scholarly journals Regenerative Role of Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury

Nephron ◽  
2020 ◽  
Vol 144 (12) ◽  
pp. 638-643
Author(s):  
Davide Medica ◽  
Sergio Dellepiane ◽  
Vincenzo Cantaluppi
Keyword(s):  
Acute Kidney Injury ◽  
Clinical Trials ◽  
Extracellular Vesicles ◽  
Therapeutic Option ◽  
Kidney Injury ◽  
Glomerular Injury ◽  
Paracrine Factors ◽  
Short And Long Term

Acute kidney injury (AKI) is a frequent complication of hospital admission and worsens short- and long-term patients’ prognosis. Currently, AKI treatment remains supportive and no therapy has proven significant benefit in clinical trials. Stem cells (SCs) are a promising therapeutic option, but their translation to the clinical setting is limited by the risk of rejection or aberrant differentiation. Numerous studies have shown how SC effects are mediated by paracrine factors such as extracellular vesicles (EVs). In this review, we describe the preclinical evidence about EV efficacy in acute tubular and glomerular injury and the recently generated clinical data.

Short- and Long-term Outcomes of Kidney Transplants From Very Small (≤15 kg) Pediatric Donors With Acute Kidney Injury

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Christoph Troppmann ◽  
Chandrasekar Santhanakrishnan ◽  
Ghaneh Fananapazir ◽  
Junichiro Sageshima ◽  
Kathrin M. Troppmann ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Kidney Transplants ◽  
Long Term Outcomes ◽  
Short And Long Term ◽  
Pediatric Donors

Acute Kidney Injury following Cardiac Surgery

2015 ◽  
pp. 451-480
Author(s):  
Bryan Romito ◽  
Joseph Meltzer
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Surgical Techniques ◽  
Kidney Injury ◽  
Renal Physiology ◽  
General Management ◽  
Novel Biomarkers ◽  
Short And Long Term ◽  
And Function

The primary goal of this chapter is to provide the reader with an overview of basic renal physiology and function and to review the identification, pathogenesis, and treatment of acute kidney injury following cardiac surgery. Particular focus will be directed toward the diagnostic criteria for acute kidney injury, short- and long-term impacts on patient outcomes, role of novel biomarkers, mechanisms of acute renal injury, general management principles, preventative strategies, and the influence of anesthetic and surgical techniques on its development. The content of this chapter will serve to underscore a particularly harmful but likely underappreciated problem affecting patients in the cardiothoracic critical care setting.

scholarly journals Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy

2019 ◽  
Vol 35 (3) ◽  
pp. 477-483 ◽  
Author(s):  
Francesco Cavallin ◽  
Giulia Rubin ◽  
Enrico Vidal ◽  
Elisa Cainelli ◽  
Luca Bonadies ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hypoxic Ischemic Encephalopathy ◽  
Prognostic Role ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Ischemic Encephalopathy

scholarly journals Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1240 ◽  
Author(s):  
Grange ◽  
Skovronova ◽  
Marabese ◽  
Bussolati
Keyword(s):  
Clinical Trials ◽  
Stem Cell ◽  
Extracellular Vesicles ◽  
Therapeutic Option ◽  
Genetic Material ◽  
Kidney Injury ◽  
Convincing Evidence ◽  
Apoptosis And Inflammation ◽  
Injury Models ◽  
New Strategies

Extracellular vesicles (EVs) are membranous vesicles containing active proteins, lipids, and different types of genetic material such as miRNAs, mRNAs, and DNAs related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. In fact, several reports provide convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells (MSCs) in different kidney injury models. Described mechanisms involve the reprogramming of injured cells, cell proliferation and angiogenesis, and inhibition of cell apoptosis and inflammation. Besides, the therapeutic use of MSC-EVs in clinical trials is under investigation. This review will focus on MSC-EV applications in preclinical models of acute and chronic renal damage including recent data on their use in kidney transplant conditioning. Moreover, ongoing clinical trials are described. Finally, new strategies to broaden and enhance EV therapeutic efficacy by engineering are discussed.

scholarly journals Contrast-Induced Acute Kidney Injury: Short- and Long-Term Implications

2011 ◽  
Vol 31 (3) ◽  
pp. 300-309 ◽  
Author(s):  
Steven D. Weisbord ◽  
Paul M. Palevsky
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Short And Long Term

scholarly journals Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Fei Zhao ◽  
Li-Xin Feng ◽  
Qian Liu ◽  
Hong-Shen Wang ◽  
Cheng-Yuan Tang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Quality Control ◽  
Kidney Injury ◽  
Protective Role ◽  
Mitochondrial Quality Control ◽  
Therapy Strategy ◽  
Nrf2 Signaling Pathway ◽  
Short And Long Term ◽  
Renal Tubular

Contrast-induced acute kidney injury (CI-AKI) is the third common cause of acute kidney injury (AKI), which is associated with poor short- and long-term outcomes. Currently, effective therapy strategy for CI-AKI remains lacking. Stanniocalcin-1 (STC1) is a conserved glycoprotein with antiapoptosis and anti-inflammatory functions, but the role of STC1 in controlling CI-AKI is unknown. Here, we demonstrated a protective role of STC1 in contrast-induced injury in cultured renal tubular epithelial cells and CI-AKI rat models. Recombinant human STC1 (rhSTC1) regulated mitochondrial quality control, thus suppressing contrast-induced mitochondrial damage, oxidative stress, inflammatory response, and apoptotic injury. Mechanistically, activation of the Nrf2 signaling pathway contributes critically to the renoprotective effect of STC1. Together, this study demonstrates a novel role of STC1 in preventing CI-AKI and reveals Nrf2 as a molecular target of STC1. Therefore, this study provides a promising preventive target for the treatment of CI-AKI.

scholarly journals Influence of acute kidney injury on short- and long-term outcomes in patients undergoing cardiac surgery: risk factors and prognostic value of a modified RIFLE classification

Critical Care ◽  
2013 ◽  
Vol 17 (6) ◽  
pp. R293 ◽  
Author(s):  
Juan C Lopez-Delgado ◽  
Francisco Esteve ◽  
Herminia Torrado ◽  
David Rodríguez-Castro ◽  
Maria L Carrio ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Prognostic Value ◽  
Kidney Injury ◽  
Long Term Outcomes ◽  
Rifle Classification ◽  
Short And Long Term

scholarly journals Acute Kidney Injury Definition and Diagnosis: A Narrative Review

2018 ◽  
Vol 7 (10) ◽  
pp. 307 ◽  
Author(s):  
Joana Gameiro ◽  
Jose Agapito Fonseca ◽  
Sofia Jorge ◽  
Jose Lopes
Keyword(s):  
Acute Kidney Injury ◽  
Treatment Strategies ◽  
Kidney Injury ◽  
Diagnostic Methods ◽  
Common Diagnosis ◽  
Patients At Risk ◽  
Short And Long Term ◽  
Patient Prognosis ◽  
Care Costs

Acute kidney injury (AKI) is a complex syndrome characterized by a decrease in renal function and associated with numerous etiologies and pathophysiological mechanisms. It is a common diagnosis in hospitalized patients, with increasing incidence in recent decades, and associated with poorer short- and long-term outcomes and increased health care costs. Considering its impact on patient prognosis, research has focused on methods to assess patients at risk of developing AKI and diagnose subclinical AKI, as well as prevention and treatment strategies, for which an understanding of the epidemiology of AKI is crucial. In this review, we discuss the evolving definition and classification of AKI, and novel diagnostic methods.

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