Abstract 19204: Higher Physical Activity and Lower Sedentary Time are Associated With Less Insulin Resistance and Favorable Adipokine Profile: The Framingham Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Nicole L Spartano ◽  
Meredith D Stevenson ◽  
Vanessa Xanthakis ◽  
Martin G Larson ◽  
Charlotte Andersson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Fatty Acid ◽  
Metabolic Diseases ◽  
Sedentary Time ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Community Based ◽  
Cross Sectional ◽  
Fatty Acid Binding

Background: Physical activity (PA) and sedentary time (ST) are associated with metabolic diseases. More PA and less ST may also be associated with a more favorable adipokine profile and greater insulin sensitivity, even in the absence of weight loss. We tested this hypothesis by relating a comprehensive panel of adipokines in relation to accelerometry-determined PA measures in a community-based cohort. Methods: We assessed PA and ST using Actical accelerometers in 2109 participants from Framingham Heart Study Generation 3 and Omni 2 cohorts (mean age 40 y, 54% F) free of diabetes. Circulating adipokines, C-reactive protein (CRP), insulin-like growth factor (IGF)-1 and insulin resistance (HOMA-IR) were dependent variables, and steps/day, moderate to vigorous PA (MVPA), and ST/weartime were independent variables in multivariable regression analyses. We adjusted for cohort, age, sex, season of exam, overnight wear, residence (New England or other), body mass index (BMI), cardiovascular disease, hypertension, and smoking. Models for PA were also adjusted for ST, and models for ST also adjusted for MVPA. Results: Overall, 49% of participants met the PA Guidelines (>150 min/wk MVPA). Higher MVPA and more steps per day were associated with lower insulin resistance and CRP levels. More steps were also associated with lower leptin and higher IGF-1 levels. ST was positively associated with insulin resistance (p<0.001), but this relation was not significant after adjusting for MVPA. ST was associated with higher leptin, adipocyte fatty acid-binding protein (FABP)4 and retinol binding protein (RBP)4 levels. Conclusions: Our cross-sectional study of a community-based sample demonstrated associations of PA and ST with metabolic factors and several adipokines, after adjusting for BMI. These findings may provide clues linking PA to cardiometabolic risk by influencing insulin resistance and inflammation, compared to ST potentially modulating fatty acid binding proteins.

Abstract MP032: Greater Physical Activity Assessed by Accelerometry is Associated with Favorable Adipokine Profile in the Community: Cross-sectional Observations from The Framingham Third Generation Cohort

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Nicole L Glazer ◽  
Kerrie Nelson ◽  
Lisa M Sullivan ◽  
Joanne M Murabito ◽  
Ramachandran S Vasan
Keyword(s):  
Physical Activity ◽  
Binding Protein ◽  
Vigorous Physical Activity ◽  
Objective Assessment ◽  
Cardiometabolic Health ◽  
Study Cohort ◽  
Community Based ◽  
Cross Sectional ◽  
Fatty Acid Binding ◽  
Large Community

Background: Adipokines, produced by adipose tissues, contribute to the development of obesity-related metabolic traits. It is unclear, however, if greater physical activity favorably affects cardiometabolic profiles by influencing levels of key adipokines. We related physical activity, as measured by accelerometry, to circulating levels of novel adipokines, including retinol binding protein-4 (RBP4), adipocyte-fatty acid binding protein (A-FABP), adiponectin, leptin and leptin-receptor (LEP-R), in a large community-based sample. Methods: We evaluated 2063 participants in the 3rd generation Framingham Heart Study cohort (mean age 47 years, 55% female) who underwent objective assessment of moderate-to-vigorous physical activity (MVPA) by an accelerometer. MVPA was measured in total minutes, and in bouts ≥10 minutes (MVPA10) and nonbouts (MVPA<10 minutes). Blood adipokine levels were log-transformed and related to MVPA, using separate regression models for each adipokine, adjusted for age, sex, smoking, and season. Results: On average, participants engaged in 28 minutes/day of MVPA, 19 minutes/day of nonbout MVPA and 9 minutes/day of MVPA10. Mean adipokine levels were 40.7 ± 10.7 ng/ml for RBP-4, 18.6 ± 10.3 ng/ml for A-FABP, 11.4 ± 12.9 ng/ml for leptin, 19.6 ± 8.6 ng/ml for LEP-R, and 8.7 ± 5.5 ng/ml for adiponectin. Total MVPA, as well as MVPA10 and nonbout MVPA, were inversely related to leptin and A-FABP and positively associated with levels of adiponectin (See Table). The directionality of the observed associations - positive for adiponectin and negative for leptin and A-FABP- were consistent with greater physical activity being related to a more favorable cardiometabolic profile. Conclusions: In our cross-sectional study of a large community-based sample, both bout and nonbout MVPA were significantly related to a favorable adipokine profile. Additional longitudinal observations are warranted to assess if physical activity influences cardiometabolic health through alterations in adipokine levels.

scholarly journals Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients

2018 ◽  
Vol 25 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Riley Bove ◽  
Brain C Healy ◽  
Alexander Musallam ◽  
Pejvak Soltany ◽  
Camilo Diaz-Cruz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Disease Duration ◽  
Binding Protein ◽  
Longitudinal Models ◽  
Cross Sectional ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Multiple Sclerosis Patients

Background: Increased adiposity is a risk factor for multiple sclerosis (MS) and is associated with increased disability scores. Adipokines may mediate the effects of adiposity on MS disease course. Objective: The objective of this study is to examine the association between the adipokines (leptin and fatty acid binding protein-4, FABP4) and clinical course in individuals with MS. Methods: Subjects (18–65 years) with relapsing-remitting MS or clinically isolated syndrome and <10 year disease duration were selected from a longitudinal clinical study. Cross-sectional and longitudinal models assessed the relationship between two adipokines (leptin and FABP4) and disease severity in women and men, adjusting for age, disease duration and disease type, Vitamin D level, testosterone level, and as well by body mass index (BMI). Results: Mean age of subjects ( N = 163, 56% women) was 39.3 years. Higher FABP4 levels were associated with higher Expanded Disability Status Scale (EDSS) scores in women in both univariate and multivariate analyses (odds ratio: 1.30; p = 0.005). In men, higher FABP4 level was significantly associated with change in EDSS over time (estimate: 0.0062; p = 0.035). We found no association of FABP4 levels with time to next relapse or a measure of processing speed. Conclusion: FABP4 levels may be associated with increased disability in both men and women with MS independent of effects of BMI and other hormones. Future studies should expand these analyses and further explore downstream mechanisms of adiposity-related effects in MS.

scholarly journals Associations between Fatty Acid-Binding Protein 4–A Proinflammatory Adipokine and Insulin Resistance, Gestational and Type 2 Diabetes Mellitus

Cells ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 227 ◽  
Author(s):  
Marcin Trojnar ◽  
Jolanta Patro-Małysza ◽  
Żaneta Kimber-Trojnar ◽  
Bożena Leszczyńska-Gorzelak ◽  
Jerzy Mosiewicz
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Clinical Aspects ◽  
Diabetic Patients ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

There is ample scientific evidence to suggest a link between the fatty acid-binding protein 4 (FABP4) and insulin resistance, gestational (GDM), and type 2 (T2DM) diabetes mellitus. This novel proinflammatory adipokine is engaged in the regulation of lipid metabolism at the cellular level. The molecule takes part in lipid oxidation, the regulation of transcription as well as the synthesis of membranes. An involvement of FABP4 in the pathogenesis of obesity and insulin resistance seems to be mediated via FABP4-dependent peroxisome proliferator-activated receptor γ (PPARγ) inhibition. A considerable number of studies have shown that plasma concentrations of FABP4 is increased in obesity and T2DM, and that circulating FABP4 levels are correlated with certain clinical parameters, such as body mass index, insulin resistance, and dyslipidemia. Since plasma-circulating FABP4 has the potential to modulate the function of several types of cells, it appears to be of extreme interest to try to develop potential therapeutic strategies targeting the pathogenesis of metabolic diseases in this respect. In this manuscript, representing a detailed review of the literature on FABP4 and the abovementioned metabolic disorders, various mechanisms of the interaction of FABP4 with insulin signaling pathways are thoroughly discussed. Clinical aspects of insulin resistance in diabetic patients, including women diagnosed with GDM, are analyzed as well.

Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects

Metabolism ◽  
1999 ◽  
Vol 48 (5) ◽  
pp. 655-657 ◽  
Author(s):  
Tetsuo Hayakawa ◽  
Yukihiro Nagai ◽  
Erika Nohara ◽  
Haruhisa Yamashita ◽  
Toshinari Takamura ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Japanese Subjects
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