scholarly journals High Dietary Inflammatory Index Is Associated With Increased Plaque Vulnerability of Carotid in Patients With Ischemic Stroke

Stroke ◽  
2020 ◽  
Vol 51 (10) ◽  
pp. 2983-2989
Author(s):  
Min Peng ◽  
Ling Wang ◽  
Yaqian Xia ◽  
Lei Tao ◽  
Yujing Liu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Vulnerable Plaque ◽  
Fruits And Vegetables ◽  
Atherosclerotic Plaques ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Vulnerable Plaques ◽  
Ct Attenuation ◽  
Remodeling Index

Background and Purpose: Long-term dietary patterns can influence the intensity of systemic inflammation and, therefore, the development of atherosclerosis. This study aimed to evaluate the association between dietary inflammatory index (DII) and vulnerability characteristics of carotid atherosclerotic plaques in patients with ischemic stroke. Methods: Patients with ischemic stroke within 7 days of onset were enrolled. DII was calculated from 32 food components with the help of a food frequency questionnaire. Vulnerable plaque was defined as presence of artery positive remodeling (remodeling index >1.1) and low CT attenuation plaques (<35 HU) on carotid arteries by computed tomography angiography. Results: Of the 398 enrolled patients, 144 (36.2%) were detected with vulnerable plaque. Their DII ranged from −4.58 to 4.18. Patients with vulnerable plaques consumed less nutrients with anti-inflammatory properties, less fruits and vegetables (85.6±64.3 versus 94.6±74.4 g/d, P =0.027), and less nuts (5.66±7.14 versus 8.84±15.9 g/d, P =0.024) than patients without vulnerable plaques. Patients with vulnerable plaque had higher DII than patients without vulnerable plaque (−0.26±1.54 versus −0.64±1.53, P =0.018). Logistic regression analysis revealed that DII was associated with vulnerable plaques after adjusted for major confounding factors (odds ratio=1.307; 95% CI, 1.113–1.533). Conclusions: DII is associated with the vulnerability of carotid plaques in patients with ischemic stroke. Considering a possible causal relationship, the mechanisms underlying the association between diet and atherosclerosis warrant further study.

scholarly journals Long-term associations between inflammatory dietary scores in relation to long-term C-reactive protein status measured 12 years later: findings from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort

2017 ◽  
Vol 117 (2) ◽  
pp. 306-314 ◽  
Author(s):  
Chantal Julia ◽  
Karen E. Assmann ◽  
Nitin Shivappa ◽  
James R. Hebert ◽  
Michael D. Wirth ◽  
...  
Keyword(s):  
Underlying Mechanism ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
Reactive Protein ◽  
Modifiable Factors ◽  
Dietary Records

AbstractChronic low-grade inflammation has been recognised as a key underlying mechanism for several chronic diseases, including cancer and CVD. Nutrition represents a host of key modifiable factors that influence chronic inflammation. Dietary inflammatory scores were developed to assess the inflammatory potential of the diet and have been associated with inflammatory biomarkers in cross-sectional and short-term longitudinal studies. The objective of this study was to investigate the relationship between the dietary inflammatory index (DII), the alternate dietary inflammatory index (ADII) and long-term C-reactive protein (CRP). We also tested age as an effect modifier of this relationship. Participants were selected in the Supplémentation en Vitamines et Minéraux Antioxydants study, which included subjects aged 45–60 years old for men and 35–60 years old for women in 1994. Participants with ≥3 24-h dietary records at baseline and a CRP measurement at the 12-year follow-up evaluation were included in the present study (n 1980). The relationships between the DII and ADII and elevated CRP (>3 mg/l) were investigated using logistic multivariable regression. All analyses were stratified by age (cut-off at median age=50 years old). The overall associations between DII and ADII and long-term CRP were not statistically significant (Ptrend across tertiles=0·16 for DII and 0·10 for ADII). A quantitative interaction was found between ADII score and age (P=0·16 for ADII, 0·36 for DII). In stratified analyses the ADII was significantly prospectively associated with CRP only in younger participants: OR tertile 3 v. tertile 1: 1·79 (95 % CI 1·04, 3·07). Pro-inflammatory diets may have long-term effect on CRP only in younger subjects.

scholarly journals Vulnerable atherosclerotic plaques of coronary arteries in patients with stable coronary artery disease: 12-months follow-up

Kardiologiia ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 69-74
Author(s):  
N. A. Kochergin ◽  
A. M. Kochergina ◽  
A. A. Khorlampenko ◽  
V. I. Ganyukov ◽  
A. A. Shilov ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Arteries ◽  
Vulnerable Plaque ◽  
Atherosclerotic Plaques ◽  
Virtual Histology ◽  
Vulnerable Plaques ◽  
Artery Disease ◽  
Stable Cad ◽  
Over Time

Relevance. A key objective of modern cardiology is the assessment of acute coronary syndrome (ACS) risk in patients with coronary artery disease (CAD) to develop preventive measures and choose optimal treatment strategies.Objective. Detect vulnerable plaques of non-target coronary arteries in patients with stable CAD during routine percutaneous coronary intervention using virtual-histology intravascular ultrasound (VH-IVUS) and view their morphology over time.Materials and Methods. The prospective observational cohort study included 58 patients with stable CAD. After stenting of a target vessel, VH-IVUS was carried out in proximal and middle segments (6–8 cm) of a non-target coronary artery with no significant stenosis according to coronary angiography. Twelve months later, all patients underwent coronary angiography with re-IVUS of previously detected lesions. Death, myocardial infarction, rehospitalization, and unplanned myocardial revascularization due to vulnerable plaques were the endpoints of the study.Results. IVUS with virtual histology revealed 58 lesions of non-target coronary arteries in 56 (96.5 %) patients. Two patients had no lesions in non-target coronary arteries. A large necrotic core with thin cap (thin-cap fibroatheroma) was detected in 12 (20.7 %) plaques, six of which had additional ACS risk criteria (stenosis area >70 % and / or lumen area <4 mm2). Within the 12‑month follow-up period, three patients (one with a vulnerable plaque in IVUS) were hospitalized with a clinical picture of ACS. One cardiac death was registered in a patient with the IVUS vulnerable plaque. 7 of 12 vulnerable plaques stabilized in 12 months.Conclusion. 1) The data presented indicate a high rate (20.7 %) of vulnerable plaques of non-target coronary arteries in patients with stable CAD who underwent stenting; 2) Two (16.6 %) patients with vulnerable plaques reached endpoints (death and rehospitalization) within the 12‑month follow-up period; 3) An analysis of atherosclerotic plaques in non-target coronary arteries over time showed that vulnerable plaques stabilized and did not cause ACS in more than half of cases (7 of 12); 4) Plaques that were not vulnerable according to IVUS were not likely to destabilize within the 12‑month follow-up period.

Dietary Inflammatory Index and Leukoaraiosis in Patients with Ischemic Stroke

2020 ◽  
Vol 24 (5) ◽  
pp. 473-477
Author(s):  
X. Gong ◽  
W. Shan ◽  
K. Yuan ◽  
Z. Lu ◽  
M. Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index

Association between the dietary inflammatory index and all-cause mortality in colorectal cancer long-term survivors

2018 ◽  
Vol 144 (6) ◽  
pp. 1292-1301 ◽  
Author(s):  
Ilka Ratjen ◽  
Nitin Shivappa ◽  
Clemens Schafmayer ◽  
Greta Burmeister ◽  
Ute Nöthlings ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
All Cause Mortality ◽  
Long Term Survivors

Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study

2016 ◽  
Vol 56 (4) ◽  
pp. 1647-1655 ◽  
Author(s):  
Emmanuelle Kesse-Guyot ◽  
Karen E. Assmann ◽  
Valentina A. Andreeva ◽  
Mathilde Touvier ◽  
Lola Neufcourt ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index

Temperature Measurement of Advanced Murine Atherosclerotic Plaques

2007 ◽  
Author(s):  
Frank Gijsen ◽  
Anna Ten Have ◽  
Jolanda Wentzel ◽  
Antonius Van Der Steen
Keyword(s):  
Heart Disease ◽  
Vulnerable Plaque ◽  
Acute Coronary Syndromes ◽  
Coronary Atherosclerosis ◽  
Developmental Stages ◽  
Atherosclerotic Plaques ◽  
Fibrous Cap ◽  
Vulnerable Plaques ◽  
Coronary Syndromes ◽  
Plaque Detection

Ischaemic heart disease is most frequently caused by coronary atherosclerosis, of which the vulnerable plaque is one of the developmental stages. Rupture of a vulnerable plaque with superimposed thrombosis frequently leads to acute coronary syndromes. The major components of a vulnerable plaque are a lipid-rich, atheromatous core, and a thin fibrous cap with macrophage and macrophage infiltration (Schaar et al., 2004). After the first paper suggesting the possibility of thermographic detection of vulnerable plaques (Casscells et al., 1996), intracoronary thermography as a vulnerable plaque detection technique has been investigated. Increased metabolic activity of macrophages is suggested as the main reasons for the increased temperatures (ten Have et al., 2005).

Energy-adjusted Dietary Inflammatory Index scores predict long-term cardiovascular disease mortality and other causes of death in an ecological analysis of the Seven Countries Study

2020 ◽  
pp. 204748732090386
Author(s):  
Paolo E Puddu ◽  
Nitin Shivappa ◽  
Alessandro Menotti ◽  
James R Hébert ◽  
Hanna Tolonen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Dietary Inflammatory Index ◽  
Cardiovascular Disease Mortality ◽  
Inflammatory Index ◽  
Disease Mortality ◽  
Seven Countries Study ◽  
All Cause Mortality

Using data from the Seven Countries Study of Cardiovascular Diseases, the first study to conduct international comparisons of men in different European, USA, and Japanese cohorts, we examined the effect of diet-associated inflammation on prediction of coronary heart disease-, other major cardiovascular disease- and all-cause mortality after 50-years of follow-up. The energy-adjusted Dietary Inflammatory Index was used to quantify the effect of diet on systemic inflammation. Positive linear correlations were observed between the cohort-average energy-adjusted Dietary Inflammatory Index score and both overall death rates ( R = 0.61, p = 0.0114) and major cardiovascular disease mortality rates ( R = 0.51, p = 0.0337) but not cancer. Correlations for all-cause mortality were higher when the Belgrade outlier cohort was omitted ( R = 0.72, p = 0.0024) or when analyses were adjusted for socioeconomic status ( R = 0.67, p = 0.0065). There was also a significant reverse correlation between energy-adjusted Dietary Inflammatory Index score and age at death ( R = –0.50 to –0.68, p = 0.0480 to 0.0012). Adjusting for systolic blood pressure, cholesterol, and smoking habits did not modify these correlations that were still significant. With control for these covariates a significant correlation emerged for coronary heart disease. Results obtained using a 25-year follow-up to allow unprojected data from all cohorts were similar. Results from this long-term follow-up study are consistent with a recommendation to increase consuming an anti-inflammatory diet characterized by high concentrations of fruits and vegetables and low consumption of simple carbohydrates and fats.

Long-Term Brain Atrophy after Focal Ischemic Stroke: A Longitudinal Study Applying Deformation-Based Morphometry

2004 ◽  
Vol 35 (03) ◽  
Author(s):  
S Schnaudigel ◽  
T Ugur ◽  
F Kruggel ◽  
HJ Mentzel ◽  
C Fitzek ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Longitudinal Study ◽  
Brain Atrophy ◽  
Deformation Based Morphometry

Mechanical thrombectomy in pediatric stroke: systematic review, individual patient data meta-analysis, and case series

2019 ◽  
Vol 24 (5) ◽  
pp. 558-571 ◽  
Author(s):  
Kartik Bhatia ◽  
Hans Kortman ◽  
Christopher Blair ◽  
Geoffrey Parker ◽  
David Brunacci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mechanical Thrombectomy ◽  
Case Reports ◽  
Meta Analysis ◽  
Case Series ◽  
Neurological Outcomes

OBJECTIVEThe role of mechanical thrombectomy in pediatric acute ischemic stroke is uncertain, despite extensive evidence of benefit in adults. The existing literature consists of several recent small single-arm cohort studies, as well as multiple prior small case series and case reports. Published reports of pediatric cases have increased markedly since 2015, after the publication of the positive trials in adults. The recent AHA/ASA Scientific Statement on this issue was informed predominantly by pre-2015 case reports and identified several knowledge gaps, including how young a child may undergo thrombectomy. A repeat systematic review and meta-analysis is warranted to help guide therapeutic decisions and address gaps in knowledge.METHODSUsing PRISMA-IPD guidelines, the authors performed a systematic review of the literature from 1999 to April 2019 and individual patient data meta-analysis, with 2 independent reviewers. An additional series of 3 cases in adolescent males from one of the authors’ centers was also included. The primary outcomes were the rate of good long-term (mRS score 0–2 at final follow-up) and short-term (reduction in NIHSS score by ≥ 8 points or NIHSS score 0–1 at up to 24 hours post-thrombectomy) neurological outcomes following mechanical thrombectomy for acute ischemic stroke in patients < 18 years of age. The secondary outcome was the rate of successful angiographic recanalization (mTICI score 2b/3).RESULTSThe authors’ review yielded 113 cases of mechanical thrombectomy in 110 pediatric patients. Although complete follow-up data are not available for all patients, 87 of 96 (90.6%) had good long-term neurological outcomes (mRS score 0–2), 55 of 79 (69.6%) had good short-term neurological outcomes, and 86 of 98 (87.8%) had successful angiographic recanalization (mTICI score 2b/3). Death occurred in 2 patients and symptomatic intracranial hemorrhage in 1 patient. Sixteen published thrombectomy cases were identified in children < 5 years of age.CONCLUSIONSMechanical thrombectomy may be considered for acute ischemic stroke due to large vessel occlusion (ICA terminus, M1, basilar artery) in patients aged 1–18 years (Level C evidence; Class IIb recommendation). The existing evidence base is likely affected by selection and publication bias. A prospective multinational registry is recommended as the next investigative step.

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