scholarly journals Secondary Alopecia Neoplastica Mimicking Alopecia Areata following Breast Cancer

2020 ◽  
Vol 13 (2) ◽  
pp. 627-632
Author(s):  
Efthymia Skafida ◽  
Ioanna Triantafyllopoulou ◽  
Ioannis Flessas ◽  
Michael Liontos ◽  
Konstantinos Koutsoukos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alopecia Areata ◽  
Private Practice ◽  
Skin Lesions ◽  
Cutaneous Metastases ◽  
Gastrointestinal Metastasis ◽  
Lobular Cancer ◽  
History Of ◽  
Uncommon Case ◽  
Metastatic Sites

Cutaneous metastases from visceral carcinomas are relatively uncommon, with an overall incidence ranging from 0.7 to 9%. Diagnosis of scalp metastases usually escapes clinicians and dermatologists due to the fact that these metastases are mimicking other benign dermatological conditions. Herein, we present an uncommon case of scalp alopecia neoplastica mimicking alopecia areata due to breast cancer; a 43-year-old woman diagnosed with lobular cancer 3 years previously presented with acute loss of hair in well-circumscribed areas of the scalp and was diagnosed with alopecia areata by a private-practice dermatologist. She was then reevaluated, and due to her history of breast cancer, a biopsy from the scalp was performed and revealed alopecia neoplastica. At the same time that the skin lesions were recognized as disease involvement, the patient presented with dyspepsia, and endoscopy of the upper and lower gastrointestinal tract also revealed metastasis to the stomach and bowel. Gastrointestinal metastasis may occur with several types of cancer, but the stomach and bowel are rare metastatic sites for breast cancer.

Cutaneous Metastases in Patients with Rectal Cancer: A Report of Six Cases

2008 ◽  
Vol 74 (2) ◽  
pp. 138-140 ◽  
Author(s):  
Leo M. Gazoni ◽  
Traci L. Hedrick ◽  
Philip W. Smith ◽  
Charles M. Friel ◽  
Brian R. Swenson ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cause Of Death ◽  
Metastatic Disease ◽  
Retrospective Review ◽  
Skin Lesions ◽  
Rectal Tumor ◽  
Cutaneous Metastases ◽  
History Of ◽  
Disseminated Disease ◽  
Visceral Malignancy

Cutaneous metastases from rectal cancer are rare manifestations of disseminated disease and uniformly represent dismal survival. A retrospective review of six patients with rectal cancer metastatic to the dermis was performed. The diagnosis of rectal cancer was made concurrently with the diagnosis of the dermal metastases in all six patients. A 100 per cent histopathologic concordance existed between the tissue of the dermal metastases and primary rectal tumor. The progression of systemic metastatic disease was the cause of death in 83.3 per cent of patients (5/6). No patient survived more than 7 months from the time of diagnosis. Recognition of suspicious skin lesions as possible harbingers of undiagnosed visceral malignancy is important in managing patients both with and without a history of previous cancer.

Multiple, disseminated cutaneous metastases of vulvar squamous cell carcinoma

2004 ◽  
Vol 14 (2) ◽  
pp. 384-387
Author(s):  
F. Ghaemmaghami ◽  
M. Modares ◽  
N. Behtash ◽  
A. Z. Moosavi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Lesions ◽  
External Beam Radiation ◽  
Cutaneous Metastases ◽  
Beam Radiation ◽  
Chemotherapy Drugs ◽  
Inguinal Lymphadenectomy ◽  
History Of

Cutaneous metastases of vulvar carcinoma are extremely rare and have been reported in six patients so far. Our patient, who is the seventh one, is a 38-year-old woman with a history of diabetes mellitus.After detecting stage III squamous cell carcinoma of the vulva, she underwent radical vulvectomy and bilateral inguinal lymphadenectomy. She received 6000 cGy external beam radiation for positive margins. Six months later, she came back with multiple advanced skin lesions. Biopsy was performed and lesions were confirmed as cutaneous metastases.For her palliation, some chemotherapy drugs were prescribed. She is on her sixth chemotherapy cycle, but these skin lesions are somewhat a preterminal event and there is no well-established treatment for this phase of disease.

Prostate adenocarcinoma and cutaneous metastases

2020 ◽  
pp. 205141582095475
Author(s):  
Jeff John ◽  
Tanya Wantenaar ◽  
John Lazarus ◽  
Ken Kesner
Keyword(s):  
Prostate Cancer ◽  
Skin Lesions ◽  
Prostate Adenocarcinoma ◽  
Cutaneous Lesions ◽  
Cutaneous Metastases ◽  
Primary Malignancy ◽  
Level Of Evidence ◽  
History Of ◽  
Adenocarcinoma Of The Prostate ◽  
Nodular Lesions

Prostate cancer is the second most frequently diagnosed cancer in men and the fifth leading cause of mortality worldwide. Men of African descent with prostate adenocarcinoma tend to present late with advanced, aggressive and often metastatic disease. Cutaneous metastases are extremely rare, with the incidence reported to be as low as 0.36%. We report a case of prostate adenocarcinoma with cutaneous metastases. A 69-year-old African male known to the urology unit, with metastatic adenocarcinoma of the prostate, presented with a two-week history of pale-to-purple large nodular lesions on the skin of his left hemiscrotum and smaller nodules on the penile shaft. Punch biopsies of the scrotal nodules revealed metastatic prostate adenocarcinoma. Bilateral orchidectomy and excision of the cutaneous lesions were performed. Although cutaneous metastases are rare, more so in patients with adenocarcinoma of the prostate, any skin lesions in patients with a known primary malignancy should raise a suspicion of metastasis. All physicians should therefore have a low threshold for the biopsy of any unusual skin lesion in patients with known prostate cancer. Level of evidence: 5.

scholarly journals Lower Extremity Cutaneous Lesions as the Initial Presentation of Metastatic Adenocarcinoma of the Colon

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Dhyan Rajan ◽  
Mitanshu Shah ◽  
Pooja Raghavan ◽  
Shanza Mujeeb ◽  
Sadat Rashid ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Metastatic Disease ◽  
Skin Lesions ◽  
Initial Presentation ◽  
Cutaneous Lesions ◽  
Cutaneous Metastases ◽  
Surgical Incision ◽  
History Of ◽  
Adenocarcinoma Of The Colon ◽  
New Skin

Cutaneous metastases from colorectal cancers are rare and are usually present on the abdominal wall or previous surgical incision sites. Remote cutaneous lesions have been reported, however, often occur in the setting of widespread metastatic disease including other visceral secondaries. We present a case of lower extremity cutaneous metastases as the first sign of metastatic disease in a patient with adenocarcinoma of the colon. This case illustrates that new skin lesions may be the initial presentation of metastatic disease in a patient with a history of cancer.

Unusual Presentation of Breast Metastasis Mimicking Skin Abscess

2020 ◽  
Author(s):  
Armaghan Kazeminejad ◽  
Mohammad Jafar Ghahari ◽  
Ali Mirabi ◽  
Lotfollah Davoodi ◽  
Mohammad Tabarestani
Keyword(s):  
Breast Cancer ◽  
Clinical Presentation ◽  
Left Breast ◽  
Breast Metastasis ◽  
Common Site ◽  
Cutaneous Metastases ◽  
Invasive Ductal Breast Carcinoma ◽  
Erythrocyte Sedimentation ◽  
History Of ◽  
One Year

The primary malignant tumor that most commonly metastasizes to the skin in women is breast cancer and manifest variety forms of clinical presentation. Breast cancer has the ability to metastasize to any site such as the ovaries, lung, liver, bone, brain, gastrointestinal tract and skin. The skin is not a common site for metastatic spread. We would like to report a case of a 56 years old female patient with an infectious mass in her left inframammary fold with discharge. The patients had a one-year history of left breast pruritus and with a mass which increased in size over two months. There was axillary lymphadenopathy, tenderness, and erythema of breast skin around the mass in the physical examination and just elevated erythrocyte sedimentation rate in laboratory tests. The patient did not benefit from antimicrobial therapy. The histological examination revealed a tumor with sheets of malignant cells and many necrotic areas. The diagnosis was invasive ductal breast carcinoma, cutaneous metastases, and lymphatic embolization.

scholarly journals Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of 6% Miltefosine Solution, a Topical Chemotherapy in Cutaneous Metastases From Breast Cancer

2001 ◽  
Vol 19 (21) ◽  
pp. 4150-4159 ◽  
Author(s):  
R. Leonard ◽  
J. Hardy ◽  
G. van Tienhoven ◽  
S. Houston ◽  
P. Simmonds ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Failure ◽  
Palliative Treatment ◽  
Skin Lesions ◽  
Phase Iii ◽  
Depth Of Invasion ◽  
Cutaneous Metastases ◽  
Double Blind ◽  
Skin Reactions ◽  
Double Blind Placebo

PURPOSE: To compare 6% miltefosine solution (Miltex; Asta Medica, Frankfurt, Germany), a new topical cytostatic drug, with placebo as palliative treatment for cutaneous metastases from breast cancer. PATIENTS AND METHODS: In a double-blind, placebo-controlled, multicenter phase III study, a total of 52 patients with inoperable progressive skin lesions from histologically or cytologically confirmed breast cancer, not manageable by radiotherapy or systemic treatment, with superficial or flat skin lesions (estimated depth of invasion ≤ 1 cm) were randomized to receive either 6% miltefosine solution or placebo. The solution was applied at the dose of 2 drops/10 cm2, once daily during the first week and twice daily thereafter until treatment failure. RESULTS: Treatment groups were well balanced for patient characteristics at study entry except for a small difference in age. Time to treatment failure (TTF), the primary parameter of this study, showed miltefosine solution to be significantly superior to placebo (P = .007); the median TTF in the miltefosine solution group was nearly three times longer than that in the placebo group (56 days v 21 days). The rate of response based on intention to treat patients was 33.3% for miltefosine solution compared with 3.7% for placebo (P = .006). Cutaneous reactions were seen mainly in the miltefosine group, with the type and frequency similar to those observed in previous studies. CONCLUSION: 6% Miltefosine solution is confirmed as an effective palliative treatment option for cutaneous metastases from breast cancer. Skin reactions, when present, are well tolerated and only occasionally require cessation of treatment.

A Rare Case of Spinal Leprosy Mimicking Spinal Tuberculosis

2019 ◽  
pp. 33
Author(s):  
K Thuraikumar ◽  
V Naveen ◽  
Mustaqim A ◽  
Arieff AA ◽  
K Shri ◽  
...  
Keyword(s):  
Back Pain ◽  
Soft Tissue ◽  
Histopathological Examination ◽  
Posterior Instrumentation ◽  
Spinal Tuberculosis ◽  
Previous History ◽  
Skin Lesions ◽  
Titanium Implants ◽  
Paravertebral Abscess ◽  
History Of

Introduction: Spinal tuberculosis is the most common manifestation of extrapulmonar y tuberculosis. A combination of leprosy and tuberculosis is a rare entity.Case report: A 44-year-old male patient working as a laborer presented to our hospital with complaints of severe back pain and swelling over the back, difficulty in walking, associated with constitutional symptoms. On admission, he was febrile and had leukocytosis. Initial spine X-ray showed end plate destruction and increase in soft tissue shadow at the level of T8-T9. CT spine revealed thoracic paravertebral collection extending from T7 to T9 levels, suggest ive of tuberculous spondylitis with cold abscess. Patient refused a transpedicular biopsy and was started on anti-tubercular therapy. Two weeks after commencement of treatment, he developed worsening back pain and weakness of the lower extremities. MRI spine showed a paravertebral abscess and posterior soft tissue edema involving level of T7 to T11. Patient underwent a posterior decompression, debridement and posterior instrumentation. He was discharged well, there was improvement of his lower limb power. Upon clinic review, he complained of multiple hyperpigmented, painless, nonpruritic skin lesions over the trunk and back. No previous history of eczema, psoriasis and Tinea corporis. Given the history of allergy, initial impression was hypersensitivity reaction towards the titanium implants, and he was started on anti-histamines. However, there was no improvements seen. Histopathological examination of skin lesions revealed presence of granuloma within the dermis layer, composed of epitheloid, histiocytes, lymphocytes and plasma cells. Wade-Fite stain for Mycobacterium leprae is positive. Slit skin smear shows multibacillary leprosy. Patient was started on multidrug therapy (rifampicin, clofazimine and dapsone) for 1 year. He has recovered well.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 33

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