Abstract P079: Impact of Combined Exercise Training in an Experimental Model of Hypertension Associated With Menopause

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Guilherme Shimojo ◽  
Danielle Dias ◽  
Christiane Malfitano ◽  
Iris Sanches ◽  
Maria-Cláudia Irigoyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Arterial Pressure ◽  
Experimental Model ◽  
Systolic Arterial Pressure ◽  
Female Rats ◽  
Additional Increase ◽  
Combined Exercise ◽  
And Oxidative Stress ◽  
Combined Exercise Training

In this study we tested the hypothesis that the cardiovascular autonomic dysfunction plays an important role on the management of inflammation and oxidative stress, and that these dysfunctions may in turn be modulated by combined exercise training in an experimental model of hypertension and menopause. Female rats were divided into (n=7/group): control (C) and hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing combined (aerobic+resistance) training (THO). We observed an additional increase in HO group (176±4 mmHg) in relation to H group (165±3 mmHg). However, the THO group (155±3 mmHg) showed a reduction of arterial pressure associated with resting bradycardia. The HO group (50.78±4.61 mmHg2) presented an additional impairment in systolic arterial pressure variability when compared to C and H groups (23.69±0.45 and 34.09±2.37 mmHg2); this dysfunction was not observed in THO group (30.09±2.03 mmHg2). Additionally, an attenuation on vascular sympathetic modulation and an improvement in baroreflex sensitivity were found in the THO when compared to HO group. There was an increase in TNF-α in sedentary hypertensive groups (H and HO vs. C), which was not observed in THO group. Ovariectomy induced an additional increase in cardiac and renal oxidative stress, which were reduced in THO group. The THO group presented an increase in total antioxidant capacity when compared to the other groups. In conclusion, combined exercise training was able to reduce AP associated with improvement on cardiovascular autonomic control, probably reducing cardiac and renal inflammation and oxidative stress, in an experimental model of hypertension and menopause.

scholarly journals COMBINED EXERCISE TRAINING ATTENUATES CARDIAC AND AUTONOMIC DYSFUNCTIONS IN AN EXPERIMENTAL MODEL OF MENOPAUSE AND DIABETES

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Iris Callado Sanches ◽  
Filipe Fernandes Conti ◽  
Marcos Rafael Rodrigues Soares ◽  
Hugo Garcia Quinteiro ◽  
Raquel Sirvente ◽  
...  
Keyword(s):  
Exercise Training ◽  
Experimental Model ◽  
Combined Exercise ◽  
Autonomic Dysfunctions ◽  
Combined Exercise Training

Abstract P167: Combined Exercise Training is Better than Isolated Aerobic and Resistance Exercise Training for an Experimental Model of Metabolic Syndrome and Menopausal Rats

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Filipe F Conti ◽  
Janaina O Brito ◽  
Nathalia Bernardes ◽  
Danielle S Dias ◽  
Maria C Irigoyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Exercise Training ◽  
Baroreflex Sensitivity ◽  
Resistance Exercise Training ◽  
Combined Exercise ◽  
Additional Improvement ◽  
Combined Exercise Training ◽  
Training Protocols

The aim of this study was to verify the effects of three different moderate exercise training protocols (aerobic, resistance and combined (aerobic + resistance)) in a model of metabolic syndrome and menopause on a cardiovascular parameter and oxidative stress. Female SHR rats were divided into (n=8): hypertensive (H), hypertensive ovariectomized submitted to fructose overload (100g/L in drinking water) (HFO), aerobic trained hypertensive ovariectomized submitted to fructose overload (AHOF), resistance trained hypertensive ovariectomized submitted to fructose overload (RHOF) and combined trained hypertensive ovariectomized submitted to fructose overload (CHOF). Arterial pressure (AP) signals were directly recorded. Vascular autonomic modulation was evaluated by spectral analysis. The cardiac oxidative stress was evaluated by lipoperoxidation (LPO) determination. The association of fructose overload and hormone deprivation promoted an increase in AP (HOF: 174±4 vs. H: 146±4 mmHg), heart rate (HOF: 393±10 vs. H: 352±13 bpm), VAR-SAP (HOF: 77.8±11.9 vs H: 31.1±2.6 mmHg2), LF-SAP (HOF: 10.6±2.3 vs H: 5.0±0.9 mmHg2) and LPO, and reduced baroreflex sensitivity (tachycardia response: HOF: 1.06±0.06 vs. H: 1.91±0.17 bpm/mmHg). All exercise training protocols were able to reduce LPO and LF-SAP. It was noted that only the combined exercise training was able in reducing AP (CHOF: 158±4 mm Hg) and heart rate (CHOF: 303±5 bpm). The AP reduction noted only in the CHOF group may be associated with an improve in baroreflex sensitivity, represented by an increase of tachycardic response observed only in the CHOF (1.62±0.1 bpm/mmHg) and in the AHOF (1.54 ±0.07 bpm/mmHg) groups and a reduction of VAR-PAS observed only in the CHOF (30.31±3.85 mmHg 2 ) and in the RHOF (31±2.65 mmHg 2 ) groups. In conclusion, fructose overload induced impairment in hemodynamic, vascular autonomic control and increased oxidative stress in hypertensive rats submitted to ovarian hormones deprivation. However, all exercise training protocols showed a beneficial role. Moreover, the combined exercise training showed additional improvement, suggesting that this could be a better approach than isolated aerobic and resistance training.

Effects of combined exercise training and pharmacological treatment on blood pressure and renal parameters in an experimental model of hypertension and menopause.

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Michel Pablo dos Santos Ferreira Silva ◽  
Thânia Plens Shecaira ◽  
Maycon junior Ferreira ◽  
Amanda Aparecida de Araujo ◽  
Nathalia Bernardes ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Training ◽  
Experimental Model ◽  
Pharmacological Treatment ◽  
Combined Exercise ◽  
Combined Exercise Training

Abstract 507: Combined Exercise Training Induces Additional Cardiovascular Autonomic Benefits in Comparison to Dynamic Resistance Training in Ovariectomized Diabetic Rats

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Iris C Sanches ◽  
Filipe F Conti ◽  
Hugo R Quinteiro ◽  
Morgana Buzin ◽  
Maria-Cláudia Irigoyen ◽  
...  
Keyword(s):  
Resistance Training ◽  
Exercise Training ◽  
Maximum Load ◽  
Diabetic Rats ◽  
Female Rats ◽  
Pulse Interval ◽  
Dynamic Resistance ◽  
Exercise Tests ◽  
Combined Exercise ◽  
Combined Exercise Training

The purpose of this study was to compare the cardiovascular autonomic effects between dynamic aerobic, resistance and combined exercise training in ovariectomized diabetic female rats. Female Wistar rats (200-220g) were divided into 4 ovariectomized (bilateral ovaries removal) diabetic (streptozotocin, 50mg/kg, iv) groups: sedentary (DOS) and trained by an aerobic protocol on a treadmill (DOTA), by a resistance protocol in ladder (DOTR), or by a combined protocol in ladder+treadmill on alternate days (DOTC). After 8 weeks of training, the animals were cannulated to arterial pressure (AP) recording and baroreflex sensitivity (BS) evaluation. Heart rate (HR) and systolic AP variabilities were analyzed in the time and frequency domains. Exercise training induced an increase of 77% in the run capacity in the DOTA group (DOS: 8.6±0.6; DOTA: 15.3±0.4; DOTR: 11.5±1.6; DOTC: 15.0±0.2 min), 60% in the maximum load in DOTR group (DOS: 179.7±11.0; DOTA: 167.3±1.5; DOTR: 288.4±7.5; DOTC: 284.6±10.2 % of body weight), and increases in both exercise tests in DOTC (75% and 58%, respectively). All trained animals showed normalization of diabetic induced-resting hypotension and bradycardia, associated with increased HR variance (DOS: 39.6±2.6; DOTA: 71.2±7.2; DOTR: 70.9±12.1; DOTC: 65.7±6.1 ms2) and normalization of the LF band of pulse interval (DOS: 2.7±0.3; DOTA: 5.3±0.4; DOTR: 7.2±1.5; DOTC: 6.8±0.8 ms2) (vs. DOS). The DOTA and DOTC groups (but not DOTR) had higher BS (tachycardic and bradycardic responses), and attenuation in SAP variability (DOS: 7.4±0.8; DOTA: 12.7±1.1; DOTR: 8.9±1.0; DOTC: 13.3±1.0 mmHg2) in relation to DOS. Mortality was higher in DOS group when compared to trained group. In conclusion, the results showed that dynamic aerobic, resistance or combined exercise training induced benefits in physical capacity, hemodynamic and autonomic parameters after ovarian hormone deprivation in diabetic rats. However, the combined exercise training promoted additional effects than aerobic or resistance training in this condition.

Eugenol improves tissue damage and oxidative stress in adult female rats after ovarian torsion/detorsion

2021 ◽  
pp. 1-6
Author(s):  
Bita Barghi ◽  
Majid Shokoohi ◽  
Amir Afshin Khaki ◽  
Arash Khaki ◽  
Maryam Moghimian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Female ◽  
Tissue Damage ◽  
Ovarian Torsion ◽  
Female Rats ◽  
And Oxidative Stress

McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis

Life Sciences ◽  
2021 ◽  
Vol 272 ◽  
pp. 119194
Author(s):  
Diva de Aguiar Magalhães ◽  
Jalles Arruda Batista ◽  
Stefany Guimarães Sousa ◽  
Jayro dos Santos Ferreira ◽  
Lauanda da Rocha Rodrigues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Experimental Model ◽  
Muscarinic Agonist ◽  
And Oxidative Stress

scholarly journals The Effects of Vibroacoustically Induced Microvibrations on Arterial Blood Pressure and Oxidative Stress in Rats

2014 ◽  
Vol 15 (2) ◽  
pp. 83-88
Author(s):  
Dusko Kornjaca ◽  
Vladimir Zivkovic ◽  
Nevena Barudzic ◽  
Vladimir Jakovljevic ◽  
Dragan Djuric
Keyword(s):  
Oxidative Stress ◽  
Arterial Pressure ◽  
Systolic Arterial Pressure ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Sound Waves ◽  
Initial Value ◽  
The Third ◽  
Stress Markers ◽  
Arterial Blood

ABSTRACT Vibroacoustics, a scientific field that has been intensively studied for the last thirty years, uses the properties of sound waves (infrasound, ultrasound, noise and music) to induce vibrations that, like a sound wave, may have both useful and harmful effects. Th e aim of this study was to examine the effects of vibroacoustically induced microvibrations on arterial blood pressure and markers of oxidative stress in the blood. Th e experiments were performed on Wistar male rats that had a 180-200 g body mass and were divided into control and experimental groups (6 rats in each). In the experimental group, microvibrations were induced using the Vitafon vibroacoustic apparatus (Vitafon, St. Petersburg, Russian Federation), which delivers sound waves of varying frequencies by a process called “phoning”. Up to 60 minutes of phoning time was delivered to the kidney and liver using 4 diff erent regimens that included a 5-minute stabilisation time; up to four 10-minute phoning regimens, with 5-minute breaks between each single regimen, at a 30 Hz-18000 kHz frequency range;, and 2.8 μm-12.3 μm microwave amplitudes. After the completion of a phoning regimen, animals were sacrificed and the oxidative stress markers were measured in blood samples (O2-, H2O2, nitrites, lipid peroxidation index, superoxide dismutase, catalase, and glutathione) and compared with the values of markers in the control group. Systolic arterial pressure was analysed after the acute application of up to four diff erent regimens of vibroacoustic microvibrations. Systolic arterial pressure decreased significantly during the administration of the second regimen in comparison to the control group. Systolic arterial pressure returned, almost completely, to the initial value after the administration of the third and fourth regimens. Th ere was no significant change in diastolic arterial pressure after the acute administration of up to four different regimens, although the pressure decreased slightly after the first and second regimens and returned to the initial value during the administration of the third and fourth regimens. Analysis of oxidative stress markers showed a statistically significant change in the catalase level. No statistically significant differences were found in the other oxidative stress markers analyzeanalysed. Further research is needed to clarify the physiological effects of low compared to high frequencies of vibroacoustically induced microvibrations and their possible therapeutic significance.

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