Tainted Love: The Trials and Tribulations of a Career in Animal Studies

2019 ◽  
Vol 27 (4) ◽  
pp. 361-382 ◽  
Author(s):  
Siobhan O’Sullivan ◽  
Yvette Watt ◽  
Fiona Probyn-Rapsey
Keyword(s):  
Higher Education ◽  
Animal Studies ◽  
Academic Career ◽  
Term Benefit

AbstractDeveloping an academic career can be exciting, rewarding and stimulating. It can also be challenging, disheartening, and highly insecure. Results from a survey of Animal Studies (AS) scholars identifies reasons why pursuing a career in AS might generate additional challenges, over and above those experienced by academics generally. For example, 44 percent of respondents stated that in their view, undertaking research in AS “creates challenges for an academic career.” This is compared to just 16 percent who thought that it is an advantage. Yet despite the challenges, there is much that is positive about AS. Participants described being in “dialogue with clever colleagues,” viewed their work as “totally engaging,” and reported feeling “morally useful.” This in turn affords AS scholars an authenticity that may be of long-term benefit in the competitive and constantly transforming world of higher education.

scholarly journals Private Equity in Higher Education Sector in India- Need of the Hour!

2018 ◽  
Vol 14 (1) ◽  
pp. 40-57
Author(s):  
Meenal Sharma ◽  
Gurendra Nath Bharadwaj ◽  
Shrey Kumar
Keyword(s):  
Higher Education ◽  
Social Factors ◽  
Initial Phase ◽  
Private Equity ◽  
Educational Institution ◽  
Quality Of Education ◽  
Term Benefit ◽  
Poor Management

Setting up of an educational institution is not easy and requires a lot of regulatory formalities to be completed before opening and during its operations. If it is shut down within initial phase it is painful as well as legally difficult to close it, especially in India. It has been observed that a significant number of academic institutions of technical higher education have been shut down by the promoters due to lack of financial viability, lack of knowledge of about the business, poor management, and other social factors. The present study is an attempt to find out the reasons of mass failure of many technical higher education institutions and to suggest a unique financing model in order to ensure the quality of education and long-term benefit for the promoters by maintaining financial discipline.

751 Long-term benefit of a hospital based heart failure programme: downgrading the risk of class IV patients

2003 ◽  
Vol 2 (1) ◽  
pp. 161
Author(s):  
E RYAN ◽  
C OLOUGHLIN ◽  
M LEDWIDGE ◽  
B TRAVERS ◽  
M RYDER ◽  
...  
Keyword(s):  
Heart Failure ◽  
Term Benefit ◽  
Class Iv

scholarly journals In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver

2021 ◽  
Vol 22 (14) ◽  
pp. 7502
Author(s):  
Shelby L. Oke ◽  
Kendrick Lee ◽  
Rosemary Papp ◽  
Steven R. Laviolette ◽  
Daniel B. Hardy
Keyword(s):  
Mitochondrial Dysfunction ◽  
Animal Studies ◽  
Weight Ratio ◽  
Wistar Rat ◽  
Hepatic Function ◽  
Fetal Life ◽  
Adult Rat ◽  
Catch Up ◽  
By Catch

The rates of gestational cannabis use have increased despite limited evidence for its safety in fetal life. Recent animal studies demonstrate that prenatal exposure to Δ9-tetrahydrocannabinol (Δ9-THC, the psychoactive component of cannabis) promotes intrauterine growth restriction (IUGR), culminating in postnatal metabolic deficits. Given IUGR is associated with impaired hepatic function, we hypothesized that Δ9-THC offspring would exhibit hepatic dyslipidemia. Pregnant Wistar rat dams received daily injections of vehicular control or 3 mg/kg Δ9-THC i.p. from embryonic day (E) 6.5 through E22. Exposure to Δ9-THC decreased the liver to body weight ratio at birth, followed by catch-up growth by three weeks of age. At six months, Δ9-THC-exposed male offspring exhibited increased visceral adiposity and higher hepatic triglycerides. This was instigated by augmented expression of enzymes involved in triglyceride synthesis (ACCα, SCD, FABP1, and DGAT2) at three weeks. Furthermore, the expression of hepatic DGAT1/DGAT2 was sustained at six months, concomitant with mitochondrial dysfunction (i.e., elevated p66shc) and oxidative stress. Interestingly, decreases in miR-203a-3p and miR-29a/b/c, both implicated in dyslipidemia, were also observed in these Δ9-THC-exposed offspring. Collectively, these findings indicate that prenatal Δ9-THC exposure results in long-term dyslipidemia associated with enhanced hepatic lipogenesis. This is attributed by mitochondrial dysfunction and epigenetic mechanisms.

scholarly journals Influence of Intermittent Parathyroid Hormone (PTH) Administration on the Outcomes of Orthodontic Tooth Movement—A Systematic Review

2021 ◽  
Vol 11 (11) ◽  
pp. 5268
Author(s):  
Zohaib Khurshid ◽  
Faris Yahya Asiri
Keyword(s):  
Parathyroid Hormone ◽  
Animal Studies ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Inclusion Criteria ◽  
Medical Subject Headings ◽  
Periodontal Tissues ◽  
Minimal Bias ◽  
Intermittent Pth

Objective: The aim of this review is to summarize the effects of local and systemic PTH administration on periodontal tissues during orthodontic tooth movement. Materials and methods: An electronic search was conducted on the following databases: PubMed/MEDLINE, Google Scholar, SCOPUS and Embase. On PubMed/MEDLINE, the Medical Subject Headings (MeSH) keywords used were: “orthodontic tooth movement” OR (“tooth” (All Fields) AND “tooth movement” (All Fields)) OR “tooth movement” (All Fields)) AND (“parathyroid hormone”); all studies included using CONSORT. Results: After elimination of duplicates and articles not meeting our inclusion criteria, seven animal studies were included in this review. Although the majority of the studies suggest that PTH may a have a favorable outcome on OTM, most studies were found to have several sources of bias. Conclusion: Animal studies with minimal bias and long-term clinical studies are needed to ascertain the efficacy of intermittent PTH administration in improving the rate and retention of OTM.

scholarly journals Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine

2021 ◽  
Vol 14 (4) ◽  
pp. e242495
Author(s):  
Nagara Takao ◽  
Toshiya Murai ◽  
Hironobu Fujiwara
Keyword(s):  
Animal Studies ◽  
Significant Proportion ◽  
Antipsychotic Treatment ◽  
High Dose ◽  
Receptor Density ◽  
Treatment Resistant ◽  
Psychomotor Activity ◽  
Receptor Blockers ◽  
Dopamine Supersensitivity

Dopamine supersensitivity psychosis (DSP) frequently arises with long-term antipsychotic treatment and accounts for a significant proportion of treatment-resistant schizophrenia. The mechanism underlying DSP is thought to be a compensatory increase in dopamine receptor density in the striatum caused by long-term antipsychotic treatment. Previous animal studies have reported that antipsychotics increase serotonin 5-HT2A receptor density in the striatum and that 5-HT2A receptor blockers suppress dopamine-sensitive psychomotor activity, which may be linked to the pathophysiology of DSP. In this paper, we describe a patient who was hospitalised with treatment-resistant schizophrenia. Following treatment with high-dose antipsychotic polypharmacy for 10 weeks, the patient experienced worsening of psychotic and extrapyramidal symptoms. The patient was then started on second-generation antipsychotic asenapine while other antipsychotics were tapered off, resulting in improvement of these symptoms. Retrospectively, we presumed that the high-dose antipsychotic polypharmacy caused DSP, which was effectively treated by the potent 5-HT2A receptor antagonism of asenapine.

scholarly journals Multiple Sclerosis Treated with Antithymocyte Globulin — A Five Year Follow-Up

1978 ◽  
Vol 5 (2) ◽  
pp. 175-178 ◽  
Author(s):  
L.F. Kastrukoff ◽  
D.R. McLean ◽  
T.A. McPherson
Keyword(s):  
Multiple Sclerosis ◽  
Total Protein ◽  
Antithymocyte Globulin ◽  
Gamma Globulin ◽  
Multiple Sclerosis Patients ◽  
Term Benefit

SUMMARY:Multiple sclerosis patients treated with antithymocyte globulin (ATG) were re-evaluated after five years. No long term benefit was found. Notably, the group of patients with an elevated gamma globulin to total protein ration in their C.S.F. and who did particularly well after treatment with ATG also failed to show any long term benefit. Few long term detrimental effects of ATG immunosuppression were identified. The implications of the results are discussed as they relate to the use of immunosuppression in multiple sclerosis.

scholarly journals American Engineering Doctoral Enrollments

2015 ◽  
pp. 23-24
Author(s):  
Richard Skinner
Keyword(s):  
Higher Education ◽  
United States ◽  
International Education ◽  
Doctoral Programs ◽  
The United States ◽  
American Higher Education ◽  
Long Term Trends

International education has deep historical roots and has spurred relationships that persist for decades. In the case of the United States and the field of engineering, American dependence since the mid-1960s on other countries' students – especially Indian ones – for enrollments and graduates of engineering doctoral programs has been, is and will likely continue to be significant. But long-term trends portend a time when the appeal of American higher education may be less than has been the case.

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