Evaluation of Hearing and Balance Functions of Patients with Sickle Cell Anemia

2018 ◽  
Vol 23 (2) ◽  
pp. 122-125 ◽  
Author(s):  
Elif Tugba Sarac ◽  
Bilgehan Boke ◽  
Semsettin Okuyucu
Keyword(s):  
Hearing Loss ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Pure Tone ◽  
Mixed Type ◽  
Normal Hearing ◽  
Spontaneous Nystagmus ◽  
Control Group ◽  
Hearing Thresholds ◽  
Significant Difference

Introduction: Sickle cell anemia is a disease characterized by a wide vaso-occlusive incident from micro-vascular incident to muscularactivity. The cochlear function can also get affected by this vaso-occlusion. Objective: It is aimed at determining what kind of effects sickle cell anemia has on hearing and balance system. Methods: This study has been conducted on 46 patients with sickle cell anemia and 45 healthy individuals. For all participants, their pure tone hearing thresholds and videonystagmography (VNG) findings have been determined in 17 frequencies between 125–16.000 Hz. Results: All hearing thresholds between 125 and 16,000 Hz, pure tone averages of patients with sickle cell anemia have been found statistically significant to be higher than the corresponding values in the control group(p < 0.05). The normal hearing rate of patients with sickle cell anemia has been determined to be 71.1% conductive hearing loss (CHL) to be 4.4%, sensorineural hearing loss (SNHL) to be 22.2%, and mixed type hearing loss to be 2.2% in right ear; the normal hearing rate has been determined to be 71.1%, CHL to be 2.2%, SNHL to be 22.2%, and mixed type hearing loss to be 4.4% in left ear. Statistically significant difference has not been found between head shake, spontaneous nystagmus, optokinetic, tracking test batteries, static and dynamic positional tests used in VNG, saccade accuracy and saccade peak velocity, which are saccadic test findings of 2 groups. However, saccadic latency, which is a saccadic test finding, has been determined to be longer in patients with sickle cell anemia in comparison to the control group. Conclusion: While sickle cell anemia causes hearing deficits, it does not have any effect on the central or peripheral vestibular system.

Skull Base Factors in Relation to Hearing Impairment in Cleft Palate Children

2000 ◽  
Vol 37 (2) ◽  
pp. 166-171 ◽  
Author(s):  
S. Carrie ◽  
A. Sprigg ◽  
A.J. Parker
Keyword(s):  
Hearing Loss ◽  
Cleft Palate ◽  
Poor Quality ◽  
Normal Hearing ◽  
Outpatient Clinics ◽  
Control Group ◽  
Otologic Surgery ◽  
Soft Tissue Neck ◽  
Significant Difference ◽  
Primary Groups

Objective This investigation was performed to determine if an easily measurable, reproducible, bony parameter could be identified that might predict hearing loss in cleft palate children. Subjects In this prospective study performed at the Sheffield Children's Hospital (U.K.), 34 children with successfully repaired cleft palate who responded to a postal request for volunteers were assessed clinically, audiologically, and by lateral soft tissue neck radiography. Six children were excluded because of previous otologic surgery or poor quality radiographs. Twenty-six children who had the same series of investigations were randomly selected from routine otolaryngological outpatient clinics and acted as controls. Methods The sphenopalatine angle (SPA), which relates the facial and cranial components of the skull, was measured on each child's radiograph. Results The median SPA in the cleft palate group was significantly greater than in the control group (p = 0.01). In those cleft palate children with a hearing loss the sphenopalatine angle was smaller than in their normal hearing counterparts (p = 0.01). No significant difference was found in the SPA between the hearing loss and normal hearing controls. There was no significant difference in age ranges between the hearing and hearing loss subgroups in each of the two primary groups. Conclusions In this study, those cleft palate children with a smaller SPA have a greater incidence of hearing loss.

scholarly journals Evaluation of the concentration of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea

2010 ◽  
Vol 8 (4) ◽  
pp. 414-418 ◽  
Author(s):  
Darcielle Bruna Dias Elias ◽  
Rivelilson Mendes de Freitas ◽  
Romélia Pinheiro Gonçalves ◽  
Hemerson Yuri Ferreira Magalhães ◽  
Jacqueline Holanda de Sousa ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Serum Levels ◽  
The Other ◽  
Control Group ◽  
Clinical Variables ◽  
Short Period ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

ABSTRACT Objective: To determine the serum levels of malondialdehyde and nitrite in patients with sickle cell anemia treated or not with hydroxyurea in outpatient's setting. Methods: Of the 65 patients with sickle cell anemia selected for the study, 51 were not treated with hydroxyurea (Group 1), 14 made chronic use of hydroxyurea (Group 2) and 20 individuals had no hemoglobinopathies (Control Group). Results: The Control Group had a lower and more homogeneous concentration of malondialdehyde levels as compared to the other groups. The results of Groups 1 and 2 showed increased values of malondialdehyde levels when compared to the Control Group. Considering the values of Groups 1 and 2, there were no significant changes in the malondialdehyde levels. There was no significant difference in the serum levels of nitrite between the groups. Group 2 presented a statistically significant correlation between serum malondialdehyde levels and the clinical variables investigated. In turn, Group 1 showed correlation only with occurrence of three or more vaso-occlusive crises. There was no correlation between nitrite levels and the clinical variables. Conclusion: The results revealed that during the pathogenesis of sickle cell anemia, an increase in lipid peroxidation was observed. On the other hand, no changes in oxidative parameters were detected during treatment with hydroxyurea, probably due to the short period of treatment of the patients studied.

scholarly journals The Relevance of the High Frequency Audiometry in Tinnitus Patients with Normal Hearing in Conventional Pure-Tone Audiometry

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Veronika Vielsmeier ◽  
Astrid Lehner ◽  
Jürgen Strutz ◽  
Thomas Steffens ◽  
Peter M. Kreuzer ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Normal Hearing ◽  
High Frequency Hearing Loss ◽  
Additional Information ◽  
Tinnitus Severity ◽  
Hearing Thresholds ◽  
High Frequency Audiometry

Objective. The majority of tinnitus patients suffer from hearing loss. But a subgroup of tinnitus patients show normal hearing thresholds in the conventional pure-tone audiometry (125 Hz–8 kHz). Here we explored whether the results of the high frequency audiometry (>8 kHz) provide relevant additional information in tinnitus patients with normal conventional audiometry by comparing those with normal and pathological high frequency audiometry with respect to their demographic and clinical characteristics.Subjects and Methods. From the database of the Tinnitus Clinic at Regensburg we identified 75 patients with normal hearing thresholds in the conventional pure-tone audiometry. We contrasted these patients with normal and pathological high-frequency audiogram and compared them with respect to gender, age, tinnitus severity, pitch, laterality and duration, comorbid symptoms and triggers for tinnitus onset.Results. Patients with pathological high frequency audiometry were significantly older and had higher scores on the tinnitus questionnaires in comparison to patients with normal high frequency audiometry. Furthermore, there was an association of high frequency audiometry with the laterality of tinnitus.Conclusion. In tinnitus patients with normal pure-tone audiometry the high frequency audiometry provides useful additional information. The association between tinnitus laterality and asymmetry of the high frequency audiometry suggests a potential causal role for the high frequency hearing loss in tinnitus etiopathogenesis.

scholarly journals Association between Ocular Pseudoexfoliation and Sensorineural Hearing Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nandini Vijaya Singham ◽  
Mimiwati Zahari ◽  
Mohammadreza Peyman ◽  
Narayanan Prepageran ◽  
Visvaraja Subrayan
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
The Body ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Speech Comprehension ◽  
Hearing Thresholds ◽  
Significant Difference

Background. Our study aimed to investigate an association between ocular pseudoexfoliation (PXF) and sensorineural hearing loss (SNHL) and to compare them with age and sex matched controls without pseudoexfoliation.Method. This was a case-control study of 123 patients which included 68 cases with PXF (at least one eye) and 55 controls without pseudoexfoliation. Pure-tone audiometry (PTA) was done for these patients at sound frequencies taken as important for speech comprehension, that is, 250 Hertz (Hz), 500 Hz, 1000 Hz, and 2000 Hz.Results. There were 41 patients with pseudoexfoliation syndrome (PXE) and 27 with pseudoexfoliative glaucoma (PXEG). The majority of patients with hearing loss (60%;n=51) were PXF patients and the remaining 40%(n=34)were controls. Below average hearing thresholds were significantly higher in the pseudoexfoliation group compared to the control group (P=0.01; odds ratio (OR), 3.00; 95% confidence interval (CI), 1.25–7.19). However, there was no significant difference in the mean hearing threshold levels between the three groups (PXE, PXEG, and controls) in either ear (ANOVA, right ear:P=0.46and left earP=0.36).Conclusion. Our study found an association between PXF and SNHL, confirming that PXF can involve organs in the body other than the eye.

Distortion Product Emissions in Normal-Hearing and Low-Frequency Hearing Loss Carriers of Genes for Waardenburg's Syndrome

1997 ◽  
Vol 106 (3) ◽  
pp. 220-225 ◽  
Author(s):  
Xue Zhong Liu ◽  
Valerie E. Newton
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Low Frequency ◽  
Normal Hearing ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product ◽  
Initial Results

Eight patients with Waardenburg's syndrome (WS) with normal hearing and 3 additional patients exhibiting a low-frequency hearing loss were tested for the level of the acoustic distortion product 2f1-f2 by means of the Otodynamics Distortion Product Analyser (ILO92). Wide notches in distortion product otoacoustic emissions (DPOAEs) between 1,000 and 3,000 Hz were found in 7 (12 ears, 87.5%) examined patients with normal audiograms, which was a significantly higher rate than that found in the control group (10%). The 3 patients with low-frequency hearing loss gave a consistent pattern in audiometric configuration shown by both pure tone audiograms and DPOAEs. It is concluded from these initial results that DPOAEs may be a useful approach to identifying subclinical pathologic aberrations in the inner ear in WS patients, and may be a predictor of low-frequency sensorineural hearing loss.

scholarly journals Left ventricular function and cardiac valvar annular dimensions among children with sickle cell anemia compared to those with hemoglobin AA type in Enugu, Nigeria

2021 ◽  
Vol 33 (2) ◽  
pp. 127-134
Author(s):  
Josephat M Chinawa ◽  
Awore T Chinawa ◽  
Edmund N Ossai ◽  
Bartholomew F Chukwu ◽  
Ikenna K Ndu ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Left Ventricular ◽  
Control Group ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
Cardiac Surgeons

BackgroundEnumerating the relationship between cardiac structures, function and chamber sizes in children with sickle cell anemia would help in delineating some cardiovascular abnormalities which will aid the Pediatric cardiologist and the cardiac surgeons in a number of decision-making situations.ObjectivesThe objectives of this study are to assess the dimension of cardiac structures and left ventricular function in children with sickle cell anemia in steady state and controls using echocardiography.MethodsA cross-sectional prospective study that assessed cardiac structures and left ventricular function among fifty-one children with sickle cell anemia (HBSS) and compared with fifty children with HB AA type serving as controls.ResultsA significant high proportion of children with sickle cell anemia had abnormal Valvar dimension and left ventricular function above two standard deviations (2-SD) from the mean of the standard population compared to the control group, showing a statistically significant difference (χ2 = 10.42, p= 0.001). All the mean annular valves diameter, left ventricular internal dimension in systole and diastole, inter-sinus distance diameter and sinu-tubular junction diameter are higher in children with sickle cell anemia than controls and this is statistically significant. (p<0.005). ConclusionThis result shows that children with sickle cell anemia have increased valvar size diameter compared with those with normal hemoglobin type. A significantly higher proportion of respondents in type SS group had abnormal left ventricular systolic and diastolic dysfunction when compared with those in type AA group

scholarly journals A Controlled Comparison of Auditory Steady-State Responses and Pure-Tone Audiometry in Patients with Hearing Loss

2017 ◽  
Vol 96 (10-11) ◽  
pp. E47-E52
Author(s):  
Raman Wadhera ◽  
Sharad Hernot ◽  
Sat Paul Gulati ◽  
Vijay Kalra
Keyword(s):  
Hearing Loss ◽  
Steady State ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Conductive Hearing Loss ◽  
Pure Tone Audiometry ◽  
Normal Hearing ◽  
Sensorineural Hearing ◽  
Hearing Thresholds ◽  
Conductive Hearing

We performed a prospective interventional study to evaluate correlations between hearing thresholds determined by pure-tone audiometry (PTA) and auditory steady-state response (ASSR) testing in two types of patients with hearing loss and a control group of persons with normal hearing. The study was conducted on 240 ears—80 ears with conductive hearing loss, 80 ears with sensorineural hearing loss, and 80 normal-hearing ears. We found that mean threshold differences between PTA results and ASSR testing at different frequencies did not exceed 15 dB in any group. Using Pearson correlation coefficient calculations, we determined that the two responses correlated better in patients with sensorineural hearing loss than in those with conductive hearing loss. We conclude that measuring ASSRs can be an excellent complement to other diagnostic methods in determining hearing thresholds.

scholarly journals Does Hearing Thresholds Vary Across Different Blood Groups?

2019 ◽  
Vol 09 (01) ◽  
pp. 17-21
Author(s):  
Archana Rai Sarve ◽  
Megha K. ◽  
Devika Hem
Keyword(s):  
Blood Group ◽  
Pure Tone ◽  
Normal Hearing ◽  
Blood Groups ◽  
Hearing Thresholds ◽  
Significant Difference ◽  
Group A ◽  
A Prospective Study ◽  
Study Participants ◽  
Post Hoc

AbstractThe current study aimed at identifying the relationship between the blood group and hearing thresholds. The objective of the study was to identify if there is a difference in the pure tone audiometric thresholds of individuals with different blood groups, and to identify if there is a difference between pure tone audiometric thresholds of males and females of the same blood group. A prospective study was performed involving 80 normal hearing individuals between the age of 18 and 40 years. All participants included in the study had normal hearing (< 25 dBHL) and were Rh+. Participants complaining or giving indications of any kind of cochlear or retrocochlear pathological conditions were excluded from the study. Participants were grouped based on their blood groups. Each group consisted of 20 participants. Thresholds were established for frequencies ranging from 125 Hz to 20 KHz. Descriptive statistical analysis was done for mean and standard deviation. Bonferroni post hoc analysis was carried out for multiple comparisons, and the results revealed that there was no statistically significant difference in thresholds observed among different blood groups.

Comparison of pulmonary function tests in patients with sickle cell anemia and sickle beta-thalassemia referring to the hematology clinic of Bandar Abbas Shahid Mohammadi Hospital with the control group in 2019-2020

2021 ◽  
Author(s):  
Arash Rahimi ◽  
Mohammad amin Rashidi ◽  
Abolhasan Rasti
Keyword(s):  
Pulmonary Function ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Pulmonary Function Tests ◽  
Beta Thalassemia ◽  
Control Group ◽  
Case Group ◽  
Statistical Population ◽  
Significant Difference ◽  
Bandar Abbas

Aim: Due to the high prevalence of sickle cell anemia and beta-shaped sickle cell thalassemia in this region, we decided to conduct this study with the aim of investigating the status of pulmonary function in these patients in Bandar Abbas. Method: The statistical population in this study included all patients with sickle cell anemia and sickle cell beta-thalassemia who had referred to the hematology clinic from 2019-2020, which was equal to 60 people. Also, the workers who had referred to the specialized lung clinic for periodic health tests entered the study by observing the criteria for leaving the review as a control group. Participants were subjected to spirometry and pulmonary volumes were measured. Result: The patients in the case group, 39 (65%) were from sickle cell anemia, and 21 (35%) were from the sickle cell beta-thalassemia. In this study, all the studied parameters had a significant difference between the study group and the control, except for the mean age (p=0.906). In the control group, the values of FEV1 (Forced expiratory volume in 1 second), FVC (Forced vital capacity), and FEF25-75% (Forced expiratory flow 25-75%) are higher than these values in the case group, and this difference is significant (P <0.001). Conclusion: The results of the present study showed that the levels of FEV1, FVC and FEF 25-75% in the control group are higher than these values in the patient group and this difference is significant.

Comparison of auditory electrophysiological responses in normal-hearing patients with and without tinnitus

2011 ◽  
Vol 125 (7) ◽  
pp. 668-672 ◽  
Author(s):  
S Singh ◽  
S K Munjal ◽  
N K Panda
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Auditory Brainstem Responses ◽  
Control Group ◽  
Distortion Product ◽  
Significant Difference ◽  
Central Activity ◽  
Middle Latency

AbstractIntroduction:Tinnitus is a disturbing symptom and is often the main reason for otology referral. It is usually associated with hearing loss of varying aetiology, and is thought to begin in the cochlea, with later abnormal central activity. We hypothesise that tinnitus without hearing loss may be caused by central and subcortical abnormalities and altered outer hair cell function.Aim:To compare the auditory brainstem responses, middle latency responses and otoacoustic emissions in normal-hearing individuals with and without tinnitus.Methodology:The audiological test results of 25 normal hearing subjects with tinnitus (age 18–45 years) were determined, and compared with those of a control group.Results:A statistically significant difference was found between study group tinnitus ears vs control group ears, as regards wave I latency prolongation, shortening of wave V and absolute I–III and I–V interpeak latency, enlargement of wave Na and Pa amplitude, and distortion product and transient evoked otoacoustic emission signal-to-noise ratios. There was no statistically significant difference between unilateral vs bilateral tinnitus ears.Conclusion:The pathogenesis and optimum management of tinnitus are still unclear. It often occurs with primary ear disease, usually associated with hearing loss, but may occur in patients with normal hearing. Observed changes in auditory brainstem and middle latency responses indicate central auditory alterations. Tinnitus involves both peripheral and central activity, and complete audiological and neurophysiological investigation is required. Management should be based on both audiological and neurophysiological findings.

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