scholarly journals Dietary and Genetic Effects on LDL Size Measures in Baboons

1996 ◽  
Vol 16 (12) ◽  
pp. 1448-1453 ◽  
Author(s):  
Amareshwar T.K. Singh ◽  
David L. Rainwater ◽  
Candace M. Kammerer ◽  
R. Mark Sharp ◽  
Mahmood Poushesh ◽  
...  

Genetic and dietary effects on LDL phenotypes, including predominant LDL particle diameter, LDL size distribution, and non–HDL cholesterol and apoB concentrations, were investigated in 150 pedigreed baboons that are members of 19 sire groups. Baboons were fed a sequence of three defined diets differing in levels of fat and cholesterol. Increasing dietary fat had relatively little effect on two measures of LDL particle size. However, increasing the level of cholesterol in the diet resulted in larger increases of the predominant LDL particle diameters and in the proportion of stain on LDLs >28 nm. As expected, apoB and non–HDL cholesterol concentrations significantly increased when levels of dietary fat and cholesterol were increased. Correlations among the LDL phenotypes suggested that several different aspects of the LDL phenotype were captured by the four LDL measures across the three diets. Genetic effects indicated by sire group membership were significant both for expression of the LDL phenotypes and for response to changes in diet.

Author(s):  
S. Cazares ◽  
J. A. Barrios ◽  
C. Maya ◽  
G. Velásquez ◽  
M. Pérez ◽  
...  

Abstract An important physical property in environmental samples is particle size distribution. Several processes exist to measure particle diameter, including change in electrical resistance, blocking of light, the fractionation of field flow and laser diffraction (these being the most commonly used). However, their use requires expensive and complex equipment. Therefore, a Digital Microscopic Imaging Application (DMIA) method was developed adapting the algorithms used in the Helminth Egg Automatic Detector (HEAD) software coupled with a Neural Network (NN) and Bayesian algorithms. This allowed the determination of particle size distribution in samples of waste activated sludge (WAS), recirculated sludge (RCS), and pretreated sludge (PTS). The recirculation and electro-oxidation pre-treatment processes showed an effect in increasing the degree of solubilization (DS), decreasing particle size and breakage factor with ranges between 44.29%, and 31.89%. Together with a final NN calibration process, it was possible to compare results. For example, the 90th percentile of Equivalent Diameter (ED) value obtained by the DMIA with the corresponding result for the laser diffraction method. DMIA values: 228.76 μm (WAS), 111.18 μm (RCS), and 84.45 μm (PTS). DMIA processing has advantages in terms of reducing complexity, cost and time, and offers an alternative to the laser diffraction method.


2013 ◽  
Vol 6 (3) ◽  
pp. 4123-4152 ◽  
Author(s):  
Y. Cai ◽  
J. R. Snider ◽  
P. Wechsler

Abstract. This work describes calibration methods for the particle sizing and particle concentration systems of the passive cavity aerosol spectrometer probe (PCASP). Laboratory calibrations conducted over six years, in support of the deployment of a PCASP on a cloud physics research aircraft, are analyzed. Instead of using the many calibration sizes recommended by the PCASP manufacturer, a relationship between particle diameter and scattered light intensity is established using three sizes of mobility-selected polystyrene latex particles, one for each amplifier gain stage. In addition, studies of two factors influencing the PCASP's determination of the particle size distribution – amplifier baseline and particle shape – are conducted. It is shown that the PCASP-derived size distribution is sensitive to adjustments of the sizing system's baseline voltage, and that for aggregate spheres, a PCASP-derived particle size and a sphere-equivalent particle size agree within uncertainty dictated by the PCASP's sizing resolution. Robust determination of aerosol concentration, and size distribution, also require calibration of the PCASP's aerosol flowrate sensor. Sensor calibrations, calibration drift, and the sensor's non-linear response are documented.


2020 ◽  
Vol 142 (7) ◽  
Author(s):  
Pei Fu ◽  
Yuansheng Song ◽  
Jian Yang ◽  
Qiuwang Wang

Abstract Gradient particle size anode has shown great potential in improving the electrical performance of anode-supported solid oxide fuel cells (SOFCs). In this study, a 3D comprehensive model is established to study the effect of various gradient particle size distribution on the cell electrical performance for the anode microstructure optimization. The effect of homogeneous particle size on the cell performance is studied first. The maximum current density of homogeneous anode SOFC is obtained for the comparison with the electrical performance of gradient anode SOFC. Then the effect of various gradient particle size distribution on the cell molar fraction, polarization losses, and electronic current density distribution is analyzed and discussed in detail. Results show that increasing the particle diameter gradient can effectively reduce the anodic concentration overpotential. Decreasing the particle diameter of anode functional layer 2 is beneficial for reducing the activation and ohmic overpotentials. On these bases, the comprehensive electrical performance of SOFCs with gradient particle size anode and homogeneous anode is compared to highlight the optimal gradient particle diameter distribution. In the studied cases of this work, the gradient particle diameter of 0.7 μm, 0.4 μm, and 0.1 μm at anode support layer (ASL), anode functional layer 1, and anode functional layer 2 (case 3) is the optimal particle size distribution.


2010 ◽  
Vol 21 (6) ◽  
pp. 676-680 ◽  
Author(s):  
Masatoshi Akashi ◽  
Tsukasa Otani ◽  
Atsuko Shimosaka ◽  
Yoshiyuki Shirakawa ◽  
Jusuke Hidaka

2001 ◽  
Vol 44 (4) ◽  
pp. 24-27 ◽  
Author(s):  
David Ensor ◽  
Jenni Elion ◽  
Jan Eudy

The Helmke Drum test method to measure particles shed from garments was developed twenty years ago. It consists of a tumbling drum containing the garment under test. A probe connected to an optical particle counter is used to transport the sample from the drum. Dilution air is drawn into the drum from the surrounding cleanroom. The optical particle counters at the time of development were limited in resolution to 0.5 μm diameter. This particle size requirement is still in the current version of IEST-RP-CC003.2, Garment Systems Considerations for Cleanrooms and Other Controlled Environments. A question was raised in the current IEST Contamination Control Working Group 003, "Garment System Considerations for Cleanrooms and Other Controlled Environments," as to whether the method could be extended to smaller particle diameters. The method would benefit by including measurements of smaller particle diameters for two reasons: the higher particle counts expected for sub-0.5 μm particles might improve the statistics of the method; and there is a growing need to consider contamination by ultra-fine particles during the manufacture of high performance products. We hypothesized that the size distribution of particles released by garments follows a power law similar to that for cleanroom classes. The form of the power law distribution is N(d) = Ad(-B), where N(d) is the cumulative concentration greater to or equal to d, d is the particle diameter, and A and B are statistically determined coefficients. The size distributions from a number of Helmke Drum tests were analyzed and were found to be highly correlated to the power law equation. However, the slopes appeared to vary depending on the type of garment tested. These results support including guidance with respect to particle size in the Helmke Drum test section in the upcoming revision of IEST-RP-CC003.2.


2014 ◽  
Vol 70 (11) ◽  
pp. 1873-1879 ◽  
Author(s):  
G. Garofalo ◽  
M. Carbone ◽  
P. Piro

The study analyzed the particle size distribution of particulate matter (PM) retained in two catch basins located, respectively, near a parking lot and a traffic intersection with common high levels of traffic activity. Also, the treatment performance of a filter medium was evaluated by laboratory testing. The experimental treatment results and the field data were then used as inputs to a numerical model which described on a qualitative basis the hydrological response of the two catchments draining into each catch basin, respectively, and the quality of treatment provided by the filter during the measured rainfall. The results show that PM concentrations were on average around 300 mg/L (parking lot site) and 400 mg/L (road site) for the 10 rainfall-runoff events observed. PM with a particle diameter of <45 μm represented 40–50% of the total PM mass. The numerical model showed that a catch basin with a filter unit can remove 30 to 40% of the PM load depending on the storm characteristics.


2017 ◽  
Vol 899 ◽  
pp. 95-100
Author(s):  
Kássia Graciele dos Santos ◽  
L.V. Ferreira ◽  
Ricardo Correa Santana ◽  
Marcos Antonio de Souza Barrozo

Spouted bed simulations are usually performed using only one granular phase with a mean particle diameter representing the entire particle mixture, instead of a particle size distribution. In this study, the effect of the particle size distribution is accounted through the simulation of a mixture with five granular phases. The results showed that the particle segregation occurs. Larger particles are more concentrated in the upper region, while the smaller particles are preferably positioned in the lower region of the bed. Computational simulation using CFD method reproduced well the segregation experiments with different participle sizes of sand.


2020 ◽  
Vol 205 ◽  
pp. 03010
Author(s):  
Tiancheng Liang ◽  
Jinwei Zhang ◽  
Chuanyou Meng ◽  
Nailing Xiu ◽  
Bo Cai ◽  
...  

The conductivity of the proppant-packs is critical in the productivity of hydraulically fractured wells. Proppants are also the best medium for studying particle packing. Sand and ceramic media are two most common proppants used for hydraulic fracturing. This study focuses on investigate the relation between conductivity and properties of proppant-packs, the particle-size distribution, porosity and mean particle diameter have been measured. The porosity of the proppant pack under zero pressure is determined from bulk density and apparent density. To accurately measure the porosity under variable closed stress conditions, the compressed width was taken into consideration. The particle size distribution was measured from sieve analysis. The paper presents results obtained by conducting routine conductivity test on a variety of proppants. The conductivity-porosity relationships are nonlinear. The conductivity is most sensitive to mean grain size, followed by closed stress, and then sorting. Larger median diameter always correlates to higher conductivity at low stress. Loss of conductivity with stress is more severe for large particles sands than small particles. The binomial method can be used to calculate the conductivity of different types and mesh proppants, which is shown to fit conductivity-mean diameter data successfully. The research is of guiding significance to choose the proper size distribution proppants in hydraulic fracturing. Meanwhile, the binomial method is a better predictor of proppant-packs conductivity based on particle size distribution.


2013 ◽  
Vol 275-277 ◽  
pp. 2411-2414 ◽  
Author(s):  
Song Lin Yi ◽  
Zhi Ming Wang ◽  
Xian Zhong Yi ◽  
Wei Chang

The properties of particle size distribution of rock cuttings and its shape characteristics are the most important parameters to petroleum drilling engineering. The samples of rock drill-cuttings are collected from 7 wells within the depths of 3500 m in Liaohe Oilfield of China. The particle size distribution laws of these rock samples with the average diameter over 74 μm are analyzed. The result shows that the drill cuttings feature obvious sheet shape and the size distribution curve of the particles is mainly related to the formation rocks and drilling bits. While drilling at the well depths of between 0 and 2000m by the cone bits, particle size distribution of drill cuttings has a form of approximately power function, the probability particle diameter being 8.50~9.27 mm. Drilling at the depths of between 2000 and 2800 m by the cone bits, the size distribution of cuttings has a form of nearly function, the probability particle diameter being 3.04~4.67 mm. Drilling at the depths under 2800m by PDC bits, the size distribution has a form of nearly the Rayleigh distribution, the probability rock diameter being 0.91~0.94 mm.


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