Interleukin-1 and Interleukin-6 Polymorphisms Might Influence Predisposition to Hemorrhagic Cerebral Vascular Diseases: A Meta-Analysis

2021 ◽  
pp. 1-7
Author(s):  
Jianjian Lin ◽  
Weiqiao Zhang ◽  
Zhengzhong Wang ◽  
Fei Zhao
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Interleukin 6 ◽  
Web Of Science ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Vascular Diseases ◽  
Meta Analyses ◽  
The Relationship ◽  
Cerebral Vascular

<b><i>Background:</i></b> Interleukin-1 (<i>IL-1</i>) and <i>IL-6</i> polymorphisms might influence predisposition to hemorrhagic cerebral vascular diseases, but the results of already published studies regarding relationship between <i>IL-1/IL-6</i> polymorphisms and hemorrhagic cerebral vascular diseases were still controversial and ambiguous. <b><i>Objectives:</i></b> The authors designed this meta-analysis to more precisely estimate the relationship between <i>IL-1/IL-6</i> polymorphisms and hemorrhagic cerebral vascular diseases by pooling the results of already published related studies. <b><i>Methods:</i></b> The authors searched PubMed, EMBASE, Web of Science, and CNKI for already published studies. Eighteen already published studies were pooled analyzed in this meta-analysis. <b><i>Results:</i></b> The pooled meta-analyses’ results showed that distributions of <i>IL-1A</i> rs1800587, <i>IL-1B</i> rs16944, and <i>IL-6</i> rs1800796 polymorphisms among patients and controls differed significantly. Moreover, distribution of the <i>IL-6</i> rs1800795 polymorphism among patients and controls from Asians also differed significantly. Further analyses showed similar findings for <i>IL-1A</i> rs1800587, <i>IL-1B</i> rs16944, and <i>IL-6</i> rs1800796 polymorphisms in aneurysmal subarachnoid hemorrhage (aSAH) subgroup. <b><i>Conclusions:</i></b> This meta-analysis suggested that <i>IL-1A</i> rs1800587, <i>IL-1B</i> rs16944, and <i>IL-6</i> rs1800796 polymorphisms might influence susceptibility to hemorrhagic cerebral vascular diseases, especially for aSAH. Moreover, <i>IL-6</i> rs1800795 might influence susceptibility to hemorrhagic cerebral vascular diseases in Asians.

scholarly journals Corticosteroids in the Management of Hyponatremia, Hypovolemia, and Vasospasm in Subarachnoid Hemorrhage: A Meta-Analysis

2016 ◽  
Vol 42 (3-4) ◽  
pp. 263-271 ◽  
Author(s):  
Akshitkumar M. Mistry ◽  
Eva A. Mistry ◽  
Nishant Ganesh Kumar ◽  
Michael T. Froehler ◽  
Matthew R. Fusco ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Patient Outcomes ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Meta Analysis ◽  
Random Effects Model ◽  
Significant Morbidity ◽  
Corticosteroid Administration ◽  
Symptomatic Vasospasm ◽  
Meta Analyses ◽  
Mineralocorticoid Activity

Background: Cerebral vasospasm and sodium and fluid imbalances are common sequelae of aneurysmal subarachnoid hemorrhage (SAH) and cause of significant morbidity and mortality. Studies have shown the benefit of corticosteroids in the management of these sequelae. We have reviewed the literature and analyzed the available data for corticosteroid use after SAH. Methods: PubMed, EMBASE, and Cochrane electronic databases were searched without language restrictions, and 7 observational, controlled clinical studies of the effect of corticosteroids in the management of SAH patients were identified. Data on sodium and fluid balances, symptomatic vasospasm (SVS), and outcomes were pooled for meta-analyses using the Mantel-Haenszel random effects model. Results: Corticosteroids, specifically hydrocortisone and fludrocortisone, decreased natriuretic diuresis and incidence of hypovolemia. Corticosteroid administration is associated with lower incidence of SVS in the absence of nimodipine, but does not alter the neurological outcome. Conclusions: Supplementation of corticosteroids with mineralocorticoid activity, such as hydrocortisone or fludrocortisone, helps in maintaining sodium and volume homeostasis in SAH patients. Larger trials are warranted to confirm the effects of corticosteroids on SVS and patient outcomes.

Meta-analysis and Scientific Mapping of Well-being and Job Performance

2020 ◽  
Vol 23 ◽  
Author(s):  
Oscar Iván Gutiérrez ◽  
Jean David Polo ◽  
Milton José Zambrano ◽  
Diana Carolina Molina
Keyword(s):  
Job Performance ◽  
Web Of Science ◽  
Meta Analysis ◽  
Well Being ◽  
Science Base ◽  
Prisma Statement ◽  
And Performance ◽  
Meta Analyses ◽  
The Relationship ◽  
Productive Worker

Abstract In this article, we present a meta-analysis and a scientific mapping about the relationship between different types of well-being and job performance. We followed The PRISMA statement for reporting systematic reviews and meta-analyses (Moher et al., 2009), and conduct the search in Web of Science, SCOPUS, Ebscohost, Proquest, and Jstor databases. We identified 43 studies from 1994 to early 2020 that represent 45 independent samples, 34,221 participants, and 77 correlations between four types of well-being and six of job performance. Meta-analysis results show that are different forms of relations between types and there is not only one form to explain the happy-productive worker hypothesis. The scientific mapping shows that there are seven clusters of topics about well-being and job performance in the Web of Science base articles: (I) Burnout and axiety, (II) Stress and depression, (III) Individual resources, (IV) Work context, (V) Work engagement and commitment, (VI) Justice, and (VII) Human resources practices. We organize the topics from each cluster in the different groups of variables of the contextual model of individual work, well-being and performance (van Veldhoven & Peccei, 2015) to explain their impact in well-being and job performance. We included the observations of our analysis and identified the future key directions for the field.

Associations Between Common Polymorphisms of CDKN2B-AS and Susceptibility to ASCVD

Angiology ◽  
2020 ◽  
Vol 71 (10) ◽  
pp. 934-941
Author(s):  
Yupeng Huang ◽  
Hongyan Jin ◽  
Guokang Yang
Keyword(s):  
Myocardial Infarction ◽  
Web Of Science ◽  
Meta Analysis ◽  
Vascular Diseases ◽  
East Asians ◽  
Literature Research ◽  
Genetic Biomarkers ◽  
Artery Disease ◽  
Meta Analyses ◽  
Positive Results

This meta-analysis was conducted to estimate associations between CDKN2B antisense ( CDKN2B-AS) polymorphisms and susceptibility to atherosclerotic cardio-cerebral vascular diseases (ASCVD). A systematic literature research of PubMed, Medline, Web of Science, Embase, and CNKI was performed to identify eligible studies. Overall, 34 studies were included for meta-analyses. Pooled overall analyses showed that rs1333040, rs1333049, rs2383206, and rs2383207 polymorphisms were associated with susceptibility to ASCVD in the whole population. Further analyses by ethnicity revealed that all investigated polymorphisms were associated with susceptibility to ASCVD in East Asians. Moreover, rs2383206, rs2383207, rs10757274, and rs10757278 polymorphisms were associated with susceptibility to ASCVD in West Asians, while rs2383206, rs10757274, and rs10757278 were associated with susceptibility to ASCVD in Caucasians. When we stratified eligible studies by type of disease, positive results were found for all investigated polymorphisms in patients with coronary artery disease (CAD) or myocardial infarction, whereas positive results were only detected for rs2383206 and rs10757274 polymorphisms in patients with ischemic stroke (IS). Our findings suggest that rs1333040, rs1333049, rs2383206, rs2383207, rs10757274, and rs10757278 polymorphisms might serve as genetic biomarkers of CAD, and rs2383206 and rs10757274 polymorphisms might serve as genetic biomarkers of IS.

Interleukin Polymorphisms and Predisposition of Systemic Lupus Erythematosus: A Meta-Analysis

2021 ◽  
pp. 1-9
Author(s):  
Zongqing Liu ◽  
Tong Sun ◽  
Linjian Song ◽  
Xiaoxing Xue ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Systemic Lupus ◽  
Comprehensive Search ◽  
Meta Analyses

<b><i>Background:</i></b> It is plausible that interleukin polymorphisms may affect predisposition of autoimmune disorders such as systemic lupus erythematosus (SLE), but the results of so far published studies remain controversial. <b><i>Objectives:</i></b> The authors conducted this meta-analysis to clarify relationships between interleukin-1 (<i>IL-1</i>)<i>/</i>interleukin-4 (<i>IL-4</i>)<i>/</i>interleukin-6 (<i>IL-6</i>)<i>/</i>interleukin-10 (<i>IL-10</i>) polymorphisms and SLE by pooling the findings of eligible studies. <b><i>Methods:</i></b> A comprehensive search of PubMed, EMBASE, Web of Science, and CNKI was endorsed by the authors to identify already published studies. Fifty-seven studies were found to be eligible for meta-analyses. <b><i>Results:</i></b> The overall pooled meta-analyses yielded positive findings for <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −31 T/C, <i>IL-6</i> −174 G/C, <i>IL-4</i> −590 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms. In addition, we also detected similar positive findings for <i>IL-1B</i> −511 C/T, <i>IL-4</i> −590 C/T, <i>IL-10</i> −592 A/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms in Asians, and such positive findings were also observed for <i>IL-1A</i> −889 C/T, <i>IL-6</i> −174 G/C, and <i>IL-10</i> −1,082 A/G polymorphisms in Caucasians. <b><i>Conclusions:</i></b> The meta-analyses’ results suggest that <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −31 T/C, <i>IL-6</i> −174 G/C, <i>IL-4</i> −590 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms might affect predisposition of SLE.

scholarly journals Predicted the P2RX7 rs3751143 polymorphism is associated with cancer risk: a meta-analysis and systematic review

2021 ◽  
Vol 41 (2) ◽  
Author(s):  
Bi-jun Wang ◽  
Jun-yi Chen ◽  
Yu Guan ◽  
Da-chao Liu ◽  
Zi-chuan Cao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Purinergic Receptor ◽  
Meta Analysis ◽  
Collective Effects ◽  
Test Results ◽  
Heterogeneity Test ◽  
Meta Analyses ◽  
Risk Of Cancer ◽  
The Relationship

Abstract Background: Both meta-analyses and systematic reviews were used to assess the relationship between purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) rs3751143 polymorphism and the risk of cancer. Materials and methods: The data used in this research were collected from Google Scholar, Web of Science, CNKI, and Wan Fang Data databases. The final retrieval ended on 22 February 2019. The strength of correlation was assessed using odds ratios and 95% confidence intervals. Based on the heterogeneity test results, fixed-effect (Mantel–Haenszel) or random-effects (DerSimonian–Laird) models were selected to summarise the collective effects. Results: Eight separate studies containing 1462 cancer cases and 3037 controls were enrolled. Overall, there was no significant association between P2RX7 rs3751143 polymorphism and the risk of cancer in the allelic, homozygous, heterozygous, dominant, or recessive models. Conclusions: Our meta-analysis indicates that there is no significant association between P2RX7 rs3751143 polymorphism and the risk of cancer in the allelic, homozygous, heterozygous, dominant, and recessive models.

scholarly journals Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Junfei Zhu ◽  
Bin Guo ◽  
Min Fu ◽  
Wushuang Guo ◽  
Yifang Yuan ◽  
...  
Keyword(s):  
Risk Factor ◽  
Interleukin 6 ◽  
Chronic Periodontitis ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Caucasian Population ◽  
Dominant Model ◽  
Case Control Studies ◽  
Meta Analyses

Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility.Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The meta-analyses were performed using STATA 12.0.Results. 21 studies were yielded. Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560–0.849,P=0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568–0.838,P<0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577–0.980,P=0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576–0.944,P=0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497–0.845,P=0.001; GC versus GG: OR = 0.621, 95% CI = 0.441–0.876,P=0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470–0.896,P=0.009).Conclusion. IL-6 174 polymorphism is associated with CP susceptibility. In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP.

A Meta-Analysis of Interviews and Cognitive Ability

2013 ◽  
Vol 12 (4) ◽  
pp. 157-169 ◽  
Author(s):  
Philip L. Roth ◽  
Allen I. Huffcutt
Keyword(s):  
Cognitive Ability ◽  
Meta Analysis ◽  
Incremental Validity ◽  
Employment Interviews ◽  
Moderator Analysis ◽  
The Future ◽  
Research Questions ◽  
Meta Analyses ◽  
The Relationship

The topic of what interviews measure has received a great deal of attention over the years. One line of research has investigated the relationship between interviews and the construct of cognitive ability. A previous meta-analysis reported an overall corrected correlation of .40 ( Huffcutt, Roth, & McDaniel, 1996 ). A more recent meta-analysis reported a noticeably lower corrected correlation of .27 ( Berry, Sackett, & Landers, 2007 ). After reviewing both meta-analyses, it appears that the two studies posed different research questions. Further, there were a number of coding judgments in Berry et al. that merit review, and there was no moderator analysis for educational versus employment interviews. As a result, we reanalyzed the work by Berry et al. and found a corrected correlation of .42 for employment interviews (.15 higher than Berry et al., a 56% increase). Further, educational interviews were associated with a corrected correlation of .21, supporting their influence as a moderator. We suggest a better estimate of the correlation between employment interviews and cognitive ability is .42, and this takes us “back to the future” in that the better overall estimate of the employment interviews – cognitive ability relationship is roughly .40. This difference has implications for what is being measured by interviews and their incremental validity.

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