Abstract 16403: Prevalence and Sex Differences in Early-onset Atrial Fibrillation - A Nation-wide Primary Care Study in Norway

Background: Several studies have reported a male:female ratio of 4:1 in lone atrial fibrillation (AF) populations. However, there have been few reports on the young population with AF, and no reports from a primary care setting. Here, we describe prevalence and sex-differences in early-onset AF in a nation-wide register-based study in the primary care sector in Norway. Methods: In Norway, with a population of 5.4 million, healthcare is publicly financed and all general practitioner (GP) claims have been recorded in the Norwegian Control and Payment of Health Reimbursement (KUHR) registry, since 2006. We identified all individuals aged ≥18 and <50 years registered with ≥1 AF diagnosis code (International Classification of Primary Care (ICPC) K78), from 2006-2019 in the KUHR registry. Based on population estimates from Statistics Norway, we calculated the prevalence of early-onset AF in 2019, as a total, by sex, and by age groups: 18-29, 30-39, 40-49. Results: We identified 5563 individuals (28.5% women, age 18-49 years) aged 18-49 in 2019 with AF diagnosed <age 50 years. In 2019, the prevalence of early-onset AF registered in all individuals up to age 50 was 0.24% (women: 0.14% (1585/1114821), men 0.34% (3978/1176555), p=1.4x10 -205 ) with a ratio of 2.5 men:women. In individuals aged 18-29 the prevalence was 0.05% (women 0.04% (164/410367), men 0.07% (292/435001), p=79x10 -8 ). For the age group 30-39 years the prevalence was 0.19% (women 0.12% (408/349639), men 0.27% (985/367730), p=3.9x10 -49 ). For the age group 40-49 years the prevalence was 0.51% (women 0.29% (1013/354815), men 0.72% (2701/373824), p=1.39x10 -155 ). Conclusion: We show that the prevalence of early-onset AF in a nation-wide primary care population is 0.24% and that the sex-difference in prevalence is smaller than previously reported in early-onset and lone AF studies. Our findings underline the need of increased awareness of AF as a disease in the young, and particularly to women in the youngest age-groups.

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Tower Running—Participation, Performance Trends, and Sex Difference

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17061902 ◽

2020 ◽

Vol 17 (6) ◽

pp. 1902 ◽

Cited By ~ 1

Author(s):

Daniel Stark ◽

Stefania Di Gangi ◽

Caio Victor Sousa ◽

Pantelis Nikolaidis ◽

Beat Knechtle

Keyword(s):

Sex Differences ◽

Statistical Model ◽

Sex Difference ◽

Random Effects ◽

Age Groups ◽

Repeated Measurements ◽

Stair Climbing ◽

Age Group ◽

Performance Trends ◽

The Difference

Though there are exhaustive data about participation, performance trends, and sex differences in performance in different running disciplines and races, no study has analyzed these trends in stair climbing and tower running. The aim of the present study was therefore to investigate these trends in tower running. The data, consisting of 28,203 observations from 24,007 climbers between 2014 and 2019, were analyzed. The effects of sex and age, together with the tower characteristics (i.e., stairs and floors), were examined through a multivariable statistical model with random effects on intercept, at climber’s level, accounting for repeated measurements. Men were faster than women in each age group (p < 0.001 for ages ≤69 years, p = 0.003 for ages > 69 years), and the difference in performance stayed around 0.20 km/h, with a minimum of 0.17 at the oldest age. However, women were able to outperform men in specific situations: (i) in smaller buildings (<600 stairs), for ages between 30 and 59 years and >69 years; (ii) in higher buildings (>2200 stairs), for age groups <20 years and 60–69 years; and (iii) in buildings with 1600–2200 stairs, for ages >69 years. In summary, men were faster than women in this specific running discipline; however, women were able to outperform men in very specific situations (i.e., specific age groups and specific numbers of stairs).

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Trends and Rural-Urban Differences in Asthma Hospitalizations in Saskatchewan 1970-1989

Canadian Respiratory Journal ◽

10.1155/1994/503252 ◽

1994 ◽

Vol 1 (4) ◽

pp. 229-234 ◽

Cited By ~ 7

Author(s):

A Senthilselvan

Keyword(s):

Regression Models ◽

Age Groups ◽

Age Group ◽

Hospitalization Rates ◽

Rural And Urban ◽

Asthma Hospitalization ◽

Group Sex ◽

Rate Ratios ◽

Rural Dwellers

OBJECTIVE: To examine the trends in hospitalization rates for atsthma in Saskatchewan from 1970 to 1989 and to investigate the differences in asthma hospitalization rates between rural and urban dwellers.DESIGN: Asthma hospitalization rates were calculated for the age groups O to 4, 5 to 9. 10 to 14, 15 to 24. 25 to 34. 35 to 49 and 50 to 64 years for the period between 1970 and 1989. Only the first admission in each year for each person was included in the analysis. As the classification of asthma changed in 1978. trends in asthma hospitalization rates were investigated separately for the periods 1970 to 1978 and 1979 to 1989. respectively. Rate ratios were obtained for male/female and rural/urban comparisons by fitting Poisson regression models.SETTING: The hospitalization data for respiratory diseases for the province of Saskatchewan were examined by age group, sex and place or residence.RESULT: No significant increases were observed in asthma hospitalization rates lrorn 1970 to 1978. In the period 1979 to 1989. asthma hospitalization rates increased significantly among children under four years from 4.31/1000 in 1979 to 7.04/1000 in 1989. Among children under 14 years. asthma hospitalization rates were greater in boys than in girls . The converse was true for adults aged 15 and above, with women having a higher hospitalization rate for asthma than men . In adults aged 35 and above. rural dwellers had higher hospitalization rates for asthma than urban dwellers throughout the study period. In other age groups, although rural dwellers had higher asthma hospitalization rates than did urban dwellers during 1970 to 1984. the differences disappered duri ng 1985 to 1989.CONCLUSION: Further studies are required to find reasons for the increase in asthma hospitalizations among young children under four years old and for the differences between rural and urban dwellers in the age group 35 years and above.

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Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation

Personalized Medicine ◽

10.2217/pme-2017-0076 ◽

2018 ◽

Vol 15 (2) ◽

pp. 93-102 ◽

Cited By ~ 2

Author(s):

Federico Denti ◽

Christian Paludan-Müller ◽

Søren-Peter Olesen ◽

Stig Haunsø ◽

Jesper Hastrup Svendsen ◽

...

Keyword(s):

Atrial Fibrillation ◽

Genetic Variation ◽

Sodium Channel ◽

Early Onset ◽

Lone Atrial Fibrillation ◽

Functional Consequences

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Sex differences in non-communicable disease prevalence in China: a cross-sectional analysis of the China Health and Retirement Longitudinal Study in 2011

BMJ Open ◽

10.1136/bmjopen-2017-017450 ◽

2017 ◽

Vol 7 (12) ◽

pp. e017450 ◽

Cited By ~ 4

Author(s):

Yan Liu ◽

Guofeng Liu ◽

Hongjiang Wu ◽

Weiyan Jian ◽

Sarah H Wild ◽

...

Keyword(s):

Sex Differences ◽

Heart Disease ◽

Longitudinal Study ◽

Lung Disease ◽

Chronic Lung Disease ◽

Communicable Disease ◽

Age Groups ◽

Sociodemographic Factors ◽

Age Group ◽

Cross Sectional

ObjectivesTo describe the sex differences in the prevalence of non-communicable diseases (NCDs) in adults aged 45 years or older in China.DesignCross-sectional study.SettingNationally representative sample of the Chinese population 2011.Participants8401 men and 8928 women over 45 years of age who participated in the first wave of the China Health and Retirement Longitudinal Study (CHARLS).Outcome measuresSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. Sex differences in NCDs were described using logistic regression to generate odds ratios (OR) with adjustment for sociodemographic factors and health-related behaviours. All analyses were stratified by age group for 45–64-year-old and ≥65-year-old participants.ResultsIn both age groups, men reported better overall health than women. The crude prevalence of heart disease, cancer and arthritis was higher while that of stroke and chronic lung disease was lower in women than in men. After adjustment, ORs (95% CI) for the 45–64 and ≥65 year age groups were 0.70 (0.58 to 0.84) and 0.66 (0.54 to 0.80), respectively, for arthritis for men compared with women. In contrast, ORs were 1.66 (1.09 to 2.52) and 2.12 (1.36 to 3.30) for stroke and 1.51 (1.21 to 1.89) and 1.43 (1.09 to 1.88) for chronic lung disease for men compared with women. ORs for heart disease (0.65 (0.52 to 0.80)) were lower in men than in women only in the 45–64 year age group.ConclusionsOdds of arthritis were lower while those of stroke and chronic lung disease were higher in men than in women in both age groups. However, odds of heart disease were lower in men than in women, but only in the group of individuals aged 45–64 years.

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Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early‐onset lone atrial fibrillation

Annals of Noninvasive Electrocardiology ◽

10.1111/anec.12661 ◽

2019 ◽

Vol 24 (6) ◽

Author(s):

Mariam B. Seifert ◽

Morten S. Olesen ◽

Ingrid E. Christophersen ◽

Jonas B. Nielsen ◽

Jonas Carlson ◽

...

Keyword(s):

Atrial Fibrillation ◽

Genetic Variants ◽

Early Onset ◽

Electrical Activation ◽

Lone Atrial Fibrillation

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Age groups changes in self-rated health: A prospective longitudinal study over a 20-year period using Health Survey of North Trøndelag data

Scandinavian Journal of Public Health ◽

10.1177/1403494820904626 ◽

2020 ◽

pp. 140349482090462

Author(s):

Frode Lysberg ◽

Siw Tone Innstrand ◽

Milada Cvancarova Småstuen ◽

Cathrine Lysberg ◽

Magnhild Mjåvatn Høie ◽

...

Keyword(s):

Sex Differences ◽

Health Survey ◽

Age Groups ◽

Older Age ◽

Age Group ◽

Middle Aged ◽

Prospective Longitudinal Study ◽

Future Studies ◽

Self Rated Health ◽

Prospective Longitudinal

Background: The aim of the study was to investigate changes in self-rated health (SRH) between different age groups and sexes over a 20-year period. Methods: Data were retrieved from the large longitudinal Health Survey of North Trøndelag, Norway, which includes data collected from more than 190,000 participants aged 20–70+ years between the years 1984 and 2008. Data were analysed using logistic regression and adjusted for sex. Results: From 1984 to 2008, the odds of scoring higher on SRH decreased by 46% in the youngest age group (20–29 years) and increased by approximately 35% in the middle-aged and older age groups (40–70+ years). When considering sex differences, women in most age groups scored lower than the men on their SRH. Conclusions: Our finding suggest a trending shift in SRH, with a reduction in the youngest age group (20–29 years) and an increase in the middle-aged and older age groups (40–70+ years). Despite the sex differences being small, our data indicate that in most age groups, women tend to score lower than men on their SRH. Future studies should focus on these trends to understand better the mechanisms underlying these changes in SRH and to follow future trends to see if the trend is reinforced or diminished.

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