Malignant Transformation of Nodular Hidradenoma in the Lower Leg

Nodular hidradenoma (NH) is a benign adnexal tumor that arises from either eccrine or apocrine sweat glands. NH can originate from any cutaneous site, but the most common sites are the head and anterior surface of the trunk, with very rare cases in the extremities. Long-standing NH has been reported to undergo malignant transformation to malignant NH (MNH); however, its occurrence in the lower leg is extremely rare with only one other case reported to date. In this report, we present a rare case of MNH occurring in the lower leg which was resected with the intent to make a diagnosis. At the final follow-up after 11 months, no local recurrence or metastasis has been observed.

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Case Report and Literature Review of Nodular Hidradenoma, a Rare Adnexal Tumor That Mimics Breast Carcinoma, in a 20-Year-Old Woman

Laboratory Medicine ◽

10.1093/labmed/lmy084 ◽

2019 ◽

Vol 50 (3) ◽

pp. 320-325

Author(s):

Vanya Jaitly ◽

Richard Jahan-Tigh ◽

Tatiana Belousova ◽

Hui Zhu ◽

Robert Brown ◽

...

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Breast Carcinoma ◽

Literature Review ◽

Sweat Glands ◽

Rare Presentation ◽

Adnexal Tumor ◽

Nodular Hidradenoma ◽

Growing Mass ◽

Uncommon Tumor

Abstract Nodular hidradenoma is an uncommon cutaneous adnexal tumor arising from sweat glands. In the skin, it usually presents as a solitary dermal nodule; excision is curative in most cases. In rare instances, it may present as a breast mass and can mimic breast carcinoma clinically and radiologically, causing diagnostic dilemmas for the treating physician and pathologist. Herein, we discuss a case of nodular hidradenoma in a 20-year-old Hispanic woman as a rapidly growing mass in the breast that mimicked breast carcinoma. We discuss the rare presentation of this uncommon tumor and the differential diagnosis of this entity, as well as the results of our literature review on the topic.

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RARE-31. TREATMENT OUTCOME OF CHILDREN WITH PLEOMORPHIC XANTHOASTROCYTOMA: RETROSPECTIVE ANALYSIS – A SINGLE INSTITUTION EXPERIENCE

Neuro-Oncology ◽

10.1093/neuonc/noz175.954 ◽

2019 ◽

Vol 21 (Supplement_6) ◽

pp. vi228-vi228

Author(s):

Ossama Maher ◽

Toba Niazi ◽

Ziad Khatib ◽

John Ragheb

Keyword(s):

Local Recurrence ◽

Retrospective Analysis ◽

Malignant Transformation ◽

Cranial Nerve ◽

Pleomorphic Xanthoastrocytoma ◽

Braf V600e ◽

Biological Behavior ◽

High Local Recurrence Rate ◽

Cranial Nerve Palsies

Abstract BACKGROUND Pleomorphic xanthoastrocytoma (PXA) and anaplastic pleomorphic xanthoastrocytoma (APXA) are two types of rare astrocytomas in pediatrics. There is limited literature reporting their outcomes. METHODS A retrospective analysis of pediatric patients with diagnosis of PXA and APXA treated at Nicklaus Children’s Hospital was conducted using descriptive measures. RESULTS A chart review of patients with brain tumors from 2001 to 2019 revealed that 13 patients (median age 6 years, range 2–17 years) were diagnosed with non-metastatic PXA (n=12) and APXA (n=1). Six patients (46%) were male. Clinical presentation included seizures (n=8), headaches (n=2) cranial nerve palsies (n=2). Diagnostic imaging showed tumor in the temporal lobe (n=5), parietal lobe (n=2), temporoparietal lobe (n=2), frontal lobe (n=1), occipital lobe (n=1), others (n=2). BRAF V600E mutation were identified in three of five analyzed tumors including PXA (n=4) and APXA (n=1). Surgical intervention consisted of gross total resection (n=8) and near/subtotal resection (n=5). Ten patients (76%) required a second surgery (median 2; range 1–4) due to local recurrence. The median time to recurrence was 3 years (range 6 months - 7 years). Three patients (23%) had malignant transformation of PXA, which occurred three to eight years from the initial surgery; one of them also had extensive spinal metastasis. Focal radiation was given to six patients (46%) due to multiple recurrence (n=2), malignant transformation (n=3), APXA (n=1). At a median follow up of 8 years (range 3 to 20 years), eight patients remain alive, three patients had lost to follow up, two patients died from progressive disease. Long-term sequelae varied as follows; seizures (n=5), motor weakness (n=4), cranial nerve palsies (n=2), and learning disability (n=1). CONCLUSION PXA is associated with high local recurrence rate and uncommonly malignant transformation to APXA in pediatrics, which requires close follow-up due to unpredictable biological behavior of these tumors.

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Corneal erforation casused by eyelid margin trichilemmal carcinoma: A case report

10.21203/rs.2.421/v1 ◽

2019 ◽

Author(s):

Liying Zhang ◽

Zhirong Lin ◽

Huping Wu

Keyword(s):

Rare Case ◽

The Elderly ◽

Corneal Perforation ◽

Slit Lamp ◽

Blurred Vision ◽

Eyelid Margin ◽

Case Presentation ◽

Adnexal Tumor ◽

History Of

Abstract Background: Trichilemmal carcinoma (TLC) is a rare malignant adnexal tumor predominantly affecting the scalp, eyelids, neck and face of the elderly. Here, we firstly report a rare case of corneal perforation caused by TLC grown in eyelid margin. Case presentation: A 68-year-old female presented with two months history of unprovoked redness, pain and blurred vision in the left eye. On slit-lamp examination, a 1×2mm aseptic corneal perforation embedded by iris prolapsed was noted. After excluding other causes through examinations and case history inquiry, we speculated that the severe MGD and subsequent BKC might be the cause. In order to prevent the ulcer enlargement and intraocular infection, the patient was treated with penetrating keratoplasty immediately. However, a terrible phenomenon has aroused our concern that several small nodules gradually developed on the eyelid margin, accompanied with bleeding, burst and madarosis postoperatiely. The biopsy revealed the eyelid was involved by TLC and then the lesionectomy was performed immediately. There was no evidence of local recurrence and metastasis during 1 year follow-up. Conclusions: The involvement of eyelid margin by TLC, and subsequent BKC and corneal perforation were very rare and it has not been reported yet. The concomitant BKC can be gradually healed after rectifying eyelid margin by total excision of TLC. It is very important to offer careful follow-up to all patients.

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A Rare Case of an Osteoid Osteoma of the Rib Treated under Computed Tomography Guidance: A Case Report and Review of the Literature

Case Reports in Oncology ◽

10.1159/000441835 ◽

2015 ◽

Vol 8 (3) ◽

pp. 509-514 ◽

Cited By ~ 3

Author(s):

Sakiko Mizuno ◽

Ukei Anazawa ◽

Hiraku Hotta ◽

Naofumi Asano ◽

Michiro Susa ◽

...

Keyword(s):

Computed Tomography ◽

Case Report ◽

Local Recurrence ◽

Osteoid Osteoma ◽

Rare Case ◽

Review Of The Literature ◽

Skeletal Tissue ◽

Minimal Invasiveness ◽

Computed Tomography Guidance

Osteoid osteoma (OO) usually occurs in the extremities of young adults. The tumor can arise in any part of the skeletal tissue; however, it is rarely found in the rib, with limited reports to date. In this report, we present a rare case of OO arising in the rib, which was successfully treated under computed tomography guidance with minimal invasiveness. At the final follow-up after 4 years, no local recurrence was observed.

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Inflammatory myofibroblastic tumours of the respiratory system and the impact of the varying patterns

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2016.0033 ◽

2016 ◽

Vol 98 (1) ◽

pp. e8-e10 ◽

Cited By ~ 1

Author(s):

JV Lodhia ◽

TD Christensen ◽

SE Trotter ◽

ES Bishay

Keyword(s):

Local Recurrence ◽

Malignant Transformation ◽

Respiratory System ◽

Surgical Procedure ◽

Complete Resection ◽

Anatomical Location ◽

The Impact

Inflammatory fibroblastic tumours are very rare. They are mostly located in the respiratory system. We present three cases of patients with fibroblastic tumours. The diversity of inflammatory fibroblastic tumours in the respiratory system and the surgical considerations are discussed. Our recommendation is that treatment should include a complete resection to prevent local recurrence and malignant transformation, and follow-up review should reflect the procedure carried out, especially in terms of the anatomical location and the extent of the surgical procedure performed.

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A rare case of a digital papillary carcinoma of the hand with secondary conservative management

Journal of Surgical Case Reports ◽

10.1093/jscr/rjz403 ◽

2020 ◽

Vol 2020 (1) ◽

Author(s):

Rabeet Khan ◽

Renu Irri ◽

Effie Katsarma

Keyword(s):

Early Detection ◽

Papillary Carcinoma ◽

Management Strategy ◽

Rare Case ◽

Histological Analysis ◽

Significant Risk ◽

Sweat Glands ◽

Hands And Feet ◽

Palm Of The Hand

Abstract A digital papillary carcinoma (DPC) is a cancer of the sweat glands which develops on the digits of the hands and feet. With an incidence of 0.08 per 1 000 000 people/year, it is often initially misdiagnosed as a simple ganglion although it has a significant risk of metastasis. Histological analysis is beneficial in the formal diagnosis of DPCs. In this report, we present a rare case of DPC affecting the palm of the hand, rather than the more commonly reported DPC of the digits. We discuss the management strategy utilized in this case and the various prognostic considerations taken into account when deciding on an amputation versus local excision surgical approach. All cases of DPC require regular follow up imaging for early detection of recurrence or new metastases to maximize prognosis.

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Seeding of a parotid pleomorphic adenoma

The Journal of Laryngology & Otology ◽

10.1017/s0022215100130993 ◽

1995 ◽

Vol 109 (7) ◽

pp. 671-673 ◽

Cited By ~ 9

Author(s):

D. J. Commins ◽

D. Roberts ◽

C. Fisher ◽

N. M. Breach

Keyword(s):

Local Recurrence ◽

Pleomorphic Adenoma ◽

Malignant Transformation ◽

Radical Surgery ◽

Distant Metastases ◽

Younger Patients ◽

Primary Procedure ◽

Recurrent Pleomorphic Adenoma

AbstractRecurrent pleomorphic adenoma of the parotid usually occurs in the distribution of the primary procedure. There are numerous reports of widespread local recurrence and a few reported cases of distant metastases. Extensive seeding throughout the entire ipsilateral neck is rare. Treatment involves a combination of radical surgery and radiotherapy. The potential for malignant transformation demands close follow-up of younger patients particularly.

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Ameloblastic fibroma: A rare case report with 7-year follow-up

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1504190a ◽

2015 ◽

Vol 143 (3-4) ◽

pp. 190-194 ◽

Cited By ~ 2

Author(s):

Araújo de ◽

Adna Barros ◽

Cássia de ◽

Arlei Cerqueira ◽

Dos Nunes

Keyword(s):

Malignant Transformation ◽

Rare Case ◽

Case Reports ◽

Permanent Teeth ◽

Proliferation Index ◽

Ameloblastic Fibroma ◽

Rare Case Report ◽

Long Term Follow Up

Introduction. Ameloblastic fibroma (AF) is a rare benign odontogenic tumor that usually occurs in the first two decades of life. It affects adolescents and young adults and is found in the mandible and with a higher frequency in the posterior region of this segment. There are rare case reports with a long-term follow-up. Case Outline. We report the case of a 6-year-old boy with extensive ameloblastic fibroma in the mandible. Treatment consisted of enucleation and bone curettage, with the preservation of permanent teeth adjacent to the tumor. Clinical and radiographic follow-up of the patient over a period of 7 years showed no signs of recurrence or malignant transformation. Conclusion. Patients with AF should be under follow-up for prolonged periods of time, even in cases exhibiting a low proliferation index, because of the potential for recurrence and malignant transformation of this tumor.

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Odontogenic carcinosarcoma with dentinoid: a rare case report

Journal of International Medical Research ◽

10.1177/03000605211045555 ◽

2021 ◽

Vol 49 (9) ◽

pp. 030006052110455

Author(s):

Xing Niu ◽

Biying Huang ◽

Jing Yang ◽

Xue Qiao ◽

Lijie Chen ◽

...

Keyword(s):

Case Report ◽

Local Recurrence ◽

Rare Case ◽

Tumor Resection ◽

Clinical Manifestations ◽

Odontogenic Tumor ◽

Maxillary Molar ◽

Rare Case Report ◽

Sinus Tumor

Odontogenic carcinosarcoma is a very rare malignant odontogenic tumor, characterized by malignant epithelial and mesenchymal components. Studies have reported several cases of odontogenic carcinosarcoma, mainly in the upper and lower jaws, with malignant clinical manifestations. Herein, we present the case of a 58-year-old woman with odontogenic carcinosarcoma with dentinoid in the left maxilla. The invasion range was large, and the left maxillary molar was missing. Histology revealed odontogenic carcinosarcoma with bidirectional differentiation characteristics and comprising three components: malignant epithelium, malignant interstitium, and dentinoid. The patient subsequently underwent nasal endoscopic sinus tumor resection, and she recovered well after surgery. After a strict 4-year follow-up, to date, there are still no signs of disease or local recurrence. To our knowledge, this is the first reported case of odontogenic carcinosarcoma with dentinoid. Our study describes the clinical, morphological, and immunohistochemical characteristics of this case, and distinguishes it from related diseases.

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Isolated giant plexiform neurofibroma of lower back: a rare case presentation

International Surgery Journal ◽

10.18203/2349-2902.isj20200320 ◽

2020 ◽

Vol 7 (2) ◽

pp. 581

Author(s):

Devansh Mishra ◽

Nitin Wasnik ◽

Priyanka Sakarkar

Keyword(s):

Malignant Transformation ◽

Rare Case ◽

Plexiform Neurofibroma ◽

Neurofibromatosis Type ◽

Lower Back ◽

Patient Reported ◽

Rare Benign Tumor ◽

Married Female

Plexiform neurofibroma is a rare benign tumor of the peripheral tissue cells that develops in the perineurium that is often considered pathognomonic of neurofibromatosis type 1 (NF1 or von Recklinghausen disease). They occur most frequently in the craniomaxillofacial region, rarely on back and extremities. They are extremely vascular and there is 15-20% potential for malignant transformation. A 35-year-old married female presented with painless swelling in left lower back that began at around 8 years of age. The swelling gradually increased in size. The patient reported embarrassment over the disfigurement caused by the mass. Her medical history was unremarkable and none of the relatives was known to be affected. Surgical resection of the swelling with primary closure was done. Histopathology findings were consistent with neurofibromatosis. Hereby reporting a rare case of isolated plexiform neurofibroma of lower back which was surgically cured as a perusal of rare entity. We also try to emphasize on the need of sprightful clinical diagnosis with multidisciplinary approach in the management of these type of tumors. Finally, we insist on the need of a long term clinical and radiological follow-up of these patients to assess post resection recurrence or malignant transformation.

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