P4-111: Longitudinal effects on cognitive function associated with homocysteine and B vitamin status in late adulthood

2008 ◽  
Vol 4 ◽  
pp. T701-T701
Author(s):  
Lawrence J. Whalley ◽  
Kellie Rance ◽  
Susan Duthie ◽  
Helen Fox ◽  
John Starr ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Late Adulthood ◽  
Vitamin Status ◽  
Longitudinal Effects ◽  
B Vitamin

scholarly journals The Effect of Whey and Soy Protein Isolates on Cognitive Function in Older Australians with Low Vitamin B12: A Randomised Controlled Crossover Trial

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 19 ◽  
Author(s):  
Ian Zajac ◽  
Danielle Herreen ◽  
Kathryn Bastiaans ◽  
Varinderpal Dhillon ◽  
Michael Fenech
Keyword(s):  
Cognitive Function ◽  
Vitamin B12 ◽  
Soy Protein ◽  
Crossover Trial ◽  
Soy Protein Isolate ◽  
Protein Isolate ◽  
Cognitive Improvement ◽  
Vitamin Status ◽  
Randomised Controlled ◽  
B Vitamin

Whey protein isolate (WPI) is high in vitamin B12 and folate. These and other related markers (holotranscobalamin, methylmalonic acid and homocysteine) have been linked with cognitive health. This study explored the efficacy of WPI for improving cognitive function via delivery of vitamin B12. Moderately vitamin B12-deficient participants aged between 45 and 75 years (n = 56) were recruited into this randomised controlled crossover trial. Participants (55% female) consumed 50 g whey (WPI; active) or soy protein isolate (SPI; control) for eight weeks. Following a 16-week washout phase, they consumed the alternative supplement. Consumption of WPI significantly improved active B12 and folate status but did not result in direct improvements in cognitive function. However, there was evidence of improvement in reaction time (p = 0.02) and reasoning speed (p = 0.04) in the SPI condition for females. Additional analyses showed that changes in active B12, HcY and folate measures during WPI treatment correlated with improvements in cognitive function (all p < 0.05). Results indicate that WPI itself did not result in improved cognitive function but some evidence of benefit of SPI for females was found. However, consistent with previous research, we present further evidence of a role for active B12, HcY and folate in supporting cognitive improvement in adults with low B vitamin status.

B-vitamin status and cognitive function in older people

2011 ◽  
Vol 24 (3) ◽  
pp. 281-282 ◽  
Author(s):  
C. O. Donovan ◽  
G. Horigan ◽  
H. McNulty
Keyword(s):  
Cognitive Function ◽  
Older People ◽  
Vitamin Status ◽  
B Vitamin

scholarly journals Homocysteine, B vitamin status, and cognitive function in the elderly

2002 ◽  
Vol 75 (5) ◽  
pp. 908-913 ◽  
Author(s):  
Susan J Duthie ◽  
Lawrence J Whalley ◽  
Andrew R Collins ◽  
Steve Leaper ◽  
Kerstin Berger ◽  
...  
Keyword(s):  
Cognitive Function ◽  
The Elderly ◽  
Vitamin Status ◽  
B Vitamin

scholarly journals Dietary Pattern Is Associated with Homocysteine and B Vitamin Status in an Urban Chinese Population

2003 ◽  
Vol 133 (11) ◽  
pp. 3636-3642 ◽  
Author(s):  
Xiang Gao ◽  
Manjiang Yao ◽  
Megan A. McCrory ◽  
Guansheng Ma ◽  
Yanping Li ◽  
...  
Keyword(s):  
Dietary Pattern ◽  
Chinese Population ◽  
Vitamin Status ◽  
B Vitamin

scholarly journals Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats

Nutrients ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 26 ◽  
Author(s):  
Vegard Lysne ◽  
Elin Strand ◽  
Gard Svingen ◽  
Bodil Bjørndal ◽  
Eva Pedersen ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Vitamin Status ◽  
B Vitamin

scholarly journals Physical activity and brain plasticity in late adulthood

2013 ◽  
Vol 15 (1) ◽  
pp. 99-108 ◽  
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Human Brain ◽  
Brain Function ◽  
Brain Plasticity ◽  
Cortical Atrophy ◽  
Late Adulthood ◽  
Biological Basis ◽  
Emotional Function ◽  
The Brain

The human brain shrinks with advancing age, but recent research suggests that it is also capable of remarkable plasticity, even in late life. In this review we summarize the research linking greater amounts of physical activity to less cortical atrophy, better brain function, and enhanced cognitive function, and argue that physical activity takes advantage of the brain's natural capacity for plasticity. Further, although the effects of physical activity on the brain are relatively widespread, there is also some specificity, such that prefrontal and hippocampal areas appear to be more influenced than other areas of the brain. The specificity of these effects, we argue, provides a biological basis for understanding the capacity for physical activity to influence neurocognitive and neuropsychiatric disorders such as depression. We conclude that physical activity is a promising intervention that can influence the endogenous pharmacology of the brain to enhance cognitive and emotional function in late adulthood.

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