scholarly journals Differential Expression of the Whole Blood Transcriptome in Pediatric Septic Shock

2020 ◽  
Author(s):  
J. Yang ◽  
K. Gala ◽  
K. Wong ◽  
R. Janarthanam ◽  
M. Zinter ◽  
...  
Keyword(s):  
Septic Shock ◽  
Differential Expression ◽  
Whole Blood ◽  
Blood Transcriptome

scholarly journals A sepsis gene expression signature in the whole blood.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Gene Expression ◽  
Septic Shock ◽  
Differential Expression ◽  
Whole Blood ◽  
Clinical Relevance ◽  
Gene Expression Signature ◽  
Infectious Agent ◽  
Gene Signature ◽  
Sepsis And Septic Shock ◽  
Microarray Datasets

Sepsis is a leading cause of mortality (1). We mined published and public microarray datasets (2, 3) to identify differentially expressed genes in the whole blood of patients with sepsis. We observed significant changes in the expression of 78 genes in patients with sepsis and septic shock. Differential expression of these genes was associated with the septic state (independent of infectious agent) and observed in children and adults. The identification of these genes may be useful in the understanding of the biology of sepsis; this gene signature, upon validation, could have clinical relevance as a diagnostic measure.

scholarly journals Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma

2012 ◽  
Vol 31 (1) ◽  
pp. 76 ◽  
Author(s):  
Adel M Zaatar ◽  
Chun Lim ◽  
Chin Bong ◽  
Michelle Mei Lee ◽  
Jian Ooi ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Treatment Response ◽  
Whole Blood ◽  
Blood Transcriptome

scholarly journals Differential expression of miRNAs in acute myeloid leukemia quantified by Nextgen sequencing of whole blood samples

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213078 ◽  
Author(s):  
Aakriti Pandita ◽  
Poornima Ramadas ◽  
Aarati Poudel ◽  
Nibal Saad ◽  
Ankit Anand ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Differential Expression ◽  
Whole Blood ◽  
Myeloid Leukemia ◽  
Blood Samples ◽  
Nextgen Sequencing ◽  
Whole Blood Samples ◽  
Acute Myeloid

Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity

2020 ◽  
Author(s):  
Abel Plaza-Florido ◽  
Signe Altmäe ◽  
Francisco J. Esteban ◽  
Cristina Cadenas-Sanchez ◽  
Concepción M. Aguilera ◽  
...  
Keyword(s):  
Whole Blood ◽  
Transcriptome Profile ◽  
Blood Transcriptome

scholarly journals WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice

2017 ◽  
Vol 1 (16) ◽  
pp. 1274-1286 ◽  
Author(s):  
Marcela Gatica-Andrades ◽  
Dimitrios Vagenas ◽  
Jessica Kling ◽  
Tam T. K. Nguyen ◽  
Helen Benham ◽  
...  
Keyword(s):  
Septic Shock ◽  
Immune Response ◽  
Mouse Model ◽  
Differential Expression ◽  
Inflammatory Cytokines ◽  
Key Points ◽  
Wnt Ligands ◽  
Pro Inflammatory Cytokines

Key Points Differential expression of WNT ligands in patients with septic shock and a mouse model of endotoxemia correlates with inflammatory cytokines. WNT ligands and WNT/β-catenin signaling positively regulate lipopolysaccharide-induced pro-inflammatory cytokines without impairing IL-10.

scholarly journals Changes in Whole Blood Transcriptome during Peanut-Induced Anaphylaxis and Correlation with Symptoms

2019 ◽  
Vol 143 (2) ◽  
pp. AB423
Author(s):  
Paul J. Turner ◽  
Nandinee Patel ◽  
Monica Ruiz-Garcia ◽  
Isabel J. Skypala ◽  
Stephen R. Durham ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Transcriptome
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