scholarly journals Making the choice between bioelectrical impedance measures for body hydration status assessment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dmitry M. Davydov ◽  
Andrey Boev ◽  
Stas Gorbunov
Keyword(s):  
Body Schema ◽  
Bioelectrical Impedance ◽  
Information Criterion ◽  
The Body ◽  
Whole Body ◽  
Hydration Status ◽  
Status Assessment ◽  
Best Fitting ◽  
Body Compartments ◽  
Fitting In

AbstractSituational or persistent body fluid deficit (i.e., de- or hypo-hydration) is considered a significant health risk factor. Bioimpedance analysis (BIA) has been suggested as an alternative to less reliable subjective and biochemical indicators of hydration status. The present study aimed to compare various BIA models in the prediction of direct measures of body compartments associated with hydration/osmolality. Fish (n = 20) was selected as a biological model for physicochemically measuring proximate body compartments associated with hydration such as water, dissolved proteins, and non-osseous minerals as the references or criterion points. Whole-body and segmental/local impedance measures were used to investigate a pool of BIA models, which were compared by Akaike Information Criterion in their ability to accurately predict the body components. Statistical models showed that ‘volumetric-based’ BIA measures obtained in parallel, such as distance2/Rp, could be the best approach in predicting percent of body moisture, proteins, and minerals in the whole-body schema. However, serially-obtained BIA measures, such as the ratio of the reactance to resistance and the resistance adjusted for distance between electrodes, were the best fitting in predicting the compartments in the segmental schema. Validity of these results should be confirmed on humans before implementation in practice.

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