Age and Gender Dependence of Maximum Forced Expiratory Tracheal Collapse in Healthy Subjects.

Abstract Background There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). We asked whether the reference ranges for CT levels were age- and gender-dependent in the serum of a pediatric cohort. Methods A total of 6090 serum samples of 2639 subjects of the LIFE-Child cohort aged between 1 month and 17.9 years were analyzed by the CT electrochemiluminescence immunoassay (ECLIA). Reference intervals were estimated using the LMS method. For clinical validation the serum of 28 patients (61 samples) with MEN 2 and 106 patients (136 samples) with thyroid diseases were analyzed. Results CT levels showed a clear age- and gender-dependence with significantly higher values in boys (p<0.01). An accelerated decline of CT levels from newborn to children at the age of 4 and 5 years was observed for both sexes. A cure for MTC was demonstrated in 71% of MEN 2 patients after thyroidectomy, whereas 5 patients remained suspicious for micrometastasis or relapse. Only 1.5% of our patients with thyroid diseases revealed increased CT levels. Conclusions This is the largest study to establish novel pediatric reference ranges from the CT values of healthy subjects. It allows a precise laboratory monitoring of CT in pediatric patients with MEN 2. Thyroid diseases did not have a relevant influence on CT levels in our pediatric cohort.

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Reference interval by the indirect approach of serum thyrotropin (TSH) in a Mediterranean adult population and the association with age and gender

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2018-0957 ◽

2019 ◽

Vol 57 (10) ◽

pp. 1587-1594 ◽

Cited By ~ 7

Author(s):

Bruna Lo Sasso ◽

Matteo Vidali ◽

Concetta Scazzone ◽

Luisa Agnello ◽

Marcello Ciaccio

Keyword(s):

Healthy Subjects ◽

Indirect Method ◽

Adult Population ◽

Reference Interval ◽

University Hospital ◽

Thyroid Peroxidase ◽

Free Triiodothyronine ◽

Age And Gender ◽

And Gender ◽

Effect Of Age

Abstract Background The serum concentration of thyrotropin (TSH) represents a first-line test in diagnostic algorithms. The estimation of TSH reference intervals (RIs) is still a matter of debate due to the high prevalence of subclinical disease making difficult the definition of truly healthy subjects. The aim of this study was to estimate TSH RIs in healthy subjects and to evaluate the effect of age and gender on TSH concentration. Methods Forty-four thousand one hundred and fifty-six TSH data were collected between July 2012 and April 2018 at the Department of Laboratory Medicine, University-Hospital, Palermo. Common and sex-specific RIs were estimated by Arzideh’s indirect method after exclusion of individuals younger than 15 years, subjects with repeated TSH tests and with abnormal free thyroxine (fT4), free triiodothyronine (fT3) or anti-thyroid-peroxidase antibodies. The combined effect of age and gender on TSH values was evaluated. Results RIs estimated in the selected individuals (n = 22602) were, respectively, 0.18–3.54 mIU/L (general), 0.19–3.23 mIU/L (men) and 0.18–3.94 mIU/L (women). Women showed significantly higher median TSH than men (1.46 vs. 1.39 mIU/L; p < 0.0001). Both in men and in women, median TSH decreased along with age; however, although up to 60 years in both men and women showed similar values, afterwards women showed constantly higher TSH than men. Accordingly, statistical analysis showed a significant interaction between gender and age (p = 0.001), suggesting that the effect of age on TSH is different between genders. Conclusions Our findings suggest that the indirect method, with appropriate cleaning of data, could be useful to define TSH RIs.

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4D flow MRI of the aorta demonstrates age- and gender-related differences in aortic size and blood flow velocity in healthy subjects

Journal of Cardiovascular Magnetic Resonance ◽

10.1186/1532-429x-17-s1-p39 ◽

2015 ◽

Vol 17 (S1) ◽

Cited By ~ 2

Author(s):

Julio Garcia ◽

Kelly B Jarvis ◽

Susanne Schnell ◽

SC Malaisrie ◽

Colleen Clennon ◽

...

Keyword(s):

Blood Flow ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Healthy Subjects ◽

4D Flow Mri ◽

4D Flow ◽

Age And Gender ◽

Flow Mri ◽

And Gender ◽

Aortic Size

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Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.41.7.1562 ◽

1997 ◽

Vol 41 (7) ◽

pp. 1562-1565 ◽

Cited By ~ 55

Author(s):

S C Chien ◽

A T Chow ◽

J Natarajan ◽

R R Williams ◽

F A Wong ◽

...

Keyword(s):

Renal Function ◽

Healthy Subjects ◽

Age Groups ◽

The Elderly ◽

Gender Effects ◽

Pharmacokinetic Parameters ◽

Age And Gender ◽

Male And Female ◽

Young Males ◽

And Gender

The influence of age and gender on the pharmacokinetics of levofloxacin in healthy subjects receiving a single oral 500-mg dose of levofloxacin was investigated in this parallel design study. Six young males (aged 18 to 40 years), six elderly males (aged > or = 65 years), six young females (aged 18 to 40 years), and six elderly females (aged > or = 65 years) were enrolled and completed the study. The study reveals that the bioavailability (rate and extent) of levofloxacin was not affected by either age or gender. In both age (young and elderly) and gender (male and female) groups of subjects, peak concentrations in plasma were reached at approximately 1.5 h after dosing; renal clearance of levofloxacin accounted for approximately 77% of total body clearance, and approximately 76% of the administered dose was recovered unchanged in urine over the 36 h of collection. The apparent differences in the calculated pharmacokinetic parameters for levofloxacin between the age groups (young versus elderly) and between the gender groups (males versus females) could be explained by differences in renal function among the subjects. A single dose of 500 mg of levofloxacin administered orally to both young and old, male and female healthy subjects was found to be safe and well tolerated. As the differences in levofloxacin kinetics between the young and the elderly or the males and the females are limited and are mainly related to the renal function of the subjects, dose adjustment based on age or gender alone is not necessary.

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Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History

Disease Markers ◽

10.1155/2020/8393075 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Haiting Wu ◽

Xiaoyan Wang ◽

Zhe Yang ◽

Qing Zhao ◽

Yubing Wen ◽

...

Keyword(s):

Iga Nephropathy ◽

Healthy Subjects ◽

Sandwich Elisa ◽

Clinical Manifestations ◽

Serum Levels ◽

Healthy Individuals ◽

Oxford Classification ◽

Age And Gender ◽

Capture Antibody ◽

And Gender

Purpose. CD89 (FcαRI), the receptor of IgA, can shed from cells to form complexes with IgA in serum and is supposed to participate in the pathogenesis of IgA nephropathy (IgAN). There are contradictory results on their utility in clinical practice. This study is aimed at investigating whether sCD89-IgA complexes can help in the diagnosis or evaluation of the disease. Methods. A sandwich ELISA was established using anti-CD89 as a capture antibody and HRP-conjugated anti-IgA as a detection antibody. This method was used to measure serum levels of sCD89-IgA complexes in IgAN patients without immunosuppressant history and healthy subjects. Correlations between serum levels of sCD89-IgA complexes and disease severity were analyzed. Results. Serum sCD89-IgA complexes increased with age (P<0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals (P<0.001). Serum sCD89-IgAN significantly predicted IgAN diagnosis (AUC = 0.762 (0.640-0.883), P<0.001). But sCD89-IgA complexes did not correlate with baseline clinical manifestations, oxford classification, or renal function deteriorate speed. Conclusions. Serum sCD89-IgA complexes can guide diagnosis of IgAN in patients without immunosuppressant history, but provide limited help in clinicopathologic prediction.

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Voxel-based analysis of whole-brain effects of age and gender on dopamine transporter SPECT imaging in healthy subjects

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-012-2207-8 ◽

2012 ◽

Vol 39 (11) ◽

pp. 1778-1783 ◽

Cited By ~ 32

Author(s):

Alexandre Eusebio ◽

Jean-Philippe Azulay ◽

Mathieu Ceccaldi ◽

Nadine Girard ◽

Olivier Mundler ◽

...

Keyword(s):

Dopamine Transporter ◽

Healthy Subjects ◽

Spect Imaging ◽

Age And Gender ◽

Whole Brain ◽

And Gender

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Central and cerebrovascular effects of leg crossing in humans with sympathetic failure

Clinical Science ◽

10.1042/cs20090038 ◽

2010 ◽

Vol 118 (9) ◽

pp. 573-581 ◽

Cited By ~ 11

Author(s):

Mark P.M. Harms ◽

Wouter Wieling ◽

Willy N.J.M. Colier ◽

Jacques W.M. Lenders ◽

Niels H. Secher ◽

...

Keyword(s):

Arterial Pressure ◽

Healthy Subjects ◽

Cerebral Perfusion ◽

Peripheral Resistance ◽

Transcranial Doppler Ultrasound ◽

Blood Velocity ◽

Healthy Controls ◽

Age And Gender ◽

And Gender ◽

The Relationship

Leg crossing increases arterial pressure and combats symptomatic orthostatic hypotension in patients with sympathetic failure. This study compared the central and cerebrovascular effects of leg crossing in patients with sympathetic failure and healthy controls. We addressed the relationship between MCA Vmean (middle cerebral artery blood velocity; using transcranial Doppler ultrasound), frontal lobe oxygenation [O2Hb (oxyhaemoglobin)] and MAP (mean arterial pressure), CO (cardiac output) and TPR (total peripheral resistance) in six patients (aged 37–67 years; three women) and age- and gender-matched controls during leg crossing. In the patients, leg crossing increased MAP from 58 (42–79) to 72 (52–89) compared with 84 (70–95) to 90 (74–94) mmHg in the controls. MCA Vmean increased from 55 (38–77) to 63 (45–80) and from 56 (46–77) to 64 (46–80) cm/s respectively (P<0.05), with a larger rise in O2Hb [1.12 (0.52–3.27)] in the patients compared with the controls [0.83 (−0.11 to 2.04) μmol/l]. In the control subjects, CO increased 11% (P<0.05) with no change in TPR. By contrast, in the patients, CO increased 9% (P<0.05), but also TPR increased by 13% (P<0.05). In conclusion, leg crossing improves cerebral perfusion and oxygenation both in patients with sympathetic failure and in healthy subjects. However, in healthy subjects, cerebral perfusion and oxygenation were improved by a rise in CO without significant changes in TPR or MAP, whereas in patients with sympathetic failure, cerebral perfusion and oxygenation were improved through a rise in MAP due to increments in both CO and TPR.

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