Abstract 14049: Correlation of Cellular Indices and D-dimer/fibrinogen Ratio to Gender Differences in 6-minute Walk Test Distance in Patients Presenting With Acute Pulmonary Embolism

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Nathalie Antonios ◽  
Dalila Masic ◽  
Katerina Porcaro ◽  
Sorcha Allen ◽  
Alexandru Marginean ◽  
...  
Keyword(s):  
Gender Differences ◽  
Pulmonary Embolism ◽  
Complete Blood Count ◽  
Walking Distance ◽  
Walk Test ◽  
Lymphocyte Ratio ◽  
Inflammatory State ◽  
Test Distance ◽  
Minute Walk ◽  
D Dimer

Introduction: The six-minute walk test (6MWT) is a simple and well-validated test to assess functional status and predict morbidity and mortality in several chronic cardiopulmonary disease states. Neutrophil to Lymphocyte ratio (NLR) reflects a pro inflammatory state. Increased platelet to lymphocyte ratio (PLR) has been associated with increase in thrombus burden. Elevated D-dimer to fibrinogen ratio (D/f) reflects fibrinolysis activation. No study has investigated the correlation of these indices with gender differences in 6MWT in patients presenting with pulmonary embolism (PE). Methods: We retrospectively evaluated all acute PE patients from our Pulmonary Embolism Response Team Registry who completed a 6MWT during their initial hospitalization. Differential complete blood count data along with d-dimer and fibrinogen were collected within 24 hours prior to PE diagnosis. Results: A total of 186 patients underwent baseline 6MWT and lab tests between March 2016 and January 2020. The mean walking distance for males (765 ft) was further than females (519 ft; figure 1). NLR, PLR, and D/f did not correlate with 6MWT in males. In females, NLR, PLR, and D/f had a negative correlation with walking distance (r = -0.20, p <0.05; r = -3.0, p<0.01; and r = -0.15, p<0.05; figure 2) Conclusions: Female patients, in our study, had significantly shorter walking distance after acute presentation in PE. This may reflect higher inflammatory and prothrombotic state. Future studies will need to expand on these findings.

scholarly journals Targeting Paretic Propulsion and Walking Speed With a Soft Robotic Exosuit: A Consideration-of-Concept Trial

2021 ◽  
Vol 15 ◽  
Author(s):  
Franchino Porciuncula ◽  
Teresa C. Baker ◽  
Dheepak Arumukhom Revi ◽  
Jaehyun Bae ◽  
Regina Sloutsky ◽  
...  
Keyword(s):  
Training Program ◽  
Walking Speed ◽  
Gait Training ◽  
Walking Distance ◽  
Walk Test ◽  
Long Distance ◽  
Trailing Limb Angle ◽  
Test Distance ◽  
6 Minute Walk Test ◽  
Minute Walk

Background: Soft robotic exosuits can facilitate immediate increases in short- and long-distance walking speeds in people with post-stroke hemiparesis. We sought to assess the feasibility and rehabilitative potential of applying propulsion-augmenting exosuits as part of an individualized and progressive training program to retrain faster walking and the underlying propulsive strategy.Methods: A 54-yr old male with chronic hemiparesis completed five daily sessions of Robotic Exosuit Augmented Locomotion (REAL) gait training. REAL training consists of high-intensity, task-specific, and progressively challenging walking practice augmented by a soft robotic exosuit and is designed to facilitate faster walking by way of increased paretic propulsion. Repeated baseline assessments of comfortable walking speed over a 2-year period provided a stable baseline from which the effects of REAL training could be elucidated. Additional outcomes included paretic propulsion, maximum walking speed, and 6-minute walk test distance.Results: Comfortable walking speed was stable at 0.96 m/s prior to training and increased by 0.30 m/s after training. Clinically meaningful increases in maximum walking speed (Δ: 0.30 m/s) and 6-minute walk test distance (Δ: 59 m) were similarly observed. Improvements in paretic peak propulsion (Δ: 2.80 %BW), propulsive power (Δ: 0.41 W/kg), and trailing limb angle (Δ: 6.2 degrees) were observed at comfortable walking speed (p's &lt; 0.05). Likewise, improvements in paretic peak propulsion (Δ: 4.63 %BW) and trailing limb angle (Δ: 4.30 degrees) were observed at maximum walking speed (p's &lt; 0.05).Conclusions: The REAL training program is feasible to implement after stroke and capable of facilitating rapid and meaningful improvements in paretic propulsion, walking speed, and walking distance.

scholarly journals The body weight-walking distance product as a superior parameter in determining the VO2 on-kinetics in coronary artery disease

2019 ◽  
Author(s):  
Isadora S. Rocco ◽  
Walter J. Gomes ◽  
Hayanne O. Pauletti ◽  
Marcela Viceconte ◽  
Bruna C. Matos-Garcia ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
The Body ◽  
Walking Distance ◽  
Walk Test ◽  
Artery Disease ◽  
Test Distance ◽  
6 Minute Walk Test ◽  
Minute Walk

Abstract Background The 6-minute walk test distance is frequently used to assess functional capacity of cardiac disease population. Nevertheless, anthropometric differences can confound or misestimate performance, which highlights the need for new parameters. This study aims to investigate the potential of the body weight-walking distance product (D.W), compared to 6-minute walk test distance, to predict exercise capacity measured by VO 2 on-kinetics in coronary artery disease (CAD) patients.Methods Cross-section study in a tertiary-care reference institution. Forty-six participants with multiarterial CAD with and without left ventricular dysfunction underwent a 6-minute walk test with simultaneous use of mobile telemetric cardiopulmonary monitoring to evaluate oxygen uptake (VO 2 ) on-kinetics and other cardiorespiratory responses.Results Perceived effort Borg for lower limb fatigue was only correlated with the D.W (p=0.007). The percent-predicted and actual distance were only modestly to moderately correlated with VO 2 on-kinetics (p<0.05). All the associations of VO 2 on-kinetics parameters were improved by showing a stronger correlation to the D.W (p<0.0001), which also had a larger effect size to identify differences between coronary disease patients compared to distance ( d =1.32 vs d =0.84).Conclusion The D.W demonstrates potential as a measure superior to the distance in determining VO 2 on-kinetics in participants with CAD with and without left ventricular dysfunction.

The six‐minute walk test distance predicts mortality in cirrhosis – a cohort of 694 patients awaiting liver transplantation

2021 ◽  
Author(s):  
ThucNhi T. Dang ◽  
Maryam Ebadi ◽  
Juan G. Abraldes ◽  
Jennifer Holman ◽  
Jon Ashmead ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Walk Test ◽  
Six Minute Walk Test ◽  
Test Distance ◽  
Minute Walk

scholarly journals Long-Term Re-Admission after Hospital Discharge in Patients Admitted with Acute Heart Failure: The Prognostic Value of the Six-Minute Walk Test Distance

OALib ◽  
2018 ◽  
Vol 05 (09) ◽  
pp. 1-11
Author(s):  
Dakaboué Germain Mandi ◽  
Dangwé Temoua Na？bé ◽  
Joel Bamouni ◽  
Rélwendé Aristide Yaméogo ◽  
Yibar Kambiré ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hospital Discharge ◽  
Acute Heart Failure ◽  
Prognostic Value ◽  
Walk Test ◽  
Six Minute Walk Test ◽  
Test Distance ◽  
Minute Walk

scholarly journals HIV infection is an independent risk factor for decreased 6-minute walk test distance

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0212975 ◽  
Author(s):  
Tom E. Robertson ◽  
Mehdi Nouraie ◽  
Shulin Qin ◽  
Kristina A. Crothers ◽  
Cathy J. Kessinger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hiv Infection ◽  
Independent Risk Factor ◽  
Walk Test ◽  
Test Distance ◽  
6 Minute Walk Test ◽  
Minute Walk

Walkway Length, But Not Turning Direction, Determines the Six-Minute Walk Test Distance in Individuals With Stroke

2011 ◽  
Vol 92 (5) ◽  
pp. 806-811 ◽  
Author(s):  
Shamay S. Ng ◽  
William W. Tsang ◽  
Tracy H. Cheung ◽  
Josiben S. Chung ◽  
Fenny P. To ◽  
...  
Keyword(s):  
Walk Test ◽  
Six Minute Walk Test ◽  
Test Distance ◽  
Minute Walk

scholarly journals Ambulatory vital signs in the workup of pulmonary embolism using a standardized 3-minute walk test

CJEM ◽  
2015 ◽  
Vol 17 (3) ◽  
pp. 270-278
Author(s):  
Qamar Amin ◽  
Jeffrey J. Perry ◽  
Ian G. Stiell ◽  
Subhra Mohapatra ◽  
Abdulaziz Alsadoon ◽  
...  
Keyword(s):  
Heart Rate ◽  
Pulmonary Embolism ◽  
Oxygen Saturation ◽  
Tertiary Care ◽  
Heart Rate Change ◽  
Rate Change ◽  
Walk Test ◽  
Tertiary Care Centre ◽  
Absolute Decrease ◽  
Minute Walk

AbstractObjectiveDiagnosing pulmonary embolism can be difficult given its highly variable clinical presentation. Our objective was to determine whether a decrease in oxygen saturation or an increase in heart rate while ambulating could be used as an objective tool in the diagnosis of pulmonary embolism.MethodsThis was a two-site tertiary-care-centre prospective cohort study that enrolled adult emergency department or thrombosis clinic patients with suspected or newly confirmed pulmonary embolism. Patients were asked to participate in a standardized 3-minute walk test, which assessed ambulatory heart rate and ambulatory oxygen saturation. The primary outcome was pulmonary embolism.ResultsWe enrolled 114 patients, including 30 with pulmonary embolism (26.3%). A ≥2% absolute decrease in ambulatory oxygen saturation and an ambulatory change in heart rate >10 beats per minute (BPM) were significantly associated with pulmonary embolism. An ambulatory heart rate change of >10 BPM had a sensitivity of 96.6% (95% confidence interval [CI] 83.3 to 99.4) and a specificity of 31.0% (95% CI 22.1 to 45.0) for pulmonary embolism. A ≥2% absolute decrease ambulatory oxygen saturation had a sensitivity of 80.2% (95% CI 62.7 to 90.5) and a specificity of 39.3% (95% CI 29.5 to 50.0) for pulmonary embolism. The combination of both variables yielded a sensitivity of 100.0% (95% CI 87.0 to 100.0) and a specificity of 11.0% (95% CI 6.6 to 21.0).ConclusionIn summary, our study found that an ambulatory heart rate change of >10 BPM or a ≥2% absolute decrease in ambulatory oxygen saturation from baseline during a standardized 3-minute walk test are highly correlated with pulmonary embolism. Although the findings appear promising, neither of these variables can currently be recommended as a screening tool for pulmonary embolism until larger prospective studies examine their performance either alone or with pre-existing rules.

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