scholarly journals Dynamic Encoding of Effort and Reward throughout the Execution of Action by External Globus Pallidus Neurons in Monkeys

2018 ◽  
Vol 30 (8) ◽  
pp. 1130-1144 ◽  
Author(s):  
Simon Nougaret ◽  
Sabrina Ravel

Humans and animals must evaluate the costs and expected benefits of their actions to make adaptive choices. Prior studies have demonstrated the involvement of the basal ganglia in this evaluation. However, little is known about the role of the external part of the globus pallidus (GPe), which is well positioned to integrate motor and reward-related information, in this process. To investigate this role, the activity of 126 neurons was recorded in the associative and limbic parts of the GPe of two monkeys performing a behavioral task in which different levels of force were required to obtain different amounts of liquid reward. The results first revealed that the activity of associative and limbic GPe neurons could be modulated not only by cognitive and limbic but also motor information at the same time, both during a single period or during different periods throughout the trial, mainly in an independent way. Moreover, as a population, GPe neurons encoded these types of information dynamically throughout the trial, when each piece of information was the most relevant for the achievement of the action. Taken together, these results suggest that GPe neurons could be dedicated to the parallel monitoring of task parameters essential to adjusting and maintaining goal-directed behavior.

Author(s):  
Albert K. Toh ◽  
Yupo Chan

Although the topic of supply chain (SC) and logistics (L) has been discussed in many fora, placing it in today’s cyber (e) space is still a subject that receives little attention. This paper analyzes the role of e-SC/L in the context of global business to business (B2B) electronic commerce (e-commerce). A major beneficiary of e-SC/L are small and medium enterprises (SMEs), who can leverage information technology to bypass the extra cost associated with employing a third-party broker, who traditionally bridges the gap between suppliers and retailers. In this paper, a framework for incorporating both e-commerce and e-SC/L for SMEs is proposed in an e-marketplace context. The model consists of a trading platform with e-SC/L capabilities, and a classification scheme for different levels e-SC/L collaboration, presented with relevant types of information, communication and transportation technology (ICTT) needed to facilitate the design of each collaboration level. Included in the highest level are transportation, identification, and modeling and simulation technologies that enable the design of effective forward-looking collaboration.


2003 ◽  
Vol 90 (2) ◽  
pp. 961-971 ◽  
Author(s):  
Irina N. Beloozerova ◽  
Mikhail G. Sirota

The parietal cortex receives both visual- and motor-related information and is believed to be one of the sites of visuo-motor coordination. This study for the first time characterizes integration of visual and motor information in activity of neurons of parietal area 5 during locomotion under conditions that require visuo-motor coordination. The activity of neurons was recorded in cats during walking on a flat surface—a task with no visuo-motor coordination required (flat locomotion), walking along a horizontal ladder or a series of barriers—a task requiring visuo-motor coordination for an accurate foot placement on surface that is heterogeneous along the direction of progression (ladder and barriers locomotion), and walking along a narrow pathway—a task requiring visuo-motor coordination on surface homogeneous along the direction of progression (narrow locomotion). During flat locomotion, activity of 66% of the neurons was modulated in rhythm of stepping, usually with one peak per cycle. During ladder and barrier locomotion, the proportion of rhythmically active neurons significantly increased, their modulation became stronger, and the majority of neurons had two peaks of activity per cycle. During narrow locomotion, however, the activity of neurons was similar to that during flat locomotion. We concluded that, during locomotion, parietal area 5 integrates two types of information: signals about the activity of basic locomotion mechanisms and signals about heterogeneity of the surface along the direction of progression. We describe here the modes of integration of these two types of information during locomotion.


2010 ◽  
Vol 1 (3) ◽  
pp. 1-17
Author(s):  
Albert K. Toh ◽  
Yupo Chan

Although the topic of supply chain (SC) and logistics (L) has been discussed in many fora, placing it in today’s cyber (e) space is still a subject that receives little attention. This paper analyzes the role of e-SC/L in the context of global business to business (B2B) electronic commerce (e-commerce). A major beneficiary of e-SC/L are small and medium enterprises (SMEs), who can leverage information technology to bypass the extra cost associated with employing a third-party broker, who traditionally bridges the gap between suppliers and retailers. In this paper, a framework for incorporating both e-commerce and e-SC/L for SMEs is proposed in an e-marketplace context. The model consists of a trading platform with e-SC/L capabilities, and a classification scheme for different levels e-SC/L collaboration, presented with relevant types of information, communication and transportation technology (ICTT) needed to facilitate the design of each collaboration level. Included in the highest level are transportation, identification, and modeling and simulation technologies that enable the design of effective forward-looking collaboration.


2021 ◽  
Vol 15 ◽  
Author(s):  
Lei Xiao ◽  
Todd F. Roberts

Basal ganglia (BG) circuits integrate sensory and motor-related information from the cortex, thalamus, and midbrain to guide learning and production of motor sequences. Birdsong, like speech, is comprised of precisely sequenced vocal elements. Learning song sequences during development relies on Area X, a vocalization related region in the medial striatum of the songbird BG. Area X receives inputs from cortical-like pallial song circuits and midbrain dopaminergic circuits and sends projections to the thalamus. It has recently been shown that thalamic circuits also send substantial projections back to Area X. Here, we outline a gated-reinforcement learning model for how Area X may use signals conveyed by thalamostriatal inputs to direct song learning. Integrating conceptual advances from recent mammalian and songbird literature, we hypothesize that thalamostriatal pathways convey signals linked to song syllable onsets and offsets and influence striatal circuit plasticity via regulation of cholinergic interneurons (ChIs). We suggest that syllable sequence associated vocal-motor information from the thalamus drive precisely timed pauses in ChIs activity in Area X. When integrated with concurrent corticostriatal and dopaminergic input, this circuit helps regulate plasticity on medium spiny neurons (MSNs) and the learning of syllable sequences. We discuss new approaches that can be applied to test core ideas of this model and how associated insights may provide a framework for understanding the function of BG circuits in learning motor sequences.


2009 ◽  
Author(s):  
Elena Zinchenko ◽  
Jesse Snedeker
Keyword(s):  

Author(s):  
Gulbarshyn Chepurko ◽  
Valerii Pylypenko

The paper examines and compares how the major sociological theories treat axiological issues. Value-driven topics are analysed in view of their relevance to society in times of crisis, when both societal life and the very structure of society undergo dramatic change. Nowadays, social scientists around the world are also witnessing such a change due to the emergence of alternative schools of sociological thought (non-classical, interpretive, postmodern, etc.) and, subsequently, the necessity to revise the paradigms that have been existed in sociology so far. Since the above-mentioned approaches are often used to address value-related issues, building a solid theoretical framework for these studies takes on considerable significance. Furthermore, the paradigm revision has been prompted by technological advances changing all areas of people’s lives, especially social interactions. The global human community, integral in nature, is being formed, and production of human values now matters more than production of things; hence the “expansion” of value-focused perspectives in contemporary sociology. The authors give special attention to collectivities which are higher-order units of the social system. These units are described as well-organised action systems where each individual performs his/her specific role. Just as the role of an individual is distinct from that of the collectivity (because the individual and the collectivity are different as units), so too a distinction is drawn between the value and the norm — because they represent different levels of social relationships. Values are the main connecting element between the society’s cultural system and the social sphere while norms, for the most part, belong to the social system. Values serve primarily to maintain the pattern according to which the society is functioning at a given time; norms are essential to social integration. Apart from being the means of regulating social processes and relationships, norms embody the “principles” that can be applied beyond a particular social system. The authors underline that it is important for Ukrainian sociology to keep abreast of the latest developments in the field of axiology and make good use of those ideas because this is a prerequisite for its successful integration into the global sociological community.


Author(s):  
Admink Admink ◽  
Сергій Виткалов ◽  
Валентина Вігула

Розглядається організаційно-культурна діяльність одного з помітних у регіональному просторі Західного Полісся фотомитця – Олександра Купчинського, а саме виставковий її вектор, втілений в презентації артефактів світового фотомистецтва; видавничий, розглянутий у  контексті  друку  різноманітних  фотоальбомів  із  творів експонентів, організація творчих зустрічей художньої інтелігенції міста з питань обговорення актуальних питань культурного розвитку, заснування фотоклубу тощо. Доводиться, що втрата зв’язку з Батьківщиною, у якій би формі це не відбувалося, не дозволяє митцю творчо самореалізуватися повною мірою. The importance and problematic range of local government reform in the regions of the country and ways of its solution in the field of culture are analyzed. The most effective steps are proposed for management structures at different levels to change attitudes of both the management and the local population regarding different cultural practices. Emphasis is placed on the role of sectoral methodological services in the implementation of this reform. The experience of other countries in activating the local population in this process is emphasized. An attempt has been made to offer effective, in the authors' opinion, solutions to the reform. Emphasis is placed on the educational factor.


Author(s):  
Shaun Blanchard

This book sheds further light on the nature of church reform and the roots of the Second Vatican Council (1962–65) through a study of eighteenth-century Catholic reformers who anticipated the Council. The most striking of these examples is the Synod of Pistoia (1786), the high-water mark of late Jansenism. Most of the reforms of the Synod were harshly condemned by Pope Pius VI in the bull Auctorem fidei (1794), and late Jansenism was totally discredited in the ultramontane nineteenth-century Church. Nevertheless, much of the Pistoian agenda—such as an exaltation of the role of bishops, an emphasis on infallibility as a gift to the entire Church, religious liberty, a simpler and more comprehensible liturgy that incorporates the vernacular, and the encouragement of lay Bible reading and Christocentric devotions—was officially promulgated at Vatican II. The career of Bishop Scipione de’ Ricci (1741–1810) and the famous Synod he convened are investigated in detail. The international reception (and rejection) of the Synod sheds light on why these reforms failed, and the criteria of Yves Congar are used to judge the Pistoian Synod as “true or false reform.” This book proves that the Synod was a “ghost” present at Vatican II. The council fathers struggled with, and ultimately enacted, many of the same ideas. This study complexifies the story of the roots of the Council and Pope Benedict XVI’s “hermeneutic of reform,” which seeks to interpret Vatican II as in “continuity and discontinuity on different levels” with past teaching and practice.


2021 ◽  
pp. 216770262095934
Author(s):  
Julia M. Sheffield ◽  
Holger Mohr ◽  
Hannes Ruge ◽  
Deanna M. Barch

Rapid instructed task learning (RITL) is the uniquely human ability to transform task information into goal-directed behavior without relying on trial-and-error learning. RITL is a core cognitive process supported by functional brain networks. In patients with schizophrenia, RITL ability is impaired, but the role of functional network connectivity in these RITL deficits is unknown. We investigated task-based connectivity of eight a priori network pairs in participants with schizophrenia ( n = 29) and control participants ( n = 31) during the performance of an RITL task. Multivariate pattern analysis was used to determine which network connectivity patterns predicted diagnostic group. Of all network pairs, only the connectivity between the cingulo-opercular network (CON) and salience network (SAN) during learning classified patients and control participants with significant accuracy (80%). CON-SAN connectivity during learning was significantly associated with task performance in participants with schizophrenia. These findings suggest that impaired interactions between identification of salient stimuli and maintenance of task goals contributes to RITL deficits in participants with schizophrenia.


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