Abstract 906: Age-Dependent Modifications in Cardiac Myofilament Proteins are Graded by Overall Health, Measured as Frailty, in Aging Male and Female C57BL/6 Mice

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Alice Kane ◽  
Elise S Bisset ◽  
Kaitlyn Keller ◽  
W G Pyle ◽  
Susan E Howlett
Keyword(s):  
Aging Male ◽  
Male And Female ◽  
Age Dependent ◽  
Cardiac Myofilament

Investigating over-dispersion; Moniliformis (Acanthocephala) and rats

Parasitology ◽  
1984 ◽  
Vol 88 (2) ◽  
pp. 317-331 ◽  
Author(s):  
D. W. T. Cromptom ◽  
A. E. Keymer ◽  
S. E. Arnold
Keyword(s):  
Experimental Investigation ◽  
Male And Female ◽  
Parasite Survival ◽  
Tentative Hypothesis ◽  
Age Dependent ◽  
Outbred Strain ◽  
Ad Libitum ◽  
Over Dispersion ◽  
Age And Sex ◽  
Host Heterogeneity

SUMMARYAn analysis of the frequency distribution of numbers of Moniliformis dubius in rats of an outbred strain of Wistar origin (CFHB) and feeding ad libitum on Oxoid 41B diet, showed that over-dispersion occurred regardless of the age and sex of the rats and the infective dose given (12, 20 or 40 cystacanths/rat). Over-dispersion was also shown to be independent of variability in the age and sex of the cystacanths given. The analysis demonstrated that the over-dispersion declined as the course of the infection proceeded. As expected, parasite survival was found to be age-dependent with female worms living longer, on average, than males, and both male and female worms living longer in rats given 12 as opposed to 20 cystacanths. Possible mechanisms for generating the over-dispersion observed during this work are discussed and a tentative hypothesis, invoking host heterogeneity with regard to carbohydrate availability in the small intestine, is proposed for further experimental investigation.

scholarly journals Age- and Gender-Related Changes in Ligament Components

2001 ◽  
Vol 38 (5) ◽  
pp. 527-532 ◽  
Author(s):  
T Osakabe ◽  
M Hayashi ◽  
K Hasegawa ◽  
T Okuaki ◽  
T M Ritty ◽  
...  
Keyword(s):  
Female Group ◽  
Dependent Manner ◽  
Age And Gender ◽  
Male And Female ◽  
Extracellular Matrix Components ◽  
Age Dependent ◽  
Mineral Components ◽  
Cross Links ◽  
Matrix Components ◽  
And Gender

The age- and gender-related changes in extracellular matrix components (elastin, elastin cross-links, fibrillin, collagen and glycoprotein) and mineral components (calcium, Ca; phosphorus, P) in human lumbar yellow ligaments were investigated using samples obtained from surgical specimens. The mineral (Ca and P) contents increased with ageing ( r=0·703 and r=0·772, respectively), whereas the contents of matrix components tended to decrease with ageing (elastin r= −0·261, elastin cross-links r= −0·213, fibrillin r= −0·494; collagen r= −0·322 and glycoprotein r= −0·143). Comparison of the male and female groups revealed that the ligament elastin content and elastin cross-links decreased in the male group, whereas the ligament collagen content decreased in the female group significantly in an age-dependent manner ( r= −0·788, r= −0·753 and r= −0·721, respectively). These findings demonstrate age- and gender-related changes in mineral and matrix components (especially elastin and collagen) in the lumbar yellow ligaments in the Japanese population. It is suggested that elastin and collagen metabolism in ligaments changes both with age and according to gender.

scholarly journals Age-dependent changes in cocaine sensitivity across early ontogeny in male and female rats: possible role of dorsal striatal D2High receptors

2015 ◽  
Vol 232 (13) ◽  
pp. 2287-2301 ◽  
Author(s):  
Sanders A. McDougall ◽  
Shannon E. Eaton ◽  
Alena Mohd-Yusof ◽  
Cynthia A. Crawford
Keyword(s):  
Early Ontogeny ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Age Dependent

Hepatic Microsomal Propranolol Metabolism in Aging Male and Female Rats

1991 ◽  
Vol 80 (2) ◽  
pp. 199-200 ◽  
Author(s):  
Shoichi Fujita ◽  
Ryozo Ishida ◽  
Sakae Obara ◽  
Kenichi Kitani ◽  
Tokuji Suzuki
Keyword(s):  
Female Rats ◽  
Aging Male ◽  
Male And Female ◽  
Male And Female Rats
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