Abstract TP169: Migraine Phenotypic Spectrum in a CADASIL Cohort: Mayo Clinic Florida

Objective: To characterize migraine in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Background: CADASIL serves as a key model of a monoallelic stroke disease. A portion of patients have coexistent migraine with aura, yet the relationship between migraine and the pathophysiology of CADASIL is poorly understood. Design/Methods: We performed a prospective study of adults with a confirmed genetic diagnosis of CADASIL, age-matched controls with migraine with aura (MA), and headache-free controls. The Migraine Disability Assessment Questionnaire (MIDAS) and Headache Impact Test (HIT-6) were used to quantify migraine-related disability. Subjects were followed for one year after enrollment. Results: We enrolled 88 subjects, which included 33 subjects with CADASIL, 32 subjects without CADASIL but with MA, and 23 control subjects without CADASIL or MA. Mean age was 53.6 (range, 22-86), 64.8% (57/88) were females, and 83% (73/88) were white. Of the CADASIL subjects, 61% (20/33) suffered from MA (CAD/+MA). Aura semiology amongst the CAD/+MA and MA patients were as follows: visual (80% vs 81%), sensory (75% vs 81%), speech (75% vs 50%), motor (30% vs 50%), brain stem (60% vs 81%) and retinal (30% vs 25%). Mean MIDAS scores at enrollment were comparable between the CAD/+MA and MA populations (32.3 vs 33.5), as were mean HIT-6 scores (56.3 vs 56.9). Discussion: These preliminary results do not show a significant difference in migraine disability between CADASIL migraineurs and chronic migraineurs. Minor differences were observed in aura distribution between the two groups, although further investigations are needed to better understand the underlying pathology of CADASIL and migraine.

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Comparison of the repair of permanent tympanic membrane perforations by hydrocolloidal dressing and paper patch

The Journal of Laryngology & Otology ◽

10.1017/s0022215100131986 ◽

1995 ◽

Vol 109 (11) ◽

pp. 1041-1047 ◽

Cited By ~ 15

Author(s):

Odd Spandow ◽

Sten Hellström ◽

Michael Dahiström ◽

Lennart Bohlin

Keyword(s):

Simple Technique ◽

Posterior Part ◽

Alternative Methods ◽

Posterior Half ◽

Occlusive Dressing ◽

Tympanic Membrane Perforations ◽

Significant Difference ◽

One Year ◽

A Prospective Study ◽

Inferior Quadrant

AbstractThirty consecutive patients with permanent perforations of their tympanic membranes (TM) present from 2.5 to 50 years (mean 18.7 years) were admitted to a prospective study using two alternative methods of dressings for closure of the perforations. An adhesive-coated hydrocolloid material was compared with a conventional dressing of vaseline impregnated rice paper patch after de-epithelialization of the perforation border. Nine of the permanent TM perforations (30 per cent), five with the hydrocolloidal dressing and four with the rice paper patch had healed when followed-up after one year. The size of eight of the central perforations that had healed was equal to or less than 25 per cent of the TM. Also one perforation with a size of 65 per cent had healed. Seven perforations were located in the posterior part of the TM:Jour in the posterior-superior quadrant, one in the inferior quadrant, one had engulfed the posterior half of the TM and one included the anterior-inferior quadrant. Only two perforations out of 14, with a size of 25 per cent or less, located in the anterior-inferior quadrant, healed. No significant difference was demonstrated between the two types of dressings. Both groups noted an immediate improvement in hearing of 10.8 and 9.3 dB, respectively, after application of the dressing.The study demonstrates that application of an occlusive dressing or paper patch in 30 per cent of patients can promote the healing of long-standing perforations. The chances for healing are better if the perforation is located in the posterior part of the TM. This simple technique immediately improved hearing and should be tried before a patient is referred for myringoplasty surgery.

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Diode Laser Trabeculoplasty in Patients with Pseudoexfoliative Glaucoma

European Ophthalmic Review ◽

10.17925/eor.2013.07.01.14 ◽

2013 ◽

Vol 07 (01) ◽

pp. 14

Author(s):

Nikola Babić ◽

Aleksandar Miljković ◽

Veljko Andreić ◽

◽

...

Keyword(s):

Diode Laser ◽

Open Angle Glaucoma ◽

Spot Size ◽

Open Angle ◽

Pseudoexfoliative Glaucoma ◽

Laser Trabeculoplasty ◽

Significant Difference ◽

Before And After ◽

One Year ◽

A Prospective Study

Aim:A prospective study was carried out to examine the efficacy of diode laser trabeculoplasty (DLT) in the treatment of pseudoexfoliative glaucoma (XFG).Material and Methods:Laser trabeculoplasty was performed by Zeiss VISULAS 532s diode pumped solid state laser on 69 eyes of 40 patients with XFG and primary open-angle glaucoma. Power of 6001,200 mW was used, with a spot size of 100 microns and a pulse of 0.10 second. One hour before DLT brimonidine 0.1 % was administered and during seven days after the treatment Dexamethasone 1 % was administered. All patients underwent complete ophthalmic evaluation before and at intervals after treatment (seven days, one, three and six months and one year postoperatively). During the follow-up period, patients were treated with the same topical anti-glaucoma medicaments as before diode laser trabeculoplasty.Results:Before treatment in XFG patients mean intraocular pressure (IOP) was 23.7±2.6 mmHg and seven days after DLT it was 16.8 ± 2.1 mmHg that is 26.9 % decrease from the baseline, on day 30 it was 14.3 ± 2.2 mmHg which is 38.3 % decrease from the baseline, after 3 months 13.9 ± 2.4 mmHg (39.0 % decrease from the baseline), after six months 13.8 ± 2.7 mmHg or 39.9 % decrease from the baseline and after one year 15.1 ± 3.1 mmHg that makes 36.3 % decrease from the baseline. No side effects (either objective or subjective) were present in examined patients.Conclusions:There is statistically significant difference between IOP before and after diode laser trabeculoplasty, so it is concluded that diode laser trabeculoplasty is an effective mode of treatment for eyes with open-angle glaucoma especially in patients with XFG.

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Changes of Temporal Processing and Hearing in Noise after Use of a Monoaural Hearing Aid in Patients with Sensorineural Hearing Loss: A Preliminary Study

Journal of Audiology & Otology ◽

10.7874/jao.2021.00038 ◽

2021 ◽

Vol 25 (3) ◽

pp. 146-151

Author(s):

Yehree Kim ◽

Chan Joo Yang ◽

Myung Hoon Yoo ◽

Chan Il Song ◽

Jong Woo Chung

Keyword(s):

Temporal Resolution ◽

Auditory Processing ◽

Hearing Aid ◽

Control Group ◽

Central Auditory Processing ◽

Speech Discrimination ◽

Hearing In Noise ◽

One Year ◽

A Prospective Study ◽

The Relationship

Background and Objectives: The relationship between hearing aid (HA) use and improvement in cognitive function is not fully known. This study aimed to determine whether HAs could recover temporal resolution or hearing in noise functions.Materials and Methods: We designed a prospective study with two groups: HA users and controls. Patients older than 45 years, with a pure tone average threshold of worse than 40 dB and a speech discrimination score better than 60% in both ears were eligible. Central auditory processing tests and hearing in noise tests (HINTs) were evaluated at the beginning of the study and 1, 3, 6, and 12 months after the use of a monaural HA in the HA group compared to the control group. The changes in the evaluation parameters were statistically analyzed using the linear mixed model.Results: A total of 26 participants (13 in the HA and 13 in the control group) were included in this study. The frequency (<i>p</i><0.01) and duration test (<i>p</i>=0.02) scores showed significant improvements in the HA group after 1 year, while the HINT scores showed no significant change.Conclusions: After using an HA for one year, patients performed better on temporal resolution tests. No improvement was documented with regard to hearing in noise.

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A Prospective Study on Accuracy of Computer-Based Fully Guided Versus Pilot-Guided Implant Surgery

Applied Sciences ◽

10.3390/app10061975 ◽

2020 ◽

Vol 10 (6) ◽

pp. 1975 ◽

Cited By ~ 1

Author(s):

Hyo Joon Kim ◽

Hee Jin Kim ◽

Seong Yong Moon

Keyword(s):

Bone Loss ◽

Mean Value ◽

Implant Surgery ◽

Implant Placement ◽

Significant Difference ◽

Computer Based ◽

Preoperative Plan ◽

One Year ◽

A Prospective Study ◽

Apical Area

The aim of this study is to compare the implant placement deviations and evaluate the 1-year post-implant placement bone loss of pilot and fully guided implant placement protocols. In the first method, the pilot drill is used for guide surgery, and the following procedure is a method for performing implant surgery in a non-guided protocol. The second method is to perform fully guided surgery. A total of 74 implants in 20 patients were included. Postoperative CT scans were used to compare the implant placement deviations with the preoperative plan. In addition, bone loss was compared one year after surgery. In shoulder area, the implant deviations from the planned positions for dx(mesio-distal), dy(bucco-lingual), dz(vertical) dimensions, mean deviations with pilot-guided protocol (n = 31) were 0.50 ± 0.42 mm, 0.61 ± 0.55 mm, 0.87 ± 0.71 mm, and 1.33 ± 0.75 mm, respectively. The corresponding deviations for fully guided protocol (n = 41) were 0.50 ± 0.52 mm, 0.29 ± 0.27 mm, 0.56 ± 0.51 mm, and 0.96 ± 0.57 mm. In apical area, the corresponding deviations for pilot-guided protocol were 0.75 ± 0.72 mm, 0.61 ± 0.46 mm, 0.98 ± 0.76 mm, and 1.54 ± 0.87 mm. Deviations for fully guided protocol were 0.91 ± 0.90 mm, 0.44 ± 0.39 mm, 0.54 ± 0.51 mm, and 1.38 ± 0.76 mm, respectively. Angular deviations were 3.33 ± 3.23° with pilot-guided protocol and 3.90 ± 1.85° with fully guided protocol. The average bone loss after 1 year was 0.50 + 0.29 mm and 0.50 ± 0.24 mm, respectively. In the shoulder area, dy(bucco-lingual) of horizontal deviations, vertical deviations, and mean value of the deviations showed a statistically significant difference between fully guided and pilot-guided (p = 0.005, p = 0.033, and p = 0.023, respectively). In the apical area, vertical deviations showed a statistically significant difference. However, the mean value of the deviations did not show a statistically significant difference (p = 0.347). There was no statistically significant difference in angular deviations (p = 0.59).

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Evaluation and comparison of type I tympanoplasty efficacy and histopathological changes to the tympanic membrane in dry and wet ear: a prospective study

The Journal of Laryngology & Otology ◽

10.1017/s0022215115002091 ◽

2015 ◽

Vol 129 (10) ◽

pp. 945-949 ◽

Cited By ~ 15

Author(s):

R Shankar ◽

R S Virk ◽

K Gupta ◽

A K Gupta ◽

A Bal ◽

...

Keyword(s):

Prospective Study ◽

Success Rate ◽

Tympanic Membrane ◽

Histopathological Examination ◽

Chronic Otitis Media ◽

Type I ◽

Significant Difference ◽

Type I Tympanoplasty ◽

One Year ◽

A Prospective Study

AbstractObjective:This study aimed to compare the success rate of type I tympanoplasty in active (wet) and inactive (dry) mucosal chronic otitis media.Methods:A prospective study was performed of 35 patients each with dry ear and wet ear undergoing type I tympanoplasty in the Otolaryngology Department, Postgraduate Institute of Medical Education and Research, India. All patients underwent type I tympanoplasty between January 2010 and June 2011 by the post-auricular approach. Samples of the remnant tympanic membrane were sent for histopathological examination.Results:After a minimum follow up of one year, the success rate was 88.6 per cent for dry ears and 80 per cent for wet ears. Neither the type (p = 0.526) nor the presence (p = 0.324) of discharge influenced the success rate. Histopathological examination of the tympanic membrane margins was performed for 46 patients: of these, 19 showed evidence of vascularity and 27 did not. There was no significant difference in success rate between groups (p = 0.115).Conclusion:The success rate was not influenced by the presence of ear discharge at the time of surgery, and tympanic membrane vascularity did not influence graft uptake.

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Correlation Between MRI Findings and Clinical Impairment In Patients With Shoulder Adhesive Capsulitis: A Prospective Study

10.21203/rs.3.rs-126930/v1 ◽

2020 ◽

Author(s):

Romain GILLET ◽

Francois ZHU ◽

Pierre PADOIN ◽

Gabriella HOSSU ◽

Aymeric RAUCH ◽

...

Keyword(s):

Signal Intensity ◽

Adhesive Capsulitis ◽

Mri Findings ◽

Significant Difference ◽

Clinical Impairment ◽

Pain Duration ◽

One Year ◽

The One ◽

A Prospective Study

Abstract Objectives: MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are widely used, but there is little information available on the association between MRI findings and clinical impairment. The aim of our study was to determine the correlation of MRI findings with the Constant-Murlay Score (CMS), pain duration, and symptoms at the one-year follow-up in AC patients. Methods: MRI of 132 patients with a clinical diagnosis of shoulder AC were prospectively studied. A radiologist examined all patients and completed the CMS just prior to MRI. Pain duration was assessed. The signal intensity and the maximal thickness of the inferior glenohumeral (IGHL) and coracohumeral (CHL) ligaments were measured by two radiologists. Medical record analysis was performed in a sub-group of 49 patients to assess correlation approximately one year after the MRI examination. Results: There was a significant difference in mean pain duration score (3.8 ± 1.2 versus 3.2 ± 0.9 and 3.8 ± 1.2 versus 3.2 ± 0.9 respectively for readers 1 and 2) and in mean mobility scores (15.7 ± 8 points versus 19.6 ± 10.1 points and 15.8 ± 8.2 points versus 19.4 ± 10 points respectively for readers 1 and 2) in patients with a high IGHL signal compared to those with a low signal (P < .05). IGHL was thicker in patients with clinical improvement at one-year follow-up compared to those presenting clinical stability or worsening (P < .05). Conclusion: In shoulder AC patients, the degree of signal intensity at the IGHL was inversely related to shoulder pain duration and range of motion, and a thickened IGHL indicated a favorable outcome at one-year follow-up.

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Sex-Hormone-Related Events in Migrainous Females. A Clinical Comparative Study Between Migraine With Aura and Migraine Without Aura

Cephalalgia ◽

10.1046/j.1468-2982.1995.015002140.x ◽

1995 ◽

Vol 15 (2) ◽

pp. 140-144 ◽

Cited By ~ 112

Author(s):

LM Cupini ◽

M Matteis ◽

E Troisi ◽

P Calabresi ◽

G Bernardi ◽

...

Keyword(s):

Oral Contraceptive ◽

Migraine With Aura ◽

Migraine Without Aura ◽

Contraceptive Use ◽

Sex Hormone ◽

Gonadal Hormone ◽

Oral Contraceptive Use ◽

Significant Difference ◽

First Time ◽

The Relationship

In this study, the relationship between hormonal-related events and migraine with aura (MA) and without aura (MO) was investigated. Subjects included 268 women suffering from MA (88) and MO (180). Data were collected on the relationship between sex-hormone-related events and migraine. Migraine during menses was observed in a significantly higher percentage of MO than MA patients ( p < 0.03). Menstrual migraine was significantly more common in MO than in MA patients ( p < 0.01). Migraine began during pregnancy in a significantly higher percentage of MA than of MO patients ( p < 0.01). No significant difference was observed between the two groups of patients regarding the onset of migraine at menarche, after menopause, in the postpartum period or during the early cycles of oral contraceptives. Also, both groups of patients showed a similar migraine course during pregnancy, oral contraceptive use and menopause. Eight patients with coexisting migraine with aura and migraine without aura attacks reported the appearance of the aura symptom for the first time in the early cycles of oral contraceptive intake. These findings suggest that gonadal hormone fluctuation may influence both types of migraine.

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Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries

Cancers ◽

10.3390/cancers13081956 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1956

Author(s):

Swathi Kaliki ◽

Xunda Ji ◽

Yihua Zou ◽

Riffat Rashid ◽

Sadia Sultana ◽

...

Keyword(s):

Regional Lymph Node ◽

Collaborative Study ◽

National Income ◽

Signs And Symptoms ◽

Lag Time ◽

Primary Healthcare Centre ◽

Significant Difference ◽

Treatment Centre ◽

A Prospective Study ◽

The Relationship

Background: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes. Methods: We performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019. Results: The following factors were significantly different among different countries based on national-income level: age at diagnosis of RB (p = 0.001), distance from home to nearest primary healthcare centre (p = 0.03) and mean lag time between detection of first symptom to visit to RB treatment centre (p = 0.0007). After adjusting for country income, increased lag time between onset of symptoms and diagnosis of RB was associated with higher chances of an advanced tumour at presentation (p < 0.001), higher chances of high-risk histopathology features (p = 0.003), regional lymph node metastasis (p < 0.001), systemic metastasis (p < 0.001) and death (p < 0.001). Conclusions: There is a significant difference in the lag time between onset of signs and symptoms and referral to an RB treatment centre among countries based on national income resulting in significant differences in the presenting features and clinical outcomes.

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A prospective study of the differential changes in serum thyroglobulin and its autoantibodies during propylthiouracil or radioiodine therapy of patients with Graves' disease

Acta Endocrinologica ◽

10.1530/acta.0.0990379 ◽

1982 ◽

Vol 99 (3) ◽

pp. 379-385 ◽

Cited By ~ 23

Author(s):

Ulla Feldt-Rasmussen ◽

Karine Bech ◽

John Date ◽

Per Hyltoft Petersen ◽

Klaus Johansen

Keyword(s):

Steady Increase ◽

Graves Disease ◽

Treatment Level ◽

Serum Thyroglobulin ◽

Significant Difference ◽

Molecular Sizes ◽

Pre Treatment ◽

One Year ◽

A Prospective Study ◽

Secondary Rise

Abstract. Measurement of serum thyroglobulin (Tg) and its autoantibody (TgAb) by radioimmunological methods was performed in 48 patients with Graves' disease during treatment with radioiodine (n = 16) or propylthiouracil (PTU) (n = 32). Twenty-five of the 48 patients were TgAb positive, their sera being inaccessible to measurement of serum Tg. TgAb showed only minor changes during PTU treatment, whereas TgAb fell rapidly after radioiodine, in 5 of 16 patients to unmeasurable levels, followed by a secondary rise to 4.5 times pre-treatment level after 20 weeks. Serum Tg showed a steady increase during the first weeks after radioiodine treatment, but fell to lower levels after one year. PTU caused only minor changes in the serum Tg concentration. There was no shift in molecular sizes of either Tg or TgAb during the course of the treatments. Five of 16 131I-treated patients developed myxoedema, 4 of whom were TgAb positive. Another 3 patients had high increases in TgAb without myxoedema. Six of 18 patients had relapse of thyrotoxicosis after withdrawal of PTU-treatment. There was no significant difference in serum concentrations of TgAb or Tg between those developing relapse and those remaining in remission, and it is concluded that serum Tg is a poor predictor of relapse in medically treated thyrotoxicosis.

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Analysis of the relationship between different prognosis factors in patients with advanced colon cancer and progression-free survival.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e15518 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e15518-e15518

Author(s):

Eduardo Richardet ◽

Ignacio Magi ◽

Luciana Paola Acosta ◽

Maria gimena Ferreira ◽

Matias Molina ◽

...

Keyword(s):

Colon Cancer ◽

Statistical Significance ◽

Progression Free Survival ◽

Free Survival ◽

Advanced Colon Cancer ◽

Number Of Patients ◽

Significant Difference ◽

One Year ◽

The Relationship

e15518 Background: Colon tumors are a heterogeneous group of disease. As a result of the accumulation of different genetic and epigenetic alterations, the mutation of the RAS, BRAF oncogene and microsatellite instability stands out. A new line of research are immunological and inflammatory factors, the infiltrating lymphocytes of the tumor stroma (TILs) and the neutrophil to lymphocyte radio (NLR) have been studied by our work team. We understood could that these factors were associated with the survival rate in our patients. The main objective of this reseach is to determine the relationship between NLR and progression-free survival (PFS) in patients with advanced colon cancer. Secondary objective is to determine the relationship between the location of the primary tumor, RAS status, TILs, and PFS. in the same group of patients. Methods: A total of 93 medical records of patients with advanced colon cancer was analyzed. Those pts who had recieved first-line chemotherapy treatment with a FOLFOX scheme plus a monoclonal antibody were included. All patients had to have a minimum follow-up of 12 months. Regarding NLR, the patients were classified into two groups: high ( = > 4) and low ( < 4). Four TILs cut-off points were determined: > 40% intense; between 11-40% moderate, 1-10% mild, and 0% absent, which were group into two categories: intense and moderate; slight and absent. Localization was divided into left and right, and KRAS status was divided into mutated and wild-type (WT). PFS was calculated using the Kaplan-Meier test. Results: The median PFS of the general population was 8.74 (7.39-11.07) months. The median PFS was 9.86 (7.82-13.41) vs 5.09 (4.43-10.84) months for low and high NLR respectively, with statistical significance (p: 0.01). When the percentage of patients without progression after one year of treatment was analyzed, the difference was 45% vs 14% in favor of NLR < 4 on ≥4, this difference was also statistically significant (p: 0.02). PFS in relation to TILs after one year of follow up was 33% (8.61 months) for moderate-intense infiltrate vs 30% of mild-absent (7.10 months). PFS was 9.79 months for KRAS WT pts vs 7.82 months for mutated KRAS. In terms of location, PFS was 9.79 months for the left colon vs 8.28 months for the right colon. These factors did not have a statistically significant difference. Conclusions: The results of the study show how NLR < 4 is a prognostic factor with a positive impact on PFS. It should be noted that the median survival rates were numerically higher in moderate-intense vs mild-absent TILs, also in KRAS WT vs mutated and in left vs right location. It should also be noted that the possibly there was not a statistically significant difference between them due to the limited number of patients per what we will continue working on in the recruitment and analysis of these patients.

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