Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries

Background: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes. Methods: We performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019. Results: The following factors were significantly different among different countries based on national-income level: age at diagnosis of RB (p = 0.001), distance from home to nearest primary healthcare centre (p = 0.03) and mean lag time between detection of first symptom to visit to RB treatment centre (p = 0.0007). After adjusting for country income, increased lag time between onset of symptoms and diagnosis of RB was associated with higher chances of an advanced tumour at presentation (p < 0.001), higher chances of high-risk histopathology features (p = 0.003), regional lymph node metastasis (p < 0.001), systemic metastasis (p < 0.001) and death (p < 0.001). Conclusions: There is a significant difference in the lag time between onset of signs and symptoms and referral to an RB treatment centre among countries based on national income resulting in significant differences in the presenting features and clinical outcomes.

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Concomitant Rash and Blood Dyscrasias in Geriatric Psychiatry Patients Treated with Carbamazepine

Annals of Pharmacotherapy ◽

10.1345/aph.17445 ◽

1998 ◽

Vol 32 (9) ◽

pp. 884-887 ◽

Cited By ~ 21

Author(s):

Marshall Cates ◽

Richard Powers

Keyword(s):

Blood Count ◽

Geriatric Patients ◽

Complete Blood Count ◽

Case Reports ◽

Signs And Symptoms ◽

Geriatric Psychiatry ◽

Drug Induced ◽

Carbamazepine Therapy ◽

A Prospective Study ◽

The Relationship

BACKGROUND: Rashes and blood dyscrasias are disconcerting adverse effects associated with carbamazepine therapy. Rashes are quite common, as are mild blood dyscrasias, such as mild leukopenias. Fortunately, severe rashes and blood dyscrasias are rare. There are few reports on the relationship between carbamazepine-induced rashes and blood dyscrasias, including a prospective study in which rash appeared concomitantly with leukopenia and/or thrombocytopenia in 10 patients, two case reports in which simultaneous rash and agranulocytosis occurred, and two case reports in which rashes served as harbingers of fatal aplastic anemia. CASE REPORTS: We report two cases of concomitant rashes and blood dyscrasias in geriatric psychiatry patients receiving carbamazepine therapy for bipolar disorder. One patient was found to have a severe leukopenia within several days after rash onset. The other patient was discovered to have a severe leukopenia and thrombocytopenia within about a month after rash onset. DISCUSSION: Current hematologic monitoring guidelines for carbamazepine rely heavily on the recognition of signs and symptoms of blood dyscrasias by clinicians and patients. We believe that our cases support the suggestion that patients who develop rashes receive more vigilant monitoring of the complete blood count, should carbamazepine therapy be continued. Given the currently available case reports and the fact that the incidence of drug-induced blood dyscrasias increases with advanced age, this recommendation may be particularly relevant for geriatric patients. CONCLUSIONS: Further study is required to establish whether carbamazepine-induced concomitant rashes and blood dyscrasias are valid associations insofar as monitoring is concerned.

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Correlation between the Condyle Position and Intra-Extraarticular Clinical Findings of Temporomandibular Dysfunction

European Journal of Dentistry ◽

10.1055/s-0039-1698905 ◽

2011 ◽

Vol 05 (03) ◽

pp. 354-360 ◽

Cited By ~ 8

Author(s):

Sevgi Sener ◽

Faruk Akgunlu

Keyword(s):

Signs And Symptoms ◽

Clinical Findings ◽

Test Reliability ◽

Upper Cervical Spine ◽

Significant Difference ◽

Upper Cervical ◽

Condyle Position ◽

Condylar Position ◽

The Difference ◽

The Relationship

ABSTRACTObjectives: To investigate the relationship between different clinical findings and condyle position. Methods: Tenderness on masseter (MM), temporal (TM), lateral pyterigoid (LPM), medial pyterigoid (MPM) and posterior cervical (PSM) muscles, limitation, deviation and deflection in opening of mouth, clicking, crepitating, tenderness on lateral palpation of temporomandibular joint (TMJ) area for each side of 85 patients were evaluated. Each side of patients was categorized into the clinical findings: no sign and/or symptom of temporomandibular dysfunctions (TMDs), only extraarticular findings and only intraarticular findings, extra and intraarticular findings. Condyle positions of 170 TMJs were determined the narrowest anterior (a) and posterior interarticular distance (p) on midsagittal MRIs of condyles and expressed as p/a ratio and these ratio were transformed into logarithmic base e. Spearman’s Correlation was used to investigate the relationship between the condyle position and the clinical findings. The difference between the condyle positions of different groups was tested by T test. Reliability statistic was used to determine intra-observer concordance of two measurements of condylar position. Results: A significant relationship was found between the condyle position and tenderness of PSM. There was no significant difference between the groups in aspect of the condyle position. Occlusion and condyle position correlated with significantly. Conclusions: The inclination of the upper cervical spine and craniocervical angulations can cause the signs and symptoms of TMD and condyle position is not main cause of TMDs alone but it may be effective together with other possible etiological factors synergistically. (Eur J Dent 2011;5:354-360)

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Asymptomatic Bacteriuria in Pregnant Women

Journal of Nepal Medical Association ◽

10.31729/jnma.2193 ◽

2013 ◽

Vol 52 (192) ◽

Author(s):

Achala Thakur ◽

Ratna Baral ◽

Pritha Basnet ◽

Rubina Rai ◽

Ajay Agrawal ◽

...

Keyword(s):

Pregnant Women ◽

Urine Culture ◽

Asymptomatic Bacteriuria ◽

Signs And Symptoms ◽

Acinetobacter Species ◽

Significant Difference ◽

Culture Sensitivity ◽

Pregnancy Urine ◽

A Prospective Study ◽

In Pregnancy

Introduction: Asymptomatic bacteriuria is the significant presence of bacteria in urine of an individual without symptoms. The aim of the study is to determine the prevalence of asymptomaticbacteriuria in pregnant women. Methods: This study was a prospective study conducted in the department of Obstetrics and Gynaecology at B. P. Koirala Institute of Health Sciences. The duration of the study was six monthsfrom January to June 2012. A total of 600 pregnant women were enrolled. All women were clinically identified to have no signs and symptoms of UTI. Clean catch midstream urine sample was collectedfrom each patient into a sterile vial. The urine samples were examined for microscopic and culture sensitivity test. Results: Out of 600 pregnant women, 52 were positive for significant bacteriuria with a prevalence rate of 8.7%. There was a significant difference in prevalence of asymptomatic bacteriuria withrespect to trimester (p=0.005). Age did not show any significant difference in the prevalence of asymptomatic bacteriuria (p=0.807). There was not any significant difference in the prevalence ofasymptomatic bacteriuria with respect to parity (p=0.864) and booking status (p=0.397). Escherichia coli (35%), Acinetobacter species (15%), Enterococcus species (12%) and Klebsiella pneumoniae (10%)were the common isolates. Most of the isolates were sensitive either to Nitrofurantoin, Norfloxacin or Amikacin. Conclusions: Asymptomatic bacteriuria is common in pregnancy. Urine culture sensitivity should be carried out routinely on all pregnant patients in order to prevent the dangerous complicationsassociated with it. Keywords: asymptomatic bacteriuria in pregnancy; urine culture and sensitivity.

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Two Recombinant Tissue Factor Reagents Compared to Conventional Thromboplastins for Determination of International Normalised Ratio: A Thirty-three-laboratory Collaborative Study

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650586 ◽

1996 ◽

Vol 76 (03) ◽

pp. 372-376 ◽

Cited By ~ 6

Author(s):

S Kitchen ◽

I Jennings ◽

T A L Woods ◽

I D Walker ◽

F E Preston ◽

...

Keyword(s):

Tissue Factor ◽

Collaborative Study ◽

Routine Clinical Practice ◽

Significant Difference ◽

The Mean ◽

Recombinant Technology ◽

The Uk ◽

Local Use ◽

The Relationship

SummaryRecent advances in recombinant technology have led to the development of prothrombin time (PT) reagents containing recombinant tissue factor which has been lipidated to allow expression of procoagulant activity. In this study we have compared International Normalised Ratios (INRs) determined using two such reagents and conventional thromboplastins in widespread use in the UK.Lyophilised plasma samples from eight different warfarinised patients were distributed to 33 laboratories in the UK. Each participant determined prothrombin times on 20 local fresh normal plasmas (used to derive mean normal PT and calculate INR) and the eight lyophilised samples, using manual technique and the following thromboplastins; Recombiplastin (Ortho Diagnostics Ltd); Innovin (Baxter Diagnostics Ltd); the conventional thromboplastin in local use.For eight plasmas the mean INRs determined with different reagents were as follows: Innovin (33 laboratories) - 3.4; Manchester Reagent (MR = 8 laboratories) - 3.4; Recombiplastin (33 laboratories) - 3.7; Instrumentation Laboratory (IL = 13 laboratories) - 4.4.Mean INR results with Recombiplastin were on average 7% greater than those obtained with Innovin, 8% greater than results with MR and 18% less than INRs with IL thromboplastin. There was no significant difference between results obtained with Innovin and MR. In contrast INRs obtained with IL were markedly (mean 28%) greater than results obtained with Innovin.This study employed lyophilised plasma and it is possible that some of the relationships described are influenced by this. However, the lyo-philisation process employed did not influence the relationship between INRs of warfarinised plasmas obtained by the four main reagents described, indicating that the results are relevant to routine clinical practice.In conclusion, our data show some important differences are present between INRs determined using Recombiplastin, Innovin and two conventional thromboplastins.

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The impact of the application of corporate governance rules and principles on improving institutional performance

Journal of University of Human Development ◽

10.21928/juhd.v3n1y2017.pp203-229 ◽

2017 ◽

Vol 3 (1) ◽

pp. 203

Author(s):

Ammar Shihab Ahmed ◽

Osman Amin Ahmad

Keyword(s):

Corporate Governance ◽

National Income ◽

Institutional Performance ◽

Economic Implications ◽

Rules And Principles ◽

The Subject ◽

A Prospective Study ◽

Relationship Of ◽

The Impact ◽

The Relationship

It is the subject of corporate governance topics important due to the increasing moral hazard in the departments of joint stock companies practices resulting from the separation of management from ownership, which have opposite interests, which generated a host of problems between the two parties, which has affected negatively on the old and new investors to invest their money's confidence in joint-stock companies after the Crisis series the scandals, which affected major joint-stock companies, which led in turn to a decline in investment at the level of the overall economy and increasing unemployment, low national income, which has economic implications and social bad, hence the term corporate governance, the result of those problems are addressed by defining the obligations and rights of both the administration and other parties relevant, and that the application of the rules of corporate governance is very important to improve corporate performance, which has economic implications and his meeting positive. I have been conducting a prospective study on one of the joint-stock companies through the distribution of a questionnaire to some of the shareholders and employees in order to identify the extent of the application of corporate governance rules and principles of it, and the relationship of the company with other parties of non-contributors and has research found that the company management is working to their advantage and lack of attention to the interests of small shareholders and some foreign parties, which are at the heart of the application of the rules of banking governance.

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Abstract TP169: Migraine Phenotypic Spectrum in a CADASIL Cohort: Mayo Clinic Florida

Stroke ◽

10.1161/str.51.suppl_1.tp169 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Patrick Glover ◽

Neethu Gopal ◽

Mohammed Badi ◽

Eric Goldstein ◽

Josephine F Huang ◽

...

Keyword(s):

Migraine With Aura ◽

Genetic Diagnosis ◽

Significant Difference ◽

One Year ◽

A Prospective Study ◽

The Relationship ◽

Headache Impact ◽

Chronic Migraineurs ◽

Underlying Pathology ◽

Assessment Questionnaire

Objective: To characterize migraine in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Background: CADASIL serves as a key model of a monoallelic stroke disease. A portion of patients have coexistent migraine with aura, yet the relationship between migraine and the pathophysiology of CADASIL is poorly understood. Design/Methods: We performed a prospective study of adults with a confirmed genetic diagnosis of CADASIL, age-matched controls with migraine with aura (MA), and headache-free controls. The Migraine Disability Assessment Questionnaire (MIDAS) and Headache Impact Test (HIT-6) were used to quantify migraine-related disability. Subjects were followed for one year after enrollment. Results: We enrolled 88 subjects, which included 33 subjects with CADASIL, 32 subjects without CADASIL but with MA, and 23 control subjects without CADASIL or MA. Mean age was 53.6 (range, 22-86), 64.8% (57/88) were females, and 83% (73/88) were white. Of the CADASIL subjects, 61% (20/33) suffered from MA (CAD/+MA). Aura semiology amongst the CAD/+MA and MA patients were as follows: visual (80% vs 81%), sensory (75% vs 81%), speech (75% vs 50%), motor (30% vs 50%), brain stem (60% vs 81%) and retinal (30% vs 25%). Mean MIDAS scores at enrollment were comparable between the CAD/+MA and MA populations (32.3 vs 33.5), as were mean HIT-6 scores (56.3 vs 56.9). Discussion: These preliminary results do not show a significant difference in migraine disability between CADASIL migraineurs and chronic migraineurs. Minor differences were observed in aura distribution between the two groups, although further investigations are needed to better understand the underlying pathology of CADASIL and migraine.

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Determining the Relationship Between Fever of Without focus and Latent Pneumonia in Feverish Children in Bandar Abbas, Iran

Disease and Diagnosis ◽

10.34172/ddj.2021.09 ◽

2021 ◽

Vol 10 (2) ◽

pp. 47-50

Author(s):

Mohammad Meidari ◽

Mehran Ahmadi ◽

Marjan Tari Verdi ◽

Shahram Zare ◽

Maryam Mohammadian ◽

...

Keyword(s):

Emergency Department ◽

Unknown Origin ◽

Signs And Symptoms ◽

Pediatric Emergency ◽

Significant Difference ◽

The Mean ◽

The Difference ◽

Bandar Abbas ◽

Wbc Count ◽

The Relationship

Background: Fever is one of the most common causes of children’s referral to the emergency department, for which in 20% of cases no clear source is found. Latent pneumonia is not easily differentiable as one of the differential diagnoses of fever of unknown origin (FUO). This study aimed to determine the relationship between FUO and latent pneumonia in feverish children referring to pediatric emergency department. Materials and Methods: The present analytical research was carried out on 220 children with FUO aged 3-36 months referred to pediatric hospital of Bandar Abbas, Iran in 2019. To find the signs and symptoms, demographic information, history, and physical examination results were recorded by a physician using a predetermined checklist. Chest x-ray and blood sample were prepared for white blood cell (WBC) count, C-reactive protein (CRP), and absolute neutrophil count (ANC). Results: The mean age of the patients was 18.38±8.6 months. There was no significant difference between the mean fever, pulse rate, respiratory rate, WBC count, erythrocyte sedimentation rate (ESR), and ANC among the three groups differentiated by their diagnosis. The mean CRP in the bacterial pneumonia group was 68.17±24.13, while it was 35.00±20.43 in the viral infection group and 35.71±26.20 in the group of other diseases; the difference was statistically significant (P=0.004). Conclusion: Although there was no significant difference between WBC, ANC, and ESR and latent pneumonia, there was a significant difference between CRP and latent pneumonia, whose value was larger in these patients.

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Relationship between Thyroglobulin and Tumor Detectabilily with Thallium-201 in Differentiated Thyroid Cancer

Nuklearmedizin ◽

10.1055/s-0038-1632238 ◽

2000 ◽

Vol 39 (01) ◽

pp. 10-15 ◽

Cited By ~ 1

Author(s):

S. P. Müller ◽

Ch. Reiners ◽

A. Bockisch ◽

Katja Brandt-Mainz

Keyword(s):

Thyroid Cancer ◽

Differentiated Thyroid Cancer ◽

Roc Analysis ◽

Tsh Suppression ◽

Significant Difference ◽

Test Specificity ◽

The Relationship ◽

Tumor Scintigraphy ◽

Tsh Stimulation

Summary Aim: Tumor scintigraphy with 201-TICI is an established diagnostic method in the follow-up of differentiated thyroid cancer. We investigated the relationship between thyroglobulin (Tg) level and tumor detectability. Subject and methods: We analyzed the scans of 122 patients (66 patients with proven tumor). The patient population was divided into groups with Tg above (N = 33) and below (N = 33) 5 ng/ml under TSH suppression or above (N = 33) and below (N = 33) 50 ng/ml under TSH stimulation. Tumor detectability was compared by ROC-analysis (True-Positive-Fraction test, specificity 90%). Results: There was no significant difference (sensitivity 75% versus 64%; p = 0.55) for patients above and below 5 ng/ml under TSH suppression and a just significant difference (sensitivity 80% versus 58%; p = 0.04) for patients above and below 50 ng/ml under TSH stimulation. In 18 patients from our sample with tumor, Tg under TSH suppression was negative, but 201-TICI-scan was able to detect tumor in 12 patients. Conclusion: Our results demonstrate only a moderate dependence of tumor detectability on Tg level, probably without significant clinical relevance. Even in patients with slight Tg elevation 201-TICI scintigraphy is justified.

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Fecundity and Gonado-somatic Index of Trichiurus lepturus (Linnaeus, 1758) Along the Zamboanga del Norte Coast

International Journal of Emerging Research in Management and Technology ◽

10.23956/ijermt.v6i7.196 ◽

2018 ◽

Vol 6 (7) ◽

pp. 120

Author(s):

Ma. Dulce C. Guillena

Keyword(s):

Sex Ratio ◽

Stock Assessment ◽

Chi Square ◽

Moon Phases ◽

Ovary Weight ◽

Moment Coefficient ◽

Trichiurus Lepturus ◽

Significant Difference ◽

The Relationship ◽

Somatic Index

Gonado-somatic index and fecundity are tools for measuring the sexual maturity and ability of animals to reproduce. This study investigates the reproduction of Trichiurus lepturus. Specifically, this aimed to determine the sex ratio, the GSI, the relationship between fecundity and total length, fecundity and total weight, fecundity and ovary weight. The Descriptive Method of research was used. Percentage and chi-square was utilized in determining the percentage of occurrence and sex ratio respectively. Pearson r Product Moment Coefficient of Correlation was used to determine the relationships of the parameters. The study revealed that females outnumbered males and the sex ratio for different month showed significant difference. Spawning season was observed to occur in November and December as revealed in its GSI values and it synchronized with the full and new moon phases. Fecundity is positively correlated with body weight, body size, and ovary weight where ovary weight is observed to be the best index for fecundity. The results of this study could be used further for formal stock assessment of cutlassfish fishery.

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Rendimento de grãos de soja e de milho, no Rio Grande do Sul, não difere entre eventos El Niño Oscilação Sul

Agrometeoros ◽

10.31062/agrom.v26i1.26376 ◽

2018 ◽

Vol 26 (1) ◽

Author(s):

Ronaldo Matzenauer ◽

Bernadete Radin ◽

Alberto Cargnelutti Filho

Keyword(s):

El Niño ◽

El Nino ◽

Southern Oscillation ◽

Rio Grande ◽

La Niña ◽

Rio Grande Do Sul ◽

La Nina ◽

Significant Difference ◽

Income Data ◽

The Relationship

O objetivo deste trabalho foi avaliar a relação entre o fenômeno El Niño Oscilação Sul - ENOS e o rendimento de grãos de soja e de milho no Rio Grande do Sul e verificar a hipótese de que os eventos El Niño são favoráveis e os eventos La Niña são prejudiciais ao rendimento de grãos das culturas. Foram utilizados dados de rendimento de grãos dos anos agrícolas de 1974/75 a 2016/17, e relacionados com as ocorrências de eventos ENOS. Foram analisados os dados de rendimento observados na colheita e os dados estimados com a remoção da tendência tecnológica. Os resultados mostraram que não houve diferença significativa do rendimento médio de grãos de soja e de milho na comparação entre os eventos ENOS. Palavras-chave: El Niño, La Niña, safras agrícolas. Abstract – The objective of this work was to evaluate the relationship between the El Niño Southern Oscillation (ENSO) phenomenon with the grain yield of soybean and maize in Rio Grande do Sul state, Brazil and to verify the hypothesis that the El Niño events are favorable and the La Niña events are harmful to the culture’s grain yields. Were used data from the agricultural years of 1974/75 to 2016/17, and related to the occurrence of ENOS events. We analyzed income data observed at harvest and estimated data with technological tendency was removed. The results showed that there was no significant difference in the average yield of soybeans and corn in the comparison between events.

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