Abstract P417: Critical Knowledge Gaps in Characterizing Cognitive Impairment Among Intracerebral Hemorrhage Patients: Systematic Review of Contemporary Literature

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Thomas Potter ◽  
Jennifer Meeks ◽  
Osman Khan ◽  
Vivek Misra ◽  
Gavin W Britz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Intracerebral Hemorrhage ◽  
Animal Studies ◽  
English Literature ◽  
The Elderly ◽  
Sociodemographic Factors ◽  
Critical Knowledge ◽  
History Of ◽  
High Degree

Introduction: Despite emerging evidence, trajectories of cognitive impairment (CI) among patients with spontaneous intracerebral hemorrhage (ICH) are not well characterized. Methods: We conducted a systematic review of literature within PubMed, using keywords [“Intracerebral hemorrhage” OR “ICH”] AND “Cognitive Impairment,” after 2010. Articles reporting assessments of post ICH CI were included. Articles limited to pre-clinical (animal) studies, non-English literature, other intracranial hemorrhages, traumatic ICH, narrative reviews, and patient under 18 years were excluded. Results: Based on selection criteria, we included 16 articles (graphic) that provide an assessment of post-ICH CI. Post-ICH CI had a reported incidence of up to 85% within the first 2 weeks. The proportion of ICH patients who experience an incident CI across a longer follow up time period have been reported with a high degree of variability; with reports at 3 (32.5 - 71%), 4 (78%), 6 (37 - 63.3%), 9 (47.1 - 100%), 18 (51%), 30 (25.8%), 40 (23%), 45.6 (52 - 64%) and 60 (37.4%) months. Though the assessment scales utilized are variable; 12 (75%) reports employed a version of Montreal Cognitive Assessment or Information Questionnaire on Cognitive Decline in the Elderly. Lobar ICH was well identified, while non-lobar ICHs were variably grouped. Imaging markers have been reported in 10 (62.5%) reports. Though most studies report comorbidities and sociodemographic factors; stroke-specific severity / functional scales and genetic factors have only been considered by 2 (12.5%) articles each. Conclusions: At least 1 in 3 ICH survivors experience post-ICH CI over 12 months. There is an overall paucity of data on post-ICH CI, which highlights a critical need to characterize the natural history of post ICH CI in prospective cohorts and develop standardized assessment protocols for CI among ICH patients.

Letter to the Editor Regarding “Cognitive Impairment After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis”

2021 ◽  
Vol 151 ◽  
pp. 306
Author(s):  
Mayra Alejandra Uribe-Monterroza ◽  
Harold Andrés Caballero-Rueda ◽  
Katherine Tatiana Mora-Mora ◽  
Michael Gregorio Ortega-Sierra ◽  
Ivan David Lozada-Martínez
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Intracerebral Hemorrhage ◽  
Meta Analysis ◽  
Letter To The Editor

The effectiveness of serious games in improving memory among elderly people with cognitive impairment: A systematic review and meta-analysis (Preprint)

2021 ◽  
Author(s):  
Alaa Abd-alrazaq ◽  
Dari Alhuwail ◽  
Eiman Al-Jafar ◽  
Arfan Ahmed ◽  
Shuja Mohd Reagu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Verbal Memory ◽  
Serious Games ◽  
Meta Analysis ◽  
The Elderly ◽  
Quality Of Evidence ◽  
Meta Analyses

BACKGROUND Memory, one of the main cognitive functions, is known to decline by age. Serious games have been used for improving memory among the elderly. The effectiveness of serious games in improving memory has been investigated by several systematic reviews; however, they are limited by design and methodological weaknesses. OBJECTIVE This study aims to assess the effectiveness of serious games in improving memory among the elderly with cognitive impairment. METHODS A systematic review of randomized controlled trials (RCTs) was carried out. The search sources included searching 8 databases, screening reference lists of the included studies and relevant reviews, and checking studies that cited the included studies. Two reviewers independently carried out the study selection, data extraction, risk of bias assessment, and quality of evidence appraisal. Extracted data were synthesized using a narrative approach and a statistical approach (i.e., meta-analysis), as appropriate. RESULTS Out of 466 citations retrieved, 18 studies met the eligibility criteria of this review. Of those, 15 RCTs were eventually included in 10 meta-analyses. We found that serious games are more effective than no or passive interventions in improving non-verbal memory (P=0.002) and working memory (P=0.02), but not verbal memory (P=0.13). The review also showed that serious games are more effective than conventional exercises in improving verbal memory (P=0.004), but not for non-verbal memory (P=0.12) and working memory (P=0.49). Serious games were as effective as conventional cognitive activities in improving verbal memory (P=0.07), non-verbal memory (P=0.94), and working memory (P=0.08) among the elderly with cognitive impairment. Lastly, the effect of adaptive serious games on working memory was comparable to non-adaptive serious games (P=0.08). CONCLUSIONS Serious games have the potential to improve verbal, non-verbal, and working memory among elderly people with cognitive impairment. However, our findings should be interpreted cautiously given that most meta-analyses were based on a few studies (≤3) and judged to have a low quality of evidence. Therefore, serious games should be offered as supplemental to existing proven and safe interventions, rather than a complete substitute until further, more robust evidence is available. Future studies should investigate the short and long-term effects of serious games on memory and other cognitive abilities among people from different age groups with or without cognitive impairment.

scholarly journals Moxibustion for cognitive impairment: a systematic review and meta-analysis of animal studies

2020 ◽  
pp. 100680
Author(s):  
Sungmin Aum ◽  
Seon Choe ◽  
Mudan Cai ◽  
Ui Min Jerng ◽  
Jun-Hwan Lee
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Animal Studies ◽  
Meta Analysis

scholarly journals Relationship between cognition and frailty in elderly: A systematic review

2015 ◽  
Vol 9 (2) ◽  
pp. 110-119 ◽  
Author(s):  
Allan Gustavo Brigola ◽  
Estefani Serafim Rossetti ◽  
Bruna Rodrigues dos Santos ◽  
Anita Liberalesso Neri ◽  
Marisa Silvana Zazzetta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Search Strategy ◽  
Web Of Science ◽  
The Elderly ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
The Subject ◽  
The Relationship

OBJECTIVE: The aim of this study was to analyze the relationship between cognition and frailty in the elderly. METHODS: A systematic review on the currently existing literature concerning the subject was carried out. The search strategy included LILACS, SCOPUS, SciELO, PsycINFO, PubMed and Web of Science databases. RESULTS: A total of 19 studies were selected for review, from which 10 (52.6%) were cross-sectional and 9 (47.4%) longitudinal, and the majority Brazilian. All of the studies established a link between cognition and frailty. There was a relationship between components of frailty and the cognitive domains. Risk of Mild Cognitive Impairment (MCI), dementia and mortality were all evidenced in the relationship between frailty and cognitive impairment. CONCLUSION: The theory remains limited, but results show the variables that appear to be linked to cognition and frailty in elderly. This data can help in implementing actions to improve the quality of life among elderly.

scholarly journals Frequency and associated factors of amnestic mild cognitive impairment at four senior citizen clubs in Lima, Peru

2019 ◽  
Vol 13 (3) ◽  
pp. 321-328 ◽  
Author(s):  
Sofía S. Sánchez ◽  
Jesus Abanto ◽  
Arantxa Sanchez-Boluarte ◽  
Alicia Boluarte-Carbajal ◽  
Danilo Sanchez-Coronel ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Associated Factors ◽  
Senior Citizen ◽  
The Elderly ◽  
Amnestic Mild Cognitive Impairment ◽  
History Of ◽  
Or History ◽  
Activity Questionnaire

ABSTRACT Amnestic mild cognitive impairment (aMCI) is a subtle alteration in cognitive function that does not affect day-to-day activities and can precede Alzheimer's dementia. An increase in the prevalence of both these conditions is expected given the growing elderly population and recognizing risk factors can help reduce the burden. Objective: the aim of this study was to determine the frequency and associated factors of aMCI in senior citizen clubs (SCC) at four districts with different socioeconomic status in Lima, Peru. Methods: we applied Petersen's criteria to determine the presence of the condition in an interview which included the use of the Memory Alteration Test (M@T) and the Pfeffer Functional Activity Questionnaire (PFAQ). Results: sixty-three out of 352 (17.9%) participants had aMCI. Factors associated with this condition were older age, fewer years of education at marriage whereas being from the SCC La Molina (district with highest socioeconomic status and resources for activities for the elderly) were associated with not having aMCI. There was no difference for sex, body mass index or history of hypertension. Conclusion: this predementia stage is frequent and usually undetected in urban Lima. Tools such as the M@T could help general practitioners detect this condition before its progression to dementia.

scholarly journals Cognitive impairment and fear of falling in elderly with different social support levels: Findings from a community survey in Central Vietnam

2019 ◽  
Author(s):  
Thi Hue Man Vo ◽  
Keiko Nakamura ◽  
Kaoruko Seino ◽  
Hoang Thuy Linh Nguyen ◽  
Thang Van Vo
Keyword(s):  
Social Support ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Marital Status ◽  
Fear Of Falling ◽  
The Elderly ◽  
Related Factors ◽  
Support Level ◽  
High Social Support ◽  
History Of

Abstract Background Fear of falling (FoF) in the elderly is one of the major public health concerns in this era of aging of the population. Identifying risk factors is a step towards devising interventions for FoF. The aim of this study was to determine the prevalence of FoF and the associations between cognitive impairment and FoF by the social support level, after adjustments for potential confounders. Methods Data from the “Health needs assessment of elderly in Thua Thien Hue Province, Vietnam in 2018” survey of 725 elderly aged 60 years or older were used for analysis. FoF was assessed using the Fall Efficacy Scale - International. High FoF was defined as a score above 28. The Multidimensional Scale of Perceived Social Support was used to measure the perception of support. Logistic regression analysis was performed to investigate the factors that might be significantly (p <0.05) associated with the FoF. Results The prevalence of high FoF among the elderly was 40.8%. Female gender, advanced age, a marital status of single or formerly married, living alone, history of injury, history of falls, chronic diseases (arthritis and/or hypertension), limitations of the IADL and BADL, visual difficulty and walking difficulty, low social support, and cognitive impairment were all significantly associated with a high FoF. After adjustments for the age, gender, marital status, history of falls and health-related factors, cognitive impairment remained significantly associated with a high FoF among the elderly with a low to moderate social support level (OR = 2.97, 95% CI 1.49-5.89), but not in those with a high social support level. Conclusions Impairment of cognitive function was associated with a high FoF among the elderly who perceived themselves as having low or moderate support levels, even after adjustments for socio demographic and physical functional factors. However, this association was not observed among the elderly who perceived themselves as having high social support levels. Fall prevention programs for the elderly with various levels of social support should be carefully devised, keeping in mind the cognitive function levels of the target recipients.

scholarly journals A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Haitao Sun ◽  
Guohua Zhang ◽  
Bolun Ai ◽  
Huimin Zhang ◽  
Xiangyi Kong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Adverse Effect ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Elderly Patients ◽  
Meta Analysis ◽  
The Elderly ◽  
Independent Effect ◽  
Related Phenomenon

Abstract Background The potential risk for cognitive impairment following surgery and anesthesia is a common concern, especially in the elderly and more fragile patients. The risk for various neurocognitive effects is thus an area of importance. The independent impact of surgery and anesthesia is still not known. Likewise, the independent effect of different drugs used during anesthesia is a matter of debate, as is the number and amounts of drugs used and the “depth of anesthesia.” So, understanding the drug-related phenomenon and mechanisms for postoperative cognitive impairment is essential. This meta-analysis aims to compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function in elderly patients with lung cancer. Methods This study is a systematic review and meta-analysis for controlled clinical studies. Public-available online databases were searched to identify eligible randomized placebo-controlled trials or prospective cohort studies concerning the effects of propofol and sevoflurane on postoperative cognitive function. The primary endpoints are postoperative mini-mental state examination (MMSE) scores at various time points; the secondary endpoint is the serum S100beta concentration 24 h after surgery. Standard mean differences (SMDs) along with 95% confidence intervals (CIs) were extracted and analyzed using random or fixed-effects models. Analyses regarding heterogeneity, risk of bias assessment, and sensitivity were performed. Results We searched 1626 eligible publications and 14 studies of 1404 patients were included in the final analysis. The majority of included studies had been undertaken in Asian populations. Results suggested that propofol has a greater adverse effect on cognitive function in the elderly patients with lung cancer than sevoflurane. There were significant differences in issues of MMSE 6 h (11 studies; SMD -1.391, 95% CI -2.024, − 0.757; p < 0.001), MMSE 24 h (14 studies; SMD -1.106, 95% CI -1.588, − 0.624; p < 0.001), MMSE 3d (11 studies; SMD -1.065, 95% CI -1.564, − 0.566; p < 0.001), MMSE 7d (10 studies; SMD -0.422, 95% CI -0.549, − 0.295; p < 0.001), and serum S100beta concentration at 1 day after surgery (13 studies; SMD 0.746, 95% CI 0.475, 1.017; p < 0.001). Conclusion Propofol has a more significant adverse effect on postoperative cognitive function in elderly patients with lung cancer than sevoflurane.

Comorbidity of normotensive hydrocephalia and Parkinson’s disease

2021 ◽  
Vol 26 (2) ◽  
pp. 30-36
Author(s):  
V. V. Yudina ◽  
O. N. Voskresenskaya ◽  
G. K. Yudina
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Subsequent Development ◽  
The Elderly ◽  
Transcranial Sonography ◽  
History Of ◽  
Clinical Triad ◽  
Gait Disturbances ◽  
The Brain

Normotensive hydrocephalus (NTH) is a syndrome characterized by enlarged ventricles of the brain, gait disturbance, cognitive impairment, and incontinence. In the elderly with gait disturbances of unspecified etiology, NTH should always be excluded. It is especially difficult to diagnose NTH in patients with neurodegenerative diseases, primarily with idiopathic Parkinson’s disease (PD), and vice versa, to diagnose PD in patients with NTH. We report on an 80-year-old patient with a five-year history of NTH, manifested by the classic clinical triad of symptoms and the subsequent development of Parkinson’s syndrome 3 years after the debut of NTH. MRI of his brain revealed ventriculomegaly and transcranial sonography did hyperechogenicity of the substantia nigra on the left, with an area of 0.41 cm2, which made it possible to diagnose two comorbid diseases in the patient, namely, normotensive hydrocephalus and Parkinson’s disease.

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