scholarly journals Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor FcγRIIIb

2021 ◽  
pp. 1-4
Author(s):  
Beatriz Valle Del Barrio ◽  
Silvia Maya-Enero ◽  
J.J. Rodríguez-Sevilla ◽  
Carme Canals Surís ◽  
Alba Bosch Llobet ◽  
...  
Keyword(s):  
Case Report ◽  
Birth Weight ◽  
Skin Infections ◽  
Igg Antibodies ◽  
Immunofluorescence Test ◽  
Maternal Hypertension ◽  
Severe Infections ◽  
Immune Neutropenia ◽  
Neonatal Neutropenia ◽  
Rule Out

Introduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions. Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an FcγRIIIb deficiency. The father was 1(a+b+c–) and the neonates were 1(a–b+c–). A strongly positive result was observed in the granulocyte immunofluorescence test against paternal neutrophils (IgG antibodies). IgG anti-CD16b isoantibodies were detected in the mother’s breast milk. Neutropenia resolved after 28 days without requiring any specific treatments. Discussion: Even though neonatal alloimmune neutropenia (NAN) is usually benign and self-limiting, some patients pre­sent with delayed separation of the umbilical cord, mild skin infections, omphalitis, or severe infections like pneumonia, sepsis, and meningitis. Thus, it is important to rule out NAN in case of neonatal neutropenia.

Effect of Maternal Hypertension on Neonatal Neutropenia and Risk of Nosocomial Infection

PEDIATRICS ◽  
1992 ◽  
Vol 90 (3) ◽  
pp. 430-435
Author(s):  
Ana Mouzinho ◽  
Charles R. Rosenfeld ◽  
Pablo J. Sanchez ◽  
Rick Risser
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nosocomial Infection ◽  
Prospective Study ◽  
Gestational Age ◽  
Pregnancy Induced Hypertension ◽  
Increased Risk ◽  
Induced Hypertension ◽  
Maternal Hypertension ◽  
Neonatal Neutropenia

Neonatal neutropenia occurs in ∼50% of newborns delivered by women with pregnancy-induced hypertension. It is thought to be transient, independent of birth weight and gestational age, and unassociated with significant risks, including infection. It recently was suggested that neonatal neutropenia occurs primarily in smaller, younger neonates, is related to the severity of pregnancy-induced hypertension, and importantly, may be associated with an increased risk for nosocomial infection. We examined these points in a large inborn population in consecutive years, performing retrospective (n = 110, 1989) and prospective (n = 151, 1990) studies in low birth weight (≤2200 g) neonates delivered by women with pregnancy-induced hypertension. Overall, 40% to 50% of neonates studied developed neonatal neutropenia, and they were younger and smaller (P < .01) than non-neutropenic neonates. In the prospective study, neutropenic neonates were more likely to have mothers with severe pregnancy-induced hypertension (P < .001), and the incidence of neonatal neutropenia was primarily among neonates <30 weeks of gestation and <1500 g birth weight, ∼80% vs 35% to 45% in older, larger neonates or infants (P < .001). Although nosocomial infection occurred more frequently among the group of neutropenic neonates in the prospective study (P < .02), the incidence was similar to that in matched non-neutropenic controls delivered of normotensive women. Thrombocytopenia (<100 000/mm3) was not more frequent in neutropenic neonates. Although neonatal neutropenia occurs in 40% to 50% of low birth weight neonates from pregnancies complicated by pregnancy-induced hypertension, this primarily reflects an incidence of 80% among neonates <30 weeks gestation. There is no apparent increased risk for development of nosocomial infection or thrombocytopenia.

Postnatally acquired CMV meningitis diagnosed via BioFire FilmArray: A case report

2020 ◽  
pp. 1-6
Author(s):  
A. Stark ◽  
J. Peterson ◽  
K. Weimer ◽  
C. Hornik
Keyword(s):  
Case Report ◽  
Birth Weight ◽  
Breast Milk ◽  
Premature Infants ◽  
Gold Standard ◽  
Very Low Birth Weight ◽  
Definitive Treatment ◽  
Cmv Infection ◽  
Term Infants ◽  
Low Birth Weight Infant

Postnatally acquired cytomegalovirus (CMV) is commonly acquired via breast milk, with premature infants more frequently developing symptoms of CMV infection in comparison to term infants. Meningitis is a rare clinical manifestation of CMV infection. The diagnosis of meningitis is difficult to make in infants, particularly those who are preterm. Consequentially, broad-spectrum empiric antimicrobial coverage is often administered for several days while waiting for current gold standard CSF testing to result. The BioFire FilmArray (BFA) simultaneously tests for 14 different pathogens, including CMV, allowing for quicker diagnosis and shorter time to definitive treatment. Here, we report a very low birth weight infant with postnatally acquired CMV meningitis, the first to our knowledge to be diagnosed using the BioFire FilmArray.

scholarly journals Osteoporosis-Related Simultaneous Four Joints Fractures and Dislocation after a Seizure: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4
Author(s):  
Abdullah S. AlOmran
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Clinical Examination ◽  
Epileptic Seizures ◽  
Antiresorptive Therapy ◽  
Multiple Fractures ◽  
Steroid Use ◽  
Skeletal Injury ◽  
History Of ◽  
Rule Out

A case of steroid-induced osteoporosis-related multiple fractures and dislocations are described after a seizure is reported. Patient had two years history of steroid use with no supplement or antiresorptive therapy. There was a delay in the diagnosis which affected an otherwise good outcome in such situations. It is recommended that patients on steroid should be given calcium, vitamin D, and an antiresorptive. Furthermore, a meticulous clinical examination is required in patients who are on steroids and suffer epileptic seizures to rule out skeletal injury.

scholarly journals Neurocysticercosis presenting as bipolar disorder: a case report

2021 ◽  
Vol 34 (6) ◽  
pp. e100663
Author(s):  
Surbhi Batra ◽  
Sumit Kumar ◽  
Lokesh Singh Shekhawat
Keyword(s):  
Bipolar Disorder ◽  
Case Report ◽  
Depressive Symptoms ◽  
Affective Disorder ◽  
Postpartum Period ◽  
Bipolar Affective Disorder ◽  
Taenia Solium ◽  
Manic Episode ◽  
Symptoms And Signs ◽  
Rule Out

Neurocysticercosis is the most common neuro-parasitosis caused by the larval stage of Taenia solium. The most common manifestations include seizures and hydrocephalus. Psychiatric abnormalities are relatively rare but depressive symptoms are frequent in patients with neurocysticercosis. However, mania as a presentation is relatively rare. Pregnancy and the postpartum period are relatively vulnerable times and they can lead to reactivation of existing neurocysterci lesions. We are discussing the case of a 23-year-old female patient with neurocysticercosis leading to the reactivation of lesions in the peripartum and postpartum period leading to bipolar affective disorder. Improvement in the patient was seen with a combination of antipsychotics, antihelmintics, antiepileptics and steroids, along with improved radiological signs of neurocysterci lesions. Although neurocysticercosis is a common illness, its prevalence presenting as a manic episode is merely 2.6% and, hence, missed easily. Therefore, it is important to rule out organic aetiology in patients even with a classic presentation of bipolar affective disorder and those having any other neurological symptoms and signs.

scholarly journals Cone beam-computed tomography as an indispensable tool in the management of radiculous premolar: a case report

2016 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Shristhi Sharma ◽  
Ananth Raghav Sharma ◽  
Vivek Kumar Rai ◽  
Ronak Choudhary
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Cone Beam Computed Tomography ◽  
Anatomical Variations ◽  
Endodontic Treatment ◽  
Cone Beam ◽  
Internal Anatomy ◽  
Indispensable Tool ◽  
Rule Out

Background: Internal anatomy of maxillary first premolars is particularly multifaceted on account of the variation in number of roots and canal configuration. Maxillary first premolars with 3 roots are called as small molar or “radiculous” because of their similar anatomy to the maxillary first molars. The most demanding step in endodontic treatment is identification and proper access to pulp canals of certain teeth with atypical canal configurations. Methods of identification of such premolars can be by various aides.Case Presentation: The present case describes the application of Cone Beam-Computed Tomography in the diagnosis of extra root with extra canal in a three rooted maxillary right first premolar.Conclusions: Proper knowledge of the anatomical variations is a must for an endodontist to make a treatment successful. Utilizing the latest technology along with the traditional concepts can surely rule out the inaccuracy in the treatment involved in such cases.

scholarly journals Case Report: A rare cause of oral bullae: Angina bullosa hemorrhagica

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1974 ◽  
Author(s):  
Salih Levent Cinar ◽  
Demet Kartal ◽  
Özlem Canöz ◽  
Murat Borlu ◽  
Ayten Ferahbas
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Hematological Disorders ◽  
Benign Disorder ◽  
Proper Diagnosis ◽  
Rule Out

Angina bullosa hemorrhagica (ABH) is a benign disorder of the oral cavity. Clinically, oral, blood-filled blisters are seen. To give a proper diagnosis, one should rule out any other cause. We aim to present this case in order to emphasize this rare cause of oral bullae which is necessary to be differentiated from many serious dermatological and hematological disorders.

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